Smart medicine最新文献

{"title":"Association of cesarean delivery timing with pelvic floor muscle function and urine incontinence: A propensity score-matched study.","authors":"Yiyao Chen, Chuangchuang Xu, Qimanguli Saiding, Xiaolei Chi, Lei Chu, Xianjing Wang, Xinliang Chen","doi":"10.1002/SMMD.20220018","DOIUrl":"10.1002/SMMD.20220018","url":null,"abstract":"<p><p>Pelvic floor dysfunction is a common gynecological disease that adversely affects women's quality of life and mental health. Delivery is considered a significant independent risk factor for pelvic floor dysfunction. Surface electromyography (sEMG) values for the pelvic floor muscles (PFM) have been shown to differ according to different delivery modes. This study aimed to compare sEMG results between intrapartum and antepartum cesarean delivery (CD), 42-60 days after delivery. Data of women who underwent CD at the International Peace Maternity and Child Health Hospital were collected from September 2021 to December 2021. Myotrac Infiniti System was used to measure the electromyographic activity of PFM after 42-60 days of parturition. Propensity score matching (1:1) was applied to achieve a balance in baseline data between the two groups (intrapartum and antepartum CD). A total of 200 paired cases were selected for statistical analysis. In the propensity score-matched analysis, there were no statistically significant differences in PFM sEMG between women with antepartum or intrapartum CD (<i>p</i> > 0.05 for all). We observed similar results with postpartum urinary incontinence (24 [12.0] vs. 21 [10.5]; adjusted odds ratio (aOR), 1.12 [95% confidence interval (CI) 0.60-2.12]; <i>p</i> = 0.717) and stress urinary incontinence (12 [6.0] vs. 14 [7.0]; aOR, 0.80 [95% CI 0.35-1.80]; <i>p</i> = 0.596) as outcomes. After excluding participants with intrapartum CD when the cervix was dilated <6 cm, all sEMG of PFM had a comparable level of risk in both the antepartum and intrapartum CD groups. There were no significant differences in sEMG of the PFM and the incidence of urinary incontinence between patients undergoing intrapartum or antepartum CD. Excluding women who underwent intrapartum CD when the cervix was dilated to <6 cm produced little change in results. Thus, different opportunities for CD may not impact the sEMG of the PFM and the incidence of urinary incontinence.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220018"},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46494252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stem cells for organoids.","authors":"Shutong Qian, Jiayi Mao, Zhimo Liu, Binfan Zhao, Qiuyu Zhao, Bolun Lu, Liucheng Zhang, Xiyuan Mao, Liying Cheng, Wenguo Cui, Yuguang Zhang, Xiaoming Sun","doi":"10.1002/SMMD.20220007","DOIUrl":"10.1002/SMMD.20220007","url":null,"abstract":"<p><p>Organoids are three-dimensional (3D) cell culture systems that simulate the structures and functions of organs, involving applications in disease modeling, drug screening, and cellular developmental biology. The material matrix in organoids can provide a 3D environment for stem cells to differentiate into different cell types and continuously self-renew, thereby realizing the in vitro culture of organs, which has received extensive attention in recent years. However, some challenges still exist in organoids, including low maturity, high heterogeneity, and lack of spatiotemporal regulation. Therefore, in this review, we summarized the culturing protocols and various applications of stem cell-derived organoids and proposed insightful thoughts for engineering stem cells into organoids in view of the current shortcomings, to achieve the further application and clinical translation of stem cells and engineered stem cells in organoid research.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220007"},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41611393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing biomedical engineering technologies for reproductive medicine.","authors":"Yujuan Zhu, Bin Kong, Rui Liu, Yuanjin Zhao","doi":"10.1002/SMMD.20220006","DOIUrl":"10.1002/SMMD.20220006","url":null,"abstract":"<p><p>Infertility is a rising global health issue with a far-reaching impact on the socioeconomic livelihoods. As there are highly complex causes of male and female infertility, it is highly desired to promote and maintain reproductive health by the integration of advanced technologies. Biomedical engineering, a mature technology applied in the fields of biology and health care, has emerged as a powerful tool in the diagnosis and treatment of infertility. Nowadays, various promising biomedical engineering approaches are under investigation to address human infertility. Biomedical engineering approaches can not only improve our fundamental understanding of sperm and follicle development in bioengineered devices combined with microfabrication, biomaterials, and relevant cells, but also be applied to repair uterine, ovary, and cervicovaginal tissues and restore tissue function. Here, we introduce the infertility in male and female and provide a comprehensive summary of the various promising biomedical engineering technologies and their applications in reproductive medicine. Also, the challenges and prospects of biomedical engineering technologies for clinical transformation are discussed. We believe that this review will promote communications between engineers, biologists, and clinicians and potentially contribute to the clinical transformation of these innovative research works in the immediate future.