Aesthetic Plastic Surgery最新文献

{"title":"Evaluation of Serum Irisin, Leptin, Adiponectin, Resistin, and Galectin-3 Levels and Their Relationship with Ultrasonographic Subcutaneous Fat Thickness in Patients with Lipedema.","authors":"Esra Şahingöz Bakırcı, Gülseren Demir Karakılıç, Emin Kaymak","doi":"10.1007/s00266-026-06279-z","DOIUrl":"https://doi.org/10.1007/s00266-026-06279-z","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to compare serum adiponectin, leptin, resistin, irisin, and galectin-3 levels between patients with lipedema and healthy controls, and to examine their relationship with subcutaneous adipose tissue thickness.</p><p><strong>Methods: </strong>In this cross sectional case control study, 40 female patients with lipedema and 36 age and body mass index matched healthy controls were included. Serum levels of adiponectin, leptin, resistin, irisin, and galectin-3 were measured using enzyme-linked immunosorbent assay. Subcutaneous adipose tissue thickness was assessed by ultrasonography at predefined anatomical sites. Pain intensity, functional status, and quality of life were evaluated. Correlation analyses were performed to investigate associations between biomarkers and ultrasonographic findings.</p><p><strong>Results: </strong>Serum adiponectin, leptin, resistin, irisin, galectin-3, and routine biochemical parameters did not differ significantly between groups (all p > 0.05). Subcutaneous adipose tissue thickness was significantly higher in all measured regions in the lipedema group (p < 0.001). Biomarker levels did not differ according to lipedema stage (all p > 0.05). Among the evaluated biomarkers, only serum leptin showed a weak positive correlation with anterior thigh subcutaneous adipose tissue thickness (rho = 0.399, p = 0.014). In secondary comparisons, patients with lipedema reported higher pain scores and lower functional capacity and quality of life (all p < 0.05).</p><p><strong>Conclusion: </strong>Serum adiponectin, leptin, resistin, irisin, and galectin-3 levels were similar between patients with lipedema and healthy controls despite significantly increased subcutaneous adipose tissue thickness. Only leptin showed a weak positive correlation with anterior thigh subcutaneous adipose tissue thickness. These findings suggest that circulating biomarkers may not adequately reflect local adipose tissue alterations in lipedema. Further studies are needed to clarify their role in the pathophysiology of lipedema.</p><p><strong>Level of evidence iii: </strong>This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors   www.springer.com/00266 .</p>","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of Multimodal Large Language Models (LLMs) for Detecting Tuberous Breast Deformity from Standardized Photographs: A Descriptive in Silico Study.","authors":"Edoardo Caimi, Stefano Vaccari, Alessandro Marco Lupacchini, Mattia Federico Cavallero, Simone Furlan, Riccardo Di Giuli, Valeria Bandi, Barbara Catania, Alessandra Veronesi, Marco Klinger, Francesco Klinger, Valeriano Vinci, Alberto Paderno","doi":"10.1007/s00266-026-06283-3","DOIUrl":"https://doi.org/10.1007/s00266-026-06283-3","url":null,"abstract":"<p><strong>Background: </strong>Tuberous breast deformity (TBD) is frequently missed outside specialist units, delaying treatment and compounding psychosocial harm. Vision-enabled large language models (LLMs) could facilitate earlier recognition, but their diagnostic accuracy for TBD has not been quantified. The aim of this study was to benchmark four state-of-the-art multimodal LLMs in [1] detecting TBD from standardized photographs and [2] proposing evidence-based surgical strategies.</p><p><strong>Methods: </strong>In this single-center, retrospective in-silico study we analyzed 400 photographs (frontal and lateral views) from 200 women aged 16-40 years (100 TBD, 100 controls). GPT-4o, Claude 3 Opus, Gemini 2.5 Pro and DeepSeek V3 were interrogated with a two-tier prompting protocol. Diagnostic accuracy, sensitivity, specificity, PPV, NPV and AUROC were calculated against a surgeon-established reference standard, and 95% CIs were computed by Wilson method. Treatment outputs were independently scored [1-5] by two blinded plastic surgeons; reliability was assessed with the intraclass correlation coefficient (ICC).</p><p><strong>Results: </strong>GPT-4o achieved the highest overall accuracy (0.94), sensitivity (0.92) and specificity (0.93); AUROC = 0.88. Claude 3 Opus, Gemini 2.5 Pro and DeepSeek V3 followed with accuracies of 0.90, 0.82 and 0.85, respectively. Mean treatment-quality scores paralleled diagnostic performance: GPT-4o = 4.0 ± 0.4, Claude 3 Opus = 2.8 ± 0.5, Gemini 2.5 Pro = 2.6 ± 0.5, DeepSeek V3 = 2.3 ± 0.5; rater agreement was excellent (ICC = 0.94).