Smart medicine最新文献_第5页

Armored probiotics for oral delivery. 用于口服的装甲益生菌

Smart medicine Pub Date : 2023-07-20 eCollection Date: 2023-11-01 DOI: 10.1002/SMMD.20230019

Xinyuan Yang, Chong Wang, Qiao Wang, Zhuohao Zhang, Weimin Nie, Luoran Shang

引用次数: 0

Functional biomaterials for the diagnosis and treatment of peritoneal surface malignancies. 功能性生物材料在腹膜表面恶性肿瘤诊断和治疗中的应用

Smart medicine Pub Date : 2023-07-13 eCollection Date: 2023-08-01 DOI: 10.1002/SMMD.20230013

Xiusen Qin, Mingli Su, Huili Guo, Binying Peng, Rui Luo, Junwen Ye, Hui Wang

引用次数: 0

Fabricating biomimetic materials with ice-templating for biomedical applications. 用于生物医学应用的冰模板仿生材料的制备

Smart medicine Pub Date : 2023-07-05 eCollection Date: 2023-08-01 DOI: 10.1002/SMMD.20230017

Xiang Lin, Lu Fan, Li Wang, Anne M Filppula, Yunru Yu, Hongbo Zhang

{"title":"Fabricating biomimetic materials with ice-templating for biomedical applications.","authors":"Xiang Lin, Lu Fan, Li Wang, Anne M Filppula, Yunru Yu, Hongbo Zhang","doi":"10.1002/SMMD.20230017","DOIUrl":"10.1002/SMMD.20230017","url":null,"abstract":"The proper organization of cells and tissues is essential for their functionalization in living organisms. To create materials that mimic natural structures, researchers have developed techniques such as patterning, templating, and printing. Although these techniques own several advantages, these processes still involve complexity, are time-consuming, and have high cost. To better simulate natural materials with micro/nanostructures that have evolved for millions of years, the use of ice templates has emerged as a promising method for producing biomimetic materials more efficiently. This article explores the historical approaches taken to produce traditional biomimetic structural biomaterials and delves into the principles underlying the ice-template method and their various applications in the creation of biomimetic materials. It also discusses the most recent biomedical uses of biomimetic materials created via ice templates, including porous microcarriers, tissue engineering scaffolds, and smart materials. Finally, the challenges and potential of current ice-template technology are analyzed.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20230017"},"PeriodicalIF":0.0,"publicationDate":"2023-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11236069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44967688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monitoring silica core@shell nanoparticle-bacterial film interactions using the multi-parametric surface plasmon resonance technique. 监测二氧化硅core@shell使用多参数表面等离子体共振技术的纳米粒子-细菌膜相互作用

Smart medicine Pub Date : 2023-06-26 eCollection Date: 2023-08-01 DOI: 10.1002/SMMD.20230012

Rawand A Mustafa, Petteri Parkkila, Jessica M Rosenholm, Hongbo Zhang, Tapani Viitala

{"title":"Monitoring silica core@shell nanoparticle-bacterial film interactions using the multi-parametric surface plasmon resonance technique.","authors":"Rawand A Mustafa, Petteri Parkkila, Jessica M Rosenholm, Hongbo Zhang, Tapani Viitala","doi":"10.1002/SMMD.20230012","DOIUrl":"10.1002/SMMD.20230012","url":null,"abstract":"In a healthcare setting, biofilms are a major source of infection and difficult to eradicate once formed. Nanoparticles (NPs) can be designed to effectively penetrate biofilms to more efficiently either deliver antibiotic drugs throughout the biofilm matrix or elicit inherent antibiofilm activity. Antibacterial cerium oxide (CeO2) NPs were employed as core material and coated with a mesoporous silica shell (MSN) to generate cerium oxide coated mesoporous silica NPs (CeO2@MSN). Detailed studies of NP-biofilm interactions are required to rationally develop NP platforms to prevent biofilm-related infections. This work developed and implemented a unique label-free analysis platform for the real-time monitoring of bacterial biofilm formation and then assessed the interactions of antibacterial NPs. An analysis platform which allows bacterial biofilms to grow and develop in situ in flow within the multi-parametric surface plasmon resonance (MP-SPR) instrument was established. This enabled simultaneous monitoring and detection of biofilm growth phases, structure, and interactions between differentially charged CeO2@MSNs and bacterial biofilms. Positively charged antibacterial NPs (polyethyleneimine functionalized CeO2@MSNs) were found to be the most efficient to penetrate the biofilm. The MP-SPR analysis platform was shown to be a powerful tool for monitoring biofilm development in real-time and to analyze biofilm properties and NP-biofilm interactions.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20230012"},"PeriodicalIF":0.0,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11236032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49663174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Near-infrared light-responsive Nitric oxide microcarrier for multimodal tumor therapy. 近红外光反应型一氧化氮微载体用于多模式肿瘤治疗

