Aesthetic Plastic Surgery最新文献

{"title":"The Influence of Age and Gender on Forehead Soft Tissue Thickness: A Magnetic Resonance Imaging-Based Study.","authors":"Cagri Cakmakoglu, Grzegorz Kwiecien, Layne N Raborn, James R Gatherwright, Addison Barnett, Marjorie Kragel, Pierce L Janssen, James E Zins","doi":"10.1007/s00266-025-04957-y","DOIUrl":"https://doi.org/10.1007/s00266-025-04957-y","url":null,"abstract":"<p><strong>Background: </strong>Variations in soft tissue thickness related to age and gender are clinically significant for addressing facial aging and planning esthetic interventions. Previous studies have assessed skin thickness using various methods, including ultrasonography and biopsies, but data specifically examining forehead soft tissue thickness by age and gender are limited.</p><p><strong>Objective: </strong>This study aimed to investigate the effects of age and gender on forehead soft tissue thickness using MRI, a non-invasive modality that provides excellent contrast resolution and reliable measurements.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 160 Caucasian adults (80 females, 80 males) aged 20-99 years, grouped by decade. We measured midline and lateral forehead soft tissue thickness in the sagittal plane on T1-weighted MRI sections, from skin to external cortical lamina, in the lower, middle, and upper thirds. Statistical analyses were performed using factorial ANOVA to assess the impact of age and gender.</p><p><strong>Results: </strong>Males had significantly greater forehead soft tissue thickness than females at all ages and across most regions. Notable differences were observed in the midline (5.4 mm in males vs. 5.0 mm in females; p = 0.043) and in the lower third of the lateral forehead (9.4 mm in males vs. 8.6 mm in females; p = 0.008). Thickness increased from the third to the fifth decade, peaking between ages 40-49, then declining in later decades, particularly in the lower third.</p><p><strong>Conclusion: </strong>Forehead soft tissue thickness varies significantly by age and gender, highlighting the importance of considering these differences in planning esthetic procedures for optimal outcomes.</p><p><strong>Level of evidence iv: </strong>This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .</p>","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Septal Extension Graft on Functional and Esthetic Outcomes in Patients with Severe Nasal Deviation: A Systematic Review and Meta-analysis.","authors":"Abdulrahman Alosaimi, Sulaiman Althobaiti, Mohammed Alhejaily, Hassan Assiri","doi":"10.1007/s00266-025-04934-5","DOIUrl":"https://doi.org/10.1007/s00266-025-04934-5","url":null,"abstract":"<p><strong>Background: </strong>Severe nasal deviation is a complex deformity affecting the esthetics and functionality of the nose, creating an asymmetrical appearance due to septal misalignment. Advances in nasal anatomy and biomechanics have led to the use of grafting materials, such as septal extension grafts. However, its efficacy remains inconclusive. This study investigated the impact of septal extension grafts on the functional and esthetic outcomes in severe nasal deviation.</p><p><strong>Methods: </strong>A literature search was conducted using PubMed, Google Scholar, MEDLINE, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL) from inception to date. Studies were selected based on predefined eligibility criteria, and the Cochrane Risk of Bias in Non-randomized Studies of Interventions (ROBINS-I) tool was used to assess bias risk.</p><p><strong>Results: </strong>The search yielded 1,242 records, of which 18 were included for 1763 patients. Most studies reported statistically significant improvements in Nasal Obstruction Symptom Evaluation (NOSE) scores and nasal symmetry. Improved esthetic outcomes and patient satisfaction were observed after septal extension graft procedures. Patients also experienced increased tip projection and reduced dorsal deviation, with p<0.001 in most studies. The revision rate was significantly lower (OR 0.02, 95% CI 0.00-0.09, p<0.00001). However, slight complications were observed, including tip stiffness (affecting up to 45.5% of patients) and tip deviation (11.4%).