Smart medicine最新文献_第9页

Nurturing the marriages of urinary liquid biopsies and nano-diagnostics for precision urinalysis of prostate cancer. 促进尿液活检和纳米诊断的结合，用于前列腺癌的精确尿液分析

Smart medicine Pub Date : 2023-02-14 eCollection Date: 2023-02-01 DOI: 10.1002/SMMD.20220020

Caizhi Liao, Zhihao Wu, Chan Lin, Xiaofeng Chen, Yaqun Zou, Wan Zhao, Xin Li, Guangqi Huang, Baisheng Xu, Giovanni E Briganti, Yan Qi, Xianshu Wang, Tao Zeng, Alain Wuethrich, Hongzhi Zou

{"title":"Nurturing the marriages of urinary liquid biopsies and nano-diagnostics for precision urinalysis of prostate cancer.","authors":"Caizhi Liao, Zhihao Wu, Chan Lin, Xiaofeng Chen, Yaqun Zou, Wan Zhao, Xin Li, Guangqi Huang, Baisheng Xu, Giovanni E Briganti, Yan Qi, Xianshu Wang, Tao Zeng, Alain Wuethrich, Hongzhi Zou","doi":"10.1002/SMMD.20220020","DOIUrl":"10.1002/SMMD.20220020","url":null,"abstract":"Prostate cancer remains the second-most common cancer diagnosed in men, despite the increasingly widespread use of serum prostate-specific antigen (PSA) screening. The controversial clinical implications and cost benefits of PSA screening have been highlighted due to its poor specificity, resulting in a high rate of overdiagnosis and underdiagnosis. Thus, the development of novel biomarkers for prostate cancer detection remains an intriguing challenge. Urine is emerging as a source for prostate cancer biomarker discovery. Currently, new urine biomarkers already outperform serum PSA in clinical diagnosis. Meanwhile, the advances in nanotechnology have provided a suite of diagnostic tools to study prostate cancer in more detail, sparking a new era of biomarker discoveries. In this review, we envision that future prostate cancer diagnosis will probably integrate multiplex nano-diagnostic approaches to detect novel urinary biomarkers. However, challenges remain in differentiating indolent from aggressive cancers to better inform treatment decisions, and clinical translation still needs to be overcome.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220020"},"PeriodicalIF":0.0,"publicationDate":"2023-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11236013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42464952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microfluidic preparation of optical sensors for biomedical applications. 用于生物医学应用的光学传感器的微流体制备

Smart medicine Pub Date : 2023-02-12 eCollection Date: 2023-02-01 DOI: 10.1002/SMMD.20220027

Qiao Wang, Chong Wang, Xinyuan Yang, Jiali Wang, Zhuohao Zhang, Luoran Shang

引用次数: 0

Tissue adhesives for wound closure. 伤口闭合用组织粘接剂

Smart medicine Pub Date : 2023-02-12 eCollection Date: 2023-02-01 DOI: 10.1002/SMMD.20220033

Bin Kong, Cheng Qi, Huan Wang, Tiantian Kong, Zhou Liu

{"title":"Tissue adhesives for wound closure.","authors":"Bin Kong, Cheng Qi, Huan Wang, Tiantian Kong, Zhou Liu","doi":"10.1002/SMMD.20220033","DOIUrl":"10.1002/SMMD.20220033","url":null,"abstract":"Tissue adhesives have raised much attention from scientists in recent years. They have been extensively utilized in various medical fields, such as wound closure, due to the advantages of being simple, time-saving, and avoiding the problems and complications associated with surgical sutures. Besides, the tissue adhesives can absorb wound exudates and promote tissue repair. The rapid evolution in the field of tissue adhesives has resulted in the development of various adhesives with excellent mechanical properties and superior functions. However, many challenges still restrict their use in numerous clinical applications. In this paper, we present an up-to-date review of tissue adhesives for wound closure. We mainly discussed the fundamental design requirements for the adhesives, the fabrication of tissue adhesives, and the application of tissue adhesives on skin healing, corneal patch, and gastrointestinal tissues. We then highlighted the current challenges and unmet needs and delineated potential new clinical development directions for future adhesives. The progress in tissue adhesives will provide novel approaches for wound management and has the potential to supply effective treatments for a variety of medical applications.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220033"},"PeriodicalIF":0.0,"publicationDate":"2023-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48894533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional microneedles for wearable electronics. 可穿戴电子产品用功能微针

