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Computer controllability experiments on a cardiac action potential model. 心脏动作电位模型的计算机可控性实验。
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1994-04-01
C V Papadopoulos, S M Capetanaki
{"title":"Computer controllability experiments on a cardiac action potential model.","authors":"C V Papadopoulos,&nbsp;S M Capetanaki","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Recent advances in single cell and single channel recording techniques have lead to the generation of more accurate descriptions of cardiac muscle cell ion channel kinetics and the development of a new mathematical model of its action potential, the Luo and Rudy model. In order to study the propagation, effects of drugs by spatial simulations, it is first necessary to develop a means to control some characteristics of action potential given by this model. Presented here are the results of computer implementation, validation, and controllability experiments of the Luo-Rudy model of cardiac action potential.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"26 2","pages":"75-82"},"PeriodicalIF":0.0,"publicationDate":"1994-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18747701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrastructural evaluation of the rat parotid gland after six-week-intoxication with lead acetate. 醋酸铅中毒6周后大鼠腮腺超微结构的观察。
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1994-04-01
A Andrzejewska, B Szynaka, W Stokowska
{"title":"Ultrastructural evaluation of the rat parotid gland after six-week-intoxication with lead acetate.","authors":"A Andrzejewska,&nbsp;B Szynaka,&nbsp;W Stokowska","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Clinical and experimental data point to the unfavorable effect of lead compounds on the oral cavity condition. The aim of this study was to analyse ultrastructural changes in the parotid gland of rats subjected to intoxication with lead acetate. The experiment was carried out on 24 Wistar rats divided into 4 groups, 6 animals in each. Group I animals were given aqueous solution of lead acetate of lead concentration 50 mg/dm3(50ppm), group II-500 mg/dm3(500ppm), group III-1,000 mg/dm3(1,000ppm). Control animals drank tap water. All the rats were sacrificed after six weeks of the experiment and material was collected for ultrastructural studies and evaluation of lead level in the tissue dry mass. A three fold increase in lead levels in the parotid gland was observed in group I and a tenfold increase in groups II and III. In all experimental ultrastructural examinations revealed groups in which lead impaired secretion of alveolar cells, damaged mitochondria and disturbed the lipid balance. The greatest destructive changes were observed in group III.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"26 2","pages":"65-8"},"PeriodicalIF":0.0,"publicationDate":"1994-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18748443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morphology and phase composition of urinary calculi. 尿路结石的形态和相组成。
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1994-04-01
J Lutosławska-Rogóz, S A Hodorowicz
{"title":"Morphology and phase composition of urinary calculi.","authors":"J Lutosławska-Rogóz,&nbsp;S A Hodorowicz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Forty seven urinary calculi were examined by means of X-ray powder diffraction (including both the Debye-Scherrer technique and powder diffractometer study) and infrared spectroscopy in order to determine their phase composition. The stones were collected in the period of two years from patients in Southern Poland, most of them consisting of calcium oxalate monohydrate as the only one or one of the few components.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"26 2","pages":"43-7"},"PeriodicalIF":0.0,"publicationDate":"1994-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18748440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Observations on gastric histology, endoscopy appearance and Helicobacter pylori after corrective surgery for bile reflux gastritis. 胆汁反流性胃炎矫治术后胃组织学、胃镜检查及幽门螺杆菌的观察。
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1994-01-01
K Bielecki, J J Zawadzki
{"title":"Observations on gastric histology, endoscopy appearance and Helicobacter pylori after corrective surgery for bile reflux gastritis.","authors":"K Bielecki,&nbsp;J J Zawadzki","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study was designed to look for the presence of Campylobacter pylori in patients who had Roux-en-Y procedure to control symptoms of severe alkaline reflux gastritis (ARG) and to correlate findings with endoscopy and histology. Twenty five patients, who had been operated on for ARG during the last 15 years, were recruited into this study (mean age: 53 years). Surgical procedures were performed by a single surgeon (K.B.). Clinical symptoms of ARG improved after corrective surgery in all cases, but endoscopic pictures remained abnormal in 14 of 25 patients and histological gastritis was observed in all cases. Helicobacter pylori were detected in 8 patients using an urease test performed on gastric mucosa biopsies (CLO-Gistbrocades test). All 8 patients had their biliary diversion 10 or more years earlier, suggesting that H-pylori colonisation of the gastric mucosa develops only slowly once the bile reflux has been stopped. Longitudinal studies, looking for the presence of H-pylori in postoperative stomachs, may help in determining whether they have a role in the aethiology of the peptic ulcer and gastritis, or whether it really is only an innocent bystander.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"26 1","pages":"9-12"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18808893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Some haemorheological factors and transcutaneous PO2 in patients with a peripheral arterial occlusive disease after treatment with naftidrofuryl. 外周动脉闭塞性疾病患者接受纳替呋喃治疗后的血液流变学因素和经皮PO2。
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1994-01-01
K Krupiński, M Bielawiec, A Szpak, A Płonowski
