American Journal of Hypertension最新文献

Hypertension Rounds: Successful treatment with evocalcet for resistant hypertension induced by asymptomatic primary hyperparathyroidism.

IF 3.2 3区医学

American Journal of Hypertension Pub Date : 2025-03-23 DOI: 10.1093/ajh/hpaf042

Sumie Sakamoto, Mamiko Ohara, Masatoshi Matsunami, Tomo Suzuki

引用次数: 0

Strategies for Success: Million Hearts® Hypertension Control Champions.

IF 3.2 3区医学

American Journal of Hypertension Pub Date : 2025-03-23 DOI: 10.1093/ajh/hpaf040

Jessica Barnett, Adam S Vaughan, Judith Hannan, Haley Stolp, Janet S Wright, Fátima Coronado

{"title":"Strategies for Success: Million Hearts® Hypertension Control Champions.","authors":"Jessica Barnett, Adam S Vaughan, Judith Hannan, Haley Stolp, Janet S Wright, Fátima Coronado","doi":"10.1093/ajh/hpaf040","DOIUrl":"https://doi.org/10.1093/ajh/hpaf040","url":null,"abstract":"Background: Among the 119.9 million U.S. adults with hypertension, an estimated 92.9 million have systolic blood pressure ≥ 130 mm Hg or diastolic blood pressure ≥ 80 mm Hg. Million Hearts® is an initiative co-led since 2011 by the Centers for Disease Control and Prevention (CDC) and the Centers for Medicare and Medicaid Services (CMS). The program drives improvement in hypertension control by celebrating high-achieving clinicians, practices, and health systems each year as Million Hearts Hypertension Control Champions. Champions have validated control rates of 80% or higher.Methods: Using data from each Champion, we summarized their key characteristics and quantified their use of various evidence-based strategies. We calculated summary statistics for application data provided by Champions based on the initiative's five-year cycles of operation (2012-2015; 2017-2020; 2022-2024).Results: From 2012 to 2024, a total of 199 Hypertension Control Champions from 44 states were recognized; mean prevalence of systolic blood pressure < 140 mm Hg and diastolic blood pressure < 90 mm Hg was 82%. Overall, Champions reported using multiple evidence-based strategies to help their patients achieve hypertension control. The top 3 strategies were electronic medical record (EMR) usage, patient supports including self-measured blood pressure monitoring (SMBP), and team-based care.Conclusions: The Million Hearts® Hypertension Control Champions demonstrate that hypertension control may be achievable among patients across diverse settings by implementation of evidence-based approaches.","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Antihypertensive Drugs on Rapid Decline in Estimated Glomerular Filtration Rate in Japanese Patients with Chronic Kidney Disease.

IF 3.2 3区医学

American Journal of Hypertension Pub Date : 2025-03-23 DOI: 10.1093/ajh/hpaf041

Kenta Fujimoto, Masao Kikuchi, Michikazu Nakai, Tsuneo Konta, Kunitoshi Iseki, Kazuhiko Tsuruya, Kunihiro Yamagata, Ichiei Narita, Toshiki Moriyama, Yugo Shibagaki, Masato Kasahara, Masahide Kondo, Koichi Asahi, Tsuyoshi Watanabe, Koichi Kaikita, Shouichi Fujimoto

