Smart medicine最新文献_第5页

Biomineralize Mitochondria in Metal-Organic Frameworks to Promote Mitochondria Transplantation From Non-Tumorigenic Cells Into Cancer Cells. 金属-有机框架中的生物矿化线粒体促进线粒体从非致瘤细胞向癌细胞的移植。

Smart medicine Pub Date : 2025-02-26 eCollection Date: 2025-03-01 DOI: 10.1002/smmd.134

Jun-Nian Zhou, Chang Liu, Yonghui Wang, Yong Guo, Xiao-Yu Xu, Elina Vuorimaa-Laukkanen, Oliver Koivisto, Anne M Filppula, Jiangbin Ye, Hongbo Zhang

{"title":"Biomineralize Mitochondria in Metal-Organic Frameworks to Promote Mitochondria Transplantation From Non-Tumorigenic Cells Into Cancer Cells.","authors":"Jun-Nian Zhou, Chang Liu, Yonghui Wang, Yong Guo, Xiao-Yu Xu, Elina Vuorimaa-Laukkanen, Oliver Koivisto, Anne M Filppula, Jiangbin Ye, Hongbo Zhang","doi":"10.1002/smmd.134","DOIUrl":"10.1002/smmd.134","url":null,"abstract":"Mitochondria are crucial to cellular physiology, and growing evidence highlights the significant impact of mitochondrial dysfunction in diabetes, aging, neurodegenerative disorders, and cancers. Therefore, mitochondrial transplantation shows great potential for therapeutic use in treating these diseases. However, transplantation process is notably challenging due to very low efficiency and rapid loss of bioactivity post-isolation, leading to poor reproducibility and reliability. In this study, we develop a novel strategy to form a nanometer-thick protective shell around isolated mitochondria using Metal-Organic Frameworks (MOFs) through biomineralization. Our findings demonstrate that this encapsulation method effectively maintains mitochondria bioactivity for at least 4 weeks at room temperature. Furthermore, the efficiency of intracellular delivery of mitochondria is significantly enhanced through the surface functionalization of MOFs with polyethyleneimine (PEI) and the cell-penetrating peptide Tat. The successful delivery of mitochondria isolated from non-tumorigenic cells into cancer cells results in notable tumor-suppressive effects. Taken together, our technology represents a significant advancement in mitochondria research, particularly on understanding their role in cancer. It also lays the groundwork for utilizing mitochondria as therapeutic agents in cancer treatment.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"4 1","pages":"e134"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11862567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MXene-Integrated Responsive Hydrogel Microneedles for Oral Ulcers Healing. mxene集成反应性水凝胶微针用于口腔溃疡愈合。

Smart medicine Pub Date : 2025-02-26 eCollection Date: 2025-03-01 DOI: 10.1002/smmd.135

Chuanhui Song, Minhui Lu, Ning Li, Hongcheng Gu, Minli Li, Ling Lu, Yu Wang

引用次数: 0

Correction to "Reregulated Mitochondrial Dysfunction Reverses Cisplatin Resistance Microenvironment in Colorectal Cancer". 更正“再调节线粒体功能障碍逆转结直肠癌顺铂耐药微环境”。

Smart medicine Pub Date : 2025-02-25 eCollection Date: 2025-03-01 DOI: 10.1002/smmd.70001

引用次数: 0

Change in p53 nuclear localization in response to extracellular matrix stiffness. 细胞外基质硬度对p53核定位的影响。

Smart medicine Pub Date : 2025-02-20 eCollection Date: 2025-03-01 DOI: 10.1002/smmd.117

Yan Zu, Jing Du, Yipu Xu, Mengying Niu, Canlin Hong, Chun Yang

引用次数: 0

Microfluidic 3D printing hydrogels based on fish liver decellularized extracellular matrix for liver regeneration. 基于鱼肝脱细胞细胞外基质的微流控3D打印水凝胶用于肝脏再生。

IF 12.8

Smart medicine Pub Date : 2024-12-22 eCollection Date: 2024-12-01 DOI: 10.1002/SMMD.20240056

Haozhen Ren, Danqing Huang, Mengdi Qiu, Lingling Xue, Shaoshi Zhu, Jingjing Gan, Cheng Chen, Dayu Chen, Jinglin Wang

