Breathing pattern in tetraplegics during exposure to hypoxia and hypercapnia.

M Pokorski, T Morikawa, Y Honda
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Abstract

The question was investigated of whether thoracic feedback could play a role in shaping the tidal and frequency components of the breathing pattern. The changes in the breathing pattern of tetraplegic subjects were examined and compared with those of normal subjects during hypoxic and hypercapnic rebreathing tests, using data from our previous study. The breathing pattern was evaluated from diagramatic spirograms, constructed at an SaO2 80% and P(ET)CO2 of 55 mmHg. Chemical drive increased VT and shortened T1 and TE in both groups, but tetraplegics responded with a 60% smaller increase in VT. Since the mean inspiratory flow, VT/T1, was the same in either gas condition in both groups, the smaller VT in tetraplegics was due entirely to a shorter T1. These results show that ventilation in tetraplegics is more shallow and rapid, and it implicates thoracic feedback in modulation of the respiratory pattern.

暴露于缺氧和高碳酸血症时四肢瘫痪患者的呼吸模式。
研究的问题是,胸部反馈是否可以在形成呼吸模式的潮汐和频率成分中发挥作用。使用我们先前研究的数据,检查四肢瘫痪受试者的呼吸模式变化,并将其与正常受试者在低氧和高碳酸血症再呼吸试验中进行比较。在SaO2浓度为80%、P(ET)CO2浓度为55 mmHg的条件下,通过螺旋图评估呼吸模式。化学驱动增加了两组的VT,缩短了T1和TE,但四肢瘫痪患者的VT增加幅度要小60%。由于两组在两种气体条件下的平均吸气流量VT/T1相同,因此四肢瘫痪患者的VT较小完全是由于较短的T1。这些结果表明,四肢瘫痪患者的通气更浅、更迅速,这可能与胸腔反馈调节呼吸模式有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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