American journal of respiratory and critical care medicine最新文献

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Open Up the Lung and Keep the Lung Vessels Open. 打通肺部,保持肺脉通畅
IF 19.3 1区 医学
American journal of respiratory and critical care medicine Pub Date : 2024-11-20 DOI: 10.1164/rccm.202410-1918LE
Arnoldo Santos, Ana-María Ioan, M Ignacio Monge, Fernando Suarez-Sipmann
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引用次数: 0
Quantitative Lung Ultrasound and Pediatric Critical Care: Any Excuse Not to Use It? 定量肺部超声和儿科重症监护:有什么理由不使用它?
IF 19.3 1区 医学
American journal of respiratory and critical care medicine Pub Date : 2024-11-18 DOI: 10.1164/rccm.202411-2144ED
Silvia Mongodi, Daniele De Luca
{"title":"Quantitative Lung Ultrasound and Pediatric Critical Care: Any Excuse Not to Use It?","authors":"Silvia Mongodi, Daniele De Luca","doi":"10.1164/rccm.202411-2144ED","DOIUrl":"https://doi.org/10.1164/rccm.202411-2144ED","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of Invasive Pulmonary Aspergillosis and Preventive and Empirical Therapy for Invasive Candidiasis in Adult Pulmonary and Critical Care Patients. An Official American Thoracic Society Clinical Practice Guideline. 成人肺部和重症监护患者侵袭性肺部曲霉菌病的治疗以及侵袭性念珠菌病的预防和经验疗法。美国胸科学会临床实践指南。
IF 19.3 1区 医学
American journal of respiratory and critical care medicine Pub Date : 2024-11-18 DOI: 10.1164/rccm.202410-2045ST
Oleg Epelbaum, Tina Marinelli, Qusay S Haydour, Kelly M Pennington, Scott E Evans, Eva M Carmona, Shahid Husain, Kenneth S Knox, Benjamin J Jarrett, Elie Azoulay, William W Hope, Ashley Meyer-Zilla, M Hassan Murad, Andrew H Limper, Chadi A Hage
{"title":"Treatment of Invasive Pulmonary Aspergillosis and Preventive and Empirical Therapy for Invasive Candidiasis in Adult Pulmonary and Critical Care Patients. An Official American Thoracic Society Clinical Practice Guideline.","authors":"Oleg Epelbaum, Tina Marinelli, Qusay S Haydour, Kelly M Pennington, Scott E Evans, Eva M Carmona, Shahid Husain, Kenneth S Knox, Benjamin J Jarrett, Elie Azoulay, William W Hope, Ashley Meyer-Zilla, M Hassan Murad, Andrew H Limper, Chadi A Hage","doi":"10.1164/rccm.202410-2045ST","DOIUrl":"https://doi.org/10.1164/rccm.202410-2045ST","url":null,"abstract":"<p><strong>Background: </strong>The incidence of invasive fungal infections is increasing in immune-competent and immune-compromised patients. An examination of the recent literature related to the treatment of fungal infections was performed to address two clinical questions. First, in patients with proven or probable invasive pulmonary aspergillosis, should combination therapy with a mold-active triazole plus echinocandin be administered vs. mold-active triazole monotherapy? Second, in critically ill patients at risk for invasive candidiasis who are non-neutropenic and are not transplant recipients, should systemic antifungal agents be administered either as prophylaxis or as empiric therapy?</p><p><strong>Methods: </strong>A multidisciplinary panel reviewed the available data concerning the two questions. The evidence was evaluated, and recommendations were generated using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach.</p><p><strong>Results: </strong>A conditional recommendation was made for patients with proven or probable invasive pulmonary aspergillosis to receive either initial combination therapy with a mold-active triazole plus an echinocandin or initial mold-active triazole monotherapy based on low-quality evidence. Further, a conditional weak recommendation was made against routine administration of prophylactic or empiric antifungal agents targeting Candida species for critically ill patients without neutropenia or a history of transplant based on low-quality evidence.</p><p><strong>Conclusions: </strong>The recommendations presented in these Guidelines are the result of an analysis of currently available evidence. Additional research and new clinical data will prompt an update in the future.</p>","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Best in Class: Immunoglobulin G as a Treatable Trait for Exacerbation Prevention in Chronic Obstructive Pulmonary Disease. 同类最佳:将免疫球蛋白 G 作为预防慢性阻塞性肺病病情恶化的可治疗特质。
