American journal of respiratory and critical care medicine最新文献

{"title":"Beyond Event Frequency: Respiratory Effort Reveals Mortality Risk in Obstructive Sleep Apnea.","authors":"Nasim Montazeri, Ankit Parekh","doi":"10.1093/ajrccm/aamag452","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag452","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":21.7,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The nexus of NEXIS - underscoring the need for rehabilitation for the critically ill patient.","authors":"Michelle E Kho, Rik Gosselink","doi":"10.1093/ajrccm/aamag455","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag455","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":21.7,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bile Acid Dysregulation in PAH: Strengthening the Liver-Lung Axis in Pulmonary Vascular Disease.","authors":"Vishal N Rao, Kurt W Prins","doi":"10.1093/ajrccm/aamag454","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag454","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":21.7,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Is Hantavirus?","authors":"Shazia Jamil, Charles Dela Cruz, Jane E Gross","doi":"10.1093/ajrccm/aamag395","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag395","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":21.7,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piperacillin-Tazobactam in High WBC Patients: Promising Signal, Premature Conclusion.","authors":"Rongqiang Liao, Xiaoyuan Zheng","doi":"10.1093/ajrccm/aamag442","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag442","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":21.7,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Liao and Zheng: Piperacillin-Tazobactam in High WBC Patients: Promising Signal, Premature Conclusion.","authors":"Daniel I Rzewnicki, Rishi Chanderraj, Sivasubramanium V Bhavani","doi":"10.1093/ajrccm/aamag443","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag443","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":21.7,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dupilumab in chronic obstructive pulmonary disease: a pooled analysis of emergency department visits, hospital admissions, and systemic corticosteroid use.","authors":"Surya P Bhatt, Fernando J Martinez, Imran Satia, Antonio Anzueto, Jean Bourbeau, Alberto Papi, Stephanie Korn, Gaëtan Deslée, Changming Xia, Jigna Heble, Mena Soliman, Mona Bafadhel","doi":"10.1093/ajrccm/aamag227","DOIUrl":"10.1093/ajrccm/aamag227","url":null,"abstract":"<p><strong>Rationale: </strong>In chronic obstructive pulmonary disease (COPD), exacerbations drive morbidity, healthcare resource utilization, and mortality. Hospitalization and emergency department (ED) visits reflect acute clinical instability. Systemic corticosteroids are usually prescribed for exacerbations, but cumulative exposure is a concern.</p><p><strong>Objectives: </strong>To evaluate the effect of dupilumab on ED visits/hospital admissions and systemic corticosteroid use in patients experiencing exacerbations.</p><p><strong>Methods: </strong>BOREAS and NOTUS, two phase 3, randomized, double-blind, placebo-controlled trials, enrolled patients (40-85 years) with COPD, moderate-to-severe airflow limitation, and type 2 inflammation (screening blood eosinophil count ≥300 cells/µL). Patients received dupilumab 300 mg (N = 938) or placebo (N = 936) for 52 weeks. Systemic corticosteroid use and annualized rate and time to first ED visit/hospital admission were assessed.</p><p><strong>Measurements and main results: </strong>Dupilumab versus placebo reduced ED visits/hospital admissions of any duration by 38% (rate ratio, 0.62 [95% CI, 0.43-0.90]; P = .0121), delayed time to first event, and reduced risk of a first event by 45% (hazard ratio, 0.55 [95% CI, 0.38-0.78]; P = .0010). Compared with placebo, systemic corticosteroid use was reduced in patients treated with dupilumab who experienced severe exacerbations by 42% (rate ratio, 0.58 [95% CI, 0.38-0.89]; P = .0126) and moderate exacerbations by 28% (rate ratio, 0.72 [95% CI, 0.60-0.87]; P = .0005).</p><p><strong>Conclusions: </strong>Dupilumab reduced ED visits/hospital admissions of any duration. Patients who experienced moderate and/or severe exacerbations required fewer systemic corticosteroids with dupilumab compared with placebo.