Steven D M Colpaert, Tamara A Garsten, Toon Sels, Marc van Cleemput
{"title":"Invited Response to: Comment on \"Sub-nipple Incision for Gland Resection in Gynecomastia, Combined with High-Definition Liposculpture Principles: Technical Refinements and a Step-by-Step Video Guide\".","authors":"Steven D M Colpaert, Tamara A Garsten, Toon Sels, Marc van Cleemput","doi":"10.1007/s00266-025-05332-7","DOIUrl":"https://doi.org/10.1007/s00266-025-05332-7","url":null,"abstract":"<p><p>Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .</p>","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lymphatic-Sparing Approaches and Liposuction Integration in Upper Body Lift Surgery.","authors":"Agostino Bruno","doi":"10.1007/s00266-025-05369-8","DOIUrl":"https://doi.org/10.1007/s00266-025-05369-8","url":null,"abstract":"","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bromelain Beyond the Nose: Translational Considerations for Breast and Body Contouring Surgery.","authors":"Agostino Bruno","doi":"10.1007/s00266-025-05309-6","DOIUrl":"https://doi.org/10.1007/s00266-025-05309-6","url":null,"abstract":"","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Regenerative Medicine for Atrophic Scars: A Systematic Review of Extracellular Vesicles, Conditioned Media, Stromal Vascular Fraction, and Mesenchymal Stem Cells.","authors":"Alireza Jafarzadeh, Seyed Soheil Hoseini, Elham Behrangi, Masoumeh Roohaninasab, Azadeh Goodarzi","doi":"10.1007/s00266-025-05284-y","DOIUrl":"https://doi.org/10.1007/s00266-025-05284-y","url":null,"abstract":"<p><strong>Introduction: </strong>Atrophic scars, caused by insufficient collagen deposition and ECM production during wound healing, significantly affect patients' quality of life. Conventional treatments often fail to achieve complete skin regeneration, prompting interest in regenerative medicine. This review evaluates the efficacy and safety of emerging regenerative therapies, including extracellular vesicles, conditioned media, stromal vascular fraction, and mesenchymal stem cells, in improving atrophic scars.</p><p><strong>Method: </strong>A systematic search was conducted on PubMed, Scopus, and Web of Science up to November 23, 2024. Relevant keywords, including \"conditioned media,\" \"Secretome,\" \"extracellular vesicles,\" \"atrophic scar,\" \"rejuvenation,\" and \"lightening,\" were used to identify studies. Articles meeting inclusion criteria underwent data extraction focusing on study design, population characteristics (mean and range), intervention details (including duration), comparison groups, clinical outcomes with statistical results, and reported adverse effects, ensuring comprehensive analysis and adherence to PRISMA guidelines.</p><p><strong>Result: </strong>Out of 186 initially identified articles, 11 studies involving 177 participants (89 females, 59 males, and 29 undefined, mean age 31.52 years) were reviewed, focusing on treatments for acne scars (82%) and striae distensae (18%). These studies evaluated stromal vascular fraction (SVF), cell-conditioned medium (CM), mesenchymal stem cells (MSC), and extracellular vesicles (EV). Significant improvements were observed with various treatments, including a 32.5% decrease in ECCA scores with adipose tissue stem cell exosome (ASCE) treatment, and greater acne scar improvements with Fractional CO<sub>2</sub> Laser combined with platelet-rich plasma compared to stem cell-conditioned medium (SC-CM). Other promising results included enhanced skin elasticity and collagen density with ADSC-CM and a 28.5% reduction in scar volume with HSCM combined with FCL. SVF treatments, including gel and Subcision, demonstrated notable improvements in striae distensae and acne scars, with significant reductions in scar volume, area, and depth. Intradermal bone marrow stem cell injections also led to significant acne scar improvements, highlighting the potential of stem cell-based and exosome treatments for skin regeneration.</p><p><strong>Conclusion: </strong>The evaluated studies indicate promising efficacy for regenerative treatments such as SVF, CM, EV, and MSC in improving acne scars and striae distensae. Significant enhancements in scar appearance, skin hydration, and patient satisfaction were observed across various combination therapies compared to controls. While these advancements offer new hope for patients with moderate to severe skin conditions, further research is needed to establish standardized protocols and long-term efficacy. The minimal reported adverse effects highlight the safety of these ","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145297716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Commentary on: Frontalis Only Contracts in One Direction: AI-Quantum Elasticity and Resistance Gradient Reveals True Nature of Forehead Muscle Movement.","authors":"Marina Landau, Jeremy B Green, Sebastian Cotofana","doi":"10.1007/s00266-025-05318-5","DOIUrl":"https://doi.org/10.1007/s00266-025-05318-5","url":null,"abstract":"","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saule A Mussabekova, Yuliya Menchisheva, Álvaro Varela Morillas
