Computer controllability experiments on a cardiac action potential model.

Abstract

Recent advances in single cell and single channel recording techniques have lead to the generation of more accurate descriptions of cardiac muscle cell ion channel kinetics and the development of a new mathematical model of its action potential, the Luo and Rudy model. In order to study the propagation, effects of drugs by spatial simulations, it is first necessary to develop a means to control some characteristics of action potential given by this model. Presented here are the results of computer implementation, validation, and controllability experiments of the Luo-Rudy model of cardiac action potential.