Tansim Akhter, Mikael Hedeland, Jonas Bergquist, Anders Larsson, Ove Axelsson, Susanne Hesselman, Alkistis Skalkidou
{"title":"Elevated Plasma Level of Arginine and Its Metabolites at Labor Among Women With Preeclampsia: A Prospective Cohort Study.","authors":"Tansim Akhter, Mikael Hedeland, Jonas Bergquist, Anders Larsson, Ove Axelsson, Susanne Hesselman, Alkistis Skalkidou","doi":"10.1093/ajh/hpae131","DOIUrl":"10.1093/ajh/hpae131","url":null,"abstract":"<p><strong>Background: </strong>Preeclampsia is associated with higher levels of asymmetric (ADMA) and symmetric (SDMA) dimethylarginines. Dimethylarginines are inhibitors of nitric oxide, a uterine smooth muscles relaxant. Women with preeclampsia experience a shorter labor duration compared with normotensive women. However, very little is known about the possible biochemical mechanisms behind these differences. We aimed to investigate if women with preeclampsia had higher levels of arginines (ADMA, SDMA, and l-arginine) at labor than controls and also investigate the association between arginines and labor duration.</p><p><strong>Methods: </strong>The study was based on data from the Swedish, Uppsala County population-based, prospective cohort BASIC, 2009-2018. Arginines were analyzed by ultra-high-performance liquid chromatography using plasma samples taken at labor from women with preeclampsia (n = 47) and normotensive pregnancy (n = 90). We also analyzed inflammation markers such as C-reactive protein, tumor necrosis factor (TNF)-R1, TNF-R2, and growth differentiation factor (GDF-15).</p><p><strong>Results: </strong>Women with preeclampsia had higher levels of ADMA (P < 0.001), SDMA (P < 0.001), l-arginine (P < 0.001), TNF-R1 (P < 0.001), TNF-R2 (P = 0.03), and GDF-15 (P < 0.01) compared with controls. Furthermore, ADMA and SDMA, not inflammation markers, were negatively correlated to labor duration in preeclampsia. No correlations were observed when comparing arginines and inflammation markers.</p><p><strong>Conclusions: </strong>Among women with preeclampsia, our novel findings of higher level of arginines, negative correlation of arginines to labor duration, and absence of correlation of arginines to inflammation markers might support the theory that it is not inflammation but arginines which could be associated with shorter labor duration in preeclampsia.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"184-191"},"PeriodicalIF":3.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11833247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alfredo Sanchez Solano, Boris Lavanderos, Elsayed Metwally, Scott Earley
{"title":"Transient Receptor Potential Channels in Vascular Mechanotransduction.","authors":"Alfredo Sanchez Solano, Boris Lavanderos, Elsayed Metwally, Scott Earley","doi":"10.1093/ajh/hpae134","DOIUrl":"10.1093/ajh/hpae134","url":null,"abstract":"<p><p>Transmural pressure and shear stress are mechanical forces that profoundly affect the smooth muscle cells (SMCs) comprising the vascular wall and the endothelial cells (ECs) lining the lumen. Pressure and flow are detected by mechanosensors in these cells and translated into appropriate responses to regulate blood pressure and flow. This review focuses on the role of the transient receptor potential (TRP) superfamily of cation channels in this process. We discuss how specific members of the TRP superfamily (TRPC6, TRPM4, TRPV1, TRPV4, and TRPP1) regulate the resting membrane and intracellular Ca2+ levels in SMCs and ECs to promote changes in vascular tone in response to intraluminal pressure and shear stress. Although TRP channels participate in vascular mechanotransduction, little evidence supports their intrinsic mechanosensitivity. Therefore, we also examine the evidence exploring the force-sensitive signal transduction pathways acting upstream of vascular TRP channels. Understanding the interplay between mechanosensors, force-induced signaling cascades, and TRP channels holds promise for the development of targeted therapies for diseases caused by vascular dysfunction.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"151-160"},"PeriodicalIF":3.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Automated Office BP Monitor Measurements: What Is The Secret Sauce?","authors":"Beverly B Green","doi":"10.1093/ajh/hpae148","DOIUrl":"10.1093/ajh/hpae148","url":null,"abstract":"","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"161-163"},"PeriodicalIF":3.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Benjamin D Boudreaux, Joseph E Schwartz, Emily K Romero, Keith M Diaz