IF 19.3 1区 医学
American journal of respiratory and critical care medicine Pub Date : 2024-11-18 DOI: 10.1164/rccm.202409-1681ED
Carolyn J Wang, Don D Sin
{"title":"Best in Class: Immunoglobulin G as a Treatable Trait for Exacerbation Prevention in Chronic Obstructive Pulmonary Disease.","authors":"Carolyn J Wang, Don D Sin","doi":"10.1164/rccm.202409-1681ED","DOIUrl":"https://doi.org/10.1164/rccm.202409-1681ED","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding Sex Differences in Right Ventricular Function through BMPR1A. 通过 BMPR1A 解码右心室功能的性别差异
IF 19.3 1区 医学
American journal of respiratory and critical care medicine Pub Date : 2024-11-18 DOI: 10.1164/rccm.202410-2048ED
Eszter N Tóth, Jessie van Wezenbeek, Frances S de Man
{"title":"Decoding Sex Differences in Right Ventricular Function through <i>BMPR1A</i>.","authors":"Eszter N Tóth, Jessie van Wezenbeek, Frances S de Man","doi":"10.1164/rccm.202410-2048ED","DOIUrl":"https://doi.org/10.1164/rccm.202410-2048ED","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simple vs Extended Lung Ultrasound Score to Guide Surfactant Replacement in the First 24h of Life. 简易与扩展肺部超声评分用于指导生命最初 24 小时内的表面活性物质补充。
IF 19.3 1区 医学
American journal of respiratory and critical care medicine Pub Date : 2024-11-18 DOI: 10.1164/rccm.202408-1521RL
Daniele De Luca, Costanza Neri, Barbara Loi, Estefania Ruiz-Gonzales, Luca Bonadies, Eugenio Baraldi, Almudena Alonso-Ojembarrena
{"title":"Simple <i>vs</i> Extended Lung Ultrasound Score to Guide Surfactant Replacement in the First 24h of Life.","authors":"Daniele De Luca, Costanza Neri, Barbara Loi, Estefania Ruiz-Gonzales, Luca Bonadies, Eugenio Baraldi, Almudena Alonso-Ojembarrena","doi":"10.1164/rccm.202408-1521RL","DOIUrl":"https://doi.org/10.1164/rccm.202408-1521RL","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":19.3,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
One for All and All for One: Multikingdom Interplay in Severe Viral Pneumonia. 人人为我,我为人人--重症病毒性肺炎中的多学科相互作用
IF 9.6 1区 医学
American journal of respiratory and critical care medicine Pub Date : 2024-11-15 DOI: 10.1164/rccm.202406-1237ED
Matthias Egger, Martin Hoenigl
{"title":"One for All and All for One: Multikingdom Interplay in Severe Viral Pneumonia.","authors":"Matthias Egger, Martin Hoenigl","doi":"10.1164/rccm.202406-1237ED","DOIUrl":"10.1164/rccm.202406-1237ED","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1176-1178"},"PeriodicalIF":9.6,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141791687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elevated Suicide Risk in Idiopathic Pulmonary Fibrosis Patients. 特发性肺纤维化患者自杀风险升高。
IF 9.6 1区 医学
American journal of respiratory and critical care medicine Pub Date : 2024-11-15 DOI: 10.1164/rccm.202407-1359LE
Jui-Ting Yu, Chen-Pi Li, Hui-Chin Chang, Shuo-Yan Gau
{"title":"Elevated Suicide Risk in Idiopathic Pulmonary Fibrosis Patients.","authors":"Jui-Ting Yu, Chen-Pi Li, Hui-Chin Chang, Shuo-Yan Gau","doi":"10.1164/rccm.202407-1359LE","DOIUrl":"10.1164/rccm.202407-1359LE","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1276-1277"},"PeriodicalIF":9.6,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141981498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obesity-related Asthma: A Pathobiology-based Overview of Existing and Emerging Treatment Approaches. 与肥胖相关的哮喘:基于病理生物学的现有和新兴治疗方法概述》。