</p><p><strong>Conclusions: </strong>Among contemporary LLMs, GPT-4o most accurately identifies TBD and delivers the most comprehensive operative plans. With expert oversight, such models could streamline aesthetic breast consultations and resident education.</p><p><strong>Level of evidence iii: </strong>Breast Surgery. This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.</p>","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ipsilateral vs. Contralateral Pedicle in Expanded Forehead Flap for Alar Necrosis: Which is Better?","authors":"Jiandong Ye, Xiancheng Wang, Kemin Yi, Yong Xu, Pei Zou, Hongli Zhao, Kai Yang, Yang Sun","doi":"10.1007/s00266-026-06249-5","DOIUrl":"https://doi.org/10.1007/s00266-026-06249-5","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the outcomes of utilizing an expanded paramedian forehead flap combined with an autologous costal cartilage framework for reconstructing alar necrosis defects caused by hyaluronic acid injection, and to compare the clinical differences between ipsilateral and contralateral pedicle designs.</p><p><strong>Methods: </strong>In this retrospective study (May 2021-August 2024), 21 patients underwent staged reconstruction: tissue expansion, flap transfer with cartilage framework based on ipsilateral (n=10) or contralateral (n=11) pedicles, followed by pedicle division and revision. Outcomes were assessed using ROE and NOSE scales and blinded photographic evaluation.</p><p><strong>Results: </strong>All flaps survived completely. Postoperative ROE increased and NOSE decreased significantly (both P < 0.05). Between-group comparisons demonstrated negligible effect sizes with wide confidence intervals, and post hoc power for the primary outcome (ROE improvement) was only 9%. No statistically significant differences were observed, but the study was underpowered to detect equivalence.</p><p><strong>Conclusion: </strong>The expanded paramedian forehead flap combined with costal cartilage rhinoplasty is an effective strategy for reconstructing this type of iatrogenic alar defect. Our preliminary, underpowered comparison suggests that both pedicle designs can yield satisfactory outcomes; however, these findings do not establish equivalence, and pedicle choice should be individualized based on patient anatomy and biomechanical considerations.</p><p><strong>Level of evidence iv: </strong>This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .</p>","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: From Etiology to Aesthetic Surgery: Mapping Knowledge Domains and Emerging Trends in Gynecomastia Research: 35-Year Bibliometric Analysis.","authors":"Kexin Deng, Yi Liu, Yu Tang, Ning Xie","doi":"10.1007/s00266-026-06290-4","DOIUrl":"10.1007/s00266-026-06290-4","url":null,"abstract":"","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149057041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-Dimensional Scanning for Reduction Mammaplasty in Asymmetric Breast Hypertrophy.","authors":"Siming Wei, Na Wang, Shuai Qiang, Zhaoxiang Zhang","doi":"10.1007/s00266-026-06285-1","DOIUrl":"https://doi.org/10.1007/s00266-026-06285-1","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Asymmetric breast hypertrophy is a common clinical presentation, primarily managed through surgical intervention. Accurate preoperative symmetry assessment is crucial for determining postoperative breast symmetry and aesthetic outcomes. However, current assessments rely heavily on surgeon experience, posing challenges for less experienced practitioners, and conventional measurement techniques fail to accurately capture bilateral breast volume and related parameters. In this study, three-dimensional (3D) scanning enabled rapid and straightforward preoperative assessment of breast morphology. This objective evaluation facilitated the optimization of postoperative breast symmetry.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective analysis was conducted on 25 female patients with asymmetric breast hypertrophy who underwent reduction mammaplasty in our department between February 2023 and February 2025. All patients underwent 3D breast scanning both preoperatively and at the 6-month postoperative follow-up. Bilateral breast volume difference and blinded observer-rated aesthetic scores were then analyzed based on the acquired data. Aesthetic evaluation of postoperative breast morphology was evaluated based on preoperative and postoperative photographs using a 5-point Likert scale (5 = excellent, 1 = poor). The assessment covered five key dimensions: (1) nipple-areola complex (NAC) position, (2) inframammary fold (IMF) height, (3) breast size, (4) breast shape, and (5) projection.