Smart medicine最新文献_第10页

Reprogramming stem cells in regenerative medicine. 再生医学中的干细胞再编程

Smart medicine Pub Date : 2022-12-25 eCollection Date: 2022-12-01 DOI: 10.1002/SMMD.20220005

Jiayi Mao, Qimanguli Saiding, Shutong Qian, Zhimo Liu, Binfan Zhao, Qiuyu Zhao, Bolun Lu, Xiyuan Mao, Liucheng Zhang, Yuguang Zhang, Xiaoming Sun, Wenguo Cui

{"title":"Reprogramming stem cells in regenerative medicine.","authors":"Jiayi Mao, Qimanguli Saiding, Shutong Qian, Zhimo Liu, Binfan Zhao, Qiuyu Zhao, Bolun Lu, Xiyuan Mao, Liucheng Zhang, Yuguang Zhang, Xiaoming Sun, Wenguo Cui","doi":"10.1002/SMMD.20220005","DOIUrl":"10.1002/SMMD.20220005","url":null,"abstract":"Induced pluripotent stem cells (iPSCs) that are generated from adult somatic cells are induced to express genes that make them pluripotent through reprogramming techniques. With their unlimited proliferative capacity and multifaceted differentiation potential and circumventing the ethical problems encountered in the application of embryonic stem cells (ESC), iPSCs have a broad application in the fields of cell therapy, drug screening, and disease models and may open up new possibilities for regenerative medicine to treat diseases in the future. In this review, we begin with different reprogramming cell technologies to obtain iPSCs, including biotechnological, chemical, and physical modulation techniques, and present their respective strengths, and limitations, as well as the recent progress of research. Secondly, we review recent research advances in iPSC reprogramming-based regenerative therapies. iPSCs are now widely used to study various clinical diseases of hair follicle defects, myocardial infarction, neurological disorders, liver diseases, and spinal cord injuries. This review focuses on the translational clinical research around iPSCs as well as their potential for growth in the medical field. Finally, we summarize the overall review and look at the potential future of iPSCs in the field of cell therapy as well as tissue regeneration engineering and possible problems. We believe that the advancing iPSC research will help drive long-awaited breakthroughs in cellular therapy.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220005"},"PeriodicalIF":0.0,"publicationDate":"2022-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49008170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bio-inspired adhesive hydrogel for biomedicine-principles and design strategies. 用于生物医学的生物灵感粘合剂水凝胶-原理和设计策略

Smart medicine Pub Date : 2022-12-25 eCollection Date: 2022-12-01 DOI: 10.1002/SMMD.20220024

Wenzhao Li, Xinyuan Yang, Puxiang Lai, Luoran Shang

{"title":"Bio-inspired adhesive hydrogel for biomedicine-principles and design strategies.","authors":"Wenzhao Li, Xinyuan Yang, Puxiang Lai, Luoran Shang","doi":"10.1002/SMMD.20220024","DOIUrl":"10.1002/SMMD.20220024","url":null,"abstract":"The adhesiveness of hydrogels is urgently required in various biomedical applications such as medical patches, tissue sealants, and flexible electronic devices. However, biological tissues are often wet, soft, movable, and easily damaged. These features pose difficulties for the construction of adhesive hydrogels for medical use. In nature, organisms adhere to unique strategies, such as reversible sucker adhesion in octopuses and nontoxic and firm catechol chemistry in mussels, which provide many inspirations for medical hydrogels to overcome the above challenges. In this review, we systematically classify bioadhesion strategies into structure-related and molecular-related ones, which cover almost all known bioadhesion paradigms. We outline the principles of these strategies and summarize the corresponding designs of medical adhesive hydrogels inspired by them. Finally, conclusions and perspectives concerning the development of this field are provided. For the booming bio-inspired adhesive hydrogels, this review aims to summarize and analyze the various existing theories and provide systematic guidance for future research from an innovative perspective.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220024"},"PeriodicalIF":0.0,"publicationDate":"2022-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48013521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multidisciplinary endeavors make future medicine smart. 多学科的努力使未来的医学智能化

Smart medicine Pub Date : 2022-12-23 eCollection Date: 2022-12-01 DOI: 10.1002/SMMD.20220031

