American Journal of Hypertension最新文献

{"title":"Correction to: D3 Dopamine Receptor Regulation of ETB Receptors in Renal Proximal Tubule Cells From WKY and SHRs.","authors":"","doi":"10.1093/ajh/hpaf111","DOIUrl":"10.1093/ajh/hpaf111","url":null,"abstract":"","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"865"},"PeriodicalIF":3.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Anxiety with Discrepancies Between Unattended and Attended Office Blood Pressure Measurement.","authors":"Marek Stopa, Katarzyna Zięba, Anna Tofilska, Barbara Bętkowska-Korpała, Grzegorz Bilo, Marek Rajzer, Agnieszka Olszanecka","doi":"10.1093/ajh/hpaf075","DOIUrl":"10.1093/ajh/hpaf075","url":null,"abstract":"<p><strong>Background: </strong>Precision of blood pressure (BP) measurements is crucial in hypertension care. Conventional office measurements (OBP) are susceptible to confounding factors, including the white coat effect. An emerging alternative is unattended automated office BP measurement (UAOBP). UAOBP values are typically lower than OBP, but factors responsible for this phenomenon remain poorly understood. The study aimed to analyze factors affecting discrepancies between these methods.</p><p><strong>Methods: </strong>Two hundred and nineteen hypertensive patients completed the State-Trait Anxiety Inventory questionnaire, assessing anxiety levels. Subsequently, BP measurements were performed using two methodologies in a randomized sequence:UAOBP: After a 5-minute rest in the examination room, BP was automatically measured three times at 1-minute intervals.OBP: Following a 5-minute rest, a physician performed three automated oscillometric measurements at 1-minute intervals.</p><p><strong>Results: </strong>The BP values obtained through UAOBP were significantly lower than those in OBP: mean (SD) 124.7 (14.4) vs. 128.2 (14.2) mmHg, P < 0.001 for systolic, and 73.3 (10.2) vs. 75.2 (10.6) mmHg, P < 0.001 for diastolic. In the multiple regression analysis, the only factors significantly affecting the differences in systolic BP measurements were trait anxiety level (β = 0.22; P = 0.02) and the order in which the measurements were taken (β = 3.5; P = 0.01). Diastolic BP differences were only predicted by the order of measurement (β = 2.8; P < 0.001).</p><p><strong>Conclusions: </strong>UAOBP appears particularly efficient in mitigating the white coat effect in patients with high levels of anxiety. Further research is needed to investigate whether this may improve the assessment of BP-related risk in such patients.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"769-776"},"PeriodicalIF":3.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orthostatic hypertension, an easy to detect cardiovascular prognostic marker that cannot be neglected.","authors":"F Saladini, M Rattazzi, P Palatini","doi":"10.1093/ajh/hpaf186","DOIUrl":"https://doi.org/10.1093/ajh/hpaf186","url":null,"abstract":"","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to \"The Need for High Quality Research Methods to Improve Scientific Understanding of the Health Impact of Dietary Sodium\".","authors":"Tatsuya Maruhashi, Yukihito Higashi","doi":"10.1093/ajh/hpaf128","DOIUrl":"10.1093/ajh/hpaf128","url":null,"abstract":"","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"861-862"},"PeriodicalIF":3.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144615831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Diabetes and Hypertension Time Course, Their Cumulative CoExposure, and PostCoronary Artery Bypass Graft Outcomes.","authors":"Mana Jameie, Behrad Saeedian, Mina Pashang, Nastaran Babajani, Ahmad Vakili-Basir, Fatemeh Chichagi, Sepehr Nayebi Rad, Arash Jalali, Mani K Askari, Shahab Toursavadkohi, Mushabbar A Syed, Adrian V Hernandez, Soheil Mansourian, Kaveh Hosseini","doi":"10.1093/ajh/hpaf074","DOIUrl":"10.1093/ajh/hpaf074","url":null,"abstract":"<p><strong>Background: </strong>The association between patient outcomes and cumulative effects of cardiovascular risk factors over time is recognized but poorly quantified. This study quantitatively addressed the impact of diabetes and hypertension duration, and their combined effect, on postcoronary artery bypass grafting (CABG) outcomes.</p><p><strong>Methods: </strong>This single-center cohort study included patients who underwent coronary angiography followed by isolated CABG (n = 10,803, median follow-up: 111.3 months) from 2007 to 2017. Study outcomes comprised all-cause mortality and major adverse cardio-cerebrovascular events (MACCE). Cox regressions were used to assess the association between risk factors' duration (<5 years, 5-10 years, ≥10 years) and study outcomes among the total cohort and stratified by the copresence of risk factors.</p><p><strong>Results: </strong>The study population aged 65.56 ± 10.00 years (75.3% male, 40.1% diabetes, and 64.1% hypertension). The risk of study outcomes increased with increasing duration of diabetes (adjusted-hazard ratio from \"0-5y\" to \"≥10y\" group for all-cause mortality: 1.37 (95% CI: 1.23-1.52) to 1.91 (1.69-2.16), and for MACCE: 1.23 (1.14-1.34) to 1.59 (1.44-1.76)). When stratified by hypertension status, the association between shorter diabetes duration and study outcomes became nonsignificant among nonhypertensive patients, while the association persisted for their hypertensive counterparts (reference group: nondiabetic patients). An increasing risk pattern was observed with longer hypertension duration (from 1.38 (1.25-1.53) to 1.51 (1.30-1.75) for all-cause mortality and 1.27 (1.18-1.37) to 1.39 (1.24-1.55) for MACCE). This risk enhancement was more pronounced when diabetes coexisted.