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220006"},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44677124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional biomaterials for osteoarthritis treatment: From research to application.","authors":"Yang Lei, Qingfei Zhang, Gaizheng Kuang, Xiaochen Wang, Qihui Fan, Fangfu Ye","doi":"10.1002/SMMD.20220014","DOIUrl":"10.1002/SMMD.20220014","url":null,"abstract":"<p><p>Osteoarthritis (OA) is a common disease that endangers millions of middle-aged and elderly people worldwide. Researchers from different fields have made great efforts and achieved remarkable progress in the pathogenesis and treatment of OA. However, there is still no cure for OA. In this review, we discuss the pathogenesis of OA and summarize the current clinical therapies. Moreover, we introduce various natural and synthetic biomaterials for drug release, cartilage transplantation, and joint lubricant during the OA treatment. We also present our perspectives and insights on OA treatment in the future. We hope that this review will foster communication and collaboration among biological, clinical, and biomaterial researchers, paving the way for OA therapeutic breakthroughs.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220014"},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41444816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Freezing biological organisms for biomedical applications.","authors":"Gaizhen Kuang, Qingfei Zhang, Jinxuan Jia, Yunru Yu","doi":"10.1002/SMMD.20220034","DOIUrl":"10.1002/SMMD.20220034","url":null,"abstract":"<p><p>Biological organisms play important roles in human health, either in a commensal or pathogenic manner. Harnessing inactivated organisms or living organisms is a promising way to treat diseases. As two types of freezing, cryoablation makes it simple to inactivate organisms that must be in a non-pathogenic state when needed, while cryopreservation is a facile way to address the problem of long-term storage challenged by living organism-based therapy. In this review, we present the latest studies of freezing biological organisms for biomedical applications. To begin with, the freezing strategies of cryoablation and cryopreservation, as well as their corresponding technical essentials, are illustrated. Besides, biomedical applications of freezing biological organisms are presented, including transplantation, tissue regeneration, anti-infection therapy, and anti-tumor therapy. The challenges and prospects of freezing living organisms for biomedical applications are well discussed. We believe that the freezing method will provide a potential direction for the standardization and commercialization of inactivated or living organism-based therapeutic systems, and promote the clinical application of organism-based therapy.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220034"},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46942944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-delivery CPT and PTX prodrug with a photo/thermo-responsive nanoplatform for triple-negative breast cancer therapy.","authors":"Wenhui Zhou, Xiaodong Ma, Jie Wang, Xiaoyu Xu, Oliver Koivisto, Jing Feng, Tapani Viitala, Hongbo Zhang","doi":"10.1002/SMMD.20220036","DOIUrl":"10.1002/SMMD.20220036","url":null,"abstract":"<p><p>Triple-negative breast cancer (TNBC) is still the most aggressive cancer in women. Combination chemotherapy holds great potential for cancer therapy; however, the off-target and side effects of free chemotherapy administration remain a major challenge. In this study, we developed a photo/thermo-responsive nanoplatform that can be used for TNBC treatment via photothermic therapy in combination with multidrug therapy. By conjugating the chemotherapy drug PTX prodrug on the surface of mesoporous silica-coated gold nanorod nanoparticles and then loading another chemotherapy drug, CPT, the Au@MSN-PTX@CPT nanoparticles exhibited great photothermal response, redox response drug release and cancer cell inhibition abilities. Otherwise, we further coated the Au@MSN-PTX@CPT nanoparticle with a temperature-sensitive polymer poly(N-isopropylacrylamide-co-methacrylic acid) (p(NIPAM-co-MAAc)), and the polymer-coated Au@MSN-PTX@TPT@polymer nanoparticles showed perfect near-infrared (NIR) light controlled drug release. Finally, the Au@MSN-PTX@CPT@polymer nanoparticles were injected into the 4T1 breast cancer mouse model. The Au@MSN-PTX@CPT@polymer nanoparticles preferably accumulated at the tumor site and had reduced chemotherapy injuries and great antitumor activity when combined with 650 nm laser treatment. In summary, our developed Au@MSN-PTX@CPT@polymer nanoparticles served as a good method for controlled chemodrug delivery and provided a good choice for TNBC combination therapy.