American journal of respiratory and critical care medicine最新文献

{"title":"SOFA-2 for Mortality Prediction in Patients Requiring Continuous Kidney Replacement Therapy","authors":"Inbae Earm,Jiyun Jung,Kipyo Kim,Woo Yeong Park,Tae Hyun Ban,Jaeyoon Park,Yong Chul Kim,Chung Hee Baek,Hyosang Kim,Chan-Young Jung","doi":"10.1093/ajrccm/aamag523","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag523","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"156 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149049091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Danjuma\u0000 et al.\u0000 : Beyond Corticosteroid Duration: Drug-Specific Pneumonitis Risk Should Inform Management of Immune Checkpoint Inhibitor Pneumonitis","authors":"Daichi Fujimoto,Kenta Murotani","doi":"10.1093/ajrccm/aamag510","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag510","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"40 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149049115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Synergistic Risk of Respiratory Effort and Obesity Phenotype in OSA Prognosis","authors":"Zi Xuan Hua,Yi Yang Shen,Meng Yao Li,Qing Yun Li","doi":"10.1093/ajrccm/aamag516","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag516","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"7 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149049090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Corticosteroid Duration: Drug-Specific Pneumonitis Risk Should Inform Management of Immune Checkpoint Inhibitor Pneumonitis","authors":"Mohammed I Danjuma,Anas Mahmoud Zayad,Ibrahim Yusuf Abubeker","doi":"10.1093/ajrccm/aamag509","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag509","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"101 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149049092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Wang et al. and Hua et al.","authors":"Hamza Nahoui, Henrik Schirmer, Gunnar Einvik, Harald Hrubos-Strøm","doi":"10.1093/ajrccm/aamag517","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag517","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":21.7,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149035640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Airway Mucus Plugs on Computed Tomography and Respiratory Outcomes in Participants with COPD and with Preserved Spirometry: Findings from a Chinese Population","authors":"Fan Wu,Fangyan Wu,Tingting Xia,Kunning Zhou,Zhishan Deng,Qi Wan,Gaoying Tang,Suyin Huang,Xiaoyan Huang,Xiaohuan Pan,Jian Zhang,Zihui Wang,Cuiqiong Dai,Lifei Lu,Xiaohui Wu,Xianliang Zeng,Erkang Yi,Zhifeng Gao,Changli Yang,Shengtang Chen,Yongqing Huang,Shuqing Yu,Yu Deng,Yumin Zhou,Pixin Ran","doi":"10.1093/ajrccm/aamag521","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag521","url":null,"abstract":"Abstract Rationale Airway mucus plugs are a prognostic marker in moderate-to-very severe chronic obstructive pulmonary disease (COPD), but their association with respiratory outcomes has been insufficiently evaluated among participants with preserved spirometry and asymptomatic COPD. Objectives To investigate the association between mucus plugs and respiratory outcomes among participants with COPD and with preserved spirometry. Methods This prospective community-based cohort study was conducted in China, from July 2019 to September 2024. Eligible participants completed baseline questionnaires, spirometry, and chest CT with follow-up. Mucus plugs were categorized as affecting 0, 1–2, or ≥ 3 lung segments. Respiratory outcomes included exacerbations, lung function decline, and spirometry-defined COPD development. Measurements and Main Results Overall, 1,939 participants (COPD: 847; preserved spirometry: 1,092) were included, and 1,740 (89%) completed the 3-year follow-up. Among participants with preserved spirometry, those with 1–2 or ≥ 3 mucus plugs had a higher exacerbation risk (RR 1.22, 95%CI 1.01–1.48; RR 1.42, 95%CI 1.11–1.81, respectively) than those without mucus plugs. Participants with ≥3 mucus plugs had a higher risk of spirometry-defined COPD development (18.2% vs. 7.6%, RR 1.71, 95%CI 1.05–2.78) and faster annual decline in FEV1/FVC than those without mucus plugs. Among participants with COPD, with mild-to-moderate COPD, or with asymptomatic COPD, the presence of ≥ 3 mucus plugs were associated with a higher total and moderate-to-severe exacerbation risk. Conclusions Baseline airway mucus plugs potentially associated with future exacerbations in participants with