American journal of respiratory and critical care medicine最新文献

{"title":"CFTR Modulators for the Treatment of COPD: The Jury Is Still Out!","authors":"Lucile Regard, Pierre-Régis Burgel","doi":"10.1164/rccm.202409-1878ED","DOIUrl":"https://doi.org/10.1164/rccm.202409-1878ED","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery and Validation of a Volatile Signature of Eosinophilic Airway Inflammation in Asthma.","authors":"Rosa Peltrini, Rebecca L Cordell, Michael Wilde, Shahd Abuhelal, Eleanor Quek, Nazanin Zounemat-Kermani, Wadah Ibrahim, Matthew Richardson, Paul Brinkman, Florence Schleich, Pierre-Hugues Stefanuto, Hnin Aung, Neil Greening, Sven Erik Dahlen, Ratko Djukanovic, Ian M Adcock, Christopher Brightling, Paul Monks, Salman Siddiqui","doi":"10.1164/rccm.202310-1759OC","DOIUrl":"10.1164/rccm.202310-1759OC","url":null,"abstract":"<p><p><b>Rationale:</b> Volatile organic compounds (VOCs) in asthmatic breath may be associated with sputum eosinophilia. We developed a volatile biomarker signature to predict sputum eosinophilia in asthma. <b>Methods:</b> VOCs emitted into the space above sputum samples (headspace) from patients with severe asthma (<i>n</i> = 36) were collected onto sorbent tubes and analyzed using thermal desorption gas chromatography-mass spectrometry (GC-MS). Elastic net regression identified stable VOCs associated with sputum eosinophilia ⩾ 3% and generated a volatile biomarker signature. This VOC signature was validated in breath samples from: <i>1</i>) patients with acute asthma according to blood eosinophilia ⩾0.3 × 10⁹cells/L or sputum eosinophilia of ⩾3% in the UK EMBER (East Midlands Breathomics Pathology Node) consortium (<i>n</i> = 65) and <i>2</i>) U-BIOPRED-IMI (Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes Innovative Medicines Initiative) consortium (<i>n</i> = 42). Breath samples were collected onto sorbent tubes (EMBER) or Tedlar bags (U-BIOPRED) and analyzed by GC-MS (GC × GC-MS for EMBER or GC-MS for U-BIOPRED). <b>Measurements and Main Results:</b> The <i>in vitro</i> headspace identified 19 VOCs associated with sputum eosinophilia, and the derived VOC signature yielded good diagnostic accuracy for sputum eosinophilia ⩾3% in headspace (area under the receiver operating characteristic curve [AUROC] 0.90; 95% confidence interval [CI], 0.80-0.99; <i>P</i> < 0.0001), correlated inversely with sputum eosinophil percentage (<i>r</i>_s = -0.71; <i>P</i> < 0.0001), and outperformed fractional exhaled nitric oxide (AUROC 0.61; 95% CI, 0.35-0.86). Analysis of exhaled breath in replication cohorts yielded a VOC signature AUROC (95% CI) for acute asthma exacerbations of 0.89 (0.76-1.0) (EMBER cohort) with sputum eosinophilia and 0.90 (0.75-1.0) in U-BIOPRED, again outperforming fractional exhaled nitric oxide in U-BIOPRED (0.62 [0.33-0.90]). <b>Conclusions:</b> We have discovered and provided early-stage clinical validation of a volatile biomarker signature associated with eosinophilic airway inflammation. Further work is needed to translate our discovery using point-of-care clinical sensors.</p>","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1101-1112"},"PeriodicalIF":19.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11544360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141183493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suction Thrombectomy and Pulmonary Artery Stenting for Pulmonary Embolism in a Single Lung Transplant.","authors":"Jason Katz, Daniel Schimmel, Marysa Leya, Alan Betensley, Mrinalini Subramani, Catherine Myers, Rade Tomic, Chitaru Kurihara, Ambalavanan Arunachalam","doi":"10.1164/rccm.202401-0235IM","DOIUrl":"10.1164/rccm.202401-0235IM","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"e12-e13"},"PeriodicalIF":19.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141282749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging the Intersection of Parenchymal Abnormalities and Pulmonary Vascular Pathways.","authors":"Rebecca R Vanderpool","doi":"10.1164/rccm.202406-1109ED","DOIUrl":"10.1164/rccm.202406-1109ED","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1075-1077"},"PeriodicalIF":19.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11544368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual Cause of Hypoxemia during Pregnancy: New Diagnosis of Pulmonary Arteriovenous Malformations.","authors":"Lu Chen, Kui Li, Hong Wen","doi":"10.1164/rccm.202402-0271IM","DOIUrl":"10.1164/rccm.202402-0271IM","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1152-1154"},"PeriodicalIF":19.