Change in p53 nuclear localization in response to extracellular matrix stiffness.

IF 11.6
Smart medicine Pub Date : 2025-02-20 eCollection Date: 2025-03-01 DOI:10.1002/smmd.117
Yan Zu, Jing Du, Yipu Xu, Mengying Niu, Canlin Hong, Chun Yang
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Abstract

Change in p53 Nuclear Localization in Response to Extracellular Matrix Stiffness Description: The cover image uses a blue sphere to represent the nucleus and a black area to represent the cytoplasm. We use orange and green to represent the subcellular localisation of p53 in cells after soft and rigid substrate treatment, respectively. It can be seen that the softer substrate significantly increased p53 nuclear localisation in chondrocytes.

细胞外基质硬度对p53核定位的影响。
细胞外基质刚度对p53细胞核定位的影响描述:封面图像用蓝色球体代表细胞核,黑色区域代表细胞质。我们用橙色和绿色分别表示软底物和硬底物处理后p53在细胞中的亚细胞定位。可见,较软的底物显著增加了p53在软骨细胞中的核定位。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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