{"title":"Reallocations of Time Between Sleep, Sedentary Behavior, and Physical Activity and Their Associations With 24-Hour Blood Pressure.","authors":"Benjamin D Boudreaux, Joseph E Schwartz, Emily K Romero, Keith M Diaz","doi":"10.1093/ajh/hpae149","DOIUrl":"10.1093/ajh/hpae149","url":null,"abstract":"<p><strong>Background: </strong>The 24-h activity cycle (24H-ACT) (sleep, sedentary behavior, light physical activity, and moderate to vigorous physical activity) may have deleterious or beneficial associations with 24-h blood pressure (24H-BP).</p><p><strong>Purpose: </strong>Estimate the short-term associated changes in 24H-BP with acutely replacing 30 min/d from one behavior of the 24H-ACT to other behaviors in employed adults.</p><p><strong>Methods: </strong>Participants (N = 659) wore an ambulatory blood pressure monitor and two accelerometers (waist and wrist) to measure 24H-BP and the 24H-ACT.</p><p><strong>Results: </strong>Replacing 30 min of sedentary behavior with 30 min of sleep was associated with lower 24-h mean systolic [ß = -0.32 mm Hg per 0.5 h (95% CI: -0.58, 0.06)] and diastolic [ß = -0.31 mm Hg per 0.5 h (95% CI: -0.50, -0.12)] blood pressure. Replacing 30 min of light physical activity with 30 min of sleep was associated with lower 24-h mean systolic [ß = -0.30 mm Hg per 0.5 h (95% CI: -0.62, 0.03,)] and diastolic blood pressure [ß = -0.34 mm Hg per 0.5 h (95% CI: -0.58, -0.11)]. No other time reallocations between 24H-ACT behaviors were associated with changes in 24H-BP.</p><p><strong>Conclusion: </strong>Replacing time in sedentary behavior or light physical activity with sleep may provide small short-term reductions in that day's 24H-BP.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"164-167"},"PeriodicalIF":3.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11833238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Time in Target Range, All-cause Mortality and Cardiovascular Diseases.","authors":"Zhijun Wu, Zhenyu Huo, Zhe Huang, Xiujuan Zhao, Guodong Wang, Chunyu Ruan, Shuohua Chen, Shouling Wu","doi":"10.1093/ajh/hpae144","DOIUrl":"https://doi.org/10.1093/ajh/hpae144","url":null,"abstract":"<p><strong>Background: </strong>Time in target range (TTR) of systolic blood pressure (SBP) is a concept characterizing the extent of blood pressure (BP) control. We aimed to compare the risk of all-cause mortality and cardiovascular diseases (CVDs) in participants with >50% time of their SBP within different target ranges.</p><p><strong>Methods: </strong>A total of 40,914 participants who had complete BP data and were free of CVDs or cancer were included. Four SBP records over 6 years were used to calculate TTR and mean levels of covariates. The death and CVD events were recorded via reviewing medical records and death certificates.</p><p><strong>Results: </strong>During a median follow-up period of 8.78 (interquartile range: 8.50-9.05) and 7.76 (interquartile range: 7.46-8.04) years, we identified 2,398 death cases and 1,995 incident CVDs, respectively. Participants who had >50%TTR >150mmHg had a higher risk of all-cause mortality (hazard ratio (HR):1.67, 95% confidence interval (CI): 1.16, 2.41) than those with >50% TTR <120mmHg. The corresponding HR was 2.06 (95%CI: 1.37,3.10) for incident CVDs. The increased risk of all-cause mortality and CVD events persisted when we adjusted the covariates measured at the 2012 visit or excluded coalminers, the hypotensive participants, the incident cases occurring the first 2 years or who used BP lowering drugs.</p><p><strong>Conclusions: </strong>Our study suggested that >50% TTR in a high target range of SBP significantly predicted the occurrence of all-cause mortality and CVDs.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"PLK2 and the GSK3β-NRF2 Axis: A Promising Therapeutic Target for Sepsis-Induced Cardiac Injury?","authors":"Raiana Anjos Moraes, Fernanda Priviero","doi":"10.1093/ajh/hpaf014","DOIUrl":"https://doi.org/10.1093/ajh/hpaf014","url":null,"abstract":"","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neiberg de Alcantara Lima, Shaun Cardozo, Andrew Johnson, Brian Reed, Steven Korzeniewski, Philip D Levy, Robert D Brook
