Smart medicine最新文献_第2页

Developing organs‐on‐chips for biomedical applications 开发用于生物医学应用的片上器官

Smart medicine Pub Date : 2024-05-21 DOI: 10.1002/smmd.20240009

Lingyu Sun, Hanxu Chen, Dongyu Xu, Rui Liu, Yuanjin Zhao

引用次数: 0

Roles of Akirin1 in early prediction and treatment of graft kidney ischemia‒reperfusion injury Akirin1 在移植肾缺血再灌注损伤的早期预测和治疗中的作用

Smart medicine Pub Date : 2024-04-02 DOI: 10.1002/smmd.20230043

Xinyuan Li, Guo Chen, Xiangle Zhou, Xiang Peng, Mao Li, Daihui Chen, Haitao Yu, W. Shi, Chunlin Zhang, Yang Li, Zhenwei Feng, Yuhua Mei, Li Li, Simin Liang, Weiyang He, Xin Gou, Jie Li

{"title":"Roles of Akirin1 in early prediction and treatment of graft kidney ischemia‒reperfusion injury","authors":"Xinyuan Li, Guo Chen, Xiangle Zhou, Xiang Peng, Mao Li, Daihui Chen, Haitao Yu, W. Shi, Chunlin Zhang, Yang Li, Zhenwei Feng, Yuhua Mei, Li Li, Simin Liang, Weiyang He, Xin Gou, Jie Li","doi":"10.1002/smmd.20230043","DOIUrl":"https://doi.org/10.1002/smmd.20230043","url":null,"abstract":"Ferroptosis is a predominant contributor to graft kidney ischemia‒reperfusion injury (IRI), resulting in delayed graft function (DGF). However, much less is known about the early predicting biomarkers and therapeutic targets of DGF, especially aiming at ferroptosis. Here, we propose a precise predicting model for DGF, relying on the Akirin1 level in extracellular vesicles (EVs) derived from recipient urine 48 h after kidney transplant. In addition, we decipher a new molecular mechanism whereby Akirin1 induces ferroptosis by strengthening TP53‐mediated suppression of SLC7A11 during the graft kidney IRI process, that is, Akirin1 activates the EGR1/TP53 axis and inhibits MDM2‐mediated TP53 ubiquitination, accordingly upregulating TP53 in two ways. Meanwhile, we present the first evidence that miR‐136‐5p enriched in EVs secreted by human umbilical cord mesenchymal stem cells (UM‐EVs) confers robust protection against ferroptosis and graft kidney IRI by targeted inhibition of Akirin1 but knockout of miR‐136‐5p in UM sharply mitigates the protection of UM‐EVs. The functional and mechanistic regulation of Akirin1 is further corroborated in an allograft kidney transplant model in wild‐type and Akirin1‐knockout mice. In summary, these findings suggest that Akirin1, which prominently induces ferroptosis, is a pivotal biomarker and target for early diagnosis and treatment of graft kidney IRI and DGF after kidney transplant.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"292 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140751254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging approaches for the development of artificial islets 开发人工胰岛的新方法

Smart medicine Pub Date : 2024-03-07 DOI: 10.1002/smmd.20230042

Jingbo Li, Lingyu Sun, Feika Bian, Stephen J. Pandol, Ling Li

{"title":"Emerging approaches for the development of artificial islets","authors":"Jingbo Li, Lingyu Sun, Feika Bian, Stephen J. Pandol, Ling Li","doi":"10.1002/smmd.20230042","DOIUrl":"https://doi.org/10.1002/smmd.20230042","url":null,"abstract":"The islet of Langerhans, functioning as a “mini organ”, plays a vital role in regulating endocrine activities due to its intricate structure. Dysfunction in these islets is closely associated with the development of diabetes mellitus (DM). To offer valuable insights for DM research and treatment, various approaches have been proposed to create artificial islets or islet organoids with high similarity to natural islets, under the collaborative effort of biologists, clinical physicians, and biomedical engineers. This review investigates the design and fabrication of artificial islets considering both biological and tissue engineering aspects. It begins by examining the natural structures and functions of native islets and proceeds to analyze the protocols for generating islets from stem cells. The review also outlines various techniques used in crafting artificial islets, with a specific focus on hydrogel‐based ones. Additionally, it provides a concise overview of the materials and devices employed in the clinical applications of artificial islets. Throughout, the primary goal is to develop artificial islets, thereby bridging the realms of developmental biology, clinical medicine, and tissue engineering.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"16 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140261118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathogen‐binding nanoparticles to inhibit host cell infection by heparan sulfate and sialic acid dependent viruses and protozoan parasites 病原体结合纳米粒子，抑制硫酸肝素和硅铝酸依赖性病毒和原生动物寄生虫对宿主细胞的感染

