American journal of respiratory and critical care medicine最新文献

{"title":"Associations of High Attenuation Area-related Proteomic Biomarkers with Fibrotic or Subpleural Interstitial Lung Abnormalities.","authors":"John S Kim,Catherine L Debban,Daniel Guzman,Riley T Hannan,Mary Salvatore,Claire McGroder,David Zhang,Anna J Podolanczuk,Daniel A Duprez,Shwu-Fan Ma,Yong Huang,Jeffrey M Sturek,Stephen S Rich,Jerome I Rotter,Rajat Deo,Ruth F Dubin,Janelle Vu Pugashetti,Jennifer M Wang,MeiLan K Han,Justin M Oldham,Imre Noth,Prescott G Woodruff,Victor E Ortega,Julie C Fanburg-Smith,Edward B Stelow,Christopher A Moskaluk,Eric A Hoffman,Christine Kim Garcia,Russell P Bowler,Peter Ganz,R Graham Barr,Ani Manichaikul","doi":"10.1164/rccm.202503-0610oc","DOIUrl":"https://doi.org/10.1164/rccm.202503-0610oc","url":null,"abstract":"RATIONALEHigh attenuation area (HAA) is a computed tomography (CT) tool that correlates with lung inflammation and fibrosis. Systemic molecular correlates of HAA (e.g., plasma proteins) may inform biological process involved in interstitial lung disease (ILD).OBJECTIVESIdentify plasma proteins that associate with HAA and correlate with a higher probability of developing new-onset fibrotic or subpleural interstitial lung abnormalities (ILA).METHODSPlasma protein levels were measured using a semiquantitative aptamer-based platform in the Multi-Ethnic Study of Atherosclerosis (MESA, n=5486) and Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS, n=1761). Linear regression models identified HAA-associated proteins after adjustment for demographic and socioeconomic factors, CT scanner parameters, study center, and batch. Associations of HAA-related proteins with new-onset fibrotic or subpleural ILA were examined in MESA participants with ILA assessments on full-lung CT 10 years later. Immunohistochemical staining of select proteins was performed in lung tissue from pulmonary fibrosis cases.MEASUREMENTS AND MAIN RESULTSThere were 75 proteins detected that were significantly associated with HAA in MESA and SPIROMICS. Gene ontology analysis of these proteins identified processes involved in immune cell chemotaxis and cellular growth and apoptosis. Seven proteins were associated with a higher probability of new-onset fibrotic or subpleural ILA in MESA and two of these, junctional adhesion molecule-like protein and GTP cyclohydrolase 1 feedback regulatory protein, stained in areas of fibrosis in lung tissue from patients with ILD.CONCLUSIONSPlasma proteins associated with more HAA are involved in immune and cellular processes and associate with new onset fibrotic-subpleural ILA.","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"28 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological Pitfalls Undermine Industrial Emission-related Lung Cancer Risk Assessment.","authors":"Dong Zhou,Hao Wang,Zhu Xiaoli","doi":"10.1164/rccm.202506-1451le","DOIUrl":"https://doi.org/10.1164/rccm.202506-1451le","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"-1 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macrophages Are Enriched Pre- and Postnatally in Hypoplastic Lungs from Patients with Congenital Diaphragmatic Hernia.","authors":"Jan Riedel,Katinka Sturm,Christopher D Pascoe,Nicole Peukert,Ophelia Aubert,Grit Gesine Ruth Hiller,Xingbin Ai,Michael Boettcher,Jan-Hendrik Gosemann,Martin Lacher,Jelena Martinovic,Alexandra Benachi,Richard Wagner","doi":"10.1164/rccm.202501-0153rl","DOIUrl":"https://doi.org/10.1164/rccm.202501-0153rl","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"58 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Residual Scars That Grow: The Hidden Threat of Delayed Pulmonary Fibrosis Post-COVID-19.","authors":"Zuhair Ali Naqvi","doi":"10.1164/rccm.202506-1558le","DOIUrl":"https://doi.org/10.1164/rccm.202506-1558le","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"24 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Naqvi: Residual Scars That Grow: The Hidden Threat of Delayed Pulmonary Fibrosis Post-COVID-19.","authors":"Matthew R Baldwin,Christine K Garcia","doi":"10.1164/rccm.202507-1624le","DOIUrl":"https://doi.org/10.1164/rccm.202507-1624le","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"7 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oh to Be Watched Over by Machines of Loving Grace: Promise and Pitfalls of Quantitative CT in Early ILD Detection.","authors":"Joseph Jacob,Anna J Podolanczuk","doi":"10.1164/rccm.202508-1946ed","DOIUrl":"https://doi.org/10.1164/rccm.202508-1946ed","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"28 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative CT in Fibrotic Interstitial Lung Disease: Two Steps Forward on a Long Journey.","authors":"Alexander Bankier","doi":"10.1164/rccm.202508-1927ed","DOIUrl":"https://doi.org/10.1164/rccm.202508-1927ed","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"40 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diaphragmatic Flutter Causing Patient-Ventilator Dyssynchrony.","authors":"Glauco Marinho Plens, Caio César Araújo Morais, Paula Cristina Breda Colpani, Thaís Gregol, Mauro Roberto Tucci, Eduardo Leite Vieira Costa, Marcelo Britto Passos Amato","doi":"10.1164/rccm.202503-0605IM","DOIUrl":"https://doi.org/10.1164/rccm.202503-0605IM","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.4,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collagen Post-Translational Modifications Are Altered in IPF Including within ECM Receptor Binding Motifs.","authors":"Juliane Merl-Pham,Larissa Rothkirch,Leonhard Binzenhöfer,Elisabeth Hennen,Naftali Kaminski,Rudolf Hatz,Juergen Behr,Stefanie M Hauck,Anne Hilgendorff,Oliver Eickelberg,Claudia A Staab-Weijnitz","doi":"10.1164/rccm.202505-1276rl","DOIUrl":"https://doi.org/10.1164/rccm.202505-1276rl","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"708 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Starting to Connect the Dots: Sleep Disordered Breathing, Obstructive Sleep Apnea, Brain Structure, and Cognition in Children.","authors":"Ignacio E Tapia, Min-Hee Lee, Raanan Arens","doi":"10.1164/rccm.202505-1307ED","DOIUrl":"https://doi.org/10.1164/rccm.202505-1307ED","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}