Smart medicine最新文献

{"title":"Recent advances in liver-on-chips: Design, fabrication, and applications.","authors":"Linjie Qiu, Bin Kong, Tiantian Kong, Huan Wang","doi":"10.1002/SMMD.20220010","DOIUrl":"10.1002/SMMD.20220010","url":null,"abstract":"<p><p>The liver is a multifunctional organ and the metabolic center of the human body. Most drugs and toxins are metabolized in the liver, resulting in varying degrees of hepatotoxicity. The damage of liver will seriously affect human health, so it is very important to study the prevention and treatment of liver diseases. At present, there are many research studies in this field. However, most of them are based on animal models, which are limited by the time-consuming processes and species difference between human and animals. In recent years, liver-on-chips have emerged and developed rapidly and are expected to replace animal models. Liver-on-chips refer to the use of a small number of liver cells on the chips to simulate the liver microenvironment and ultrastructure in vivo. They hold extensive applications in multiple fields by reproducing the unique physiological functions of the liver in vitro. In this review, we first introduced the physiology and pathology of liver and then described the cell system of liver-on-chips, the chip-based liver models, and the applications of liver-on-chips in liver transplantation, drug screening, and metabolic evaluation. Finally, we discussed the currently encountered challenges and future trends in liver-on-chips.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220010"},"PeriodicalIF":0.0,"publicationDate":"2023-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45528421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bio-inspired ionic skins for smart medicine.","authors":"Zhouyue Lei, Wentao Xu, Guogao Zhang","doi":"10.1002/SMMD.20220026","DOIUrl":"10.1002/SMMD.20220026","url":null,"abstract":"<p><p>Ionic skins are developed to mimic the mechanical properties and functions of natural skins. They have demonstrated substantial advantages to serve as the crucial interface to bridge the gap between humans and machines. The first-generation ionic skin is a stretchable capacitor comprising hydrogels as the ionic conductors and elastomers as the dielectrics, and realizes pressure and strain sensing through the measurement of the capacitance. Subsequent advances have been made to improve the mechanical properties of ionic skins and import diverse functions. For example, ultrahigh stretchability, strong interfacial adhesion, self-healing, moisturizing ability, and various sensing capabilities have been achieved separately or simultaneously. Most ionic skins are attached to natural skins to monitor bio-electrical signals continuously. Ionic skins have also been found with significant potential to serve as a smart drug-containing reservoir, which can release drugs spatially, temporally, and in a controllable way. Herein, this review focuses on the design and fabrication of ionic skins, and their applications related to smart medicine. Moreover, challenges and opportunities are also discussed. It is hoped that the development of bio-inspired ionic skins will provide a paradigm shift for self-diagnosis and healthcare.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220026"},"PeriodicalIF":0.0,"publicationDate":"2023-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44223502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Microneedles for Wearable Electronics (1/2023)","authors":"Xiaoxuan Zhang, Minhui Lu, Xinyue Cao, Yuanjin Zhao","doi":"10.1002/smmd.52","DOIUrl":"https://doi.org/10.1002/smmd.52","url":null,"abstract":"","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43937295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information","authors":"","doi":"10.1002/wer.10731","DOIUrl":"https://doi.org/10.1002/wer.10731","url":null,"abstract":"No abstract is available for this article.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43270867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue adhesives for wound closure (1/2023)","authors":"Bin Kong, Cheng Qi, Huan Wang, Tiantian Kong, Zhou Liu","doi":"10.1002/smmd.54","DOIUrl":"https://doi.org/10.1002/smmd.54","url":null,"abstract":"","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42046449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in liver‐on‐chips: design, fabrication, and applications (1/2023)","authors":"Linjie Qiu, Bin Kong, Tiantian Kong, Huan Wang","doi":"10.1002/smmd.51","DOIUrl":"https://doi.org/10.1002/smmd.51","url":null,"abstract":"","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49515905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconstruction