Smart medicine最新文献

Multifunctional Silk and Gelatin Composed Microneedle Patches for Enhanced Wound Healing.

Smart medicine Pub Date : 2025-02-26 eCollection Date: 2025-03-01 DOI: 10.1002/smmd.137

Lu Fan, Li Wang, Xiaoju Wang, Minli Li, Hongcheng Gu, Hongbo Zhang

引用次数: 0

Natural Matrine-Integrated Pollen Delivery Systems for Allergic Contact Dermatitis Treatment.

Smart medicine Pub Date : 2025-02-26 eCollection Date: 2025-03-01 DOI: 10.1002/smmd.136

Yuwei Wang, Lijun Cai, Yuanyuan Zhang, Yan Cong, Yuanjin Zhao

引用次数: 0

Biomineralize Mitochondria in Metal-Organic Frameworks to Promote Mitochondria Transplantation From Non-Tumorigenic Cells Into Cancer Cells.

Smart medicine Pub Date : 2025-02-26 eCollection Date: 2025-03-01 DOI: 10.1002/smmd.134

Jun-Nian Zhou, Chang Liu, Yonghui Wang, Yong Guo, Xiao-Yu Xu, Elina Vuorimaa-Laukkanen, Oliver Koivisto, Anne M Filppula, Jiangbin Ye, Hongbo Zhang

{"title":"Biomineralize Mitochondria in Metal-Organic Frameworks to Promote Mitochondria Transplantation From Non-Tumorigenic Cells Into Cancer Cells.","authors":"Jun-Nian Zhou, Chang Liu, Yonghui Wang, Yong Guo, Xiao-Yu Xu, Elina Vuorimaa-Laukkanen, Oliver Koivisto, Anne M Filppula, Jiangbin Ye, Hongbo Zhang","doi":"10.1002/smmd.134","DOIUrl":"10.1002/smmd.134","url":null,"abstract":"Mitochondria are crucial to cellular physiology, and growing evidence highlights the significant impact of mitochondrial dysfunction in diabetes, aging, neurodegenerative disorders, and cancers. Therefore, mitochondrial transplantation shows great potential for therapeutic use in treating these diseases. However, transplantation process is notably challenging due to very low efficiency and rapid loss of bioactivity post-isolation, leading to poor reproducibility and reliability. In this study, we develop a novel strategy to form a nanometer-thick protective shell around isolated mitochondria using Metal-Organic Frameworks (MOFs) through biomineralization. Our findings demonstrate that this encapsulation method effectively maintains mitochondria bioactivity for at least 4 weeks at room temperature. Furthermore, the efficiency of intracellular delivery of mitochondria is significantly enhanced through the surface functionalization of MOFs with polyethyleneimine (PEI) and the cell-penetrating peptide Tat. The successful delivery of mitochondria isolated from non-tumorigenic cells into cancer cells results in notable tumor-suppressive effects. Taken together, our technology represents a significant advancement in mitochondria research, particularly on understanding their role in cancer. It also lays the groundwork for utilizing mitochondria as therapeutic agents in cancer treatment.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"4 1","pages":"e134"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11862567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MXene-Integrated Responsive Hydrogel Microneedles for Oral Ulcers Healing.

Smart medicine Pub Date : 2025-02-26 eCollection Date: 2025-03-01 DOI: 10.1002/smmd.135

Chuanhui Song, Minhui Lu, Ning Li, Hongcheng Gu, Minli Li, Ling Lu, Yu Wang

引用次数: 0

Correction to "Reregulated Mitochondrial Dysfunction Reverses Cisplatin Resistance Microenvironment in Colorectal Cancer".

Smart medicine Pub Date : 2025-02-25 eCollection Date: 2025-03-01 DOI: 10.1002/smmd.70001

引用次数: 0

Change in p53 nuclear localization in response to extracellular matrix stiffness.

Smart medicine Pub Date : 2025-02-20 eCollection Date: 2025-03-01 DOI: 10.1002/smmd.117

Yan Zu, Jing Du, Yipu Xu, Mengying Niu, Canlin Hong, Chun Yang

引用次数: 0

Microfluidic 3D printing hydrogels based on fish liver decellularized extracellular matrix for liver regeneration. 基于鱼肝脱细胞细胞外基质的微流控3D打印水凝胶用于肝脏再生。

Smart medicine Pub Date : 2024-12-22 eCollection Date: 2024-12-01 DOI: 10.1002/SMMD.20240056

Haozhen Ren, Danqing Huang, Mengdi Qiu, Lingling Xue, Shaoshi Zhu, Jingjing Gan, Cheng Chen, Dayu Chen, Jinglin Wang