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;All 25 patients underwent successful reduction mammaplasty. Breast volume was assessed via 3D scanning both preoperatively and at 6 months postoperatively. The mean postoperative follow-up duration was 6.85 ± 1.54 months. The mean preoperative volume asymmetry of 148.32 mL was reduced to 15.32 mL postoperatively, representing a mean reduction of 133.00 mL (95% CI: 102.13, 163.87; p &lt; 0.001). Expressed as a percentage, the volume symmetry improved by a mean of 88.10% (95% CI: 86.03%, 90.16%), which was statistically significant compared to a null hypothesis of 0% improvement (p &lt; 0.001). With the application of the 3D scanning technique, the average observer-rated aesthetic score postoperatively was 4.40 (on a 5-point scale). Postoperative symmetry scores across all five evaluated dimensions demonstrated significant improvement relative to preoperative baseline values (p &lt; 0.001).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;In this single-surgeon, single-center case series, the implementation of 3D scanning-assisted preoperative planning was correlated with a reduction in breast volume asymmetry and an improvement in observer-rated aesthetic symmetry among patients presenting with asymmetric breast hypertrophy. These findings suggest that 3D scanning may provide objective data to assist less-experienced surgeons in decision-making regarding glandular tissue resection, potentially contributing to improved breast symmetry.&lt;/p&gt;&lt;","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149057096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SMAS Plication Facelift and Platysmaplasty Under Tumescent Local Anesthesia: a 10-Year Retrospective Evaluation of Safety, Efficacy, and Patient Satisfaction in an Outpatient Setting.","authors":"Sofia De Riso, Federico Ziani, Giovanni Arrica, Edoardo Filigheddu, Omar Shahid, Ishith Seth, Gianluca Marcaccini, Warren M Rozen, Roberto Cuomo, Corrado Rubino, Emilio Trignano","doi":"10.1007/s00266-026-06228-w","DOIUrl":"https://doi.org/10.1007/s00266-026-06228-w","url":null,"abstract":"<p><strong>Background: </strong>Facial rejuvenation increasingly uses techniques targeting the Superficial Muscular Aponeurotic System (SMAS) to achieve natural and durable outcomes. Advances in anesthesia, especially tumescent local anesthesia (TLA), have enhanced the safety and recovery of complex aesthetic procedures. This study presents a 10-year retrospective evaluation of SMAS plication facelift with platysmaplasty and submental liposuction under TLA, focusing on safety, efficacy, and patient satisfaction.</p><p><strong>Methods: </strong>Between January 2012 and December 2022, 80 consecutive ASA I-II patients (mean age 56.3 ± 4.8 years, BMI 23.4 ± 2.1 kg/m²) underwent SMAS plication facelift with midline platysmaplasty and neck liposuction under TLA. The anesthetic solution consisted of 25 mL 2% lidocaine, 8 mEq sodium bicarbonate, and 1 mL epinephrine in 1000 mL saline, yielding a final concentration of 0.049% lidocaine with 1:1,000,000 epinephrine. Mean total lidocaine dose was 100 ± 5 mg (1.4 ± 0.07 mg/kg). Mild sedation with diazepam 0.05-0.25 mg/kg was administered as needed. Median follow-up was 28 months (IQR 24-36).</p><p><strong>Results: </strong>The mean infiltrated volume was 200 ± 30 mL per patient. No conversions to general anesthesia occurred. Complication rate was 10%, including hematoma (2.5%), seroma (1.25%), dystrophic scarring (3.75%), transient paresthesia (1.25%), and pixie ear deformity (1.25%). No infections or anesthesia-related events were recorded. Patient-reported satisfaction averaged 4.01/5, with high satisfaction regarding postoperative pain management.</p><p><strong>Conclusion: </strong>This ten-year case series demonstrates TLA as a safe and effective alternative to general anesthesia for SMAS plication facelift in selected patients. The technique provides adequate analgesia, supports precise dissection with less bleeding, and minimizes postoperative edema and ecchymosis, leading to quicker recovery and improved patient comfort and satisfaction.</p><p><strong>Level of evidence iv: </strong>This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors  www.springer.com/00266 .