IF 9.6 1区 医学
American journal of respiratory and critical care medicine Pub Date : 2024-11-15 DOI: 10.1164/rccm.202406-1166SO
Meghan D Althoff, Kristina Gaietto, Fernando Holguin, Erick Forno
{"title":"Obesity-related Asthma: A Pathobiology-based Overview of Existing and Emerging Treatment Approaches.","authors":"Meghan D Althoff, Kristina Gaietto, Fernando Holguin, Erick Forno","doi":"10.1164/rccm.202406-1166SO","DOIUrl":"10.1164/rccm.202406-1166SO","url":null,"abstract":"<p><p>Although obesity-related asthma is associated with worse asthma outcomes, optimal treatment approaches for this complex phenotype are still largely unavailable. This state-of-the-art review article synthesizes evidence for existing and emerging treatment approaches for obesity-related asthma and highlights pathways that offer potential targets for novel therapeutics. Existing treatments targeting insulin resistance and obesity, including metformin and GLP-1 (glucagon-like-peptide 1) receptor agonists, have been associated with improved asthma outcomes, although GLP-1R agonist data in asthma are limited to individuals with comorbid obesity. Monoclonal antibodies approved for treatment of moderate to severe asthma generally appear to be effective in individuals with obesity, although this is based on retrospective or secondary analysis of clinical trials; moreover, although most of these asthma biologics are approved for use in the pediatric population, the impact of obesity on their efficacy has not been well studied in youth. Potential therapeutic targets being investigated include IL-6, arginine metabolites, nitro-fatty acids, and mitochondrial antioxidants, with clinical trials for each currently underway. Potential therapeutic targets include adipose tissue eosinophils and the GLP-1-arginine-advanced glycation end products axis, although data in humans are still needed. Finally, transcriptomic and epigenetic studies of \"obese asthma\" demonstrate enrichment of IFN-related signaling pathways, Rho-GTPase pathways, and integrins, suggesting that these too could represent future treatment targets. We advocate for further study of these potential therapeutic mechanisms and continued investigation of the distinct inflammatory pathways characteristic of obesity-related asthma, to facilitate effective treatment development for this unique asthma phenotype.</p>","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"1186-1200"},"PeriodicalIF":9.6,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mucosal Petechiae and Hemorrhage in Pulmonary Barotrauma in Breath-Hold Diving: Direct Observation of a Suspected Pathophysiologic Mechanism. 憋气潜水肺气压创伤中的粘膜瘀斑和出血:疑似病理生理机制的直接观察。
IF 19.3 1区 医学
American journal of respiratory and critical care medicine Pub Date : 2024-11-15 DOI: 10.1164/rccm.202308-1505IM
Fernando Silva, Emmanuel Gouin, Peter Lindholm
{"title":"Mucosal Petechiae and Hemorrhage in Pulmonary Barotrauma in Breath-Hold Diving: Direct Observation of a Suspected Pathophysiologic Mechanism.","authors":"Fernando Silva, Emmanuel Gouin, Peter Lindholm","doi":"10.1164/rccm.202308-1505IM","DOIUrl":"10.1164/rccm.202308-1505IM","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":"e14-e15"},"PeriodicalIF":19.3,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141625718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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