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Operative deliveries induce a significant activation of indoleamine 2,3-dioxygenase in human placenta: existence of a new mechanism for activating the enzyme. 手术分娩诱导人胎盘中吲哚胺2,3-双加氧酶的显著激活:一种激活酶的新机制的存在。
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1995-07-01
Y Iwamoto, R Kido
{"title":"Operative deliveries induce a significant activation of indoleamine 2,3-dioxygenase in human placenta: existence of a new mechanism for activating the enzyme.","authors":"Y Iwamoto,&nbsp;R Kido","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The physiological activating mechanism for human placental indoleamine 2,3-dioxygenase was investigated. No cell fractions of the placental homogenate were found to replace the electron-mediation activity of methylene blue from a reductant to the enzyme in the exogenous enzyme-activating system with L-ascorbic acid, B-NADPH, or B-NADH as a reductant. However, the preincubation at 37 degrees C of the supernatant fraction (10,000 x g, 30 min) prior to starting the indoleamine 2,3-dioxygenase reaction drastically caused the activation of the enzyme without added reductants and methylene blue, which suggests the existence of an endogenous indoleamine 2,3-dioxygenase-activating system. The endogenous enzyme activation was induced in the placentas delivered operatively by vacuum extraction or cesarean section much more significant degree than in those delivered normally.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"27 3","pages":"111-4"},"PeriodicalIF":0.0,"publicationDate":"1995-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19898763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retroperitoneal malignant teratoma. A case report. 腹膜后恶性畸胎瘤。一份病例报告。
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1995-07-01
E Tezel, M Sare, N Edali, M Oguz, O Uluoglu, N H Gökok
{"title":"Retroperitoneal malignant teratoma. A case report.","authors":"E Tezel,&nbsp;M Sare,&nbsp;N Edali,&nbsp;M Oguz,&nbsp;O Uluoglu,&nbsp;N H Gökok","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Retroperitoneal teratomas are rare in adults. These tumours may be benign or malignant and are composed of multiple tissues foreign to the part in which they arise. We report a malignant teratoma of retroperitoneal space. In searching the literature, we have been able to find 39 cases reported since 1937. Of the forty cases reported (including this case), only ten (25%) were malignant.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"27 3","pages":"123-5"},"PeriodicalIF":0.0,"publicationDate":"1995-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19898768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breathing pattern in tetraplegics during exposure to hypoxia and hypercapnia. 暴露于缺氧和高碳酸血症时四肢瘫痪患者的呼吸模式。
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1995-07-01
M Pokorski, T Morikawa, Y Honda
{"title":"Breathing pattern in tetraplegics during exposure to hypoxia and hypercapnia.","authors":"M Pokorski,&nbsp;T Morikawa,&nbsp;Y Honda","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The question was investigated of whether thoracic feedback could play a role in shaping the tidal and frequency components of the breathing pattern. The changes in the breathing pattern of tetraplegic subjects were examined and compared with those of normal subjects during hypoxic and hypercapnic rebreathing tests, using data from our previous study. The breathing pattern was evaluated from diagramatic spirograms, constructed at an SaO2 80% and P(ET)CO2 of 55 mmHg. Chemical drive increased VT and shortened T1 and TE in both groups, but tetraplegics responded with a 60% smaller increase in VT. Since the mean inspiratory flow, VT/T1, was the same in either gas condition in both groups, the smaller VT in tetraplegics was due entirely to a shorter T1. These results show that ventilation in tetraplegics is more shallow and rapid, and it implicates thoracic feedback in modulation of the respiratory pattern.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"27 3","pages":"97-100"},"PeriodicalIF":0.0,"publicationDate":"1995-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19900234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiac resonant oscillations in terms of finite-dimensional group representation in atrial parasystole. 心房副搏动有限维群表示的心脏共振振荡。
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1995-07-01
K Izumi, S Izumi
{"title":"Cardiac resonant oscillations in terms of finite-dimensional group representation in atrial parasystole.","authors":"K Izumi,&nbsp;S Izumi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In order to understand the variation of the atrial parasystolic cycle lengths and mutual interactions of sinus node and atrial parasystolic pacemakers, a representation theory for finite groups of invertible linear transformation on a vector space is considered. A quantitative description of manifest atrial parasystolic cycles can be provided by the mapping in the group multiplication with the use of numerical factors of 2, 4 square root of 2 pi, 2/ 4 square root of 2 pi and 2 4 square root of 2 pi. These represent operators of a linear transformation in matrix multiplication of the similarity transformation representing an isomorphism.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"27 3","pages":"101-7"},"PeriodicalIF":0.0,"publicationDate":"1995-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19900235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of 0-/-B-hydroxyethyl/rutoside on platelet function and thrombus formation in rat mesenteric vessels. 0-/- b -羟乙基/芦桃苷对大鼠肠系膜血管血小板功能及血栓形成的影响。