</p><p><strong>Conclusions: </strong>Our results highlight the significance of risk factor exposure duration in patient risk assessment. These insights could be valuable for enhancing existing risk assessment tools and developing tailored preventive strategies.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"806-817"},"PeriodicalIF":3.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Need for High-Quality Research Methods to Improve Scientific Understanding of the Health Impact of Dietary Sodium.","authors":"Norm R C Campbell","doi":"10.1093/ajh/hpaf108","DOIUrl":"10.1093/ajh/hpaf108","url":null,"abstract":"","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"859-860"},"PeriodicalIF":3.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Reactive Dicarbonyls Are Not Independently Associated With Arterial Stiffness: The Maastricht Study.","authors":"Myrthe M van der Bruggen, Marleen M J van Greevenbroek, Bart Spronck, Coen D A Stehouwer, Tammo Delhaas, Koen D Reesink, Casper G Schalkwijk","doi":"10.1093/ajh/hpaf068","DOIUrl":"10.1093/ajh/hpaf068","url":null,"abstract":"<p><strong>Background: </strong>Arterial stiffness is a strong predictor of cardiovascular diseases and all-cause mortality. Increased concentrations of highly reactive dicarbonyl compounds-methylglyoxal (MGO), glyoxal (GO), and/or 3-deoxyglucosone (3-DG)-may cause arterial stiffening via formation of advanced glycation end products, triggering maladaptive responses in vascular tissue, e.g., elastin degradation and collagen cross-linking. Therefore, we investigated in the population-based Maastricht study whether plasma MGO, GO, and 3-DG concentrations were cross-sectionally associated with carotid-to-femoral pulse wave velocity (cfPWV) and local carotid stiffness measures: pulse wave velocity (cPWV), and Young's elastic modulus (cYEM) using standardized main variables.</p><p><strong>Methods: </strong>Fasting dicarbonyl concentrations were determined by ultra-performance liquid chromatography tandem mass spectrometry in EDTA plasma collected from 2,275 participants (age 60 ± 8 years, mean ± SD; 49% women, 605 (27%) with type 2 diabetes mellitus) of the Maastricht Study, an observational, population-based cohort study. Cross-sectional associations were assessed using multivariable linear regression analysis adjusting for age, sex, mean arterial pressure (MAP), heart rate, lifestyle factors, and medication. Since arterial stiffness measures are intrinsically pressure dependent, we additionally assessed the associations with pressure-corrected counterparts, instead of statistically correcting for MAP.</p><p><strong>Results: </strong>Fasting dicarbonyl concentrations were associated with arterial stiffness measures (greater cfPWV, cPWV, and cYEM) in most crude models, but not in adjusted models. The use of pressure-corrected metrics did not materially change the association of interest.</p><p><strong>Conclusions: </strong>Fasting plasma concentrations of either MGO, GO, or 3-DG are not independently associated with arterial stiffness in this cross-sectional analysis.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"777-787"},"PeriodicalIF":3.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12448583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between ABPM Phenotypes and Cognitive Impairment in a Community-Dwelling, Older Adult Population Taking Antihypertensive Medication: A Pilot Study.","authors":"Trevor Sproule, Lana Sargent, Elvin Price, Marissa Mackiewicz, Leroy Thacker, Dave Dixon","doi":"10.1093/ajh/hpaf188","DOIUrl":"https://doi.org/10.1093/ajh/hpaf188","url":null,"abstract":"<p><strong>Background: </strong>Hypertension (HTN) is associated with an increased risk of cognitive impairment (CI). This study aimed to explore the relationship between Ambulatory BP Monitoring (ABPM) phenotypes and CI in a predominantly Black, older adult population.</p><p><strong>Methods: </strong>This cross-sectional study enrolled adults ≥60 years of age with HTN and taking ≥1 antihypertensive. Participants had three seated BP readings taken one minute apart, followed by 24-hour ABPM. CI was determined using the Mini-Mental State Examination (MMSE-2) with a cutoff score of ≤ 25. 24-hour ABPM control was defined as < 125/75, and seated BP control was defined as < 130/80 mm Hg. A sleep BP decline of < 10% was used to identify non-dippers. ABPM phenotypes were compared to categorical data measured by the MMSE-2 and analyzed using the Chi-square test. Unadjusted and adjusted (age and gender) prevalence ratios were also calculated.</p><p><strong>Results: </strong>The 69 participants included in the analysis had a mean age of 69 years, 56.5% were female, and 73.9% identified as Black/African American. CI was identified in 29% (n = 20) of the participants according to their MMSE-2 score. CI prevalence was significantly higher among participants exhibiting a non-dipping BP pattern (75% vs. 40.8%; P = 0.01), elevated sleep diastolic BP (P = 0.02), and 24-hour, awake, sleep, and seated heart rate (P < 0.05 for all).