Smart medicine Pub Date : 2023-06-14 eCollection Date: 2023-08-01 DOI: 10.1002/SMMD.20230016

Danna Liang, Gaizhen Kuang, Xiang Chen, Jianhua Lu, Luoran Shang, Weijian Sun

{"title":"Near-infrared light-responsive Nitric oxide microcarrier for multimodal tumor therapy.","authors":"Danna Liang, Gaizhen Kuang, Xiang Chen, Jianhua Lu, Luoran Shang, Weijian Sun","doi":"10.1002/SMMD.20230016","DOIUrl":"10.1002/SMMD.20230016","url":null,"abstract":"Nitric oxide (NO) has shown great potential in tumor therapy, and the development of a platform for precise and controllable NO release still needs to be explored. Herein, a microfluidic electrospray strategy is proposed for the fabrication of hydrogel microspheres encapsulating NO donors (S-nitrosoglutathione, GSNO) together with black phosphorus (BP) and chemotherapeutic doxorubicin (DOX) as microcarriers for tumor therapy. Based on the excellent photothermal property of BP and thermal sensitivity of GSNO, the microcarriers exhibit a near-infrared light (NIR)-responsive NO release behavior. Besides, the photothermal performance of the microcarriers accelerates the release of DOX. All these contribute to the excellent tumor-killing effect of the microcarriers by combining multiple therapeutic strategies including NO therapy, photothermal therapy, and chemotherapy. Moreover, it was demonstrated that the NIR-responsive NO delivery microcarriers could significantly inhibit tumor growth without apparent side effects in vivo. Therefore, it is believed that the novel NIR-responsive NO microcarriers are promising candidates in clinical tumor therapy applications.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20230016"},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11236066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43384719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roles of N6-methyladenosine epitranscriptome in non-alcoholic fatty liver disease and hepatocellular carcinoma. N6甲基腺苷表转录组在非酒精性脂肪性肝病和肝细胞癌中的作用

Smart medicine Pub Date : 2023-06-02 eCollection Date: 2023-08-01 DOI: 10.1002/SMMD.20230008

Yuyan Chen, Zhengyi Zhu, Lu Zhang, Jinglin Wang, Haozhen Ren

{"title":"Roles of N6-methyladenosine epitranscriptome in non-alcoholic fatty liver disease and hepatocellular carcinoma.","authors":"Yuyan Chen, Zhengyi Zhu, Lu Zhang, Jinglin Wang, Haozhen Ren","doi":"10.1002/SMMD.20230008","DOIUrl":"10.1002/SMMD.20230008","url":null,"abstract":"Non-alcoholic fatty liver disease (NAFLD) is a typical chronic liver disease connected to a high risk of developing hepatocellular carcinoma (HCC). The development of NAFLD and HCC has been associated with changes in epigenetics, such as histone modifications and micro RNA (miRNA)-mediated processes. Recently, in the realm of epitranscriptomics, RNA alterations have become important regulators. N6-methyladenosine (m6A) is the most common and crucial alteration for controlling mRNA stability, splicing, and translation. It is particularly important for controlling liver disease progression and hepatic function. This review aims to conclude recent research on the functions of m6A epitranscriptome in the molecular mechanisms behind NAFLD and HCC development, with special attention to the effects of m6A alteration on how HCC develops and its possible roles in the progression of NAFLD to HCC. Additionally, the review discusses the possible effects of m6A alteration on the treatment and diagnostic of NAFLD and HCC. It is crucial to remember that m6A modification is a reversible action controlled via the coordinated functions of the proteins that write and delete, enabling quick adaptability to environmental changes. The review also discusses m6A-binding proteins' function in mRNA alternative splicing, translation, and degradation and their ability to modulate mRNA stability and processing. Understanding RNA modification regulation and its part in the emergence of HCC and NAFLD may provide new avenues for diagnosing and treating these diseases.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20230008"},"PeriodicalIF":0.0,"publicationDate":"2023-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45924842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single therapeutic dose of an antiviral UL29 siRNA swarm diminishes symptoms and viral load of mice infected intranasally with HSV-1. 单次治疗剂量的抗病毒UL29 siRNA群可减轻鼻内感染HSV‐1的小鼠的症状和病毒载量