</p>","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149057084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facial-Ophthalmic Artery Connections and Facial Artery Variability: A CT Angiography-Based Anatomical Study.","authors":"Halil Altın Karataş, Mehmet Erşen","doi":"10.1007/s00266-026-06190-7","DOIUrl":"https://doi.org/10.1007/s00266-026-06190-7","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize the terminal branching patterns, dominance, and ophthalmic connections of the facial artery (FA) using bilateral CT angiography in a large adult population, with particular relevance to aesthetic and minimally invasive facial procedures.</p><p><strong>Methods: </strong>This retrospective study evaluated contrast-enhanced craniofacial CT angiography scans from 385 adults (770 hemifaces). Six major FA branches were assessed bilaterally, including inferior and superior labial, alar, nasal, angular, and forehead arteries. Terminal branching patterns, dominance, ophthalmic-origin angular arteries, and FA-OA anastomoses were analyzed for demographic associations using Chi-square tests. Bilateral symmetry was recorded descriptively based on anatomical configurations.</p><p><strong>Results: </strong>Marked inter-individual variability was observed in facial artery branching, with 70 distinct bilateral pattern combinations identified. The facial artery most commonly terminated as the nasal (35.5%) or alar artery (27.7%). Ophthalmic-origin angular arteries were identified in 19.5% of individuals, and FA-OA anastomoses in 8.3%. Facial artery dominance was significantly associated with increased ipsilateral branch presence and a higher frequency of ophthalmic-origin angular arteries (p < 0.01), while age and sex showed no significant associations with the primary branching outcomes.</p><p><strong>Conclusion: </strong>Facial artery branching demonstrates marked inter-individual variability and a substantial prevalence of facial-ophthalmic arterial connections. Knowledge of this vascular anatomy may provide supportive information in addition to standard procedural safety precautions, particularly in interventions involving the nasal dorsum and medial canthus, where vision-threatening ischemic complications are a recognized concern.</p><p><strong>Level of evidence iv: </strong>This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors   www.springer.com/00266 .</p>","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149057149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Classic Breast: Western Classical Sculpture Proportions Provide Historical Context for Contemporary Breast Aesthetics.","authors":"Or Friedman, Miri Mizrahi Reuveni, Yuval Paniri, Arnon Afek, Eitan Lavon, David Meirson","doi":"10.1007/s00266-026-06231-1","DOIUrl":"https://doi.org/10.1007/s00266-026-06231-1","url":null,"abstract":"<p><strong>Background: </strong> Contemporary aesthetic surgery planning increasingly relies on evidence-based frameworks, including the upper-to-lower pole proportion of 45:55. Critics argue this template reflects transient social media aesthetics rather than stable biological preferences. Whether Western classical sculpture-which historically informed surgical training-demonstrates proportions consistent with contemporary frameworks remains unquantified.</p><p><strong>Objectives: </strong> To quantify breast proportions in Western classical sculpture across five artistic eras and contextualize contemporary aesthetic frameworks within historical artistic tradition.</p><p><strong>Methods: </strong> From 122 sculptures spanning Hellenistic through Neoclassical eras, we extracted three-dimensional measurements using validated photogrammetric methods. Upper-to-lower pole ratios were computed from footprint measurements. Bilateral asymmetry was analyzed to assess biological realism. Measurements were normalized to 165 cm for clinical comparability.</p><p><strong>Results: </strong> Median upper-to-lower pole ratio was 47.6% [IQR 42.7-53.0], with 30.6% falling within 45 ± 3%. Era-specific medians ranged from 43.7% (Baroque) to 49.7% (Renaissance), with 80% of eras falling between 45 and 50%. Human-scaled measurements: sternal notch-to-nipple 18.5 cm (left), 18.2 cm (right); projection 7.1 cm. Consistent directional asymmetry (left > right) mirrored clinical populations (p = 0.009), demonstrating that sculptures reflect anatomical observation rather than stylized idealization.</p><p><strong>Conclusions: </strong> Western classical sculpture proportions demonstrate a morphological envelope (43-50% upper pole) that encompasses contemporary aesthetic frameworks across 2,500 years. Rather than validating a single numerical target, these findings position the modern 45:55 ratio as a refined point within a broader historical range. This contextualization provides surgeons with historical perspective when counseling patients, while acknowledging that beauty standards reflect both biological and cultural influences requiring individualized surgical planning.