{"title":"Effect of Antihypertensive Drugs on Rapid Decline in Estimated Glomerular Filtration Rate in Japanese Patients with Chronic Kidney Disease.","authors":"Kenta Fujimoto, Masao Kikuchi, Michikazu Nakai, Tsuneo Konta, Kunitoshi Iseki, Kazuhiko Tsuruya, Kunihiro Yamagata, Ichiei Narita, Toshiki Moriyama, Yugo Shibagaki, Masato Kasahara, Masahide Kondo, Koichi Asahi, Tsuyoshi Watanabe, Koichi Kaikita, Shouichi Fujimoto","doi":"10.1093/ajh/hpaf041","DOIUrl":"https://doi.org/10.1093/ajh/hpaf041","url":null,"abstract":"Background: Rapid decline in estimated glomerular filtration rate (eGFR) is linked to increased mortality and morbidity in chronic kidney disease (CKD). Few studies have focused on the risk of rapid eGFR decline. This study evaluates the association between antihypertensive drug use, blood pressure (BP) levels, and rapid eGFR decline in Japanese CKD patients.Methods: Data from 100,746 Japanese individuals aged 40-74 years with CKD were analyzed. Rapid eGFR decline was defined as an annual reduction >25%. Logistic regression was used to assess associations between antihypertensive drug use, BP levels, and rapid eGFR decline, stratified by eGFR and urinary proteinuria.Results: Rapid eGFR decline occurred in 5.8% of participants. Higher BP levels increased the risk compared to normal BP: high-normal + elevated BP (odds ratio [OR], 1.26; 95% CI: 1.12-1.41) and high BP (OR, 1.79; 95% CI: 1.59-2.02). Controlling BP to high-normal or elevated levels in patients receiving antihypertensives reduced this risk. Overall, antihypertensive drug users had approximately twice the risk of rapid eGFR decline compared to non-users. However, in proteinuric patients with preserved eGFR, the risk increase was lower (1.27 times) in the high-normal + elevated BP group compared to that in the overall cohort.Conclusion: The risk of rapid eGFR decline increased with increasing BP and decreased with controlling BP. Antihypertensive treatment was associated with a higher risk of rapid eGFR decline at all BP levels. For CKD patients with proteinuria, maintaining BP in the high-normal or elevated range may further mitigate this risk.","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ideal Cardiovascular Health Metrics and Fatal Major Adverse Cardiovascular Events in Hypertensive Patients with Blood Pressure at or above Target.

IF 3.2 3区医学

American Journal of Hypertension Pub Date : 2025-03-20 DOI: 10.1093/ajh/hpaf036

Shanshan Shi, Weihua Chen, Lin Deng, Kaihong Chen, Ying Liao

{"title":"Ideal Cardiovascular Health Metrics and Fatal Major Adverse Cardiovascular Events in Hypertensive Patients with Blood Pressure at or above Target.","authors":"Shanshan Shi, Weihua Chen, Lin Deng, Kaihong Chen, Ying Liao","doi":"10.1093/ajh/hpaf036","DOIUrl":"https://doi.org/10.1093/ajh/hpaf036","url":null,"abstract":"Background: High blood pressure (BP) is a major risk factor for cardiovascular disease (CVD) events. The ideal cardiovascular health metrics (ICVHMs) have beneficial effects on the cardiovascular system. The present study examined the association between ICVHMs and the risk of hypertension-related CVD in hypertensive patients across different BP ranges.Methods: Analyses included 31,427 adults from the National Health and Nutrition Examination Survey 2005-2018. The BP target was <130/80 mmHg and ICVHMs were defined based on the 2022 American Heart Association Presidential Advisory. Fatal major adverse cardiovascular events (MACE) were the primary outcomes. Cox proportional hazards models were used to calculate the HR and 95% CI for MACE mortality.Results: Among 31,427 participants, hypertensive patients with ≥5 ICVHMs did not appear significantly additional risk of MACE mortality compared to participants without hypertension (BP at target: HR, 1.09; 95%CI, 0.72-1.64; BP above target: HR, 0.98; 95%CI, 0.69-1.39). Compared to patients with 0-1 ICVHMs, experiencing ≥5 ICVHMs was associated with a lower MACE mortality risk (BP at target: HR, 0.60; 95%CI, 0.36-0.98; BP above target: HR, 0.43; 95%CI, 0.30-0.62). Among hypertensive patients, each increase in the number of ICVHMs was associated with a lower risk of MACE mortality (BP at target: HR, 0.86; 95%CI, 0.76-0.97; BP above target: HR, 0.84; 95%CI, 0.78-0.91), even in patients with high risk factors for CVD.Conclusions: Compared to participants without hypertension, hypertensive patients with fewer ICVHMs, regardless of whether their blood pressure is well-controlled, face a significantly higher risk of MACE mortality.","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial Intelligence to Improve Blood Pressure Control: A State-of-the-Art Review.

IF 3.2 3区医学

American Journal of Hypertension Pub Date : 2025-03-20 DOI: 10.1093/ajh/hpaf035

Amogh Karnik, Eugene Yang

引用次数: 0

Comparative outcomes of adrenalectomy, mineralocorticoid receptor antagonist, and percutaneous adrenal ablation for primary aldosteronism: a systematic review and network meta-analysis.

