American Journal of Hypertension最新文献

Brachial systolic Pressure averages twice diastolic: evidence from invasive high-fidelity pressure recordings. 臂膀收缩压平均为舒张压的两倍：来自有创高保真压力记录的证据。

IF 3.1 3区医学

American Journal of Hypertension Pub Date : 2025-10-03 DOI: 10.1093/ajh/hpaf199

Denis Chemla, Mathieu Jozwiak, Olfa Hamzaoui, Pierre Attal, Jean-Louis Teboul

{"title":"Brachial systolic Pressure averages twice diastolic: evidence from invasive high-fidelity pressure recordings.","authors":"Denis Chemla, Mathieu Jozwiak, Olfa Hamzaoui, Pierre Attal, Jean-Louis Teboul","doi":"10.1093/ajh/hpaf199","DOIUrl":"https://doi.org/10.1093/ajh/hpaf199","url":null,"abstract":"Background: Systolic arterial pressure (SAP) and diastolic arterial pressure (DAP) are key measurements in cardiovascular assessment. A recent invasive study by our group found that SAP averages twice DAP at the radial and femoral levels. Whether this relationship applies to the brachial artery and central aorta remains unknown.Methods: Guided by two systematic reviews, we conducted a secondary data analysis of studies that simultaneously reported high-fidelity invasive brachial and aortic pressures in adults undergoing cardiac catheterization. Allowing a ± 2.5% measurement error in SAP and DAP, we defined an acceptable SAP/DAP ratio range of 1.90 to 2.10.Results: Seven studies were included (n = 268; 69% male; mean age 62 years). The weighted mean brachial SAP/DAP ratio was 1.98 (141.6/71.6 mmHg) across the cohort and aligned with our hypothesis in six studies (n = 256; 95% of the population). The one study that did not support the hypothesis was a letter-format publication with a small sample size (n = 12). The hypothesis regarding the aortic SAP/DAP ratio was largely unsupported, being rejected in six studies (n = 232) and in the pooled data (1.89 = 134.7/71.4).Conclusion: This preliminary analysis shows that brachial SAP averages twice DAP within a minimal margin of measurement error. These findings highlight a potentially important hemodynamic feature of the brachial artery-and, more generally, of peripheral large arteries, in contrast to the aorta. However, broader validation is needed to assess the clinical relevance of these results beyond the predominantly older male cohort referred for catheterization, and the physiological basis of this pattern also warrants further investigation.","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145224659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overview of the 2025 American Heart Association/American College of Cardiology Blood Pressure Guideline: Perspective From Editors at the American Journal of Hypertension. 2025年美国心脏协会/美国心脏病学会血压指南概述：来自《美国高血压杂志》编辑的观点

IF 3.1 3区医学

American Journal of Hypertension Pub Date : 2025-09-30 DOI: 10.1093/ajh/hpaf181

Paul Muntner, Ernesto L Schiffrin

引用次数: 0

The rise and fall of blood pressure and cognitive function: implications for sex differences in brain health. 血压和认知功能的升降：对大脑健康性别差异的影响。

IF 3.1 3区医学

American Journal of Hypertension Pub Date : 2025-09-26 DOI: 10.1093/ajh/hpaf197

Kevin S Heffernan, Raymond R Townsend

引用次数: 0

Central Blood Pressure Reduction: Potential Clue to the Choice Between Beta-Blocker and Angiotensin Receptor Blocker. 中枢血压降低：β受体阻滞剂和血管紧张素受体阻滞剂选择的潜在线索。

IF 3.1 3区医学

American Journal of Hypertension Pub Date : 2025-09-25 DOI: 10.1093/ajh/hpaf182

Guglielmo M Trovato

引用次数: 0

Community Practices and Perceptions Regarding Blood Pressure Measurement Techniques. 关于血压测量技术的社区实践和认知。

IF 3.1 3区医学

American Journal of Hypertension Pub Date : 2025-09-23 DOI: 10.1093/ajh/hpaf195

Mingjuan Zeng, Eleanor Clapham, Dean Picone, Sonali R Gnanenthiran, Ruth Griffiths, Niamh Chapman, Aletta E Schutte