{"title":"Accuracy of a Novel High-Throughput \"Car Blood Pressure\" Measurement Protocol.","authors":"Neiberg de Alcantara Lima, Shaun Cardozo, Andrew Johnson, Brian Reed, Steven Korzeniewski, Philip D Levy, Robert D Brook","doi":"10.1093/ajh/hpaf016","DOIUrl":"https://doi.org/10.1093/ajh/hpaf016","url":null,"abstract":"<p><strong>Background: </strong>More than one in three adults with hypertension in the United States are unaware of their condition, highlighting the importance of large-scale screening campaigns. Currently, the identification of hypertension is largely limited to medical settings. To help overcome this barrier, we developed a novel high-throughput screening protocol that measures blood pressure (BP) while patients remain seated in an automobile (\"car-BP\"). The aim of this study was to provide an initial assessment of the accuracy of car-BP.</p><p><strong>Methods: </strong>Three BP readings were determined in a clinic exam room before and after three BP readings were taken while patients were seated in a parked car outside (n=100 participants). The same validated device model (Omron HEM-907XL) and BP measurement methods adhering to guidelines were used in both scenarios. The average of all 6 clinic readings was compared to the average of the 3 car-BP readings in each individual.</p><p><strong>Results: </strong>Mean clinic and car-BP readings were 120.9 ± 16.2/78.0 ± 9.9 and 118.9 ± 15.2/76.0 ± 10.0 mm Hg, respectively. The paired mean and absolute mean differences in systolic BP levels between methods were -1.92 mm Hg (95% confidence interval (CI) -3.2 to -0.7 mm Hg) and 4.8 mm Hg (95%CI 3.8 to 5.6 mm Hg), respectively. A total of 85% of participants had both systolic and diastolic BP levels ≤10 mm Hg different between measurement scenarios (meeting the a priori determined study primary outcome).</p><p><strong>Conclusions: </strong>Car-BP represents an innovative and accessible approach for potential large-scale hypertension screening campaigns.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wei Pan, Daoxin Huang, Chunjin Lin, Haozhang Huang, Qing Chen, Liman Wang, Min Li, Huizhen Yu
{"title":"Potential Therapeutic drug Targets for Hypertension Identified using Proteomics and Mendelian Randomization.","authors":"Wei Pan, Daoxin Huang, Chunjin Lin, Haozhang Huang, Qing Chen, Liman Wang, Min Li, Huizhen Yu","doi":"10.1093/ajh/hpaf011","DOIUrl":"https://doi.org/10.1093/ajh/hpaf011","url":null,"abstract":"<p><strong>Background: </strong>Hypertension (HT) is the most prevalent risk factor for cardiovascular disease (CVD) worldwide. Despite being a highly heritable trait, the underlying mechanisms of HT remain elusive due to its complex genetic architecture. Discovering disease-associated proteins with causal genetic evidence offers a potential strategy for identifying therapeutic targets for HT.</p><p><strong>Methods: </strong>We analyzed the plasma proteome of 4,657 plasma proteins from 7,213 European American (EA) participants in the ARIC study. Genome-wide association study (GWAS) data for HT were sourced from FinnGen R10, which includes 102,864 cases and 289,117 controls. Cis-Mendelian randomization (MR) was conducted to assess the causal effect of circulating proteins on the risk of HT. A multiverse sensitivity analysis was performed to evaluate the robustness of these causal relationships. Colocalization analysis was conducted to determine whether these features share the same associated single nucleotide polymorphisms (SNPs). The causal effects of HT-associated proteins were then validated using cis-protein quantitative trait loci (Cis-pQTL) genetic instruments from the deCODE database.</p><p><strong>Results: </strong>Among 1,788 proteins, genetically predicted levels of 18 plasma proteins were associated with HT in the discovery stage. Seven of these proteins showed strong support for colocalization. After replication, only ERAP1 and ACVRL1 were validated as therapeutic candidates for HT, demonstrating a negative correlation with the risk of HT.</p><p><strong>Conclusions: </strong>By combining cis-MR analysis with colocalization analysis, we identified ERAP1 and ACVRL1 as potential targets for interventions in the primary prevention of HT, with ERAP1 emerging as a particularly promising drug target after further validation.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rikki M Tanner, Byron C Jaeger, Corey K Bradley, S Justin Thomas, Yuan-I Min, Shakia T Hardy, Marguerite Ryan Irvin, Daichi Shimbo, Joseph E Schwartz, Paul Muntner
