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Modification and crosslinking strategies for hyaluronic acid‐based hydrogel biomaterials 透明质酸基水凝胶生物材料的改性和交联策略
Smart medicine Pub Date : 2023-10-30 DOI: 10.1002/smmd.20230029
Zhiqiang Luo, Yu Wang, Ye Xu, Jinglin Wang, Yunru Yu
{"title":"Modification and crosslinking strategies for hyaluronic acid‐based hydrogel biomaterials","authors":"Zhiqiang Luo, Yu Wang, Ye Xu, Jinglin Wang, Yunru Yu","doi":"10.1002/smmd.20230029","DOIUrl":"https://doi.org/10.1002/smmd.20230029","url":null,"abstract":"Abstract Hyaluronic acid (HA) is an attractive extracellular matrix‐derived polymer. The related HA‐based hydrogels are emerging to be the hotspots in the cutting edge of biomaterials. The continuous sights concentrate on exploring modification methods and crosslinking strategies to promote the advancement of HA‐based hydrogels with enhanced physical/chemical properties and enriched biological performance. Here, the advances on modification methods and crosslinking strategies for fabricating HA‐based hydrogels with diverse capacities are summarized. Firstly, the modification reactions that occur on the active hydroxyl, carboxyl and N‐acetyl groups of HA molecule are discussed. Next, the emphasis is put on various crosslinking strategies including physical crosslinking, covalent crosslinking and dynamic covalent crosslinking. Finally, we provide a general summary and give a critical viewpoint on the remaining challenges and the future development of HA‐based hydrogels. It is hoped that this review can provide new proposals for the specific design of functional hydrogel biomaterials.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"124 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136069691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging biotechnologies and biomedical engineering technologies for hearing reconstruction 听力重建的新兴生物技术和生物医学工程技术
Smart medicine Pub Date : 2023-10-27 DOI: 10.1002/smmd.20230021
Yangnan Hu, Le Fang, Hui Zhang, Shasha Zheng, Menghui Liao, Qingyue Cui, Hao Wei, Danqi Wu, Hong Cheng, Yanru Qi, Huan Wang, Tao Xin, Tian Wang, Renjie Chai
{"title":"Emerging biotechnologies and biomedical engineering technologies for hearing reconstruction","authors":"Yangnan Hu, Le Fang, Hui Zhang, Shasha Zheng, Menghui Liao, Qingyue Cui, Hao Wei, Danqi Wu, Hong Cheng, Yanru Qi, Huan Wang, Tao Xin, Tian Wang, Renjie Chai","doi":"10.1002/smmd.20230021","DOIUrl":"https://doi.org/10.1002/smmd.20230021","url":null,"abstract":"Abstract Hearing impairment is a global health problem that affects social communications and the economy. The damage and loss of cochlear hair cells and spiral ganglion neurons (SGNs) as well as the degeneration of neurites of SGNs are the core causes of sensorineural hearing loss. Biotechnologies and biomedical engineering technologies provide new hope for the treatment of auditory diseases, which utilizes biological strategies or tissue engineering methods to achieve drug delivery and the regeneration of cells, tissues, and even organs. Here, the advancements in the applications of biotechnologies (including gene therapy and cochlear organoids) and biomedical engineering technologies (including drug delivery, electrode coating, electrical stimulation and bionic scaffolds) in the field of hearing reconstruction are presented. Moreover, we summarize the challenges and provide a perspective on this field.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"55 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136318957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional adhesive hydrogels for biological interfaces 用于生物界面的功能性粘接水凝胶
Smart medicine Pub Date : 2023-10-07 DOI: 10.1002/smmd.20230024
Changyi Liu, Kexin Peng, Yilun Wu, Fanfan Fu
{"title":"Functional adhesive hydrogels for biological interfaces","authors":"Changyi Liu, Kexin Peng, Yilun Wu, Fanfan Fu","doi":"10.1002/smmd.20230024","DOIUrl":"https://doi.org/10.1002/smmd.20230024","url":null,"abstract":"Abstract Hydrogel adhesives are extensively employed in biological interfaces such as epidermal flexible electronics, tissue engineering, and implanted device. The development of functional hydrogel adhesives is a critical, yet challenging task since combining two or more attributes that seem incompatible into one adhesive hydrogel without sacrificing the hydrogel's pristine capabilities. In this Review, we highlight current developments in the fabrication of functional adhesive hydrogels, which are suitable for a variety of application scenarios, particularly those that occur underwater or on tissue/organ surface conditions. The design strategies for a multifunctional adhesive hydrogel with desirable properties including underwater adhesion, self‐healing, good biocompatibility, electrical conductivity, and anti‐swelling are discussed comprehensively. We then discuss the challenges faced by adhesive hydrogels, as well as their potential applications in biological interfaces. Adhesive hydrogels are the star building blocks of bio‐interface materials for individualized healthcare and other bioengineering areas.