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1995-04-01
K Krupiński, H K Breddin, J Giedrojć, A Bodzenta-Lukaszyk, M Bielawiec
{"title":"Effects of 0-/-B-hydroxyethyl/rutoside on platelet function and thrombus formation in rat mesenteric vessels.","authors":"K Krupiński,&nbsp;H K Breddin,&nbsp;J Giedrojć,&nbsp;A Bodzenta-Lukaszyk,&nbsp;M Bielawiec","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>0-/-B-hydroxyethyl/rutoside has been investigated for its effect on laser-induced thrombus formation in rat mesenteric venules and arterioles. The in vitro effect of this agent on platelet adhesion to bovine subendothelial extracellular matrix (ECM) and glass, on spreading and on platelet aggregation induced by ADP, collagen and epinephrine have also been studied. The animal investigations of 0-/-B-hydroxyethyl/rutoside showed an antithrombotic effect in doses between 5 and 50 mg/kg after i.v. injection. This effect was similar for both arterioles and venules damaged. After i.v. injection of minimum effective doses of 0-/-B-hydroxyethyl/rutoside, the antithrombotic effect lasted longer than 6 hrs but less than 12 hrs. In vitro, 0-/-B-hydroxyethyl/rutoside significantly inhibited platelet adhesion to bovine ECM in concentrations of 20 micrograms/ml PRP, and with 30 micrograms/ml the PRP adhesion to glass and spreading were inhibited. Epinephrine and ADP induced aggregation was inhibited in concentrations higher than 30 micrograms/ml PRP.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"27 2","pages":"39-42"},"PeriodicalIF":0.0,"publicationDate":"1995-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19899039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Origin of serum alpha-amylase isoenzymes from healthy adult rats. 健康成年大鼠血清α -淀粉酶同工酶的来源。
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1995-04-01
A Tomasik, R Tarnawski, B Beck, S Kasperczyk, Z Brzoza
{"title":"Origin of serum alpha-amylase isoenzymes from healthy adult rats.","authors":"A Tomasik,&nbsp;R Tarnawski,&nbsp;B Beck,&nbsp;S Kasperczyk,&nbsp;Z Brzoza","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In connection with common use of rats in experimental testing drug toxicity in the liver or pancreas, we checked the electrophoretic patterns of amylase isoenzymes extracted from the liver, pancreas, parotis and serum of healthy adult rats. Separation of isoenzymes was made by polyacrylamide gel electrophoresis. The results indicate the salivary glands and liver as sources of serum alpha-amylase.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"27 2","pages":"57-61"},"PeriodicalIF":0.0,"publicationDate":"1995-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19899042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postoperative wound infection in colorectal surgery. 结直肠手术术后伤口感染。
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1995-04-01
K Bielecki, H Badi, P Kamiński, J Kubiak
{"title":"Postoperative wound infection in colorectal surgery.","authors":"K Bielecki,&nbsp;H Badi,&nbsp;P Kamiński,&nbsp;J Kubiak","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Postoperative wound infection is one of common problems in a surgical ward. In our surgical department, from 1988 to December 1992, 254 cases were operated on for colorectal diseases. The indications for these operations were as follows; colorectal carcinoma (191 cases), inflammatory bowel diseases (22 cases), diverticulitis (14 cases), and others (27 cases). Of these 254 cases, 119 were males (46.85%) and 135 were females (53.15%), 211 cases (83.1%) were operated on as elective surgery, 43 cases (16.9%) as emergencies. Of these 254 cases, 36 (14.2%) had postoperative wound infection, 25 cases (11.8%) after elective surgery, and 11 cases (25.6%) postemergency operations. Of these 36 cases, 22 cases (61.11%) were males and 14 cases (38.88%) were females. In our study, postoperative wound infection was mostly noted in patients operated on for colorectal carcinoma (27 cases, 14.1%), as compared with 5 cases operated on for diverticulitis (35.7%), 2 cases for I.B.D. (9.1%) and 2 cases for other indications (7.4%). Most of these wound infections were treated with drainage and frequent dressing while 10 cases received antibiotics.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"27 2","pages":"67-9"},"PeriodicalIF":0.0,"publicationDate":"1995-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19899045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
5-fluorouracil induced cardiotoxicity in albino rats. 5-氟尿嘧啶对白化大鼠心脏毒性的影响。
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1995-04-01
S Kumar, R K Gupta, N Samal
