American journal of respiratory and critical care medicine最新文献_第7页

Diagnosing Pulmonary Tumor Thrombotic Microangiopathy Using Pulmonary Microvascular Cytology. 应用肺微血管细胞学诊断肺肿瘤血栓性微血管病。

IF 24.7 1区医学

American journal of respiratory and critical care medicine Pub Date : 2025-09-10 DOI: 10.1164/rccm.202504-1024im

Ghislain le Camus,Carole Fleury,Julien Schmidt,Adrien Picod

引用次数: 0

Oxygenation Targets and Long-Term Cognitive and Pulmonary Functions in Hypoxemic Respiratory Failure. 低氧性呼吸衰竭的氧合目标与长期认知和肺功能。

IF 24.7 1区医学

American journal of respiratory and critical care medicine Pub Date : 2025-09-08 DOI: 10.1164/rccm.202412-2499oc

Elena Crescioli,Thomas L Klitgaard,Jens Ø Riis,Ulla M Weinreich,Jens-Ulrik S Jensen,Stine R Vestergaard,Anne-Marie G Bunzel,Anne Sofie B Eriksen,Simon H Gudbjerg,Lone M Poulsen,Anne C Brøchner,Camilla B Mortensen,Trine Haberlandt,Christian N Meyer,Lone Braagaard,Jann Mortensen,Theis Lange,Anders Perner,Olav L Schjørring,Bodil S Rasmussen

{"title":"Oxygenation Targets and Long-Term Cognitive and Pulmonary Functions in Hypoxemic Respiratory Failure.","authors":"Elena Crescioli,Thomas L Klitgaard,Jens Ø Riis,Ulla M Weinreich,Jens-Ulrik S Jensen,Stine R Vestergaard,Anne-Marie G Bunzel,Anne Sofie B Eriksen,Simon H Gudbjerg,Lone M Poulsen,Anne C Brøchner,Camilla B Mortensen,Trine Haberlandt,Christian N Meyer,Lone Braagaard,Jann Mortensen,Theis Lange,Anders Perner,Olav L Schjørring,Bodil S Rasmussen","doi":"10.1164/rccm.202412-2499oc","DOIUrl":"https://doi.org/10.1164/rccm.202412-2499oc","url":null,"abstract":"RATIONALEIn intensive care unit (ICU) patients lower oxygenation targets may impair long-term cognitive function, while higher targets may impair long-term pulmonary function.OBJECTIVESTo assess the effects of a partial pressure of arterial oxygen (PaO2) target of 60 vs 90 mmHg on one-year cognitive and pulmonary functions in ICU survivors of acute hypoxemic respiratory failure.METHODS3654 patients were randomized in the Handling Oxygenation Targets in the ICU and the Handling Oxygenation Targets in COVID-19 trials: 1916 (52.4%) survived at one year, and 1244 (64.9% of survivors) were eligible. We assessed two preplanned one-year outcomes: cognitive function, measured using the global score of the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and pulmonary function, evaluated as the percentage of predicted diffusion capacity for carbon monoxide (DLCO).MEASUREMENTS AND MAIN RESULTS417/1244 (33.5%) eligible survivors were included, representing 11.4% of the original trial population. Global RBANS score was obtained in 187 survivors in the lower-oxygenation group (mean 78 [standard deviation (SD) 19]) and 188 in the higher-oxygenation group (mean 76 [SD 21]) (adjusted mean difference (MD): 2, 95% confidence interval (CI) -2 to 6). DLCO was measured in 192 survivors in the lower-oxygenation group (mean 68% [SD 22 %-points] and 195 in the higher-oxygenation group (mean 73% [SD 25 %-points]) (adjusted MD: -5 %-points, 95% CI -9 to -1 %-points).CONCLUSIONSA PaO2 target of 60 vs 90 mmHg in ICU appeared to result in similar cognitive impairment but might reduce pulmonary diffusion capacity in ICU survivors of hypoxemic respiratory failure included in this one-year follow-up.","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"56 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cystic Fibrosis: Huge Gains, but Still a Work in Progress. 囊性纤维化：巨大的进步，但仍在进行中。

IF 24.7 1区医学

American journal of respiratory and critical care medicine Pub Date : 2025-09-08 DOI: 10.1164/rccm.202508-1983ed

Andrew Bush,Bonnie W Ramsey

引用次数: 0

To B or Not to B: Germinal Center Responses in Progressive Fibrotic ILD. B或不B：进展性纤维化ILD的生发中心反应。

IF 24.7 1区医学

American journal of respiratory and critical care medicine Pub Date : 2025-09-08 DOI: 10.1164/rccm.202508-1969ed

Ashten Sherman,Benjamin D Medoff,Josalyn L Cho

引用次数: 0

Randomized Sham Controlled Trial of Targeted Lung Denervation in Patients with COPD (AIRFLOW-3). COPD患者靶向肺去神经的随机假对照试验（AIRFLOW-3）。

IF 24.7 1区医学

American journal of respiratory and critical care medicine Pub Date : 2025-09-08 DOI: 10.1164/rccm.202502-0404oc

