子痫前期妇女分娩时血浆中精氨酸及其代谢物水平升高:一项前瞻性队列研究。

IF 3.2 3区 医学 Q2 PERIPHERAL VASCULAR DISEASE
Tansim Akhter, Mikael Hedeland, Jonas Bergquist, Anders Larsson, Ove Axelsson, Susanne Hesselman, Alkistis Skalkidou
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引用次数: 0

摘要

背景:子痫前期并发症占所有妊娠的 3-5%,与不对称(ADMA)和对称(SDMA)二甲基精氨酸水平较高有关。二甲基精氨酸是一氧化氮的抑制剂,而一氧化氮是一种子宫平滑肌松弛剂。与血压正常的妇女相比,患有高血压疾病的妇女分娩时间较短。然而,人们对产程差异背后可能的生化机制知之甚少。在这项研究中,我们旨在调查患有子痫前期的妇女在分娩时是否比对照组有更高水平的精氨酸(ADMA、SDMA 和 L-精氨酸),并调查精氨酸与分娩持续时间之间的关系:研究基于瑞典乌普萨拉县 2009 年至 2018 年期间基于人口的前瞻性队列 BASIC 的数据。使用超高效液相色谱法对患有子痫前期(47 人)和正常血压妊娠(90 人)的产妇在分娩时采集的血浆样本中的精氨酸进行了分析。我们还分析了炎症指标CRP、TNF-R1、TNF-R2和GDF-15:结果:子痫前期妇女的 ADMA 水平较高(p结论:子痫前期妇女的 ADMA 水平较高,而正常妊娠妇女的 ADMA 水平较低):在患有子痫前期的妇女中,我们发现精氨酸水平较高,精氨酸与产程呈负相关,而精氨酸与炎症标志物无相关性,这可能支持了一种理论,即子痫前期妇女产程缩短与炎症无关,而是与精氨酸有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Elevated plasma level of arginine and its metabolites at labor among women with preeclampsia: A prospective cohort study.

Background: Preeclampsia complicates 3-5% of all pregnancies and is associated with higher levels of asymmetric (ADMA) and symmetric (SDMA) dimethylarginines. Dimethylarginines are inhibitors of nitric oxide, which is a uterine smooth muscles relaxant. Women with hypertensive disorders experience a shorter labor duration compared to normotensive women. However, very little is known about the possible biochemical mechanisms behind differences in labor duration. In this study we aimed to investigate if women with preeclampsia had higher levels of arginines (ADMA, SDMA and L-arginine) at labor than controls, and also investigate the association between arginines and labor duration.

Methods: The study was based on data from the Swedish, Uppsala County population-based, prospective cohort BASIC, between 2009 and 2018. Arginines were analyzed by Ultra-High Performance Liquid Chromatography using plasma samples taken at labor from women with preeclampsia (n=47) and normotensive pregnancy (n=90). We also analyzed inflammation markers CRP, TNF-R1, TNF-R2 and GDF-15.

Results: Women with preeclampsia had higher levels of ADMA (p<0.001), SDMA (p<0.001), L-arginine (p<0.001), TNF-R1 (p<0.001), TNF-R2 (p=0.03) and GDF-15 (p<0.01) compared to controls. Further, ADMA and SDMA, not inflammation markers, were negatively correlated to labor duration in preeclampsia. No correlations were observed when comparing arginines and inflammation markers.

Conclusions: Among women with preeclampsia, our novel findings of higher level of arigines, negative correlation of arginines to duration of labor and absence of correlation of arginines to inflammation markers might support the theory that it is not inflammation but arginines which could be associated with shorter duration of labor in preeclampsia.

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来源期刊
American Journal of Hypertension
American Journal of Hypertension 医学-外周血管病
CiteScore
6.90
自引率
6.20%
发文量
144
审稿时长
3-8 weeks
期刊介绍: The American Journal of Hypertension is a monthly, peer-reviewed journal that provides a forum for scientific inquiry of the highest standards in the field of hypertension and related cardiovascular disease. The journal publishes high-quality original research and review articles on basic sciences, molecular biology, clinical and experimental hypertension, cardiology, epidemiology, pediatric hypertension, endocrinology, neurophysiology, and nephrology.
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