IF 3.2 3区医学

American Journal of Hypertension Pub Date : 2025-03-18 DOI: 10.1093/ajh/hpaf029

Liyuan Yuan, Xinyi Li, Fang Sun, Yi Tang, Wuhao Wang, Wei Liu, Xiaona Sun, Yushuang Luo, Xiaona Bu, Zongshi Lu, Daoyan Liu, Qiang Li, Zhiming Zhu

{"title":"Comparative outcomes of adrenalectomy, mineralocorticoid receptor antagonist, and percutaneous adrenal ablation for primary aldosteronism: a systematic review and network meta-analysis.","authors":"Liyuan Yuan, Xinyi Li, Fang Sun, Yi Tang, Wuhao Wang, Wei Liu, Xiaona Sun, Yushuang Luo, Xiaona Bu, Zongshi Lu, Daoyan Liu, Qiang Li, Zhiming Zhu","doi":"10.1093/ajh/hpaf029","DOIUrl":"https://doi.org/10.1093/ajh/hpaf029","url":null,"abstract":"Background: Percutaneous adrenal ablation (PAA) is an effective and safe therapy for treating patients with primary aldosteronism (PA). However, its effectiveness in comparison to that of adrenalectomy (ADX) and mineralocorticoid receptor antagonists (MRAs) remains unclear.Methods: Databases were searched including: Pubmed, Embase, and The Cochrane Library. Studies were included if patients with PA who received two of three different treatments (ADX, MRAs, or PAA) and reported our interested outcomes, including blood pressure, serum potassium and the aldosterone-to-renin ratio (ARR).Results: In total of 10,681 patients from forty-seven studies were identified. Both ADX and PAA showed superior clinical success (systolic BP: ADX: -4.69 [-6.4, -2.95], PAA: -3.96 [-9.05, 0.99]; diastolic BP: ADX: -3.14 [-4.55, -1.85], PAA: -2.99 [-6.96, 0.98]) compared with MRAs. According to the Bayesian ranking curves (SUCRA values), ADX ranked first for all outcomes of interest (systolic BP: 81.02%, diastolic BP: 76.95%, serum potassium: 96.55%, and ARR: 88.03%), while PAA ranked second for all outcomes (systolic BP: 65.94%, diastolic BP: 69.66%, serum potassium: 50%, and ARR: 45.14%).Conclusions: The findings of this network meta-analysis suggest that PAA could be an alternative treatment for patients with PA who are unable to opt for surgery or MRA therapy, and its clinical and biochemical success fall between those of ADX and MRAs.","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systolic Blood Pressure Modifies the Effect of Endovascular Thrombectomy in Acute Ischemic Stroke: A Mediation Analysis. 收缩压改变急性缺血性卒中血管内取栓的效果：一个中介分析。

IF 3.2 3区医学

American Journal of Hypertension Pub Date : 2025-03-17 DOI: 10.1093/ajh/hpae155

Dingkang Xu, Peng Qi, Qiang He, Dezhi Shan, Guozheng Yang, Hongchun Yang, Peng Liu, Hui Liang, Shixiong Lei, Fuyou Guo, Daming Wang, Jun Lu