{"title":"Blood Pressure on Ambulatory Monitoring and Risk for Cardiovascular Disease and All-Cause Mortality: Ecological Validity or Measurement Reliability?","authors":"Rikki M Tanner, Byron C Jaeger, Corey K Bradley, S Justin Thomas, Yuan-I Min, Shakia T Hardy, Marguerite Ryan Irvin, Daichi Shimbo, Joseph E Schwartz, Paul Muntner","doi":"10.1093/ajh/hpae133","DOIUrl":"10.1093/ajh/hpae133","url":null,"abstract":"<p><strong>Background: </strong>The association with cardiovascular disease (CVD) is stronger for mean systolic blood pressure (SBP) estimated using ambulatory blood pressure monitoring (ABPM) vs. office measurements. Determining whether this is due to ABPM providing more measurement reliability or greater ecological validity can inform its use.</p><p><strong>Methods: </strong>We estimated the association of mean SBP based on 2 office measurements and 2, 5, 10, and 20 measurements on ABPM with incident CVD in the Jackson Heart Study (n = 773). Hazard ratios (HRs) for CVD were estimated per standard deviation higher mean SBP. CVD events were defined by incident fatal or non-fatal stroke, non-fatal myocardial infarction, or fatal coronary heart disease.</p><p><strong>Results: </strong>There were 80 CVD events over a median of 15 years. The adjusted HRs for incident CVD were 1.03 (95% CI: 0.90-1.19) for mean office SBP and 1.30 (95% CI: 1.12-1.50), 1.34 (95% CI: 1.15-1.56), 1.36 (95% CI: 1.17-1.59), and 1.38 (95% CI: 1.17-1.63) for mean SBP using the first 2, 5, 10, and 20 ABPM readings. The difference in the HRs for incident CVD ranged from 0.26 (95% CI: 0.07-0.46) to 0.35 (95% CI: 0.15-0.54) when comparing mean office SBP vs. 2, 5, 10, or 20 sequential ABPM readings. The association with incident CVD was also stronger for mean SBP based on 2, 5, 10, and 20 randomly selected ABPM readings vs. 2 office readings.</p><p><strong>Conclusions: </strong>Mean SBP based on 2 ABPM readings vs. 2 office measurements had a stronger association with CVD events. The increase in the strength of the association with more ABPM readings was small.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"111-119"},"PeriodicalIF":3.2,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shakia T Hardy, Byron C Jaeger, Kathryn Foti, Lama Ghazi, Gregory Wozniak, Paul Muntner
{"title":"Trends in Blood Pressure Control among US Adults With Hypertension, 2013-2014 to 2021-2023.","authors":"Shakia T Hardy, Byron C Jaeger, Kathryn Foti, Lama Ghazi, Gregory Wozniak, Paul Muntner","doi":"10.1093/ajh/hpae141","DOIUrl":"10.1093/ajh/hpae141","url":null,"abstract":"<p><strong>Background: </strong>Prior studies have reported a decrease in the proportion of US adults with hypertension who had controlled blood pressure (BP).</p><p><strong>Methods: </strong>We analyzed data from the National Health and Nutrition Examination Survey (n = 25,128, ≥18 years of age) to determine changes in BP control from 2013-2014 to 2021-2023. Hypertension was defined as systolic BP ≥140 mm Hg, diastolic BP ≥90 mm Hg, or antihypertensive medication use. BP control was defined as systolic BP <140 mm Hg and diastolic BP <90 mm Hg.</p><p><strong>Results: </strong>The age-adjusted prevalence of hypertension (95% CI) was 32.8% (31.2%-34.4%) in 2013-2014 and 32.0% (30.1%-33.9%) in 2021-2023. Among US adults with hypertension, the age-adjusted proportion (95% CI) with controlled BP was 54.1% (49.1%-59.2%), 48.6% (44.5%-52.7%), and 48.3% (45.8%-50.8%) in 2013-2014, 2015-2016, and 2017-2020, respectively, (P-trend = 0.058), and 51.1% (47.9%-54.3%) in 2021-2023 (P-value = 0.184 comparing 2021-2023 vs. 2017-2020). The proportion (95% CI) of US adults taking antihypertensive medication with controlled BP was 72.0% (68.5%-75.5%), 66.7% (62.9%-70.5%), and 67.8% (65.3%-70.3%) in 2013-2014, 2015-2016, and 2017-2020, respectively, (P-trend = 0.085), and 68.3% (64.8%-71.9%) in 2021-2023 (P-value = 0.654 comparing 2021-2023 vs. 2017-2020). Among non-Hispanic Black adults, BP control increased from 37.4% (95% CI 33.6%-41.1%) to 49.6% (95% CI 42.3%-56.9%) between 2017-2020 and 2021-2023 for those with hypertension (P-value = 0.005), and from 52.6% (95% CI 47.4%-57.8%) to 62.6% (95% CI 55.6%-69.7%) for those taking antihypertensive medication (P-value = 0.033). There was no difference in BP control across race/ethnicity groups in 2021-2023.</p><p><strong>Conclusions: </strong>The decline in BP control from 2013-2014 to 2017-2020 did not continue through 2021-2023. An increase in BP control occurred from 2017-2020 and 2021-2023 among non-Hispanic Black adults.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"120-128"},"PeriodicalIF":3.2,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}