Smart medicine Pub Date : 2024-03-01 DOI: 10.1002/smmd.20230046

A. Najer

{"title":"Pathogen‐binding nanoparticles to inhibit host cell infection by heparan sulfate and sialic acid dependent viruses and protozoan parasites","authors":"A. Najer","doi":"10.1002/smmd.20230046","DOIUrl":"https://doi.org/10.1002/smmd.20230046","url":null,"abstract":"Global health faces an immense burden from infectious diseases caused by viruses and intracellular protozoan parasites such as the coronavirus disease (COVID‐19) and malaria, respectively. These pathogens propagate through the infection of human host cells. The first stage of this host cell infection mechanism is cell attachment, which typically involves interactions between the infectious agent and surface components on the host cell membranes, specifically heparan sulfate (HS) and/or sialic acid (SA). Hence, nanoparticles (NPs) which contain or mimic HS/SA that can directly bind to the pathogen surface and inhibit cell infection are emerging as potential candidates for an alternative anti‐infection therapeutic strategy. These NPs can be prepared from metals, soft matter (lipid, polymer, and dendrimer), DNA, and carbon‐based materials among others and can be designed to include aspects of multivalency, broad‐spectrum activity, biocidal mechanisms, and multifunctionality. This review provides an overview of such anti‐pathogen nanomedicines beyond drug delivery. Nanoscale inhibitors acting against viruses and obligate intracellular protozoan parasites are discussed. In the future, the availability of broadly applicable nanotherapeutics would allow early tackling of existing and upcoming viral diseases. Invasion inhibitory NPs could also provide urgently needed effective treatments for protozoan parasitic infections.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"15 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140087550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrospun fiber‐based immune engineering in regenerative medicine 再生医学中的电纺纤维免疫工程

Smart medicine Pub Date : 2024-02-24 DOI: 10.1002/smmd.20230034

Yiru Xu, Qimanguli Saiding, Xue Zhou, Juan Wang, Wenguo Cui, Xinliang Chen

{"title":"Electrospun fiber‐based immune engineering in regenerative medicine","authors":"Yiru Xu, Qimanguli Saiding, Xue Zhou, Juan Wang, Wenguo Cui, Xinliang Chen","doi":"10.1002/smmd.20230034","DOIUrl":"https://doi.org/10.1002/smmd.20230034","url":null,"abstract":"Immune engineering, a burgeoning field within regenerative medicine, involves a spectrum of strategies to optimize the intricate interplay between tissue regenerative biomaterials and the host tissue. These strategies are applied across different types of biomaterials and various disease models, which encompasses finely modulating the immune response at the levels of immune cells and factors, aiming to mitigate adverse effects like fibrosis and persistent inflammation that may arise at the injury site and consequently promote tissue regeneration. With the continuous progress in electrospinning technology, the immunoregulatory capabilities of electrospun fibers have gained substantial attention over the years. Electrospun fibers, with their extracellular matrix‐like characteristics, high surface‐area‐to‐volume ratio, and reliable pharmaceutical compound capacity, have emerged as key players among tissue engineering materials. This review specifically focuses on the role of electrospun fiber‐based immune engineering, emphasizing their unique design strategies. Notably, electrospinning actively engages in immune engineering by modulating immune responses through four essential strategies: (i) surface modification, (ii) drug loading, (iii) physicochemical parameters, and (iv) biological grafting. This review presents a comprehensive overview of the intricate mechanisms of the immune system in injured tissues while unveiling the key strategies adopted by electrospun fibers to orchestrate immune regulation. Furthermore, the review explores the current developmental trends and limitations concerning the immunoregulatory function of electrospun fibers, aiming to drive the advancements in electrospun fiber‐based immune engineering to its full potential.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"76 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140433677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photothermal‐enhanced in situ supramolecular hydrogel promotes bacteria‐infected wound healing in diabetes 光热增强原位超分子水凝胶促进糖尿病细菌感染伤口愈合

Smart medicine Pub Date : 2024-02-23 DOI: 10.1002/smmd.20230047

Chen Zheng, Xuan Wu, Ming Liu, Yulong Lan, Qian Liu, Erya Cai, Zhiyong Liao, Jianliang Shen