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220036"},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45017235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioceramic materials with ion-mediated multifunctionality for wound healing.","authors":"Xiaocheng Wang, Min Tang","doi":"10.1002/SMMD.20220032","DOIUrl":"10.1002/SMMD.20220032","url":null,"abstract":"<p><p>Regeneration of both anatomic and functional integrity of the skin tissues after injury represents a huge challenge considering the sophisticated healing process and variability of specific wounds. In the past decades, numerous efforts have been made to construct bioceramic-based wound dressing materials with ion-mediated multifunctionality for facilitating the healing process. In this review, the state-of-the-art progress on bioceramic materials with ion-mediated bioactivity for wound healing is summarized. Followed by a brief discussion on the bioceramic materials with ion-mediated biological activities, the emerging bioceramic-based materials are highlighted for wound healing applications owing to their ion-mediated bioactivities, including anti-infection function, angiogenic activity, improved skin appendage regeneration, antitumor effect, and so on. Finally, concluding remarks and future perspectives of bioceramic-based wound dressing materials for clinical practice are briefly discussed.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220032"},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47385641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Responsive hydrogel microfibers for biomedical engineering.","authors":"Jiahui Guo, Zhiqiang Luo, Fengyuan Wang, Hongcheng Gu, Minli Li","doi":"10.1002/SMMD.20220003","DOIUrl":"10.1002/SMMD.20220003","url":null,"abstract":"<p><p>Responsive hydrogel microfibers can realize multiple controllable changes in shapes or properties under the stimulation of the surrounding environment, and are called as intelligent biomaterials. Recently, these responsive hydrogel microfibers have been proved to possess significant biomedical values, and remarkable progress has been achieved in biomedical engineering applications, including drug delivery, biosensors and clinical therapy, etc. In this review, the latest research progress and application prospects of responsive hydrogel microfibers in biomedical engineering are summarized. We first introduce the common preparation strategies of responsive hydrogel microfibers. Subsequently, the response characteristics and the biomedical applications of these materials are discussed. Finally, the present opportunities and challenges as well as the prospects for future development are critically analyzed.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220003"},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48650649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced surgical tool: Progress in clinical application of intelligent surgical robot.","authors":"Chao Li, Tongtong Zhang, Haoran Wang, Zhiyong Hou, Yingze Zhang, Wei Chen","doi":"10.1002/SMMD.20220021","DOIUrl":"10.1002/SMMD.20220021","url":null,"abstract":"<p><p>Surgical robot is a revolutionary tool conceived in the progress of clinical medicine, computer science, microelectronics and biomechanics. It provides the surgeon with clearer views and more comfortable surgical postures. With the assistance of computer navigation during delicate operations, it can further shorten the patient recovery time via reducing intraoperative bleeding, the risk of infection and the amount of anesthesia needed. As a comprehensive surgical revolution, surgical robot technique has a wide range of applications in related fields. This paper reviews the development status and operation principles of these surgical robots. At the same time, we also describe their up-to-date applications in different specialties and discusses the prospects and challenges of surgical robots in the medical area.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220021"},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49587134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current treatments after spinal cord injury: Cell engineering, tissue engineering, and combined therapies.","authors":"Yingbo Shen, Xinyue Cao, Minhui Lu, Hongcheng Gu, Minli Li, David A Posner","doi":"10.1002/SMMD.20220017","DOIUrl":"10.1002/SMMD.20220017","url":null,"abstract":"<p><p>Both traumatic and non-traumatic spinal cord injuries (SCIs) can be categorized as damages done to our central nervous system (CNS). The patients' physical and mental health may suffer greatly because of traumatic SCI. With the widespread use of motor vehicles and increasingly aged population, the occurrence of SCI is more frequent than before, creating a considerable burden to global public health. The regeneration process of the spinal cord is hampered by a series of events that occur following SCI like edema, hemorrhage, formation of cystic cavities, and ischemia. An effective strategy for the treatment of SCI and functional recovery still has not been discovered; however, recent advances have been made in bioengineering fields that therapies based on cells, biomaterials, and biomolecules have proved effective in the repair of the spinal cord. In the light of worldwide importance of treatments for SCI, this article aims to provide a review of recent advances by first introducing the physiology, etiology, epidemiology, and mechanisms of SCI. We then put emphasis on the widely used clinical treatments and bioengineering strategies (cell-based, biomaterial-based, and biomolecule-based) for the functional regeneration of the spinal cord as well as challenges faced by scientists currently. This article provides scientists and clinicians with a comprehensive outlook on the recent advances of preclinical and clinical treatments of SCI, hoping to help them find keys to the functional regeneration of SCI.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220017"},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43255569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}