{"title":"丙戊酸钠及其代谢物(5-OH-VPA和4-OH-VPA)对大鼠电惊厥的影响。","authors":"W Sobaniec, M Sobaniec-Lotowska","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Effects of sodium valproate (VPA) and the omega-oxidation metabolites (5-OH-VPA and 4-OH-VPA) on the electroconvulsions in rats were analyzed. The drug (100 and 200 mg/kg/day) revealed marked dose-related anticonvulsant effect which manifested themselves by shortening the convulsions time and their intensity. The anticonvulsant effect of the omega-oxidation (50, 100 and 200 mg/kg/day) were weaker compared with the parent drugs.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"26 1","pages":"29-32"},"PeriodicalIF":0.0000,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The effects of sodium valproate and its metabolites (5-OH-VPA and 4-OH-VPA) on electroconvulsions in rats.\",\"authors\":\"W Sobaniec, M Sobaniec-Lotowska\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Effects of sodium valproate (VPA) and the omega-oxidation metabolites (5-OH-VPA and 4-OH-VPA) on the electroconvulsions in rats were analyzed. The drug (100 and 200 mg/kg/day) revealed marked dose-related anticonvulsant effect which manifested themselves by shortening the convulsions time and their intensity. The anticonvulsant effect of the omega-oxidation (50, 100 and 200 mg/kg/day) were weaker compared with the parent drugs.</p>\",\"PeriodicalId\":76124,\"journal\":{\"name\":\"Materia medica Polona. Polish journal of medicine and pharmacy\",\"volume\":\"26 1\",\"pages\":\"29-32\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1994-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Materia medica Polona. Polish journal of medicine and pharmacy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materia medica Polona. Polish journal of medicine and pharmacy","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The effects of sodium valproate and its metabolites (5-OH-VPA and 4-OH-VPA) on electroconvulsions in rats.
Effects of sodium valproate (VPA) and the omega-oxidation metabolites (5-OH-VPA and 4-OH-VPA) on the electroconvulsions in rats were analyzed. The drug (100 and 200 mg/kg/day) revealed marked dose-related anticonvulsant effect which manifested themselves by shortening the convulsions time and their intensity. The anticonvulsant effect of the omega-oxidation (50, 100 and 200 mg/kg/day) were weaker compared with the parent drugs.
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