Change in p53 nuclear localization in response to extracellular matrix stiffness.

Smart medicine Pub Date : 2025-02-20 eCollection Date: 2025-03-01 DOI:10.1002/smmd.117
Yan Zu, Jing Du, Yipu Xu, Mengying Niu, Canlin Hong, Chun Yang
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Abstract

Change in p53 Nuclear Localization in Response to Extracellular Matrix Stiffness Description: The cover image uses a blue sphere to represent the nucleus and a black area to represent the cytoplasm. We use orange and green to represent the subcellular localisation of p53 in cells after soft and rigid substrate treatment, respectively. It can be seen that the softer substrate significantly increased p53 nuclear localisation in chondrocytes.

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