Luoran Shang, Yihai Cao, David A Weitz

引用次数: 0

Polyurethane-polypyrrole hybrid structural color films for dual-signal mechanics sensing. 双信号力学传感用聚氨酯-聚吡咯混合结构彩色薄膜

Smart medicine Pub Date : 2022-12-23 eCollection Date: 2022-12-01 DOI: 10.1002/SMMD.20220008

Changmin Shao, Yunru Yu, Qihui Fan, Xiaochen Wang, Fangfu Ye

引用次数: 0

Phage display for the detection, analysis, disinfection, and prevention of Staphylococcus aureus. 用于检测、分析、消毒和预防金黄色葡萄球菌的噬菌体显示器

Smart medicine Pub Date : 2022-12-23 eCollection Date: 2022-12-01 DOI: 10.1002/SMMD.20220015

Lei Tian, Kyle Jackson, Michael Chan, Ahmed Saif, Leon He, Tohid F Didar, Zeinab Hosseinidoust

{"title":"Phage display for the detection, analysis, disinfection, and prevention of Staphylococcus aureus.","authors":"Lei Tian, Kyle Jackson, Michael Chan, Ahmed Saif, Leon He, Tohid F Didar, Zeinab Hosseinidoust","doi":"10.1002/SMMD.20220015","DOIUrl":"10.1002/SMMD.20220015","url":null,"abstract":"The World Health Organization has designated Staphylococcus aureus as a global health concern. This designation stems from the emergence of multiple drug-resistant strains that already account for hundreds of thousands of deaths globally. The development of novel treatment strategies to eradicate S. aureus or mitigate its pathogenic potential is desperately needed. In the effort to develop emerging strategies to combat S. aureus, phage display is uniquely positioned to assist in this endeavor. Leveraging bacteriophages, phage display enables researchers to better understand interactions between proteins and their antagonists. In doing so, researchers have the capacity to design novel inhibitors, biosensors, disinfectants, and immune modulators that can target specific S. aureus strains. In this review, we highlight how phage display can be leveraged to design novel solutions to combat S. aureus. We further discuss existing uses of phage display as a detection, intervention, and prevention platform against S. aureus and provide outlooks on how this technology can be optimized for future applications.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220015"},"PeriodicalIF":0.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48698308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silk fibroin hydrogels for biomedical applications. 用于生物医学应用的丝素水凝胶

Smart medicine Pub Date : 2022-12-23 eCollection Date: 2022-12-01 DOI: 10.1002/SMMD.20220011

Hui Zhang, Dongyu Xu, Yong Zhang, Minli Li, Renjie Chai

引用次数: 0

Thermoelectric energy harvesting for personalized healthcare. 用于个性化医疗保健的热电能量采集

Smart medicine Pub Date : 2022-12-22 eCollection Date: 2022-12-01 DOI: 10.1002/SMMD.20220016

Wei Gao, Yang Wang, Feili Lai

{"title":"Thermoelectric energy harvesting for personalized healthcare.","authors":"Wei Gao, Yang Wang, Feili Lai","doi":"10.1002/SMMD.20220016","DOIUrl":"10.1002/SMMD.20220016","url":null,"abstract":"In recent decades, there has been increased research interest in miniaturizing and decentralizing diagnostic platforms to enable continuous personalized healthcare and free patients from long-term hospitalization. However, the lack of reliable and portable power supplies has limited the working time of the personalized healthcare platform. Compared with the current power supplies (e.g., batteries and supercapacitors) that require manual intervention, thermoelectric devices promise to continuously harvest waste heat from the human body to satisfy the energy consumption of personalized healthcare platforms. Herein, this review discusses thermoelectric energy harvesting for personalized healthcare. It begins with the fundamental concepts of different thermoelectric materials, including electron thermoelectric generators (TEGs), ionic thermogalvanic cells (TGCs), and ionic thermoelectric capacitors (TECs). Then, the wearable and implantable applications of thermoelectric devices are presented. Finally, future directions of next-generation thermoelectric devices for personalized healthcare are discussed. It is hoped that developing high-performance thermoelectric devices will change the landscape of personalized healthcare in the future.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220016"},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41417115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reregulated mitochondrial dysfunction reverses cisplatin resistance microenvironment in colorectal cancer. 重调节线粒体功能障碍逆转结直肠癌顺铂耐药微环境