Smart medicine Pub Date : 2023-05-10 eCollection Date: 2023-05-01 DOI: 10.1002/SMMD.20230009

Tuomas Lasanen, Fanny Frejborg, Liisa M Lund, Marie C Nyman, Julius Orpana, Huda Habib, Salla Alaollitervo, Alesia A Levanova, Minna M Poranen, Veijo Hukkanen, Kiira Kalke

{"title":"Single therapeutic dose of an antiviral UL29 siRNA swarm diminishes symptoms and viral load of mice infected intranasally with HSV-1.","authors":"Tuomas Lasanen, Fanny Frejborg, Liisa M Lund, Marie C Nyman, Julius Orpana, Huda Habib, Salla Alaollitervo, Alesia A Levanova, Minna M Poranen, Veijo Hukkanen, Kiira Kalke","doi":"10.1002/SMMD.20230009","DOIUrl":"10.1002/SMMD.20230009","url":null,"abstract":"Herpes simplex virus type 1 (HSV-1) is a human pathogen that causes recurrent infections. Acyclovir-resistant strains exist and can cause severe complications, which are potentially untreatable with current therapies. We have developed siRNA swarms that target a 653 base pair long region of the essential HSV gene UL29. As per our previous results, the anti-UL29 siRNA swarm effectively inhibits the replication of circulating HSV strains and acyclovir-resistant HSV strains in vitro, while displaying a good safety profile. We investigated a single intranasal therapeutic dose of a siRNA swarm in mice, which were first inoculated intranasally with HSV-1 and given treatment 4 h later. We utilized a luciferase-expressing HSV-1 strain, which enabled daily follow-up of infection with in vivo imaging. Our results show that a single dose of a UL29-targeted siRNA swarm can inhibit the replication of HSV-1 in orofacial tissue, which was reflected in ex vivo HSV titers and HSV DNA copy numbers as well as by a decrease in a luciferase-derived signal. Furthermore, the treatment had a tendency to protect mice from severe clinical symptoms and delay the onset of the symptoms. These results support the development of antiviral siRNA swarms as a novel treatment for HSV-1 infections.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20230009"},"PeriodicalIF":0.0,"publicationDate":"2023-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41580158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasound‐trigged micro/nanorobots for biomedical applications (2/2023) 用于生物医学应用的超声触发微/纳米机器人（2/2023）

Smart medicine Pub Date : 2023-05-01 DOI: 10.1002/smmd.66

Danqing Huang, Lijun Cai, Ning Li, Yuanjin Zhao

引用次数: 0

Single therapeutic dose of an antiviral UL29 siRNA swarm diminishes symptoms and viral load of mice infected intranasally with HSV‐1 (2/2023) 单次治疗剂量的抗病毒UL29 siRNA群可减轻鼻内感染HSV-1的小鼠的症状和病毒载量（2/2023）

Smart medicine Pub Date : 2023-05-01 DOI: 10.1002/smmd.65

Tuomas Lasanen, Fanny Frejborg, Liisa M. Lund, Marie C. Nyman, Julius Orpana, Huda Habib, Salla Alaollitervo, Alesia A. Levanova, M. Poranen, V. Hukkanen, Kiira Kalke

引用次数: 0

Issue Information 问题信息

Smart medicine Pub Date : 2023-05-01 DOI: 10.1111/raju.12348

引用次数: 0