{"title":"Photothermal‐enhanced in situ supramolecular hydrogel promotes bacteria‐infected wound healing in diabetes","authors":"Chen Zheng, Xuan Wu, Ming Liu, Yulong Lan, Qian Liu, Erya Cai, Zhiyong Liao, Jianliang Shen","doi":"10.1002/smmd.20230047","DOIUrl":"https://doi.org/10.1002/smmd.20230047","url":null,"abstract":"Bacterial infection can impede the healing of chronic wounds, particularly diabetic wounds. The high‐sugar environment of diabetic wounds creates a favorable condition for bacterial growth, posing a challenge to wound healing. In clinical treatment, the irregular shape of the wound and the poor mechanical properties of traditional gel adjuvants make them susceptible to mechanical shear and compression, leading to morphological changes and fractures, and difficult to adapt to irregular wounds. Traditional gel adjuvants are prepared in advance, while in situ gel is formed at the site of administration after drug delivery in a liquid state, which can better fit the shape of the wound. Therefore, this study developed an in situ HA/GCA/Fe2+‐GOx gel using a photothermal‐enhanced Fenton reaction to promote the generation of hydroxyl radicals (·OH). The generation of ·OH has an antibacterial effect while promoting the formation of the gel, achieving a dual effect. The addition of double‐bonded adamantane (Ada) interacts with the host‐guest effect of graphene oxide and the double‐bond polymerization of HAMA gel, making the entire gel system more complete. At the same time, the storage modulus (G′) of the gel increased from 130 to 330 Pa, enhancing the mechanical properties of the gel. This enables the gel to have better injectability and self‐healing effects. The addition of GOx can consume glucose at the wound site, providing a good microenvironment for the repair of diabetic wounds. The gel has good biocompatibility and in a diabetic rat wound model infected with S. aureus, it can effectively kill bacteria at the wound site and promote wound repair. Meanwhile, the inflammation of wounds treated with HA/GCA/Fe2+‐GOx + NIR was lighter compared to untreated wounds. Therefore, this study provides a promising strategy for treating bacterial‐infected diabetic wounds.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"22 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140436161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Tailoring cell sheets for biomedical applications 为生物医学应用定制细胞薄片

Smart medicine Pub Date : 2024-02-18 DOI: 10.1002/smmd.20230038

Weiwei Chen, Min Nie, Jingjing Gan, Nan Xia, Dandan Wang, Lingyun Sun

引用次数: 0

Role of pretty nanoflowers as novel versatile analytical tools for sensing in biomedical and bioanalytical applications 漂亮纳米花作为新型多功能分析工具在生物医学和生物分析应用中的传感作用

Smart medicine Pub Date : 2024-02-01 DOI: 10.1002/smmd.20230040

Şeyma Dadı, I. Ocsoy

引用次数: 0

Pioneering healthcare with soft robotic devices: A review 利用软体机器人设备开拓医疗保健领域：综述

Smart medicine Pub Date : 2024-02-01 DOI: 10.1002/smmd.20230045

Yuzhe Wang, Zhen Xie, Huishi Huang, Xinquan Liang

{"title":"Pioneering healthcare with soft robotic devices: A review","authors":"Yuzhe Wang, Zhen Xie, Huishi Huang, Xinquan Liang","doi":"10.1002/smmd.20230045","DOIUrl":"https://doi.org/10.1002/smmd.20230045","url":null,"abstract":"Recent advancements in soft robotics have been emerging as an exciting paradigm in engineering due to their inherent compliance, safe human interaction, and ease of adaptation with wearable electronics. Soft robotic devices have the potential to provide innovative solutions and expand the horizons of possibilities for biomedical applications by bringing robots closer to natural creatures. In this review, we survey several promising soft robot technologies, including flexible fluidic actuators, shape memory alloys, cable‐driven mechanisms, magnetically driven mechanisms, and soft sensors. Selected applications of soft robotic devices as medical devices are discussed, such as surgical intervention, soft implants, rehabilitation and assistive devices, soft robotic exosuits, and prosthetics. We focus on how soft robotics can improve the effectiveness, safety and patient experience for each use case, and highlight current research and clinical challenges, such as biocompatibility, long‐term stability, and durability. Finally, we discuss potential directions and approaches to address these challenges for soft robotic devices to move toward real clinical translations in the future.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"29 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140464916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunomodulation of wound healing leading to efferocytosis 导致渗出的伤口愈合免疫调节作用

Smart medicine Pub Date : 2024-01-31 DOI: 10.1002/smmd.20230036

Yun Zhao, Minxiong Li, Jiayi Mao, Yinghong Su, Xin Huang, Wenzheng Xia, Xiangfeng Leng, T. Zan

引用次数: 0