Smart medicine最新文献_第3页

Emergence and impact of theranostic‐nanoformulation of triple therapeutics for combination cancer therapy 用于癌症联合疗法的三联疗法纳米制剂的出现及其影响

Smart medicine Pub Date : 2024-01-30 DOI: 10.1002/smmd.20230035

A. Rajora, Eknath D. Ahire, Manju A. K. Rajora, Sukhvir Singh, Jaydeep Bhattacharya, Hongbo Zhang

{"title":"Emergence and impact of theranostic‐nanoformulation of triple therapeutics for combination cancer therapy","authors":"A. Rajora, Eknath D. Ahire, Manju A. K. Rajora, Sukhvir Singh, Jaydeep Bhattacharya, Hongbo Zhang","doi":"10.1002/smmd.20230035","DOIUrl":"https://doi.org/10.1002/smmd.20230035","url":null,"abstract":"Cancer remains a major global health threat necessitating the multipronged approaches for its prevention and management. Traditional approaches in the form of chemotherapy, surgery, and radiotherapy are often encountered with poor patient outcomes evidenced by high mortality and morbidity, compelling the need for precision medicine for cancer patients to enable personalized and targeted cancer treatment. There has been an emergence of smart multimodal theranostic nanoformulation for triple combination cancer therapy in the last few years, which dramatically enhances the overall safety of the nanoformulation for in vivo and potential clinical applications with minimal toxicity. However, it is imperative to gain insight into the limitations of this system in terms of clinical translation, cost‐effectiveness, accessibility, and multidisciplinary collaboration. This review paper aims to highlight and compare the impact of the recent theranostic nanoformulations of triple therapeutics in a single nanocarrier for effective management of cancer and provide a new dimension for diagnostic and treatment simultaneously.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"95 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140480774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling, applications and challenges of inner ear organoid 内耳类器官的建模、应用和挑战

Smart medicine Pub Date : 2024-01-16 DOI: 10.1002/smmd.20230028

J. Qi, Liyan Zhang, Xiaohan Wang, Xin Chen, Yiyuan Li, Tian Wang, Peina Wu, Renjie Chai

引用次数: 0

Application and prospect of the therapeutic strategy of inhibiting cellular senescence combined with pro‐regenerative biomaterials in regenerative medicine 抑制细胞衰老与促进再生的生物材料相结合的治疗策略在再生医学中的应用与展望

Smart medicine Pub Date : 2023-12-21 DOI: 10.1002/smmd.20230030

Qianyi Li, Zhenzhen Wang, Nuo Shi, Yang Qi, Wenfei Yao, Jie Yu, Yiming Lu

{"title":"Application and prospect of the therapeutic strategy of inhibiting cellular senescence combined with pro‐regenerative biomaterials in regenerative medicine","authors":"Qianyi Li, Zhenzhen Wang, Nuo Shi, Yang Qi, Wenfei Yao, Jie Yu, Yiming Lu","doi":"10.1002/smmd.20230030","DOIUrl":"https://doi.org/10.1002/smmd.20230030","url":null,"abstract":"Complete regeneration of damaged tissues/organs has always been the ultimate challenge in regenerative medicine. Aging has long been considered the basis of age‐related diseases, as senescent cells gradually accumulate in tissues with increasing age, tissues exhibit aging and normal physiological functions are inhibited. In recent years, in damaged tissues, scholars have found that the number of cells with features of cellular senescence continues to increase over time. The accumulation of senescent cells severely hinders the healing of damaged tissues. Furthermore, by clearing senescent cells or inhibiting the aging microenvironment, damaged tissues regained their original regenerative and repair capabilities. On the other hand, various biomaterials have been proved to have good biocompatibility and can effectively support cell regeneration after injury. Combining the two solutions, inhibiting the cellular senescence in damaged tissues and establishing a pro‐regenerative environment through biomaterial technology gradually reveals a new, unexpected treatment strategy applied to the field of regenerative medicine. In this review, we first elucidate the main characteristics of senescent cells from morphological, functional and molecular levels, and discuss in detail the process of accumulation of senescent cells in tissues. Then, we will explore in depth how the accumulation of senescent cells after damage affects tissue repair and regeneration at different stages. Finally, we will turn to how to promote tissue regeneration and repair in the field of regenerative medicine by inhibiting cellular senescence combined with biomaterial technology. Our goal is to understand the relationship between cellular senescence and tissue regeneration through this new perspective, and provide valuable references for the development of new therapeutic strategies in the future.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"23 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138948395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highly aqueously stable C60‐polymer nanoparticles with excellent photodynamic property for potential cancer treatment 具有优异光动力特性的高水稳定性 C60 聚合物纳米粒子，有望用于癌症治疗

Smart medicine Pub Date : 2023-12-20 DOI: 10.1002/smmd.20230033

Dan Wang, Jianyang Zhao, Roger J. Mulder, Julian Ratcliffe, Chunru Wang, Bo Wu, Jinquan Wang, Xiaojuan Hao

