Developing organs‐on‐chips for biomedical applications

Lingyu Sun, Hanxu Chen, Dongyu Xu, Rui Liu, Yuanjin Zhao
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Abstract

In recent years, organs‐on‐chips have been arousing great interest for their bionic and stable construction of crucial human organs in vitro. Compared with traditional animal models and two‐dimensional cell models, organs‐on‐chips could not only overcome the limitations of species difference and poor predict ability but also be capable of reappearing the complex cell‐cell interaction, tissue interface, biofluid and other physiological conditions of humans. Therefore, organs‐on‐chips have been regarded as promising and powerful tools in diverse fields such as biology, chemistry, medicine and so on. In this perspective, we present a review of organs‐on‐chips for biomedical applications. After introducing the key elements and manufacturing craft of organs‐on‐chips, we intend to review their cut‐edging applications in biomedical fields, incorporating biological analysis, drug development, robotics and so on. Finally, the emphasis is focused on the perspectives of organs‐on‐chips.
开发用于生物医学应用的片上器官
近年来,芯片器官以其仿生性和稳定性在体外构建人体重要器官而备受关注。与传统的动物模型和二维细胞模型相比,片上器官不仅能克服物种差异和预测能力差的限制,还能再现复杂的细胞-细胞相互作用、组织界面、生物流体等人体生理状况。因此,片上器官已被视为生物学、化学、医学等多个领域前景广阔的有力工具。从这个角度出发,我们对生物医学应用中的片上器官进行了综述。在介绍了片上器官的关键要素和制造工艺后,我们打算回顾其在生物医学领域的前沿应用,包括生物分析、药物开发、机器人技术等。最后,我们将重点关注片上器官的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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