of the alveolar‐capillary barrier in vitro based on a photo‐responsive stretchable Janus membrane (1/2023)","authors":"C. Shao, Tin M. Cao, Xiaochen Wang, Qihui Fan, Fangfu Ye","doi":"10.1002/smmd.53","DOIUrl":"https://doi.org/10.1002/smmd.53","url":null,"abstract":"","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47260693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Encoding microcarriers for biomedicine (1/2023)","authors":"Xiaowei Wei, Yixuan Shang, Yefei Zhu, Zhuxiao Gu, Dagan Zhang","doi":"10.1002/smmd.55","DOIUrl":"https://doi.org/10.1002/smmd.55","url":null,"abstract":"","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47481229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of cesarean delivery timing with pelvic floor muscle function and urine incontinence: A propensity score-matched study.","authors":"Yiyao Chen, Chuangchuang Xu, Qimanguli Saiding, Xiaolei Chi, Lei Chu, Xianjing Wang, Xinliang Chen","doi":"10.1002/SMMD.20220018","DOIUrl":"10.1002/SMMD.20220018","url":null,"abstract":"<p><p>Pelvic floor dysfunction is a common gynecological disease that adversely affects women's quality of life and mental health. Delivery is considered a significant independent risk factor for pelvic floor dysfunction. Surface electromyography (sEMG) values for the pelvic floor muscles (PFM) have been shown to differ according to different delivery modes. This study aimed to compare sEMG results between intrapartum and antepartum cesarean delivery (CD), 42-60 days after delivery. Data of women who underwent CD at the International Peace Maternity and Child Health Hospital were collected from September 2021 to December 2021. Myotrac Infiniti System was used to measure the electromyographic activity of PFM after 42-60 days of parturition. Propensity score matching (1:1) was applied to achieve a balance in baseline data between the two groups (intrapartum and antepartum CD). A total of 200 paired cases were selected for statistical analysis. In the propensity score-matched analysis, there were no statistically significant differences in PFM sEMG between women with antepartum or intrapartum CD (<i>p</i> > 0.05 for all). We observed similar results with postpartum urinary incontinence (24 [12.0] vs. 21 [10.5]; adjusted odds ratio (aOR), 1.12 [95% confidence interval (CI) 0.60-2.12]; <i>p</i> = 0.717) and stress urinary incontinence (12 [6.0] vs. 14 [7.0]; aOR, 0.80 [95% CI 0.35-1.80]; <i>p</i> = 0.596) as outcomes. After excluding participants with intrapartum CD when the cervix was dilated <6 cm, all sEMG of PFM had a comparable level of risk in both the antepartum and intrapartum CD groups. There were no significant differences in sEMG of the PFM and the incidence of urinary incontinence between patients undergoing intrapartum or antepartum CD. Excluding women who underwent intrapartum CD when the cervix was dilated to <6 cm produced little change in results. Thus, different opportunities for CD may not impact the sEMG of the PFM and the incidence of urinary incontinence.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220018"},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46494252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stem cells for organoids.","authors":"Shutong Qian, Jiayi Mao, Zhimo Liu, Binfan Zhao, Qiuyu Zhao, Bolun Lu, Liucheng Zhang, Xiyuan Mao, Liying Cheng, Wenguo Cui, Yuguang Zhang, Xiaoming Sun","doi":"10.1002/SMMD.20220007","DOIUrl":"10.1002/SMMD.20220007","url":null,"abstract":"<p><p>Organoids are three-dimensional (3D) cell culture systems that simulate the structures and functions of organs, involving applications in disease modeling, drug screening, and cellular developmental biology. The material matrix in organoids can provide a 3D environment for stem cells to differentiate into different cell types and continuously self-renew, thereby realizing the in vitro culture of organs, which has received extensive attention in recent years. However, some challenges still exist in organoids, including low maturity, high heterogeneity, and lack of spatiotemporal regulation. Therefore, in this review, we summarized the culturing protocols and various applications of stem cell-derived organoids and proposed insightful thoughts for engineering stem cells into organoids in view of the current shortcomings, to achieve the further application and clinical translation of stem cells and engineered stem cells in organoid research.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220007"},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41611393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}