Smart medicine最新文献_第2页

Bioorthogonal Janus microparticles for photothermal and chemo-therapy. 用于光热和化疗的生物正交Janus微粒子。

Smart medicine Pub Date : 2024-11-11 eCollection Date: 2024-12-01 DOI: 10.1002/SMMD.20240038

Qingfei Zhang, Gaizhen Kuang, Kai Chen, Miaoqing Zhao, Luoran Shang

{"title":"Bioorthogonal Janus microparticles for photothermal and chemo-therapy.","authors":"Qingfei Zhang, Gaizhen Kuang, Kai Chen, Miaoqing Zhao, Luoran Shang","doi":"10.1002/SMMD.20240038","DOIUrl":"https://doi.org/10.1002/SMMD.20240038","url":null,"abstract":"Bioorthogonal chemistry, recognized as a highly efficient tool in chemical biology, has shown significant value in cancer treatment. The primary objective is to develop efficient delivery strategies to achieve enhanced bioorthogonal drug treatment for tumors. Here, Janus microparticles (JMs) loaded with cyclooctene-modified doxorubicin prodrug (TCO-DOX) and tetrazine-modified indocyanine green (Tz-ICG) triggers are reported. Besides activating TCO-DOX, Tz-ICG is also a photothermal agent used in photothermal therapy (PTT), enabling the simultaneous use of biorthogonal chemotherapy and PTT. Additionally, the DOX could be significantly reduced in systemic toxicity with the modification of cyclooctene. Thus, the developed drug-carrying JMs system exhibits effective tumor cell killing in vitro and effectively inhibits tumor local progress and distant lung metastasis after postoperative treatment with good safety. These results demonstrate that the prepared JMs provide a paradigm for bioorthogonal prodrug activation and localized delivery, and hold great promise for cancer therapy as well as other related applications.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"3 4","pages":"e20240038"},"PeriodicalIF":0.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photodynamic therapy-induced precise attenuation of light-targeted semicircular canals for treating intractable vertigo. 光动力疗法诱导光靶半规管精确衰减治疗顽固性眩晕。

Smart medicine Pub Date : 2024-10-19 eCollection Date: 2024-12-01 DOI: 10.1002/SMMD.20230044

Yingkun Yang, Tong Zhao, Feixue Mi, Hongzhe Li, Pingbo Huang, Fangyi Chen

{"title":"Photodynamic therapy-induced precise attenuation of light-targeted semicircular canals for treating intractable vertigo.","authors":"Yingkun Yang, Tong Zhao, Feixue Mi, Hongzhe Li, Pingbo Huang, Fangyi Chen","doi":"10.1002/SMMD.20230044","DOIUrl":"https://doi.org/10.1002/SMMD.20230044","url":null,"abstract":"Vertigo is a common symptom of various diseases that affects a large number of people worldwide. Current leading treatments for intractable peripheral vertigo are to intratympanically inject ototoxic drugs such as gentamicin to attenuate the semicircular canal function but inevitably cause hearing injury. Photodynamic therapy (PDT) is a noninvasive therapeutic approach by precisely targeting the diseased tissue. Here, we developed a PDT-based method for treating intractable peripheral vertigo in a mouse model using a polymer-coated photosensitizer chlorin e6 excited by red light. We found that a high dose of PDT attenuated the function of both semicircular canals and otolith organs and damaged their hair cells. Conversely, the PDT exerted no effect on hearing function or cochlear hair-cell viability. These results suggest the therapeutic potential of PDT for treating intractable peripheral vertigo without hurting hearing. Besides, the attenuation level and affected area can be precisely controlled by adjusting the light exposure time. Furthermore, we demonstrated the potential of this therapeutic approach to be minimally invasive with light irradiation through bone results. Thus, our PDT-based approach for attenuating the function of the semicircular canals offers a basis for developing a less-invasive and targeted therapeutic option for treating vertigo.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"3 4","pages":"e20230044"},"PeriodicalIF":0.0,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymeric silk fibroin hydrogel as a conductive and multifunctional adhesive for durable skin and epidermal electronics. 聚合物蚕丝纤维素水凝胶作为一种用于耐用皮肤和表皮电子器件的导电多功能粘合剂。