{"title":"Highly aqueously stable C60‐polymer nanoparticles with excellent photodynamic property for potential cancer treatment","authors":"Dan Wang, Jianyang Zhao, Roger J. Mulder, Julian Ratcliffe, Chunru Wang, Bo Wu, Jinquan Wang, Xiaojuan Hao","doi":"10.1002/smmd.20230033","DOIUrl":"https://doi.org/10.1002/smmd.20230033","url":null,"abstract":"Fullerenes are a class of carbon nanomaterials that find a wide range of applications in biomedical fields, especially for photodynamic cancer therapy because of its photosensitive effect. However, hydrophobic fullerenes can only be dispersed in organic solvents which hinders their biomedical applications. Here, we report a facile method to prepare highly water‐dispersible fullerene (C60)‐polymer nanoparticles with hydrodynamic sizes of 50–70 nm. Hydrophilic random copolymers containing different ratios of polyethylene glycol methyl ether methacrylate and 2‐aminoethylmethacrylamide were synthesized for conjugating with C60 molecules through efficient nucleophilic Michael addition reaction between amine groups from hydrophilic polymer and carbon‐carbon double bonds from C60. As a result, the amphiphilic C60‐polymer conjugates could be well dispersed and nano‐assembled in water with a C60 concentration as high as 7.8 mg/mL, demonstrating a significant improvement for the solubility of C60 in an aqueous system. Owing to the high C60 content, the C60‐polymer nanoparticles showed a strong photodynamic therapy effect on human lung cancer cells (A549) under light irradiation (450 nm) in both 2D cell culture and 3D spheroid culture, while demonstrating ignorable cytotoxicity under dark. This highly efficient and convenient method to prepare water‐dispersible C60‐polymer conjugates may have a great impact on the future biomedical applications of fullerenes.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"37 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138954569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nano‐omics: Frontier fields of fusion of nanotechnology 纳米组学：纳米技术融合的前沿领域

Smart medicine Pub Date : 2023-12-14 DOI: 10.1002/smmd.20230039

Xuan Wang, Wei-Cheng Xu, Jun Li, Chen Shi, Yuanyuan Guo, Jinjun Shan, Ruogu Qi

引用次数: 0

Emerging ctDNA detection strategies in clinical cancer theranostics 新出现的ctDNA检测策略在临床癌症治疗中

Smart medicine Pub Date : 2023-11-13 DOI: 10.1002/smmd.20230031

Kexin Yi, Xiaoju Wang, Sergey K. Filippov, Hongbo Zhang

{"title":"Emerging ctDNA detection strategies in clinical cancer theranostics","authors":"Kexin Yi, Xiaoju Wang, Sergey K. Filippov, Hongbo Zhang","doi":"10.1002/smmd.20230031","DOIUrl":"https://doi.org/10.1002/smmd.20230031","url":null,"abstract":"Abstract Circulating tumor DNA (ctDNA) is naked DNA molecules shed from the tumor cells into the peripheral blood circulation. They contain tumor‐specific gene mutations and other valuable information. ctDNA is considered to be one of the most significant analytes in liquid biopsies. Over the past decades, numerous researchers have developed various detection strategies to perform quantitative or qualitative ctDNA analysis, including PCR‐based detection and sequencing‐based detection. More and more studies have illustrated the great value of ctDNA as a biomarker in the diagnosis, prognosis and heterogeneity of tumor. In this review, we first outlined the development of digital PCR (dPCR)‐based and next generation sequencing (NGS)‐based ctDNA detection systems. Besides, we presented the introduction of the emerging ctDNA analysis strategies based on various biosensors, such as electrochemical biosensors, fluorescent biosensors, surface plasmon resonance and Raman spectroscopy, as well as their applications in the field of biomedicine. Finally, we summarized the essentials of the preceding discussions, and the existing challenges and prospects for the future are also involved.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"126 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136351859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging biotechnologies and biomedical engineering technologies for hearing reconstruction (4/2023) 用于听力重建的新兴生物技术和生物医学工程技术（4/2023）

Smart medicine Pub Date : 2023-11-01 DOI: 10.1002/smmd.99

Yangnan Hu, Le Fang, Hui Zhang, Shasha Zheng, Menghui Liao, Qingyue Cui, Hao Wei, Danqi Wu, Hong Cheng, Yanru Qi, Huan Wang, Tao Xin, Tian Wang, Renjie Chai

引用次数: 0

Nano‐omics: Frontier fields of fusion of nanotechnology (4/2023) 纳米组学：纳米技术融合的前沿领域（4/2023）

Smart medicine Pub Date : 2023-11-01 DOI: 10.1002/smmd.98

Xuan Wang, Wei-Cheng Xu, Jun Li, Chen Shi, Yuanyuan Guo, Jinjun Shan, Ruogu Qi

引用次数: 0

Emerging optogenetics technologies in biomedical applications 新兴的光遗传学技术在生物医学中的应用

Smart medicine Pub Date : 2023-11-01 DOI: 10.1002/smmd.20230026

Haozhen Ren, Yi Cheng, Gaolin Wen, Jinglin Wang, Min Zhou

引用次数: 0

Exosomes: Toward a potential application in bladder cancer diagnosis and treatment 外泌体:在膀胱癌诊断和治疗中的潜在应用

Smart medicine Pub Date : 2023-10-30 DOI: 10.1002/smmd.20230027

Xiaowei Wei, Dagan Zhang, Yefei Zhu

引用次数: 0