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135254997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developing conductive hydrogels for biomedical applications 开发生物医学应用的导电水凝胶
Smart medicine Pub Date : 2023-09-15 DOI: 10.1002/smmd.20230023
Yu Wang, Jiahui Guo, Xinyue Cao, Yuanjin Zhao
{"title":"Developing conductive hydrogels for biomedical applications","authors":"Yu Wang, Jiahui Guo, Xinyue Cao, Yuanjin Zhao","doi":"10.1002/smmd.20230023","DOIUrl":"https://doi.org/10.1002/smmd.20230023","url":null,"abstract":"Abstract Conductive hydrogels have attracted copious attention owing to their grateful performances, such as similarity to biological tissues, compliance, conductivity and biocompatibility. A diversity of conductive hydrogels have been developed and showed versatile potentials in biomedical applications. In this review, we highlight the recent advances in conductive hydrogels, involving the various types and functionalities of conductive hydrogels as well as their applications in biomedical fields. Furthermore, the current challenges and the reasonable outlook of conductive hydrogels are also given. It is expected that this review will provide potential guidance for the advancement of next‐generation conductive hydrogels.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"356 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135396314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Construction of cardiac fibrosis for biomedical research. 用于生物医学研究的心脏纤维化构建
Smart medicine Pub Date : 2023-08-16 eCollection Date: 2023-08-01 DOI: 10.1002/SMMD.20230020
Yixuan Shang, Rui Liu, Jingjing Gan, Yuzhi Yang, Lingyun Sun
{"title":"Construction of cardiac fibrosis for biomedical research.","authors":"Yixuan Shang, Rui Liu, Jingjing Gan, Yuzhi Yang, Lingyun Sun","doi":"10.1002/SMMD.20230020","DOIUrl":"10.1002/SMMD.20230020","url":null,"abstract":"<p><p>Cardiac remodeling is critical for effective tissue recuperation, nevertheless, excessive formation and deposition of extracellular matrix components can result in the onset of cardiac fibrosis. Despite the emergence of novel therapies, there are still no lifelong therapeutic solutions for this issue. Understanding the detrimental cardiac remodeling may aid in the development of innovative treatment strategies to prevent or reverse fibrotic alterations in the heart. Further combining the latest understanding of disease pathogenesis with cardiac tissue engineering has provided the conversion of basic laboratory studies into the therapy of cardiac fibrosis patients as an increasingly viable prospect. This review presents the current main mechanisms and the potential tissue engineering of cardiac fibrosis. Approaches using biomedical materials-based cardiac constructions are reviewed to consider key issues for simulating in vitro cardiac fibrosis, outlining a future perspective for preclinical applications.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20230020"},"PeriodicalIF":0.0,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43788238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dimensional effect of graphene nanostructures on cytoskeleton-coupled anti-tumor metastasis. 石墨烯纳米结构对细胞骨架偶联抗肿瘤转移的尺寸效应
Smart medicine Pub Date : 2023-08-03 eCollection Date: 2023-08-01 DOI: 10.1002/SMMD.20230014
Qiqige Du, Na Li, Jiaqi Lian, Jun Guo, Yi Zhang, Feng Zhang