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11544354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141282751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Evaluation and Subgroup Evaluation of Cough Severity in Fibrotic Interstitial Lung Disease.","authors":"Yet H Khor, Christopher J Ryerson","doi":"10.1164/rccm.202405-1075LE","DOIUrl":"10.1164/rccm.202405-1075LE","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1166-1168"},"PeriodicalIF":19.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11544366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcoidosis Immunodiagnostic Test Detects IgG Antibodies against Unique Antigenic Epitopes.","authors":"Lobelia Samavati, Jaya Talreja, Changya Peng","doi":"10.1164/rccm.202406-1235LE","DOIUrl":"10.1164/rccm.202406-1235LE","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1165-1166"},"PeriodicalIF":19.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11544355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141791689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Yoshihiro and Taito: True Effect of Fludrocortisone for Septic Shock: Baseline Risk and Transitivity Concerns.","authors":"Bijan Teja","doi":"10.1164/rccm.202407-1437LE","DOIUrl":"10.1164/rccm.202407-1437LE","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1162-1163"},"PeriodicalIF":19.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11544362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward Realistic Longitudinal Monitoring of Structure-Function in Smokers.","authors":"Sylvia Verbanck, Eef Vanderhelst","doi":"10.1164/rccm.202405-1071LE","DOIUrl":"10.1164/rccm.202405-1071LE","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1163-1164"},"PeriodicalIF":19.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11544358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-Dose Morphine Does Not Cause Sleepiness in Chronic Obstructive Pulmonary Disease: A Secondary Analysis of a Randomized Clinical Trial.","authors":"Thomas J Altree, Barbara Toson, Kelly A Loffler, Magnus Ekström, David C Currow, Danny J Eckert","doi":"10.1164/rccm.202310-1780OC","DOIUrl":"10.1164/rccm.202310-1780OC","url":null,"abstract":"<p><p><b>Rationale:</b> Regular, low-dose, sustained-release morphine is frequently prescribed for persistent breathlessness in chronic obstructive pulmonary disease (COPD). However, effects on daytime sleepiness, perceived sleep quality, and daytime function have not been rigorously investigated. <b>Objectives:</b> We sought to determine the effects of regular, low-dose, sustained-release morphine on sleep parameters in COPD. <b>Methods:</b> We conducted prespecified secondary analyses of validated sleep questionnaire data from a randomized trial of daily, low-dose, sustained-release morphine versus placebo over 4 weeks commencing at 8 or 16 mg/d with blinded up-titration over 2 weeks to a maximum of 32 mg/d. Primary outcomes for these analyses were Week-1 Epworth Sleepiness Scale (ESS) and Karolinska Sleepiness Scale (KSS) scores on morphine versus placebo. Secondary outcomes included Leeds Sleep Evaluation Questionnaire scores (end of Weeks 1 and 4), KSS and ESS scores beyond Week 1, and associations between breathlessness, morphine, and questionnaire scores. <b>Measurements and Main Results:</b> One hundred fifty-six people were randomized. Week-1 sleepiness scores were not different on morphine versus placebo (ΔESS [95% confidence interval] versus placebo: 8-mg group, -0.59 [-1.99, 0.81], <i>P</i> = 0.41; 16-mg group, -0.72 [-2.33, 0.9], <i>P</i> = 0.38; ΔKSS vs. placebo, 8-mg group: 0.11 [-0.7, 0.9], <i>P</i> = 0.78; 16-mg group, -0.41 [-1.31, 0.49], <i>P</i> = 0.37). This neutral effect persisted at later time points. In addition, participants who reported reduced breathlessness with morphine at 4 weeks also showed improvement in LSEQ domain scores including perceived sleep quality and daytime function. <b>Conclusions:</b> Regular, low-dose morphine does not worsen sleepiness when used for breathlessness in COPD. Individual improvements in breathlessness with morphine may be related to improvements in sleep. Clinical trial registered with www.clinicaltrials.gov (NCT02720822).</p>","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1113-1122"},"PeriodicalIF":19.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140108760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}