</p><p><strong>Conclusion: </strong>Patients with severe nasal deviation consistently improved functional and esthetic outcomes, experienced favorable patient satisfaction, and achieved long-term stability. However, careful consideration is essential due to reported complications and occasional revision surgeries.</p><p><strong>Level of evidence iii: </strong>This review includes well-designed cohort and case-control studies, which provide moderate-quality evidence on the efficacy of septal extension grafts in treating severe nasal deviation. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .</p>","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precapsular Pocket Repositioning: An Effective Technique for Correcting Implant Malposition in Revision Breast Augmentation.","authors":"Chongxu Qiao, Zai Shi, Jingyi Xu, Junyan Miao, Kaili Yan, Shunchao Yan, Yuming Qu, Guoping Wu","doi":"10.1007/s00266-025-04964-z","DOIUrl":"https://doi.org/10.1007/s00266-025-04964-z","url":null,"abstract":"<p><strong>Background: </strong>Breast augmentation remains one of the most commonly performed cosmetic procedures worldwide. However, the reoperation rate following mammoplasty reaches up to 36%, with implant malposition being a major cause of revision surgery. Implant displacement from its intended position often necessitates corrective intervention to restore aesthetic balance. Surgical correction typically involves modifying the existing pocket or creating a new one. Despite advancements in various techniques, challenges remain in ensuring reliability, precision, and surgical simplicity. This study evaluates the use of the precapsular space to create a new pocket for correcting implant malposition.</p><p><strong>Methods: </strong>Between December 2015 and August 2024, 29 patients (52 breasts) underwent revision breast augmentation utilizing the precapsular implant repositioning technique. All patients had previously undergone breast augmentation with implants and subsequently developed implant malposition. A neoprecapsular pocket was created above the anterior capsule wall to ensure precise implant positioning. Surgical outcomes were assessed based on symptom resolution, patient satisfaction, and postoperative complications. Clinical outcomes and patient-reported satisfaction were measured using BREAST-Q scores.</p><p><strong>Results: </strong>The mean patient age was 28.8 years (range: 25-37), with an average follow-up of 7.9 months. Implant malposition was successfully corrected in all cases without postoperative complications, including capsular contracture, breast asymmetry, and symmastia. BREAST-Q results demonstrated high patient satisfaction, with significant improvements in breast appearance and symmetry achieved without an increased risk of complications.</p><p><strong>Conclusions: </strong>The precapsular pocket technique offers an effective solution for correcting implant malposition following breast augmentation. This method provides favorable aesthetic outcomes with high patient satisfaction and minimal complications, making it a promising approach for revision breast surgery.</p><p><strong>Level of evidence iv: </strong>This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .</p>","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Antiplatelet and Anticoagulant Therapy in Aesthetic Plastic Surgery: A Literature Review.","authors":"Federico Taraschi, Chiara Botti, Giovanni Botti","doi":"10.1007/s00266-025-04943-4","DOIUrl":"https://doi.org/10.1007/s00266-025-04943-4","url":null,"abstract":"<p><strong>Background: </strong>The perioperative management of anticoagulant and antiplatelet therapy in aesthetic plastic surgery is a critical challenge, especially with the increasing demand for cosmetic procedures among elderly patients. Currently, there is a notable lack of consensus in the available literature regarding the optimal perioperative management of these medications in elective aesthetic procedures.</p><p><strong>Methods: </strong>A systematic review of PubMed, Embase, and Cochrane Library databases was conducted up to September 2024 to identify studies addressing anticoagulant and antiplatelet therapy management in aesthetic plastic surgery. Inclusion criteria focused on studies related to perioperative management and bleeding risks in elective cosmetic procedures. Articles unrelated to aesthetic surgery or written in non-English languages were excluded.