{"title":"Community Practices and Perceptions Regarding Blood Pressure Measurement Techniques.","authors":"Mingjuan Zeng, Eleanor Clapham, Dean Picone, Sonali R Gnanenthiran, Ruth Griffiths, Niamh Chapman, Aletta E Schutte","doi":"10.1093/ajh/hpaf195","DOIUrl":"https://doi.org/10.1093/ajh/hpaf195","url":null,"abstract":"Background: Despite various blood pressure (BP) measurement methods being available, many people report never or infrequently having their BP measured. There is a gap between clinical guidelines and the implementation of BP monitoring. To bridge that gap, we interviewed community members to understand their practices and perceptions regarding various measurement methods.Methods: Australian adults who participated in a home BP measurement study were purposively sampled for semi-structured interviews (2023-2024).Results: Participants (n = 29) were middle-aged (mean 61 ± 12.8 years, 55% female), and most (79%) had diagnosed hypertension. All participants had real-world experience with both clinic and home BP measurements; 15 with 24-hour ambulatory monitoring (24h ABPM); 10 with kiosks; and three used cuffless BP devices. Participants described clinic BP as routine and highly valued direct feedback from doctors. Participants valued home BP due to convenience and the number of measurements they could take. Most participants reported no issues with 24h ABPM, although three experienced severe discomfort or dislike. Concerns about measurement accuracy and privacy were raised by four participants regarding kiosk BP, as devices were sometimes non-standardized and located in open areas. Most participants expressed interest in cuffless BP devices but had limited experience using them.Conclusions: We have identified barriers associated with clinic, 24-hour ABPM, HBPM, and kiosk BP that need to be addressed to enhance consumer satisfaction and increase monitoring rates, highlighting the need for a coordinated approach involving key health organizations and healthcare professionals.","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

R-Wave Peak Time and Subclinical Left Ventricular Dysfunction in Hypertensive Patients: Insights From Speckle-Tracking Echocardiography. 高血压患者的r波峰值时间和亚临床左心室功能障碍：来自斑点跟踪超声心动图的见解。

IF 3.1 3区医学

American Journal of Hypertension Pub Date : 2025-09-23 DOI: 10.1093/ajh/hpaf180

Ayca Arslan, Dogan Ilis, Inanc Artac, Muammer Karakayali, Timor Omar, Zihni Cagin, Zulfiye Kuzu, Ozcan Yagcibulut, Cengiz Burak, Yavuz Karabag, Ibrahim Rencuzogullari

{"title":"R-Wave Peak Time and Subclinical Left Ventricular Dysfunction in Hypertensive Patients: Insights From Speckle-Tracking Echocardiography.","authors":"Ayca Arslan, Dogan Ilis, Inanc Artac, Muammer Karakayali, Timor Omar, Zihni Cagin, Zulfiye Kuzu, Ozcan Yagcibulut, Cengiz Burak, Yavuz Karabag, Ibrahim Rencuzogullari","doi":"10.1093/ajh/hpaf180","DOIUrl":"https://doi.org/10.1093/ajh/hpaf180","url":null,"abstract":"Background: Hypertension (HT) is one of the most common causes of myocardial dysfunction. Although early detection of myocardial impairment remains challenging, left ventricular global longitudinal strain (LV-GLS) is a sensitive echocardiographic parameter that can identify subclinical myocardial damage. However, its application is limited in routine clinical settings. R-wave peak time (RWPT) is a simple and widely available electrocardiographic parameter that may reflect intramyocardial conduction delay and early structural remodeling. This study aimed to investigate the association between RWPT and LV-GLS in patients with HT.Methods: This prospective study included 403 patients with a confirmed diagnosis of HT. All participants underwent transthoracic echocardiography and 12-lead surface ECG. LV-GLS was assessed using speckle-tracking echocardiography. ECG images were digitized and analyzed using ImageJ software, and RWPT was defined as the interval from the onset of the QRS complex to the peak of the R-wave.Results: Patients were divided into two groups according to their LV-GLS value of -15.9%, which is defined as the cutoff value of myocardial impairment. Patients with a lower LV-GLS had significantly longer RWPT and QRS durations. In multivariate analysis, RWPT was found to be an independent predictor of impaired LV-GLS (OR: 1.085; 95% CI: 1.056-1.114; P < 0.001). ROC analysis demonstrated an AUC of 0.715 (95% CI: 0.665-0.765; P < 0.001) with a sensitivity of 64.9% and a specificity of 67.7% at a cutoff value of 45.5 ms.Conclusions: RWPT may serve as a practical, accessible, and sensitive electrocardiographic marker for detecting subclinical myocardial dysfunction in patients with HT.","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Title: Prescription Trends of Hydrochlorothiazide vs. Chlorthalidone in the United States (2019-2024). 标题：美国氢氯噻嗪与氯噻酮的处方趋势（2019-2024）。

IF 3.1 3区医学

American Journal of Hypertension Pub Date : 2025-09-23 DOI: 10.1093/ajh/hpaf190

R Asante, Z Yao, O Dzaye, P Berning, Y Jelwan, S Burka, R S Blumenthal, M J Blaha