{"title":"Dimensional effect of graphene nanostructures on cytoskeleton-coupled anti-tumor metastasis.","authors":"Qiqige Du, Na Li, Jiaqi Lian, Jun Guo, Yi Zhang, Feng Zhang","doi":"10.1002/SMMD.20230014","DOIUrl":"10.1002/SMMD.20230014","url":null,"abstract":"<p><p>Interactions between inorganic materials and living systems can be strongly influenced by the dimensional property of the materials, which can in turn impact biological activities. Although the role of biomaterials at the molecular and cellular scales has been studied, research investigating the effects of biomaterials across multiple dimensional scales is relatively scarce. Herein, comparing the effectiveness of two-dimensional graphene oxide nanosheets (GOs) and three-dimensional graphene oxide quantum dots (GOQDs) (though not zero-dimensional because of their significant surface area) in cancer therapies, we have discovered that GOs, with the same mass concentration, exhibit stronger anti-cancer and anti-tumor metastasis properties than GOQDs. Our research, which employed liquid-phase atomic force microscopy, revealed that lower-dimensional GOs create a more extensive nano-bio interface that impedes actin protein polymerization into the cytoskeleton, leading to the prevention of tumor metastasis. These results help to better understand the underlying mechanisms and offer a dimensional perspective on the potential of optimizing the properties of graphene-based materials for clinical applications, e.g., cancer therapy.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20230014"},"PeriodicalIF":0.0,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45724019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomimetic nanoparticles targeting atherosclerosis for diagnosis and therapy. 针对动脉粥样硬化的仿生纳米颗粒的诊断和治疗
Smart medicine Pub Date : 2023-08-03 eCollection Date: 2023-08-01 DOI: 10.1002/SMMD.20230015
Yuyu Li, Jifang Wang, Jun Xie
{"title":"Biomimetic nanoparticles targeting atherosclerosis for diagnosis and therapy.","authors":"Yuyu Li, Jifang Wang, Jun Xie","doi":"10.1002/SMMD.20230015","DOIUrl":"10.1002/SMMD.20230015","url":null,"abstract":"<p><p>Atherosclerosis is a typical chronic inflammatory vascular disease that seriously endangers human health. At present, oral lipid-lowering or anti-inflammatory drugs are clinically used to inhibit the development of atherosclerosis. However, traditional oral drug treatments have problems such as low utilization, slow response, and serious side effects. Traditional nanodrug delivery systems are difficult to interactively recognize by normal biological organisms, and it is difficult to target the delivery of drugs to target lesions. Therefore, building a biomimetic nanodrug delivery system with targeted drug delivery based on the pathological characteristics of atherosclerosis is the key to achieving efficient and safe treatment of atherosclerosis. In this review, various nanodrug delivery systems that can target atherosclerosis are summarized and discussed. In addition, the future prospects and challenges of its clinical translation are also discussed.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20230015"},"PeriodicalIF":0.0,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11236035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44769604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Near‐infrared light‐responsive Nitric oxide microcarrier for multimodal tumor therapy (3/2023) 近红外光响应型一氧化氮微载体用于多模式肿瘤治疗(3/2023)
Smart medicine Pub Date : 2023-08-01 DOI: 10.1002/smmd.84
D. D. Liang, Gaizhen Kuang, Xiang Chen, Jianhua Lu, Luoran Shang, Weijian Sun
{"title":"Near‐infrared light‐responsive Nitric oxide microcarrier for multimodal tumor therapy (3/2023)","authors":"D. D. Liang, Gaizhen Kuang, Xiang Chen, Jianhua Lu, Luoran Shang, Weijian Sun","doi":"10.1002/smmd.84","DOIUrl":"https://doi.org/10.1002/smmd.84","url":null,"abstract":"","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48756159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional biomaterials for the diagnosis and treatment of peritoneal surface malignancies (3/2023) 功能性生物材料用于腹膜表面恶性肿瘤的诊断和治疗(3/2023)
Smart medicine Pub Date : 2023-08-01 DOI: 10.1002/smmd.83
X. Qin, M. Su, Huili Guo, Binying Peng, Rui Luo, Junwen Ye, H. Wang
{"title":"Functional biomaterials for the diagnosis and treatment of peritoneal surface malignancies (3/2023)","authors":"X. Qin, M. Su, Huili Guo, Binying Peng, Rui Luo, Junwen Ye, H. Wang","doi":"10.1002/smmd.83","DOIUrl":"https://doi.org/10.1002/smmd.83","url":null,"abstract":"","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42690207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomimetic nanoparticles targeting atherosclerosis for diagnosis and therapy (3/2023) 用于诊断和治疗的靶向动脉粥样硬化的仿生纳米颗粒（3/2023）
Smart medicine Pub Date : 2023-08-01 DOI: 10.1002/smmd.82
Yuyu Li, Jifang Wang, Jun Xie
{"title":"Biomimetic nanoparticles targeting atherosclerosis for diagnosis and therapy (3/2023)","authors":"Yuyu Li, Jifang Wang, Jun Xie","doi":"10.1002/smmd.82","DOIUrl":"https://doi.org/10.1002/smmd.82","url":null,"abstract":"","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45550093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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