</p><p><strong>Clinical trial registration: </strong>ClinicalTrials.gov (NCT03930732, NCT04456673).</p>","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"2011-2021"},"PeriodicalIF":21.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13519320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147969574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory oscillometry in patients with chronic obstructive pulmonary disease with airway mucus plugs: insights from the ECLIPSE study.","authors":"Titilope Olanipekun, Sofia K Mettler, Nirmal Sharma, Miguel Divo, Eric Garshick, Ruben San Jose Estépar, Raul San Jose Estépar, Michael Cho, George R Washko, Alejandro A Diaz","doi":"10.1093/ajrccm/aamag244","DOIUrl":"10.1093/ajrccm/aamag244","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"2079-2082"},"PeriodicalIF":21.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13274801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148012918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astegolimab for chronic obstructive pulmonary disease with frequent exacerbations: pooled analysis of the ALIENTO and ARNASA trials.","authors":"Jadwiga A Wedzicha, Àlvar Agustí, Christopher E Brightling, Peter Calverley, James D Chalmers, Neil J Greening, MeiLan K Han, Divya Mohan, Julie Ng, Alberto Papi, Nicolas Roche, Rebecca Saenz, Katerina Samara, Ruth Tal-Singer, Claus F Vogelmeier, Xiaoying Yang, Bartolome R Celli","doi":"10.1093/ajrccm/aamag226","DOIUrl":"10.1093/ajrccm/aamag226","url":null,"abstract":"<p><strong>Rationale: </strong>The efficacy and safety of astegolimab, an anti-ST2 monoclonal antibody, was evaluated in participants with chronic obstructive pulmonary disease (COPD) and frequent exacerbations in the pivotal ALIENTO and ARNASA trials.</p><p><strong>Objectives: </strong>To report the prespecified pooled analysis of ALIENTO and ARNASA.</p><p><strong>Methods: </strong>ALIENTO and ARNASA were randomized, double-blind, placebo-controlled trials with similar designs and included participants with COPD, a history of frequent exacerbations, and current/former smoking status, irrespective of blood eosinophil count and chronic bronchitis. Participants were randomized 1:1:1 to astegolimab 476 mg every 2 weeks (Q2W), astegolimab every 4 weeks (Q4W), or placebo for 52 weeks, plus optimized maintenance therapy. The primary endpoint was annualized rate of moderate/severe exacerbations. Secondary endpoints included annualized rate of severe exacerbations. A hierarchical statistical plan was followed with hypothesis testing of secondary efficacy endpoints gated on the primary efficacy endpoint success.</p><p><strong>Measurements and main results: </strong>A total of 2682 participants were included in the pooled intent-to-treat population. Astegolimab significantly reduced the annualized rate of moderate/severe exacerbations by 15% in the Q2W arm (adjusted rate ratio, 0.85 [95% CI, 0.76-0.96]; P = .0077) and by 12% in the Q4W arm (rate ratio, 0.88 [95% CI, 0.78-0.99]; P = .0265). -A -nominally significant reduction in the annualized rate of severe COPD exacerbations (rate ratio, 0.68 [95% CI, 0.52-0.87]; P = .0028) was observed for astegolimab Q2W vs placebo. Astegolimab was well tolerated.</p><p><strong>Conclusions: </strong>Astegolimab every 2 weeks reduced the annualized rate of moderate/severe exacerbations in a clinically heterogeneous population of participants with COPD and frequent exacerbations.</p><p><strong>Clinical trial registration: </strong>ClinicalTrials.gov: NCT05037929; NCT05595642.</p>","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"2050-2060"},"PeriodicalIF":21.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13519342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147961823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary Vascular Remodeling Revealed by Spectral CT After Pulmonary Vein Stents Implantation.","authors":"Yong Luo, XueFeng Wang, Jing Chen, Yi Zhong","doi":"10.1093/ajrccm/aamag440","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag440","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":21.7,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}