Possible mechanisms of glucocorticoid--unresponsive pyrexia. Defect in lipocortin 1?

H Akama, H Tanaka, S Kawai
{"title":"Possible mechanisms of glucocorticoid--unresponsive pyrexia. Defect in lipocortin 1?","authors":"H Akama,&nbsp;H Tanaka,&nbsp;S Kawai","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Glucocorticoids have a strong anti-inflammatory action, and are indispensable in the treatment of inflammatory diseases. We had a patient with the Weber-Christian disease having an intractable high fever that did not respond to even a high-dose glucocorticoid therapy, but was responsive to a nonsteroidal antiinflammatory drug. To elucidate possible mechanisms of the glucocorticoid-unresponsive fever, we have investigated the in vitro production of two eicosanoids, prostaglandin (PG)E2 and leukotriene (LT)B4, from the peripheral blood polymorphonuclear leukocytes after stimulation by ionophore A23187. The patient's leukocytes produced much larger amount of PGE2, but the same amount of LTB4, as did those of two control groups. More interestingly, the production of eicosanoids was inhibited by dexamethasone less in the patients than in the controls. Indomethacin suppressed the production of PGE2 both in the patients and in the controls. These results might be relevant in the glucocorticoid-unresponsive pyrexia.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"27 2","pages":"75-8"},"PeriodicalIF":0.0000,"publicationDate":"1995-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materia medica Polona. Polish journal of medicine and pharmacy","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Glucocorticoids have a strong anti-inflammatory action, and are indispensable in the treatment of inflammatory diseases. We had a patient with the Weber-Christian disease having an intractable high fever that did not respond to even a high-dose glucocorticoid therapy, but was responsive to a nonsteroidal antiinflammatory drug. To elucidate possible mechanisms of the glucocorticoid-unresponsive fever, we have investigated the in vitro production of two eicosanoids, prostaglandin (PG)E2 and leukotriene (LT)B4, from the peripheral blood polymorphonuclear leukocytes after stimulation by ionophore A23187. The patient's leukocytes produced much larger amount of PGE2, but the same amount of LTB4, as did those of two control groups. More interestingly, the production of eicosanoids was inhibited by dexamethasone less in the patients than in the controls. Indomethacin suppressed the production of PGE2 both in the patients and in the controls. These results might be relevant in the glucocorticoid-unresponsive pyrexia.

糖皮质激素的可能机制——无反应性发热。脂皮质素1缺陷?
糖皮质激素具有很强的抗炎作用,在治疗炎症性疾病中是不可缺少的。我们有一个患有韦伯-基督教疾病的病人,他患有顽固性高烧,即使是高剂量的糖皮质激素治疗也没有反应,但对非甾体类抗炎药有反应。为了阐明糖皮质激素无反应性发热的可能机制,我们在体外研究了受离子载体A23187刺激的外周血多形核白细胞产生两种类二十烷素,前列腺素(PG)E2和白三烯(LT)B4。与两个对照组相比,患者的白细胞产生了大量的PGE2,但LTB4的数量相同。更有趣的是,与对照组相比,地塞米松对类二十烷酸产生的抑制作用在患者中更小。吲哚美辛抑制了患者和对照组PGE2的产生。这些结果可能与糖皮质激素无反应性发热有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信