{"title":"Some haemorheological factors and transcutaneous PO2 in patients with a peripheral arterial occlusive disease after treatment with naftidrofuryl.","authors":"K Krupiński,&nbsp;M Bielawiec,&nbsp;A Szpak,&nbsp;A Płonowski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of the present study was to investigate the influence of long term intravenous administration of naftidrofuryl (Dusodril-Lipha Arzn) twice daily in a dose of 200 mg in continuous, 4-hour infusion in 500 ml 0.9% NaCl to the patients suffering from a peripheral arterial occlusive disease (PAOD) in a clinical condition with special attention paid to transcutaneous partial oxygen pressure measurements (tcPO2) and rheographic parameters. Also the effect of treatment with naftidrofuryl on the platelet adhesion to the bovine extracellular matrix, the leukocyte adhesion to nylon fibres, and the number of platelet-leukocyte aggregates has been studied. We have found that after the naftidrofuryl treatment tcPO2 significantly increased from 38.5 +/- 0.8 mm Hg to 54.6 +/- 11.5 mm Hg, and the impedance plethysmography indexes, such as the height of the rheographic wave, the area of the rheographic wave and the rheographic index were also slightly increased. The leukocyte adherence to nylon fibres, the platelet adhesion to the extracellular matrix and the total number of platelet-leukocyte aggregates were significantly reduced after the treatment with Dusodril. On the basis of this study it seems that the observed influence of naftidrofuryl on leukocyte function in patients with PAOD is an additional mode of action of this drug that can be of new clinical value in the treatment of patients with a peripheral occlusive arterial disease. It seems that tcPO2 measurements in ischaemic legs can be recommended as a very sensitive method of monitoring the efficacy of vasoactive drugs in patients with PAOD.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"26 1","pages":"17-20"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18856848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of sodium valproate and its metabolites (5-OH-VPA and 4-OH-VPA) on electroconvulsions in rats. 丙戊酸钠及其代谢物(5-OH-VPA和4-OH-VPA)对大鼠电惊厥的影响。
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1994-01-01
W Sobaniec, M Sobaniec-Lotowska
{"title":"The effects of sodium valproate and its metabolites (5-OH-VPA and 4-OH-VPA) on electroconvulsions in rats.","authors":"W Sobaniec,&nbsp;M Sobaniec-Lotowska","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Effects of sodium valproate (VPA) and the omega-oxidation metabolites (5-OH-VPA and 4-OH-VPA) on the electroconvulsions in rats were analyzed. The drug (100 and 200 mg/kg/day) revealed marked dose-related anticonvulsant effect which manifested themselves by shortening the convulsions time and their intensity. The anticonvulsant effect of the omega-oxidation (50, 100 and 200 mg/kg/day) were weaker compared with the parent drugs.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"26 1","pages":"29-32"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18808886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Activation of blood coagulation induced by organophosphate pesticide. 有机磷农药对血液凝固的激活作用。
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1994-01-01
J Jastrzebski, M Złotorowicz, M Szczepański
{"title":"Activation of blood coagulation induced by organophosphate pesticide.","authors":"J Jastrzebski,&nbsp;M Złotorowicz,&nbsp;M Szczepański","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A case of suicidal poisoning with organophosphate pesticide, associated by acute activation of blood coagulation is presented. The heparin treatment efficiently inhibited this activation.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"26 1","pages":"33-4"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18808891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of ganglioneuroblastoma with horse-shoe kidney. 神经节神经母细胞瘤与马蹄形肾的关系。
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1994-01-01
A Oğuz, C Başaklar, S Gögüş, S Işik, A Ekmekçi
{"title":"Association of ganglioneuroblastoma with horse-shoe kidney.","authors":"A Oğuz,&nbsp;C Başaklar,&nbsp;S Gögüş,&nbsp;S Işik,&nbsp;A Ekmekçi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"26 1","pages":"35-7"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18808892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accumulation of ammonia and changes in the activity of some ammonia metabolizing enzymes during brain ischemia/reperfusion injury in rats. 大鼠脑缺血再灌注损伤过程中氨的积累及一些氨代谢酶活性的变化。
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1994-01-01
A Hołownia, M Chwiecko, R Farbiszewski
{"title":"Accumulation of ammonia and changes in the activity of some ammonia metabolizing enzymes during brain ischemia/reperfusion injury in rats.","authors":"A Hołownia,&nbsp;M Chwiecko,&nbsp;R Farbiszewski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The ammonia concentration and changes in the activity of ammonia metabolizing enzymes in the brain tissue during ischemia/reperfusion were investigated in rats. During ischemia (0.5 h) we found a statistically significant increase in brain ammonia concentration and a significant decrease in glutamate dehydrogenase activity. After 1 h of reperfusion, a further accumulation of ammonia concentration was observed. Furthermore, the brain glutamine syntethase and glutamate dehydrogenase were decreased, whereas the brain glutaminase activity was increased. The causes for the changed activities of some ammonia metabolizing enzymes in brain after ischemia/reperfusion have been discussed.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"26 1","pages":"25-7"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18808885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mineralization (calcification) of coronary arteries. 冠状动脉矿化(钙化)
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1994-01-01
M Pawlikowski, R Pfitzner, J Wachowiak
{"title":"Mineralization (calcification) of coronary arteries.","authors":"M Pawlikowski,&nbsp;R Pfitzner,&nbsp;J Wachowiak","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Mineralogical investigations of calcifications located in coronary vessels were performed on the material obtained from the endarterectomized arteries of 18 patients (15 M, 3 F, aged 36-65) during surgical revascularization procedures consisting in coronary artery bypass grafting. The samples were tested using scanning microscopy, X-ray diffractometry, infrared spectroscopy, atomic absorption spectroscopy, electron microprobe and neutron activation spectroscopy. The results of analyses were calculated with the use of computer programmes. Two types of mineralization were determined: 1. secret mineralization identified as higher than normal content of elements in biological tissues, not demonstrating any mineral grains, and 2. apparent mineralization, appearing micro- and macroscopically as grains composed mainly of hydroxyapatite containing admixture of carbonate groups, i.e. a mineral identical with apatite present in bones, or as calcification of other tissues (heart valves, lungs etc.). The authors suggest that the phenomenon of mineralization should be taken into consideration in the preventive treatment of coronary atheriosclerosis.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"26 1","pages":"3-8"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18808888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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