</p><p><strong>Level of evidence iv: </strong>This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.</p>","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intralesional Bleomycin for Genital Lymphedema-Associated Lymphatic Malformations and Lymphorrhea.","authors":"Bijun Kang, Yi Zhang, Yuan Fang, Jiajia Chen, Linghua Han, Chuchu Lu, Tianyi Shen, Shengli Li, Weigang Cao, Lingling Sheng, Ziyou Yu","doi":"10.1007/s00266-026-06260-w","DOIUrl":"https://doi.org/10.1007/s00266-026-06260-w","url":null,"abstract":"<p><strong>Background: </strong>Female genital lymphedema may occur secondary to lower-limb lymphedema following lymphadenectomy for gynecologic cancer. It is often characterized by genital lymphatic vesicles (acquired lymphatic malformations) and lymphorrhea, which are frequently overlooked but can markedly impair quality of life.</p><p><strong>Objectives: </strong>To evaluate the efficacy of intralesional bleomycin sclerotherapy for lymphatic malformations and lymphorrhea associated with genital lymphedema.</p><p><strong>Methods: </strong>We retrospectively reviewed patients treated with intralesional bleomycin sclerotherapy between June 2022 and June 2025. Outcomes were assessed by changes in the number of lymphatic vesicles and patient-reported symptoms during a median follow-up of 9 months. Treatment-related complications were also recorded.</p><p><strong>Results: </strong>A significant reduction in lymphatic vesicles was observed, with the median number decreasing from 11 (range 6-33) before treatment to 2 (range 0-6) after treatment (p<0.01). Twelve patients (54.5%) achieved complete resolution of lymphatic leakage, nine (41%) reported marked improvement, and one (4.5%) reported partial improvement. Minor complications included intralesional hemorrhage and transient hyperpigmentation.</p><p><strong>Conclusion: </strong>Intralesional bleomycin sclerotherapy appears to be a safe and effective minimally invasive treatment option for genital lymphedema-associated lymphatic malformations and lymphorrhea. This study provides additional clinical evidence for the management of this underrecognized complication of genital lymphedema.</p><p><strong>Level of evidence iv: </strong>Special Topics. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .</p>","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149029893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Efficacy of 595-nm Pulsed Dye Laser versus CO₂ Fractional Laser in the Treatment of Scars Following Cleft Lip Repair.","authors":"Haoshu Chi, Jiahui Xie, Yubo Wu, Lingyue Shen, Ming Cai","doi":"10.1007/s00266-026-06261-9","DOIUrl":"https://doi.org/10.1007/s00266-026-06261-9","url":null,"abstract":"<p><strong>Background: </strong>The development of scars presents a common clinical concern in the management of cleft lip patients. Both 595-nm pulsed dye laser (PDL) and CO₂ fractional laser are effective treatment options; however, comparative studies between these two modalities are lacking. This study is to evaluate and compare the clinical efficacy of 595-nm PDL versus CO₂ fractional laser in the treatment of post-cleft lip scars.</p><p><strong>Methods: </strong>A total of 34 patients with postoperative cleft lip scars were enrolled between May 2023 and July 2025. Participants were randomly assigned to receive either 595-nm PDL every two weeks for six sessions (n = 17), or CO₂ fractional laser every three months for two sessions (n = 17). One year post-operation, Scar assessment was performed using the Vancouver Scar Scale (VSS), which evaluates vascularity, pigmentation, pliability, and height.</p><p><strong>Results: </strong>Both groups showed statistically significant improvement in VSS scores at follow-up compared to baseline (p < 0.05). No significant differences were observed between the two laser treatments in most scar parameters; however, the 595-nm PDL group demonstrated superior outcomes in reducing vascularity.</p><p><strong>Conclusion: </strong>Both 595-nm pulsed dye laser and CO₂ fractional laser are safe and effective for treating scars after cleft lip surgery.</p><p><strong>Level of evidence i: </strong>This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors https://www.springer.com/00266 .</p>","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149029913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}