Yan Zu, Jing Du, Yipu Xu, Mengying Niu, Canlin Hong, Chun Yang
{"title":"细胞外基质硬度对p53核定位的影响。","authors":"Yan Zu, Jing Du, Yipu Xu, Mengying Niu, Canlin Hong, Chun Yang","doi":"10.1002/smmd.117","DOIUrl":null,"url":null,"abstract":"<p><p>Change in p53 Nuclear Localization in Response to Extracellular Matrix Stiffness Description: The cover image uses a blue sphere to represent the nucleus and a black area to represent the cytoplasm. We use orange and green to represent the subcellular localisation of p53 in cells after soft and rigid substrate treatment, respectively. It can be seen that the softer substrate significantly increased p53 nuclear localisation in chondrocytes.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"4 1","pages":"e117"},"PeriodicalIF":11.6000,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Change in p53 nuclear localization in response to extracellular matrix stiffness.\",\"authors\":\"Yan Zu, Jing Du, Yipu Xu, Mengying Niu, Canlin Hong, Chun Yang\",\"doi\":\"10.1002/smmd.117\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Change in p53 Nuclear Localization in Response to Extracellular Matrix Stiffness Description: The cover image uses a blue sphere to represent the nucleus and a black area to represent the cytoplasm. We use orange and green to represent the subcellular localisation of p53 in cells after soft and rigid substrate treatment, respectively. It can be seen that the softer substrate significantly increased p53 nuclear localisation in chondrocytes.</p>\",\"PeriodicalId\":74816,\"journal\":{\"name\":\"Smart medicine\",\"volume\":\"4 1\",\"pages\":\"e117\"},\"PeriodicalIF\":11.6000,\"publicationDate\":\"2025-02-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Smart medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/smmd.117\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/3/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Smart medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/smmd.117","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Change in p53 nuclear localization in response to extracellular matrix stiffness.
Change in p53 Nuclear Localization in Response to Extracellular Matrix Stiffness Description: The cover image uses a blue sphere to represent the nucleus and a black area to represent the cytoplasm. We use orange and green to represent the subcellular localisation of p53 in cells after soft and rigid substrate treatment, respectively. It can be seen that the softer substrate significantly increased p53 nuclear localisation in chondrocytes.
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