Pallav L Shah,Dirk-Jan Slebos,Richard Sue,Surya P Bhatt,Christian Ghattas,Charlie Strange,Bruno Degano,Arschang Valipour,Stephan Eisenmann,Jose De Cardenas,Charles-Hugo Marquette,Jose Soto-Soto,Frank C Sciurba,Francesca Conway,James Tonkin,Anand Tana,Nathaniel Marchetti,Jorine E Hartman,Valentin Heluain,Nicolas Guibert,Gerard J Criner,

{"title":"Randomized Sham Controlled Trial of Targeted Lung Denervation in Patients with COPD (AIRFLOW-3).","authors":"Pallav L Shah,Dirk-Jan Slebos,Richard Sue,Surya P Bhatt,Christian Ghattas,Charlie Strange,Bruno Degano,Arschang Valipour,Stephan Eisenmann,Jose De Cardenas,Charles-Hugo Marquette,Jose Soto-Soto,Frank C Sciurba,Francesca Conway,James Tonkin,Anand Tana,Nathaniel Marchetti,Jorine E Hartman,Valentin Heluain,Nicolas Guibert,Gerard J Criner, ","doi":"10.1164/rccm.202502-0404oc","DOIUrl":"https://doi.org/10.1164/rccm.202502-0404oc","url":null,"abstract":"RATIONALEAIRFLOW-3 was a 1:1 randomized, double blind, sham controlled trial of the d'Nerva Targeted Lung Denervation (TLD) System in patients with COPD.OBJECTIVEEvaluate the impact of TLD on COPD exacerbations compared to optimal medical treatment.METHODSAIRFLOW-3 patients were symptomatic (CAT ≥10) with moderate to very severe airflow obstruction (25% ≤ FEV1 ≤ 80% predicted) and GOLD E status (≥2 moderate or ≥1 severe exacerbation over prior 12 months). The primary endpoint was comparison of time-to-first moderate or severe COPD exacerbation through 12 months between the Treatment (TLD + optimal medical treatment) and Sham Control groups (sham procedure + optimal medical treatment). Secondary endpoints included rate of severe COPD exacerbations, change in quality of life (SGRQ-C and SF-36), change in lung function (FVC, FEV1, RV), and change in CAT.MEASUREMENTS AND MAIN RESULTS388 patients were randomized 1:1 at 32 sites. There was no difference between TLD compared to sham treatment in probability of participants having a moderate or severe COPD exacerbation, HR 1.268 (95% CI, 0.988 to 1.628). At 1 year, the TLD group had less dyspnea (> 1 point improvement in TDI 35.4 vs 24.1%, p 0.021) compared to sham. Post-hoc analyses revealed that failure to reach the primary endpoint was driven by an insufficient number of patients exhibiting an airway-predominant phenotype (lung hyperinflation without significant emphysema).CONCLUSIONSAIRFLOW-3 failed to meet its primary endpoint. However, post-hoc analyses identified a responder profile; a prospective multicenter randomized controlled trial is being designed to confirm these findings.","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"47 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First Multimodal EIT-PET/CT Evidence Linking Regional Airway Obstruction to Aerosol Distribution. 首个多模态EIT-PET/CT证据表明区域性气道阻塞与气溶胶分布有关。

IF 24.7 1区医学

American journal of respiratory and critical care medicine Pub Date : 2025-09-08 DOI: 10.1164/rccm.202504-0873im

Lin-Ling Cheng,Zi-Hao Liu,Xin-Lu Wang,Yuqiao Peng,Mingyi Kong,Zhanqi Zhao

引用次数: 0

From Smog to Scar: Epigenetic Signatures of Air Pollution in Interstitial Lung Disease. 从烟雾到疤痕：空气污染在间质性肺病中的表观遗传特征。

IF 24.7 1区医学

American journal of respiratory and critical care medicine Pub Date : 2025-09-08 DOI: 10.1164/rccm.202505-1139ed

Iain R Konigsberg,David Warburton

引用次数: 0

A 10,000-Foot View at Survival and Treatment with PDE5 Inhibitors in Interstitial Lung Disease Pulmonary Hypertension. PDE5抑制剂治疗间质性肺疾病肺动脉高压的生存和治疗

IF 24.7 1区医学

American journal of respiratory and critical care medicine Pub Date : 2025-09-08 DOI: 10.1164/rccm.202508-1980ed

Oksana A Shlobin,Lucilla Piccari

引用次数: 0

Pulmonary Ionocytes at the Crossroads of Absorption and Secretion: Clues from the Ferret. 肺离子细胞在吸收和分泌的十字路口：来自雪貂的线索。

IF 24.7 1区医学

American journal of respiratory and critical care medicine Pub Date : 2025-09-08 DOI: 10.1164/rccm.202508-2001ed

Martina Gentzsch

引用次数: 0

Who Will Evolve from ILA to ILD? Early Radio-Proteomic Warning Signals in the Lung. 谁将从ILA发展到ILD？肺部早期放射-蛋白质组学警告信号。

IF 24.7 1区医学

American journal of respiratory and critical care medicine Pub Date : 2025-09-08 DOI: 10.1164/rccm.202508-2007ed

David J Nagel,Eleanor Valenzi

引用次数: 0