{"title":"Title: Prescription Trends of Hydrochlorothiazide vs. Chlorthalidone in the United States (2019-2024).","authors":"R Asante, Z Yao, O Dzaye, P Berning, Y Jelwan, S Burka, R S Blumenthal, M J Blaha","doi":"10.1093/ajh/hpaf190","DOIUrl":"https://doi.org/10.1093/ajh/hpaf190","url":null,"abstract":"Background: Hydrochlorothiazide and chlorthalidone have been cornerstones of hypertension management for decades. Given the historical debate about their comparative effectiveness and cardiovascular outcomes, as well as recent clinical trial evidence, we studied prescription trends to assess the association of prescribing patterns with evolving knowledge.Methods: We analyzed prescriptions of hydrochlorothiazide and chlorthalidone from January 2019 to December 2024 using IQVIA's National Prescription Audit (NPA). Interrupted Time Series (ITS) analysis assessed inflections in prescribing practice around the December 2022 Diuretic Comparison Project (DCP) findings and the August 2020 hydrochlorothiazide US Food and Drug Administration (FDA) non-melanoma skin cancer warning.Results: On average, 3,734,790 hydrochlorothiazide and 543,402 chlorthalidone prescriptions were dispensed, a 7:1 ratio. A drop of 503,367 hydrochlorothiazide prescriptions (14%; 95% CI: -673,109 to -333,624) was observed in the first month after the FDA's warning, and the pre-warning 43,913 (95% CI: 31,701 to 56,125) monthly increase reversed to a monthly decline of 13,546 (95% CI: -16,137 to -10,954) prescriptions post-warning. After the DCP report, a slowdown of 2,738 (95% CI: -4,472 to -1,004) monthly prescriptions for chlorthalidone was seen, reducing the rate of monthly increase from 3,602 (95% CI: 1916 to 5289) to 864 (95% CI: 431 to 1298). Monthly hydrochlorothiazide prescriptions declined to -20,124 (95% CI: -26285 to -13962) post DCP report.Conclusion: The FDA warning and DCP report were associated with a decline in hydrochlorothiazide and chlorthalidone prescriptions, while the DCP report slowed chlorthalidone prescribing.","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The aldosterone plot thickens. 醛固酮图变厚。

IF 3.1 3区医学

American Journal of Hypertension Pub Date : 2025-09-20 DOI: 10.1093/ajh/hpaf192

Florian Rader, Alexander Kukuev

引用次数: 0

Clinical Utility of miR-590-5p as a Biomarker for Stratifying Disease Severity and Anticipating Adverse Perinatal Outcomes in Preeclamptic Patients. miR-590-5p作为子痫前期患者疾病严重程度分层和预测不良围产期结局的生物标志物的临床应用

IF 3.1 3区医学

American Journal of Hypertension Pub Date : 2025-09-20 DOI: 10.1093/ajh/hpaf191

Yanan Cao, Yanqiu Ding, Jie Wang

{"title":"Clinical Utility of miR-590-5p as a Biomarker for Stratifying Disease Severity and Anticipating Adverse Perinatal Outcomes in Preeclamptic Patients.","authors":"Yanan Cao, Yanqiu Ding, Jie Wang","doi":"10.1093/ajh/hpaf191","DOIUrl":"https://doi.org/10.1093/ajh/hpaf191","url":null,"abstract":"Background: Chronic hypertension, gestational hypertension (GH), and preeclampsia (PE) together comprise hypertensive disorders complicating pregnancy (HDCP). They are one of the most common complications of pregnancy. Aberrant microRNA (miRNA) expression may signal PE and adverse outcomes.Aims: Study of the clinical relevance of miR-590-5p in evaluating disease severity and predicting adverse pregnancy outcomes in PE.Methods: Totally 240 subjects were enrolled in this study, including 60 patients with GH, 120 patients with PE, and 60 healthy controls (HC). The PE group consisted of 60 mild PE (MP) and 60 severe PE (SP). The RT-qPCR was employed to detect the serum miR-590-5p expression. ROC curves and logistic regression were used to analyze their diagnostic value. PE patients were grouped by miR-590-5p expression and followed until delivery. The Kaplan-Meier method was employed to investigate the influence of miR-590-5p expression on pregnancy outcome in patients with PE.Results: MiR-590-5p expression was increased in GH, which was further elevated in PE. MiR-590-5p expression was shown to be greater in SP than in MP. MiR-590-5p could differentiate between GH/PE (AUC = 0.921, sensitivity = 80.0%, specificity = 91.7%) and MP/SP (AUC = 0.910, sensitivity = 82.0%, specificity = 85.0%). The level of miR-590-5p expression was correlated positively with blood pressure, urinary protein, and creatinine, and negatively with platelets and neonatal weight. The miR-590-5p high-expression group of patients had a lower probability of normal delivery.Conclusions: Up-regulation of miR-590-5p might help to diagnose PE, depicting the severity of PE, and positively correlate with adverse pregnancy outcomes.","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: D3 Dopamine Receptor Regulation of ETB Receptors in Renal Proximal Tubule Cells From WKY and SHRs. 修正：D3多巴胺受体调节肾近端小管细胞ETB受体来自WKY和SHRs。

IF 3.1 3区医学

American Journal of Hypertension Pub Date : 2025-09-16 DOI: 10.1093/ajh/hpaf111

引用次数: 0