</p><p><strong>Results: </strong>From 192 identified studies, 10 were included. Recommendations varied by procedure and patient risk. For high-risk surgeries like facelifts, anticoagulant cessation 48-72 h before surgery was advised. For low-risk procedures like blepharoplasty, continuation of antithrombotics was deemed safe in some cases, but consensus was lacking.</p><p><strong>Discussion: </strong>The review highlights a lack of standardization in managing anticoagulant and antiplatelet therapies in aesthetic surgery. There is an urgent need for risk-based guidelines to ensure patient safety and minimize bleeding and thromboembolic risks.</p><p><strong>Conclusion: </strong>The management of anticoagulant and antiplatelet therapy in aesthetic plastic surgery remains uncertain. Given the elective and aesthetic nature of these procedures, patient safety should always take precedence.</p><p><strong>Level of evidence iv review: </strong>This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .</p>","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress in Neck Rejuvenation Injection Therapy.","authors":"Zining Wang, Ziming Zhang, Jintian Hu","doi":"10.1007/s00266-025-04959-w","DOIUrl":"https://doi.org/10.1007/s00266-025-04959-w","url":null,"abstract":"<p><p>With the rising demand for minimally invasive cosmetic procedures, neck rejuvenation injections have gained prominence in aesthetic medicine. The neck, highly susceptible to aging and often exposed to sunlight, plays a crucial role in maintaining a youthful appearance. Traditional surgical methods for neck rejuvenation, such as surgical lifting and platysma myotomy, are effective but come with higher risks, longer recovery periods and increased costs. Nonsurgical techniques, particularly filler injections, have emerged as popular alternatives. This review explores the types of injectables used for neck rejuvenation, including hyaluronic acid derivatives, collagen, synthetic dermal fillers, botulinum toxin type A, deoxycholic acid and biological product. The review highlights the advancements, benefits and limitations of these injectables in achieving a youthful and vibrant neck appearance. Combined therapy and personalized treatment plan are emphasized, aiming for optimal aesthetic outcomes, longer-lasting effects and higher patient satisfaction.Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .</p>","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tripedicle Breast Reduction Technique: Superomedial, Central and Inferior. A Modified McKissock Technique.","authors":"Federico Ramírez Zuluaga, Diego Posada Ríos, Ana M Moreno, Natalia Mejía Jiménez","doi":"10.1007/s00266-025-04874-0","DOIUrl":"https://doi.org/10.1007/s00266-025-04874-0","url":null,"abstract":"<p><p>Aesthetic breast surgery is a frequently performed procedure. Since the 6th century, numerous methods for manipulating breast tissue have been documented. Both arterial supply and breast pedicles are well-studied, with particular emphasis on ensuring adequate blood flow to the nipple-areolar complex (NAC), the primary focus of pedicle irrigation. However, the creation of a dermoglandular pedicle with three distinct sources of blood supply has yet to be described in the literature. We present a breast reduction technique using a triple pedicle approach combined with an inverted T incision, as performed by the authors. This study includes outcomes from 227 consecutive patients treated between 2013 and 2024, with each patient followed for a 12-month period. A total of 227 patients (454 breasts) were included, with a median age of 34 years (range: 25.5-42). Among them, 81.06% (184) were classified as overweight or obese, while 18.94% (43) had a normal weight. The median weight of resected tissue was 648 grams (range: 482-817.5) for the right breast and 640 grams (range: 480-817) for the left. The overall complication rate was 2.64% (12 cases). The most frequent complication was bottoming out, followed by areolar epidermolysis, which occurred in 1.32% (6 cases). Areolar necrosis and hematoma were rare, each observed in only one patient (0.22%). The triple pedicle technique is a safe and effective breast reduction surgery option, especially for patients with large-volume breasts. This approach offers reliable blood supply to the nipple-areolar complex (NAC) and yields aesthetically pleasing results. LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors   www.springer.com/00266 ..AQ.