</p><p><strong>Conclusions: </strong>Sleep BP and heart rate were associated with a higher prevalence of CI and may offer clues as to the underlying pathophysiology of BP-associated CI. These findings warrant further study in a larger population followed longitudinally.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Therapeutic Drug Targets for Hypertension Identified Using Proteomics and Mendelian Randomization.","authors":"Wei Pan, Daoxin Huang, Chunjin Lin, Haozhang Huang, Qing Chen, Liman Wang, Min Li, Huizhen Yu","doi":"10.1093/ajh/hpaf011","DOIUrl":"10.1093/ajh/hpaf011","url":null,"abstract":"<p><strong>Background: </strong>Hypertension (HT) is the most prevalent risk factor for cardiovascular disease (CVD) worldwide. Despite being a highly heritable trait, the underlying mechanisms of HT remain elusive due to its complex genetic architecture. Discovering disease-associated proteins with causal genetic evidence offers a potential strategy for identifying therapeutic targets for HT.</p><p><strong>Methods: </strong>We analyzed the plasma proteome of 4,657 plasma proteins from 7,213 European American participants in the Atherosclerosis risk in Communities study. Genome-wide association study data for HT were sourced from FinnGen R10, which includes 102,864 cases and 289,117 controls. Cis-Mendelian randomization was conducted to assess the causal effect of circulating proteins on the risk of HT. A multiverse sensitivity analysis was performed to evaluate the robustness of these causal relationships. Colocalization analysis was conducted to determine whether these features share the same associated single nucleotide polymorphisms. The causal effects of HT-associated proteins were then validated using cis-protein quantitative trait loci (Cis-pQTL) genetic instruments from the deCODE database.</p><p><strong>Results: </strong>Among 1,788 proteins, genetically predicted levels of 18 plasma proteins were associated with HT in the discovery stage. Seven of these proteins showed strong support for colocalization. After replication, only ERAP1 and ACVRL1 were validated as therapeutic candidates for HT, demonstrating a negative correlation with the risk of HT.</p><p><strong>Conclusions: </strong>By combining cis-MR analysis with colocalization analysis, we identified ERAP1 and ACVRL1 as potential targets for interventions in the primary prevention of HT, with ERAP1 emerging as a particularly promising drug target after further validation.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"841-851"},"PeriodicalIF":3.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Estimated Daily Salt Intake from Spot Urine and Nocturnal Blood Pressure in Hypertensive Patients under Antihypertensive Treatment.","authors":"Tatsuya Maruhashi, Yoshihiko Kinoshita, Ryoji Ozono, Mitsuaki Nakamaru, Masanori Ninomiya, Jiro Oiwa, Takuji Kawagoe, Osamu Yoshida, Toshiyuki Matsumoto, Yasuo Fukunaga, Kotaro Sumii, Hironori Ueda, Nobuo Shiode, Kosuke Takahari, Yasuhiko Hayashi, Yujiro Ono, Yukiko Nakano, Masakazu Takahashi, Yasuki Kihara, Yukihito Higashi","doi":"10.1093/ajh/hpaf095","DOIUrl":"10.1093/ajh/hpaf095","url":null,"abstract":"<p><strong>Background: </strong>Excessive salt intake is a major contributor to hypertension and is associated with elevated nocturnal blood pressure (BP), particularly in the elderly and individuals with chronic kidney disease (CKD), metabolic syndrome (MetS), or diabetes, who are prone to nocturnal BP elevation in response to high salt intake. Although estimation of salt intake from spot urine is widely used, the relationship of estimated salt intake from spot urine with nighttime BP in treated patients with hypertension remains unclear.</p><p><strong>Methods: </strong>In this cross-sectional study, we analyzed 209 hypertensive patients receiving antihypertensive therapy. Estimated daily salt intake was calculated from spot urine using a validated formula. Nighttime BP was measured over a period of seven days using a home BP monitoring device.</p><p><strong>Results: </strong>The mean estimated salt intake was 9.3 ± 2.5 g/day, and the mean nighttime systolic BP was 115.6 ± 12.1 mmHg. There was no significant correlation between estimated salt intake and nighttime systolic BP (r = -0.08, P = 0.23). Multivariable linear regression analysis also showed no significant association (β=-0.070, P = 0.34). Subgroup analyses in participants aged ≥ 65 years and those with CKD, MetS, or diabetes showed no significant associations. Sensitivity analyses in participants with controlled morning BP (< 135 mmHg) and those with a ≤ 7-day interval between spot urine and nighttime BP measurements also showed no significant associations.</p><p><strong>Conclusions: </strong>Estimated salt intake from spot urine was not significantly associated with nighttime systolic BP in treated hypertensive patients, even in those prone to salt-related nocturnal BP elevation.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"818-825"},"PeriodicalIF":3.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}