Smart medicine Pub Date : 2024-09-16 eCollection Date: 2024-09-01 DOI: 10.1002/SMMD.20240027

Fanfan Fu, Changyi Liu, Zhenlin Jiang, Qingyu Zhao, Aining Shen, Yilun Wu, Wenyi Gu

{"title":"Polymeric silk fibroin hydrogel as a conductive and multifunctional adhesive for durable skin and epidermal electronics.","authors":"Fanfan Fu, Changyi Liu, Zhenlin Jiang, Qingyu Zhao, Aining Shen, Yilun Wu, Wenyi Gu","doi":"10.1002/SMMD.20240027","DOIUrl":"https://doi.org/10.1002/SMMD.20240027","url":null,"abstract":"Silk fibroin (SF)-based hydrogels are promising multifunctional adhesive candidates for real-world applications in tissue engineering, implantable bioelectronics, artificial muscles, and artificial skin. However, developing conductive SF-based hydrogels that are suitable for the micro-physiological environment and maintain their physical and chemical properties over long periods of use remains challenging. Herein, we developed an ion-conductive SF hydrogel composed of glycidyl methacrylate silk fibroin (SilMA) and bioionic liquid choline acylate (ChoA) polymer chains, together with the modification of acrylated thymine (ThyA) and adenine (AdeA) functional groups. The resulting polymeric ion-conductive SF composite hydrogel demonstrated high bioactivity, strong adhesion strength, good mechanical compliance, and stretchability. The formed hydrogel network of ChoA chains can coordinate with the ionic strength in the micro-physiological environment while maintaining the adaptive coefficient of expansion and stable mechanical properties. These features help to form a stable ion-conducting channel for the hydrogel. Additionally, the hydrogel network modified with AdeA and ThyA, can provide a strong adhesion to the surface of a variety of substrates, including wet tissue through abundant hydrogen bonding. The biocompatible and ionic conductive SF composite hydrogels can be easily prepared and incorporated into flexible skin or epidermal sensing devices. Therefore, our polymeric SF-based hydrogel has great potential and wide application to be an important component of many flexible electronic devices for personalized healthcare.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"3 3","pages":"e20240027"},"PeriodicalIF":0.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11425052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dear-PSM: A deep learning-based peptide search engine enables full database search for proteomics. Dear-PSM：基于深度学习的多肽搜索引擎，可实现蛋白质组学的全数据库搜索。

Smart medicine Pub Date : 2024-08-27 eCollection Date: 2024-09-01 DOI: 10.1002/SMMD.20240014

Qingzu He, Xiang Li, Jinjin Zhong, Gen Yang, Jiahuai Han, Jianwei Shuai

{"title":"Dear-PSM: A deep learning-based peptide search engine enables full database search for proteomics.","authors":"Qingzu He, Xiang Li, Jinjin Zhong, Gen Yang, Jiahuai Han, Jianwei Shuai","doi":"10.1002/SMMD.20240014","DOIUrl":"https://doi.org/10.1002/SMMD.20240014","url":null,"abstract":"Peptide spectrum matching is the process of linking mass spectrometry data with peptide sequences. An experimental spectrum can match thousands of candidate peptides with variable modifications leading to an exponential increase in candidates. Completing the search within a limited time is a key challenge. Traditional searches expedite the process by restricting peptide mass errors and variable modifications, but this limits interpretive capability. To address this challenge, we propose Dear-PSM, a peptide search engine that supports full database searching. Dear-PSM does not restrict peptide mass errors, matching each spectrum to all peptides in the database and increasing the number of variable modifications per peptide from the conventional 3-20. Leveraging inverted index technology, Dear-PSM creates a high-performance index table of experimental spectra and utilizes deep learning algorithms for peptide validation. Through these techniques, Dear-PSM achieves a speed breakthrough 7 times faster than mainstream search engines on a regular desktop computer, with a remarkable 240-fold reduction in memory consumption. Benchmark test results demonstrate that Dear-PSM, in full database search mode, can reproduce over 90% of the results obtained by mainstream search engines when handling complex mass spectrometry data collected from different species using various instruments. Furthermore, it uncovers a substantial number of new peptides and proteins. Dear-PSM has been publicly released on the GitHub repository https://github.com/jianweishuai/Dear-PSM.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"3 3","pages":"e20240014"},"PeriodicalIF":0.0,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11425048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developing functional hydrogels for treatment of oral diseases 开发治疗口腔疾病的功能性水凝胶