{"title":"Systolic Blood Pressure Modifies the Effect of Endovascular Thrombectomy in Acute Ischemic Stroke: A Mediation Analysis.","authors":"Dingkang Xu, Peng Qi, Qiang He, Dezhi Shan, Guozheng Yang, Hongchun Yang, Peng Liu, Hui Liang, Shixiong Lei, Fuyou Guo, Daming Wang, Jun Lu","doi":"10.1093/ajh/hpae155","DOIUrl":"10.1093/ajh/hpae155","url":null,"abstract":"Background: Systolic blood pressure (BP) is a key factor in the outcomes of patients with acute ischemic stroke (AIS) receiving endovascular thrombectomy (EVT). However, the factors that mediate the association between BP and clinical outcome are unclear.Methods: Consecutive patients with AIS in the anterior circulation underwent continuous BP monitoring for 24 hours. The 3-month modified Rankin scale (mRS) score was defined as the clinical functional outcome. The systolic BPI indices (BPIs) were successive variation, standard deviation, variability independent of mean BP (VIM), and 24-hour mean BP. Regression analysis was used to assess the correlation between different BPIs and functional outcomes, whereas mediation analysis was employed to assess the potential mediating effects of baseline risk factors through BP on functional outcomes.Results: A total of 140 of 292 patients (47.9%) achieved functional independence, and 87 (29.8%) experienced hemorrhagic transformation (HT). A history of stroke or hypertension and NIHSS score at onset were associated with SD and VIM (P < 0.05). BP variation (BPV) was still strongly associated with functional outcomes after adjustment for different risk factors. Mediation analysis revealed that stroke affected functional outcomes by affecting BPV, while the hypertension history affected functional prognosis by impacting the 24-hour mean BP and BPV. In addition, higher National Institute of Health stroke scale (NIHSS) scores were associated with increased BPV, whereas increased BPV was correlated with a greater proportion of unfavorable outcomes.Conclusions: To our knowledge, this study is the first to explore the mediating effects of different BPIs on the relationships between risk factors and functional outcomes and may provide new insights and potential mechanisms for improving AIS prognosis.","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"206-216"},"PeriodicalIF":3.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Home Blood Pressure Monitoring. 家庭血压监测。

IF 3.2 3区医学

American Journal of Hypertension Pub Date : 2025-03-17 DOI: 10.1093/ajh/hpae151

Justin Liu, Jeffrey Brettler, Uriel A Ramirez, Sophie Walsh, Dona Sangapalaarachchi, Keisuke Narita, Rushelle L Byfield, Kristi Reynolds, Daichi Shimbo

{"title":"Home Blood Pressure Monitoring.","authors":"Justin Liu, Jeffrey Brettler, Uriel A Ramirez, Sophie Walsh, Dona Sangapalaarachchi, Keisuke Narita, Rushelle L Byfield, Kristi Reynolds, Daichi Shimbo","doi":"10.1093/ajh/hpae151","DOIUrl":"10.1093/ajh/hpae151","url":null,"abstract":"The diagnosis and management of hypertension have been based primarily on blood pressure (BP) measurement in the office setting. Higher out-of-office BP is associated with an increased risk of cardiovascular disease, independent of office BP. Home BP monitoring (HBPM) consists of the measurement of BP by a person outside of the office at home and is a validated approach for out-of-office BP measurement. HBPM provides valuable data for diagnosing and managing hypertension. Another validated approach, ambulatory BP monitoring (ABPM), has been considered to be the reference standard of out-of-office BP measurement. However, HBPM offers potential advantages over ABPM including being a better measure of basal BP, wide availability to patients and clinicians, evidence supporting its use for better office BP control, and demonstrated efficacy when using telemonitoring along with HBPM. This state-of-the-art review examines the current state of HBPM and includes discussion of recent hypertension guidelines on HBPM, advantages of using telemonitoring with HBPM, use of self-titration of antihypertensive medication with HBPM, validation of HBPM devices, best practices for conducting HBPM in the clinical setting, how HBPM can be used as an implementation strategy approach to improve BP control in the United States, health equity in HBPM use, and HBPM use among specific populations. Finally, research gaps and future directions of HBPM are reviewed.","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"193-202"},"PeriodicalIF":3.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors Associated With Discussing High Blood Pressure Readings in Clinical Notes. 在临床记录中讨论高血压读数的相关因素。

IF 3.2 3区医学

American Journal of Hypertension Pub Date : 2025-03-17 DOI: 10.1093/ajh/hpae153

Cole G Chapman, Philip M Polgreen, Manish Suneja, Barry L Carter, Linnea A Polgreen