Smart medicine Pub Date : 2022-12-22 eCollection Date: 2022-12-01 DOI: 10.1002/SMMD.20220013

Yonghui Wang, Xiaodong Ma, Wenhui Zhou, Chang Liu, Hongbo Zhang

{"title":"Reregulated mitochondrial dysfunction reverses cisplatin resistance microenvironment in colorectal cancer.","authors":"Yonghui Wang, Xiaodong Ma, Wenhui Zhou, Chang Liu, Hongbo Zhang","doi":"10.1002/SMMD.20220013","DOIUrl":"10.1002/SMMD.20220013","url":null,"abstract":"Chemotherapy is one of the most basic and important treatments for malignant tumors. However, most chemotherapeutic drugs suffer from the resistance of tumor cells and lead to chemotherapy failure. Multidrug resistance (MDR) of tumor cells is the main obstacle to chemotherapy failure. The generation of MDR is not only the result of the performance of tumor cells, but the tumor microenvironment (TEM) also plays an important role in this process. The simultaneous dual intervention of cancer cells and the TEM has the potential to provide surprising results in overcoming MDR tumor therapy. Therefore, in this study, we designed a folate acid ligand-modified nanoparticle (FA-NPs) with a size of about 145 nm targeting multidrug-resistant colorectal cancer and successfully co-loaded cisplatin and Tris(2-chloroisopropyl) phosphate (TCPP). FA-NPs can enrich tumor sites through receptor-mediated endocytosis. In vitro mechanism studies have shown that nanoparticles can reverse cisplatin resistance mainly by further increasing the level of reactive oxygen species in tumor cells, breaking the homeostasis of the internal environment, then trigging mitochondrial stress, regulating drug resistance-related pathways, and improving the tumor drug resistance microenvironment; finally, the cisplatin recovers the antitumor effect with assistance from TCPP.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220013"},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43702157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microfluidic technologies for cell deformability cytometry. 微流控技术用于细胞变形性细胞测定

Smart medicine Pub Date : 2022-12-22 eCollection Date: 2022-12-01 DOI: 10.1002/SMMD.20220001

Hanxu Chen, Jiahui Guo, Feika Bian, Yuanjin Zhao

引用次数: 0

Celery-derived scaffolds with liver lobule-mimicking structures for tissue engineering transplantation. 芹菜衍生的肝小叶模拟支架用于组织工程移植

Smart medicine Pub Date : 2022-12-16 eCollection Date: 2022-12-01 DOI: 10.1002/SMMD.20220002

Jinglin Wang, Xueqian Qin, Bin Kong, Haozhen Ren

{"title":"Celery-derived scaffolds with liver lobule-mimicking structures for tissue engineering transplantation.","authors":"Jinglin Wang, Xueqian Qin, Bin Kong, Haozhen Ren","doi":"10.1002/SMMD.20220002","DOIUrl":"10.1002/SMMD.20220002","url":null,"abstract":"Decellularized scaffolds have a demonstrated value in liver tissue engineering. Challenges in this area are focused on effectively eliminating the biological rejection of scaffolds and finding a suitable liver cell source. Here, inspired by the natural microstructure of hepatic lobules, we present a novel decellularized celery-derived scaffold cultured with human-induced pluripotent stem cell-derived hepatocytes (hiPSC-Heps) bioengineering liver tissue construction. Because of the natural hollow channels, interconnected porous structures, and excellent physicochemical characterization of the decellularized celery-derived scaffold, the resultant bioengineering liver tissue can maintain the hiPSC-Heps viability and the hepatic functions in the in vitro cultures. Based on this bioengineering liver tissue, we have demonstrated its good biocompatibility and the significantly higher expressions of albumin (ALB) and periodic acid-schiff stain (PAS) when it was implanted in nude mice. These remarkable properties endow the hiPSC-Heps integrated decellularized celery scaffolds system with promising prospects in the field of liver transplantation and other regeneration medicine.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220002"},"PeriodicalIF":0.0,"publicationDate":"2022-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11236025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41646273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0