</p>","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ensuring Equal Implantation Conditions on Both Sides During Breast Augmentation: Effective Decontamination of Implantation Funnels.","authors":"Paolo Montemurro, Tarush Gupta","doi":"10.1007/s00266-025-04962-1","DOIUrl":"https://doi.org/10.1007/s00266-025-04962-1","url":null,"abstract":"<p><strong>Background: </strong>The role of mitigation strategies to decrease contamination during breast implant surgery has advanced over the years, and the utility of implantation funnels has been recently validated by several studies. However, the additional cost of using separate funnels for each breast has led surgeons to use the same funnel on both sides, which increases the risk of microbial contamination and complications such as capsular contracture in the second breast.</p><p><strong>Methods: </strong>This prospective study included ten consecutive patients undergoing primary breast augmentation. The sterility of the funnels was initially confirmed by microbiological analysis of samples taken from the tip of the funnel immediately after opening. After implantation in the right breast, a second sample set was taken from the funnel. The funnel was then decontaminated using a 2% chlorhexidine with 70% isopropyl alcohol solution, air-dried, and a third sample from the tip was taken. The decontaminated funnel was then used for the left breast implantation. These three samples were analyzed for microbial contamination.</p><p><strong>Results: </strong>Initial funnel samples were found to be sterile, meeting the manufacturer's sterility standards. However, after the initial use, all samples were contaminated with microorganisms (Staphylococcus epidermidis in seven cases and Cutibacterium acnes in three cases). Following chlorhexidine treatment, all samples were found sterile, demonstrating the effectiveness of the decontamination process.</p><p><strong>Conclusion: </strong>Reusing a single funnel for both breast implants increases the risk of microbial contamination in the second breast. However, treating the funnel with a chlorhexidine-isopropyl alcohol solution effectively restores sterility, reducing contamination risks and maintaining cost-effectiveness. This decontamination process offers a viable and cost-effective solution for enhancing patient safety and reducing complications in breast implant surgery.</p><p><strong>Level of evidence iv: </strong>This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .</p>","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Frequency Ultrasound Imaging Findings for Different Breast Fillers.","authors":"Hongli Chai, Jun Zhuang, Xueshang Su, Li Yuan, Ying Jia, Jintian Hu","doi":"10.1007/s00266-025-04880-2","DOIUrl":"https://doi.org/10.1007/s00266-025-04880-2","url":null,"abstract":"<p><strong>Background: </strong>High-frequency ultrasound is commonly used for evaluating breast filling materials and can be used to diagnose adverse reactions after breast augmentation procedures.</p><p><strong>Methods: </strong>Breast ultrasound images obtained at the Plastic Surgery Hospital of the Chinese Academy of Medical Sciences and Peking Union Medical College from January 2015 to February 2023 were analyzed and evaluated.</p><p><strong>Results: </strong>A total of 595 patients who underwent breast augmentation procedures were included in this study: 195 patients underwent prosthetic breast augmentation; 308, autologous fat filling; 77, polyacrylamide hydrogel filling; 12, expander implantation; and 2, silicone oil filling. Ultrasound could reveal complications such as intracapsular rupture, extracapsular rupture, folding, fluid accumulation, and infection after prosthesis implantation. Ultrasound could also show pathological manifestations such as necrosis, calcification, and infection of autologous fat after autologous fat transplantation and displacement, extravasation, calcification, and infection after polyacrylamide hydrogel implantation.</p><p><strong>Conclusions: </strong>High-frequency ultrasound plays an important role in the identification of breast filler materials and the diagnosis of complications after breast augmentation procedures.</p><p><strong>Level of evidence ii: </strong>This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors  www.springer.com/00266 .