Smart medicine Pub Date : 2024-07-25 DOI: 10.1002/smmd.20240020

Chuanhui Song, Rui Liu, Yile Fang, Hongcheng Gu, Yu Wang

引用次数: 0

Sustainable synthesis of carbon dots via bio‐waste recycling for biomedical imaging 通过生物废料回收可持续合成碳点，用于生物医学成像

Smart medicine Pub Date : 2024-07-17 DOI: 10.1002/smmd.20240012

Yuxin Wang, Matthew Chae, Teak-Jung Oh, Kangqiang Qiu, Kritika Mehta, Adrian Tan, Nien‐Pei Tsai, Donglu Shi, Kai Zhang, Jiajie Diao

引用次数: 0

Engineering strategies for apoptotic bodies 凋亡体工程策略

Smart medicine Pub Date : 2024-07-14 DOI: 10.1002/smmd.20240005

Zheyuan Hu, Shutong Qian, Qiuyu Zhao, Bolun Lu, Qian Lu, Yuhuan Wang, Liucheng Zhang, Xiyuan Mao, Danru Wang, Wenguo Cui, Xiaoming Sun

{"title":"Engineering strategies for apoptotic bodies","authors":"Zheyuan Hu, Shutong Qian, Qiuyu Zhao, Bolun Lu, Qian Lu, Yuhuan Wang, Liucheng Zhang, Xiyuan Mao, Danru Wang, Wenguo Cui, Xiaoming Sun","doi":"10.1002/smmd.20240005","DOIUrl":"https://doi.org/10.1002/smmd.20240005","url":null,"abstract":"Extracellular vesicles (EVs) are lipid bilayer vesicles containing proteins, lipids, nucleic acids, and metabolites secreted by cells under various physiological and pathological conditions that mediate intercellular communication. The main types of EVs include exosomes, microvesicles, and apoptotic bodies (ABs). ABs are vesicles released during the terminal stages of cellular apoptosis, enriched with diverse biological entities and characterized by distinct morphological features. As a result, ABs possess great potential in fields like disease diagnosis, immunotherapy, regenerative therapy, and drug delivery due to their specificity, targeting capacity, and biocompatibility. However, their therapeutic efficacy is notably heterogeneous, and an overdose can lead to side effects such as accumulation in the liver, spleen, lungs, and gastrointestinal system. Through bioengineering, the properties of ABs can be optimized to enhance drug‐loading efficiency, targeting precision, and multifunctionality for clinical implementations. This review focuses on strategies such as transfection, sonication, electroporation, surface engineering, and integration with biomaterials to enable ABs to load cargoes and enhance targeting, providing insights into the engineering of ABs.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"54 40","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141649714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photothermal responsive porous hollow microneedles as Chinese medicine versatile delivery system for wound healing 光热响应多孔空心微针作为促进伤口愈合的中药多功能传输系统