{"title":"Litigation and Complications Arising from Aesthetic Body Surgery: A Systematic Review.","authors":"Saule A Mussabekova, Yuliya Menchisheva, Álvaro Varela Morillas","doi":"10.1007/s00266-025-05276-y","DOIUrl":"https://doi.org/10.1007/s00266-025-05276-y","url":null,"abstract":"<p><strong>Background: </strong>Aesthetic body surgeries such as liposuction, abdominoplasty, gluteoplasty, and breast augmentation have seen a global rise. However, the growing popularity of these procedures has led to increased reports of postoperative complications and medico-legal disputes.</p><p><strong>Objective: </strong>To systematically review complications and litigation outcomes associated with aesthetic body surgeries and identify the most common risk factors contributing to legal claims.</p><p><strong>Methods: </strong>A systematic review was conducted in accordance with PRISMA guidelines (registration on PROSPERO ID: CRD420251043585). Forty-one studies published since between 2020 and 2025 were included. Complications, allegations, and legal outcomes were extracted and analysed. Risk of bias was assessed using JBI and ROBINS-I tools.</p><p><strong>Results: </strong>Infection (48.7%), fat embolism (26.8%), and hematoma (21.9%) were the most frequent complications. Gluteal fat grafting had the highest mortality and legal risk, with a 7.77% incidence of fat embolism. Inadequate informed consent was a leading allegation in over 50% of cases. Claims most often resulted in dismissal (45-76%), but 20-40% led to settlements or plaintiff verdicts, especially in cases of severe complications such as embolism or disfigurement. The pooled average of favourable verdicts for surgeons was 54.3% (95% CI: 49-59%). Publication bias was suggested by asymmetrical funnel plot distribution and high heterogeneity (I<sup>2</sup> > 90%).</p><p><strong>Conclusion: </strong>Medico-legal disputes in aesthetic body surgery commonly arise from preventable complications, especially when informed consent is inadequate or postoperative care is substandard. Standardised consent process, improved documentation, procedure-specific risk communication, and regulation of outpatient practices are critical to reducing litigation risk.</p><p><strong>Level of evidence iii: </strong>This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .</p>","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optimizing Laser-Assisted Liposuction: Efficacy, Thermal Safety, and the Need for Uniform Parameters.","authors":"Agostino Bruno","doi":"10.1007/s00266-025-05311-y","DOIUrl":"https://doi.org/10.1007/s00266-025-05311-y","url":null,"abstract":"","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Breast Implant Illness: The Case for Consensus Criteria and Multimodal Assessment.","authors":"Agostino Bruno","doi":"10.1007/s00266-025-05310-z","DOIUrl":"https://doi.org/10.1007/s00266-025-05310-z","url":null,"abstract":"","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Beyond Brazilian Butt Lifts: The Imperative of Transparent Risk Communication Across All Cosmetic Procedures on Social Media.","authors":"Agostino Bruno","doi":"10.1007/s00266-025-05313-w","DOIUrl":"https://doi.org/10.1007/s00266-025-05313-w","url":null,"abstract":"","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rodolfo M Ortiz-Flores, Alejandro Escamilla-Sanchez, Borja Cidoncha-Morcillo, Luis Mastronardi, Silvia Fontenete, Regina Garcia-Delgado
{"title":"Enhanced Facial Rejuvenation: Biostimulatory Effects of Hylan Gel Dermal Filler DX on Collagen Synthesis and Tissue Regeneration.","authors":"Rodolfo M Ortiz-Flores, Alejandro Escamilla-Sanchez, Borja Cidoncha-Morcillo, Luis Mastronardi, Silvia Fontenete, Regina Garcia-Delgado","doi":"10.1007/s00266-025-05245-5","DOIUrl":"https://doi.org/10.1007/s00266-025-05245-5","url":null,"abstract":"<p><strong>Background: </strong>Facial rejuvenation involves addressing the breakdown of collagen and elastin that occurs with aging. Hyaluronic acid (HA)-based dermal fillers have become a key non-invasive treatment, known for their volumizing effects and potential regenerative benefits. This study characterizes the physicochemical and rheological properties of Hylan Gel Dermal Filler DX, a novel filler combining HA and dextranomer microspheres, and evaluates its capacity to enhance extracellular matrix regeneration.</p><p><strong>Methods: </strong>Rheological analysis was conducted to determine viscoelastic properties, including storage modulus (G'), loss modulus (G''), and tan delta across frequencies (0.1-10 Hz). In vitro experiments with normal human dermal fibroblasts (NHDFs) and monocytes (J774A.1) assessed the effects of Hylan Gel Dermal Filler DX (HA + DX), Genefill Soft Fill (HA), HarmonyCa® (HA+CaHa), Radiesse® (CaHa), and Sculptra® (PLLA). Hydration and wound healing assays were also performed. Biomarker analysis focused on collagen types I, III, IV, VI, elastin, and cytokines (TGF-β1, IL-1β, IL-6, IL-10, TNFα).</p><p><strong>Results: </strong>Rheologically, HA + DX displayed a balanced elastic and viscous profile, supporting its structural integrity and adaptability in dynamic facial areas. HA + DX demonstrated high stimulation of collagen types I, III, IV, VI, and elastin production, with enhanced fibroblast migration and wound healing at 72 hours compared to other fillers. HA + DX also modulated cytokines, increasing TGF-β1 and IL-10 while reducing TNFα and IL-1β, suggesting anti-inflammatory and regenerative properties.</p><p><strong>Conclusions: </strong>HA + DX exhibited considerable benefits in collagen stimulation, wound healing, and cytokine modulation. Its favorable rheological characteristics and regenerative potential make it a promising option for facial rejuvenation and tissue regeneration.</p><p><strong>No level assigned: </strong>This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.</p>","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}