{"title":"5-fluorouracil induced cardiotoxicity in albino rats.","authors":"S Kumar,&nbsp;R K Gupta,&nbsp;N Samal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Since 1975, many cases of 5-fluorouracil (5-FU) associated cardiotoxicity have been described in the literature. A histopathological study of 5-FU induced cardiotoxicity was performed on 50 Swiss albino rats. Multiple interstitial myocardial hemorrhages, multifocal myofibre necroses, inflammatory reaction, vascular changes, valvulitis and pericarditis have been noted especially in the left heart ventricles of rats under study. The mechanism of 5-FU associated cardiotoxicity is controversial. A probable mechanism has been proposed; it explains the endothelial damage leading to extravasation of the drug containing blood into myocardium resulting in myofibre necroses and inflammatory reaction.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"27 2","pages":"63-6"},"PeriodicalIF":0.0,"publicationDate":"1995-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19899044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute phase response in rheumatoid arthritis patients treated with immunosuppressive drugs. 免疫抑制药物治疗类风湿关节炎患者的急性期反应。
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1995-04-01
J K Lacki, K Klama, W Samborski, S Mackiewicz, U Mackiewicz, W Muller
{"title":"Acute phase response in rheumatoid arthritis patients treated with immunosuppressive drugs.","authors":"J K Lacki,&nbsp;K Klama,&nbsp;W Samborski,&nbsp;S Mackiewicz,&nbsp;U Mackiewicz,&nbsp;W Muller","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We sought to investigate an influence of immunosuppressive drugs on acute phase response (APR) in rheumatoid arthritis (RA). Ninety-six patients (pts) were treated with methotrexate (MTX), or with cyclophosphamide (CTX) (9-intravenously, 19-orally), or with cyclosporin A (CSA). C-reactive protein (CRP), alpha-1-acid glycoprotein (AGP), and alpha-1 antichymotrypsin (ACT) serum levels were measured by rocket immunoelectrophoresis. AGP and ACT microheterogenities evaluated using immunoelectrophoresis were expressed as reactivity coefficient (RC). Clinical improvement was observed in 71.4% MTX pts, 77.8% CTX intravenously pts, 36.8% CTX orally pts, 60.0% CSA pts. The number of side effects was the highest in CTX oral group (57.9% left the study). CRP, AGP, and ACT serum levels were increased in all groups of RA pts as compared to healthy controls. CRP level decreased only after MTX and CTX intravenous treatment. Moreover, a decrease in ACT was observed in CTX intravenously treated pts. AGP-RC was lower in the initial population of RA pts as compared to healthy control. After 6 months of treatment RC became significantly higher in MTX pts only. In opposite ACT-RC in RA pts was found to be elevated as compared to controls. After the treatment it fell down. The decrease was found to be significant only in pts treated with MTX. From our study we can conclude that MTX is the safest and the most effective agent among immunosuppressive drugs applied in RA. CTX given orally causes a number of adverse reactions, which frequently make continuous and effective treatment impossible. CTX intravenously and CSA are attractive in the treatment of the patients with severe and refractory RA. A lack of clinical benefit is reflected in the absence of acute markers changes.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"27 2","pages":"47-51"},"PeriodicalIF":0.0,"publicationDate":"1995-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19899050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Possible mechanisms of glucocorticoid--unresponsive pyrexia. Defect in lipocortin 1? 糖皮质激素的可能机制——无反应性发热。脂皮质素1缺陷?
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1995-04-01
H Akama, H Tanaka, S Kawai
{"title":"Possible mechanisms of glucocorticoid--unresponsive pyrexia. Defect in lipocortin 1?","authors":"H Akama,&nbsp;H Tanaka,&nbsp;S Kawai","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Glucocorticoids have a strong anti-inflammatory action, and are indispensable in the treatment of inflammatory diseases. We had a patient with the Weber-Christian disease having an intractable high fever that did not respond to even a high-dose glucocorticoid therapy, but was responsive to a nonsteroidal antiinflammatory drug. To elucidate possible mechanisms of the glucocorticoid-unresponsive fever, we have investigated the in vitro production of two eicosanoids, prostaglandin (PG)E2 and leukotriene (LT)B4, from the peripheral blood polymorphonuclear leukocytes after stimulation by ionophore A23187. The patient's leukocytes produced much larger amount of PGE2, but the same amount of LTB4, as did those of two control groups. More interestingly, the production of eicosanoids was inhibited by dexamethasone less in the patients than in the controls. Indomethacin suppressed the production of PGE2 both in the patients and in the controls. These results might be relevant in the glucocorticoid-unresponsive pyrexia.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"27 2","pages":"75-8"},"PeriodicalIF":0.0,"publicationDate":"1995-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19898949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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