Smart medicine Pub Date : 2024-07-01 DOI: 10.1002/smmd.20240007

Wanyue Zhang, Lijun Cai, Jingjing Gan, Yuanjin Zhao

{"title":"Photothermal responsive porous hollow microneedles as Chinese medicine versatile delivery system for wound healing","authors":"Wanyue Zhang, Lijun Cai, Jingjing Gan, Yuanjin Zhao","doi":"10.1002/smmd.20240007","DOIUrl":"https://doi.org/10.1002/smmd.20240007","url":null,"abstract":"Chinese medicine is identified as a candidate for wound healing. Attempts in this field tend to develop efficient dosage forms for delivering Chinese medicine with low side effects. In this paper, we proposed novel photothermal responsive porous hollow microneedles (PRPH‐MNs) as a versatile Chinese medicine delivery system for efficient antibacterial wound treatment. The PRPH‐MNs are composed of porous resin shells with good mechanical property, hydrogel cores, and a photothermal graphene oxide hybrid substrate. The hollow structure provides sufficient space for loading the drug dispersed hydrogel, while the porous resin shells could not only block the direct contact between drugs and wound sites but also provide channels for facilitating the drug release from the core. In addition, benefiting from the photothermal effect of their substrate, the PRPH‐MNs could be heated under near‐infrared (NIR) irradiation for controllable promotion of drug release. Based on these features, we have proved that the antibacterial Chinese medicine Rhein loaded PRPH‐MNs were effective in promoting wound healing due to their good antibacterial property and on‐demand drug release. Thus, we believe that the proposed PRPH‐MNs are valuable for delivery of different drugs for clinical applications.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"220 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141692713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stevioside protects against acute kidney injury by inhibiting gasdermin D pathway. 甜菊糖苷通过抑制气敏素 D 途径防止急性肾损伤。

Smart medicine Pub Date : 2024-06-28 eCollection Date: 2024-06-01 DOI: 10.1002/SMMD.20240010

Ruochen Qiao, Hui Wang, Dasheng Li, Yu Yang, Jiaxin Shu, Xiang Song, Xiaozhi Zhao, Li Lu

{"title":"Stevioside protects against acute kidney injury by inhibiting gasdermin D pathway.","authors":"Ruochen Qiao, Hui Wang, Dasheng Li, Yu Yang, Jiaxin Shu, Xiang Song, Xiaozhi Zhao, Li Lu","doi":"10.1002/SMMD.20240010","DOIUrl":"10.1002/SMMD.20240010","url":null,"abstract":"Recent studies indicate a significant upregulation of gasdermin D (GSDMD) in acute kidney injury (AKI), a severe medical condition characterized by high morbidity and mortality globally. In this study, we identified and validated the therapeutic effects of small molecule inhibitors targeting the GSDMD pathway for AKI treatment. Using a drug screening assay, we evaluated thousands of small molecules from DrugBank against Lipopolysaccharide (LPS) and Nigericin-stimulated immortalized bone marrow-derived macrophages (iBMDMs) to discern GSDMD pathway activators. We simulated AKI in primary renal tubular epithelial cells using hydrogen peroxide (H2O2) exposure. Furthermore, AKI in mouse models was induced via cisplatin and ischemia/reperfusion. Our findings highlight stevioside as a potent GSDMD activator exhibiting minimal toxicity. Experimental results, both in vitro and in vivo, demonstrate stevioside's significant potential in alleviating renal tubular epithelial cell injury and AKI histological damage. After stevioside treatment, a notable decrease in cleaved GSDMD-N terminal levels was observed coupled with diminished inflammatory factor release. This observation was consistent in both cisplatin- and ischemia/reperfusion-induced AKI mouse models. Collectively, our research suggests that stevioside could be a promising candidate for modulating GSDMD signaling in AKI treatment.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"3 2","pages":"e20240010"},"PeriodicalIF":0.0,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digital droplet RT‐LAMP increases speed of SARS‐CoV‐2 viral RNA detection 数字液滴 RT-LAMP 提高了 SARS-CoV-2 病毒 RNA 的检测速度

Smart medicine Pub Date : 2024-06-05 DOI: 10.1002/smmd.20240008

Yuan Yuan, Perry Ellis, Ye Tao, Dimitri A. Bikos, E. Loveday, Mallory M. Thomas, J. Wilking, Connie B. Chang, Fangfu Ye, David A. Weitz

引用次数: 0