</p>","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Chemoprophylaxis and Patients' Demographics on Bleeding After Abdominal Body Contouring Procedures.","authors":"Nicholas Fadell, Daehee Jeong, Sara Iskeirjeh, Mohammed Muneer, Rana Farsakoury, Zaki Alyazji, Ghanem Aljassem, Omar Braizat, Gary B Skolnick, Justin M Sacks, Graeme E Glass, Saif M Badran","doi":"10.1007/s00266-025-04975-w","DOIUrl":"https://doi.org/10.1007/s00266-025-04975-w","url":null,"abstract":"<p><strong>Background: </strong>Despite the current increase in body contouring surgery (BCS), the impact of preoperative chemoprophylaxis on bleeding after BCS remains undetermined.</p><p><strong>Methods: </strong>A single institution retrospective cohort study examined patients undergoing abdominal BCS (abdominoplasty, lower body lift, and/or liposuction). Outcomes included estimated blood loss (EBL), hemoglobin drop on the first post-operative day, drain output, length of hospital stay, and the need for surgical evacuation of hematoma or transfusion. Statistical tests performed included chi-square, Wilcoxon signed-rank, and linear regressions using R.</p><p><strong>Results: </strong>Of the 697 patients, 136 (19.5%) received no anticoagulation, 324 (46.5%) had preoperative anticoagulation, 209 (29.9%) received both preoperative and postoperative anticoagulation, and 28 (4%) had missing data. Preoperative LMWH was linked to a 45% increase in serosanguinous drain output on day one (145 ml vs. 100 ml; p < 0.001) but did not increase bleeding risk. Male patients had higher odds of hematoma (OR 14.8, p < 0.001), greater need for blood (OR 5.13, p < 0.001) or plasma (OR 6.15, p < 0.001) transfusion, more significant hemoglobin drop (- 2.23 +/- 1.06 g/dL vs. - 1.43 +/- 1.01 g/dL, p < 0.001), and higher drain output on day one (180 mL vs. 130 mL, p < 0.001) and overall (655 mL vs. 380 mL, p < 0.001). Previous obesity surgery patients also had higher odds for hematoma (OR 3.24, p = 0.011), blood transfusion (OR 3.26, p = 0.002), and increased drain output.</p><p><strong>Conclusions: </strong>Preoperative chemoprophylaxis in BCS is associated with increased serosanguinous drain output without additional bleeding risk. Male gender and a history of obesity surgery increase the risk of hematoma, hemoglobin drop, and transfusion needs.</p><p><strong>Level of evidence iii: </strong>This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine Ratings, please refer to Table of Contents or online Instructions to Authors www.springer.com/00266 .</p>","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Fixed-Angle and Horizontal Rotor Centrifugation on Optimized Platelet-Rich Plasma Preparation.","authors":"Mengli Xie, Baoping Zhao, Jianxiang Teng, Long Yang, Zhen Wang, Shun'en Xu, Zhanyu Wu, Chuan Ye","doi":"10.1007/s00266-025-04941-6","DOIUrl":"https://doi.org/10.1007/s00266-025-04941-6","url":null,"abstract":"<p><strong>Background: </strong>Platelet-rich plasma (PRP) is extensively used in regenerative medicine; however, its preparation lacks standardization. The difference in rotor angle between fixed-angle and horizontal rotors influences PRP quality. This study aims to compare the effects of these two rotor types on PRP preparation.</p><p><strong>Methods: </strong>A total of 15 subjects were enrolled in the study, with each subject donating 80 ml of whole blood, which was then divided into two separate tubes, each containing 40 ml. PRP was prepared using two rounds of centrifugation with both fixed-angle and horizontal rotors under optimal parameters. Platelet recovery, concentration, growth factor content, and effects on cell co-culture were assessed.</p><p><strong>Results: </strong>The fixed-angle centrifuge demonstrated higher platelet recovery efficiency, increased platelet content, and greater PDGF-BB levels in the PRP, with no significant change in CD62P expression. Co-culture assays showed enhanced cell proliferation and migration with PRP prepared using the fixed-angle rotor compared to the horizontal rotor.</p><p><strong>Conclusions: </strong>Under appropriate centrifugation parameters, the fixed-angle centrifuge can extract higher quality PRP in a shorter time.</p><p><strong>Level of evidence ii: </strong>This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .</p>","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}