Smart medicine Pub Date : 2023-02-12 eCollection Date: 2023-02-01 DOI: 10.1002/SMMD.20220023

Xiaoxuan Zhang, Minhui Lu, Xinyue Cao, Yuanjin Zhao

引用次数: 0

Recent advances in liver-on-chips: Design, fabrication, and applications. 肝脏芯片的最新进展:设计、制造和应用

Smart medicine Pub Date : 2023-02-12 eCollection Date: 2023-02-01 DOI: 10.1002/SMMD.20220010

Linjie Qiu, Bin Kong, Tiantian Kong, Huan Wang

{"title":"Recent advances in liver-on-chips: Design, fabrication, and applications.","authors":"Linjie Qiu, Bin Kong, Tiantian Kong, Huan Wang","doi":"10.1002/SMMD.20220010","DOIUrl":"10.1002/SMMD.20220010","url":null,"abstract":"The liver is a multifunctional organ and the metabolic center of the human body. Most drugs and toxins are metabolized in the liver, resulting in varying degrees of hepatotoxicity. The damage of liver will seriously affect human health, so it is very important to study the prevention and treatment of liver diseases. At present, there are many research studies in this field. However, most of them are based on animal models, which are limited by the time-consuming processes and species difference between human and animals. In recent years, liver-on-chips have emerged and developed rapidly and are expected to replace animal models. Liver-on-chips refer to the use of a small number of liver cells on the chips to simulate the liver microenvironment and ultrastructure in vivo. They hold extensive applications in multiple fields by reproducing the unique physiological functions of the liver in vitro. In this review, we first introduced the physiology and pathology of liver and then described the cell system of liver-on-chips, the chip-based liver models, and the applications of liver-on-chips in liver transplantation, drug screening, and metabolic evaluation. Finally, we discussed the currently encountered challenges and future trends in liver-on-chips.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220010"},"PeriodicalIF":0.0,"publicationDate":"2023-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45528421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bio-inspired ionic skins for smart medicine. 用于智能医疗的仿生离子皮肤

Smart medicine Pub Date : 2023-02-12 eCollection Date: 2023-02-01 DOI: 10.1002/SMMD.20220026

Zhouyue Lei, Wentao Xu, Guogao Zhang

{"title":"Bio-inspired ionic skins for smart medicine.","authors":"Zhouyue Lei, Wentao Xu, Guogao Zhang","doi":"10.1002/SMMD.20220026","DOIUrl":"10.1002/SMMD.20220026","url":null,"abstract":"Ionic skins are developed to mimic the mechanical properties and functions of natural skins. They have demonstrated substantial advantages to serve as the crucial interface to bridge the gap between humans and machines. The first-generation ionic skin is a stretchable capacitor comprising hydrogels as the ionic conductors and elastomers as the dielectrics, and realizes pressure and strain sensing through the measurement of the capacitance. Subsequent advances have been made to improve the mechanical properties of ionic skins and import diverse functions. For example, ultrahigh stretchability, strong interfacial adhesion, self-healing, moisturizing ability, and various sensing capabilities have been achieved separately or simultaneously. Most ionic skins are attached to natural skins to monitor bio-electrical signals continuously. Ionic skins have also been found with significant potential to serve as a smart drug-containing reservoir, which can release drugs spatially, temporally, and in a controllable way. Herein, this review focuses on the design and fabrication of ionic skins, and their applications related to smart medicine. Moreover, challenges and opportunities are also discussed. It is hoped that the development of bio-inspired ionic skins will provide a paradigm shift for self-diagnosis and healthcare.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220026"},"PeriodicalIF":0.0,"publicationDate":"2023-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44223502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Microneedles for Wearable Electronics (1/2023) 可穿戴电子产品的功能微针(1/2023)

Smart medicine Pub Date : 2023-02-01 DOI: 10.1002/smmd.52

Xiaoxuan Zhang, Minhui Lu, Xinyue Cao, Yuanjin Zhao