{"title":"Microfluidic 3D printing hydrogels based on fish liver decellularized extracellular matrix for liver regeneration.","authors":"Haozhen Ren, Danqing Huang, Mengdi Qiu, Lingling Xue, Shaoshi Zhu, Jingjing Gan, Cheng Chen, Dayu Chen, Jinglin Wang","doi":"10.1002/SMMD.20240056","DOIUrl":"https://doi.org/10.1002/SMMD.20240056","url":null,"abstract":"Liver tissue engineering offers potential in liver transplantation, while the development of hydrogels for scalable scaffolds incorporating natural components and effective functionalities is ongoing. Here, we propose a novel microfluidic 3D printing hydrogel derived from decellularized fish liver extracellular matrix for liver regeneration. By decellularizing fish liver and combining it with gelatin methacryloyl, the hydrogel scaffold retains essential endogenous growth factors such as collagen and glycosaminoglycans. Additionally, microfluidic-assisted 3D printing technology enables precise modulation of the composition and architecture of hydrogels to fulfill clinical requirements. Benefiting from the natural source of materials, the hydrogels exhibit excellent biocompatibility and cellular proliferation capacity for incorporating induced pluripotent stem cell-derived hepatocytes (iPSC-heps). Furthermore, the macroscopic architecture and biomechanical environment of hydrogels foster optimal functional expression of iPSC-heps. Importantly, post-transplantation, the hydrogels significantly enhance survival rates and liver function in mice with acute liver failure, promoting liver regeneration and repair. These findings suggest that microfluidic 3D printed hydrogels represent promising candidates for liver transplantation and functional recovery.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"3 4","pages":"e20240056"},"PeriodicalIF":0.0,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug-phospholipid conjugate nano-assembly for drug delivery. 用于药物递送的药物-磷脂缀合纳米组装。

Smart medicine Pub Date : 2024-12-22 eCollection Date: 2024-12-01 DOI: 10.1002/SMMD.20240053

Ding Zhao, Yixiang Zhang, Fan Wang, Rames Kaewmanee, Wenguo Cui, Tianqi Wu, Yawei Du

引用次数: 0

Emerging nanoprobes for the features visualization of vulnerable atherosclerotic plaques. 新兴的纳米探针用于易损动脉粥样硬化斑块的特征可视化。

Smart medicine Pub Date : 2024-12-03 eCollection Date: 2024-12-01 DOI: 10.1002/SMMD.20240033

Xin Wang, Dan Mu, Jing Liang, Ruijing Xin, Yukun Zhang, Renyuan Liu, Mei Yao, Bing Zhang

{"title":"Emerging nanoprobes for the features visualization of vulnerable atherosclerotic plaques.","authors":"Xin Wang, Dan Mu, Jing Liang, Ruijing Xin, Yukun Zhang, Renyuan Liu, Mei Yao, Bing Zhang","doi":"10.1002/SMMD.20240033","DOIUrl":"https://doi.org/10.1002/SMMD.20240033","url":null,"abstract":"Atherosclerosis (AS) is a major cause of cardiovascular disease. In particular, the unpredictable rupture of vulnerable atherosclerotic plaques (VASPs) can cause serious cardiovascular events such as myocardial infarction, stroke, and even sudden death. Therefore, early evaluation of the vulnerability of atherosclerotic plaques is of great importance. However, clinical imaging techniques are only marginally useful in the presence of severe anatomical structural changes, making it difficult to evaluate plaque vulnerability at an early stage. With the development of molecular imaging and nanotechnology, specific nanoprobes constructed for the pathological features of VASPs have attracted much attention for their ability to visualize VASPs early and noninvasively at the cellular and molecular levels. Here, we outline the pathological features of VASPs, analyze the superiority and limitations of current clinical imaging techniques, introduce the rational design principles of nanoprobes, and systematically summarize the application of nanoprobes to visualize the features of VASPs at the cellular and molecular levels. In addition, we discussed the prospects and urgent challenges in this field, and we believe it will provide new ideas for the early and accurate diagnosis of cardiovascular diseases.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"3 4","pages":"e20240033"},"PeriodicalIF":0.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Change in p53 nuclear localization in response to extracellular matrix stiffness. 细胞外基质硬度对p53核定位的影响。

Smart medicine Pub Date : 2024-11-17 eCollection Date: 2024-12-01 DOI: 10.1002/SMMD.20240026

Yan Zu, Jing Du, Yipu Xu, Mengying Niu, Canlin Hong, Chun Yang

{"title":"Change in p53 nuclear localization in response to extracellular matrix stiffness.","authors":"Yan Zu, Jing Du, Yipu Xu, Mengying Niu, Canlin Hong, Chun Yang","doi":"10.1002/SMMD.20240026","DOIUrl":"https://doi.org/10.1002/SMMD.20240026","url":null,"abstract":"Chondrocytes are commonly applied in regenerative medicine and tissue engineering. Thus, the discovery of optimal culture conditions to obtain cells with good properties and behavior for transplantation is important. In addition to biochemical cues, physical and biomechanical changes can affect the proliferation and protein expression of chondrocytes. Here we investigated the effect of extracellular matrix stiffness on mouse articular chondrocyte phenotype, growth, and subcellular p53 localization. Chondrocytes were seeded on collagen-coated substrates varying in elasticity: 0.5 and 100 kPa. Immunocytochemical staining and immunoblotting showed that a softer substrate significantly increased p53 nuclear localization in chondrocytes. Furthermore, we identified microRNA-532 (miR-532) as a potential p53 target gene to influence cell function, indicating a new target for tissue engineering. These findings provide insight into the influence of physical cues on cell phenotype maintenance and could help improve understanding of cartilage-related pathologies such as osteoarthritis.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"3 4","pages":"e20240026"},"PeriodicalIF":0.0,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0