{"title":"Factors Associated With Discussing High Blood Pressure Readings in Clinical Notes.","authors":"Cole G Chapman, Philip M Polgreen, Manish Suneja, Barry L Carter, Linnea A Polgreen","doi":"10.1093/ajh/hpae153","DOIUrl":"10.1093/ajh/hpae153","url":null,"abstract":"Background: Blood pressure (BP) is routinely measured and recorded at healthcare visits, but high BP (HBP) measurements are not always discussed in clinical notes. Our objective was to identify patient- and visit-level factors associated with discussion of HBP measurements in clinical notes, among patients without prior diagnosis of hypertension.Methods: Data from 2016 to 2022 for all patients with any BP record of 140/90 mmHg or greater were obtained from University of Iowa Hospitals and Clinics electronic medical records. Patients with any prior hypertension diagnosis were excluded. We used a multi-level regression model to evaluate differences in the rates of discussing HBP. The model included varying intercepts for visit specialty and non-varying slopes and intercepts for patient- and visit-level features.Results: The final sample included 278,766 outpatient visits for 27,423 patients, of which 61,739 visits had HBP. Only 31% of visits with HBP had associated clinical notes with a discussion of HBP. Even in primary-care-related clinics, HBP measurements were discussed in only 70% of visits. Factors associated with decreased odds of HBP being discussed in clinical notes included fever (OR: 0.46; 95%CI: 0.24-0.86) or external injury or pain (0.84; 0.79-0.90), and a larger number of comorbidities (6+: 0.27; 0.22-0.32). Discussion of HBP in clinical notes was more likely among visits of patients with prior visits where HBP was discussed in clinical notes (12.36; 11.75-13.01).Conclusions: We found that discussion of HBP is relatively uncommon. Increasing discussion of hypertension in clinical notes could decrease hypertension-related diagnostic inertia.","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"225-232"},"PeriodicalIF":3.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obese Hypertensive Men Have Fasting Serum Concentrations of Leptin Similar to Those of Obese Normotensive Men. 肥胖高血压男性空腹血清瘦素浓度与肥胖正常高血压男性相似。

IF 3.2 3区医学

American Journal of Hypertension Pub Date : 2025-03-17 DOI: 10.1093/ajh/hpaf007

Camilla L Asferg, Ulrik B Andersen, Jan Frystyk, Allan Linneberg, Paula L Hedley, Michael Christiansen, Jørgen L Jeppesen

{"title":"Obese Hypertensive Men Have Fasting Serum Concentrations of Leptin Similar to Those of Obese Normotensive Men.","authors":"Camilla L Asferg, Ulrik B Andersen, Jan Frystyk, Allan Linneberg, Paula L Hedley, Michael Christiansen, Jørgen L Jeppesen","doi":"10.1093/ajh/hpaf007","DOIUrl":"10.1093/ajh/hpaf007","url":null,"abstract":"Background: Leptin is a hormone that is secreted by the adipocytes. In the circulation, leptin levels are directly proportional to the body fat percentage. Studies have shown that higher leptin levels are associated with an increased risk of hypertension after adjusting for body mass index (BMI). Therefore, leptin has been proposed as a mediator of obesity-related hypertension. Whether leptin is associated with hypertension when controlling for body fat percentage remains unclear.Methods: We studied 103 obese men (BMI ≥ 30.0 kg/m2). All men were healthy and were medication-free. We measured blood pressure using 24-h ambulatory blood pressure (ABP) recordings. Hypertension was defined as 24-h systolic ABP ≥ 130 mm Hg and/or 24-h diastolic ABP ≥ 80 mm Hg, and normotension was defined as 24-h ABP < 130/80 mm Hg. We measured fasting serum leptin concentrations and used dual-energy X-ray absorptiometry scanning to determine body fat percentage.Results: Of the 103 obese men, 64 were hypertensive (24-h systolic ABP-mean ± standard deviation-137 ± 11 mg Hg and 24-h diastolic ABP 83 ± 6 mm Hg) and 40 were normotensive (24-h systolic ABP 117 ± 6 mg Hg and 24-h diastolic ABP 73 ± 4 mm Hg). The 2 groups had similar fasting serum leptin concentrations (median-interquartile range; 13.4 (5.7-36.1) µg/L vs. 13.4 (5.4-27.1) µg/L, P = 0.88) and total fat mass percentage (34.8 ± 4.5% vs. 34.0 ± 4.7%, P = 0.90).Conclusions: Obese hypertensive men have serum leptin concentrations similar to those of obese normotensive men with comparable body fat percentage measurements. This finding does not support leptin's candidacy as a mediator of obesity-related hypertension.","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"233-239"},"PeriodicalIF":3.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142962008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0