preserved spirometry and COPD, and may suggest an increased risk of spirometry-defined COPD development in those with preserved spirometry.","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"12 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149049089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe primary graft dysfunction is associated with viral reactivation and mortality in latent donor cytomegalovirus infection","authors":"Marian F Colberg Poley,John R Greenland,Robert Gallop,Jonathan P Singer,Steven R Hays,Krishna Pandya,Michaela R Anderson,Jason D Christie,Daniel R Calabrese","doi":"10.1093/ajrccm/aamag528","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag528","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"166 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149049094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory Effort and Mortality in Sleep Apnea: Establishing Incremental Value","authors":"Quanxiang Wang,Peiting Hu,Hui Kong","doi":"10.1093/ajrccm/aamag515","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag515","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"13 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149049093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-year progression of CT emphysema subtypes predict lung function decline: SPIROMICS.","authors":"Emilia A Hermann, Eric A Hoffman, Elsa D Angelini, Igor Barjaktarevic, Jessica Bon, Alejandro Comellas, Christopher B Cooper, David Couper, Jeffrey L Curtis, Gerard Criner, J Michael Wells, Robert Paine, Jerry A Krishnan, Wassim Labaki, Andrew F Laine, David A Lynch, MeiLan K Han, Nadia N Hansel, Fernando J Martinez, Victor Ortega, Benjamin Smith, Yifei Sun, Prescott Woodruff, R Graham Barr","doi":"10.1093/ajrccm/aamag497","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag497","url":null,"abstract":"<p><strong>Rationale: </strong>Intermediate endpoints that predict lung function decline are needed to improve the efficiency of clinical trials in chronic obstructive pulmonary disease (COPD).</p><p><strong>Objectives: </strong>To test if one-year progression of quantitative computed tomography (QCT) measures predicts subsequent FEV₁ decline.</p><p><strong>Methods: </strong>SPIROMICS recruited individuals with ≥ 20 pack-years smoking history with or without COPD and nonsmoking controls who underwent four annual and a later fifth visit. We analyzed chest CT scans at visits one and two for machine-learned CT emphysema subtypes (combined bronchitic-apical emphysema [CBaE], diffuse emphysema) and standard QCT measures of emphysema (percent emphysema-950HU, 15th percentile HU, volume-adjusted lung density), airways, functional small airways, hyperinflation, parenchymal texture and vasculature. Linear mixed-effects models evaluated associations between one-year QCT measure changes and FEV₁ decline from visits two through five, adjusting for demographics, site, enrollment group, baseline QCT value, and time-varying anthropometrics and smoking.</p><p><strong>Measurements and main results: </strong>Among 880 participants (43% mild/moderate COPD, 17% severe COPD, 29% smoking controls, 11% nonsmoking controls), FEV₁ declined -30.4mL/year (95% CI: -34.5, -26.3). A standard deviation (SD) one-year increase in CBaE and diffuse emphysema predicted an accelerated decline in FEV1 of - 4.2 mL/year (95% CI: -8.3, -0.2) and -6.2 mL/year (95% CI: -10.7, -1.8), respectively. Changes in standard QCT emphysema measures also predicted change in FEV1 decline, but only CBaE and diffuse emphysema remained independently predictive of accelerated FEV1 decline when all were considered together.</p><p><strong>Conclusions: </strong>One-year progression of CT emphysema subtypes predicted accelerated FEV₁ decline, supporting their potential use as intermediate endpoints in COPD trials.</p>","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":" ","pages":""},"PeriodicalIF":21.7,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring Cerebral Perfusion during the Initiation of Veno-venous Extracorporeal Membrane Oxygenation","authors":"Yu K Lam,Rogier V Immink,Rokus E C van den Dool,Micah L A Heldeweg,Sijm H Noteboom,Senta J Raasveld,Denise P Veelo,Alexander P J Vlaar,Eline Kho","doi":"10.1093/ajrccm/aamag527","DOIUrl":"https://doi.org/10.1093/ajrccm/aamag527","url":null,"abstract":"","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"9 1","pages":""},"PeriodicalIF":24.7,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149049095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}