{"title":"Microfluidic 3D printing hydrogels based on fish liver decellularized extracellular matrix for liver regeneration.","authors":"Haozhen Ren, Danqing Huang, Mengdi Qiu, Lingling Xue, Shaoshi Zhu, Jingjing Gan, Cheng Chen, Dayu Chen, Jinglin Wang","doi":"10.1002/SMMD.20240056","DOIUrl":"10.1002/SMMD.20240056","url":null,"abstract":"Liver tissue engineering offers potential in liver transplantation, while the development of hydrogels for scalable scaffolds incorporating natural components and effective functionalities is ongoing. Here, we propose a novel microfluidic 3D printing hydrogel derived from decellularized fish liver extracellular matrix for liver regeneration. By decellularizing fish liver and combining it with gelatin methacryloyl, the hydrogel scaffold retains essential endogenous growth factors such as collagen and glycosaminoglycans. Additionally, microfluidic-assisted 3D printing technology enables precise modulation of the composition and architecture of hydrogels to fulfill clinical requirements. Benefiting from the natural source of materials, the hydrogels exhibit excellent biocompatibility and cellular proliferation capacity for incorporating induced pluripotent stem cell-derived hepatocytes (iPSC-heps). Furthermore, the macroscopic architecture and biomechanical environment of hydrogels foster optimal functional expression of iPSC-heps. Importantly, post-transplantation, the hydrogels significantly enhance survival rates and liver function in mice with acute liver failure, promoting liver regeneration and repair. These findings suggest that microfluidic 3D printed hydrogels represent promising candidates for liver transplantation and functional recovery.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"3 4","pages":"e20240056"},"PeriodicalIF":12.8,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug-phospholipid conjugate nano-assembly for drug delivery. 用于药物递送的药物-磷脂缀合纳米组装。

IF 12.8

Smart medicine Pub Date : 2024-12-22 eCollection Date: 2024-12-01 DOI: 10.1002/SMMD.20240053

Ding Zhao, Yixiang Zhang, Fan Wang, Rames Kaewmanee, Wenguo Cui, Tianqi Wu, Yawei Du

引用次数: 0

Emerging nanoprobes for the features visualization of vulnerable atherosclerotic plaques. 新兴的纳米探针用于易损动脉粥样硬化斑块的特征可视化。

IF 12.8

Smart medicine Pub Date : 2024-12-03 eCollection Date: 2024-12-01 DOI: 10.1002/SMMD.20240033

Xin Wang, Dan Mu, Jing Liang, Ruijing Xin, Yukun Zhang, Renyuan Liu, Mei Yao, Bing Zhang

{"title":"Emerging nanoprobes for the features visualization of vulnerable atherosclerotic plaques.","authors":"Xin Wang, Dan Mu, Jing Liang, Ruijing Xin, Yukun Zhang, Renyuan Liu, Mei Yao, Bing Zhang","doi":"10.1002/SMMD.20240033","DOIUrl":"10.1002/SMMD.20240033","url":null,"abstract":"Atherosclerosis (AS) is a major cause of cardiovascular disease. In particular, the unpredictable rupture of vulnerable atherosclerotic plaques (VASPs) can cause serious cardiovascular events such as myocardial infarction, stroke, and even sudden death. Therefore, early evaluation of the vulnerability of atherosclerotic plaques is of great importance. However, clinical imaging techniques are only marginally useful in the presence of severe anatomical structural changes, making it difficult to evaluate plaque vulnerability at an early stage. With the development of molecular imaging and nanotechnology, specific nanoprobes constructed for the pathological features of VASPs have attracted much attention for their ability to visualize VASPs early and noninvasively at the cellular and molecular levels. Here, we outline the pathological features of VASPs, analyze the superiority and limitations of current clinical imaging techniques, introduce the rational design principles of nanoprobes, and systematically summarize the application of nanoprobes to visualize the features of VASPs at the cellular and molecular levels. In addition, we discussed the prospects and urgent challenges in this field, and we believe it will provide new ideas for the early and accurate diagnosis of cardiovascular diseases.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"3 4","pages":"e20240033"},"PeriodicalIF":12.8,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Change in p53 nuclear localization in response to extracellular matrix stiffness. 细胞外基质硬度对p53核定位的影响。

IF 12.8

Smart medicine Pub Date : 2024-11-17 eCollection Date: 2024-12-01 DOI: 10.1002/SMMD.20240026

Yan Zu, Jing Du, Yipu Xu, Mengying Niu, Canlin Hong, Chun Yang

引用次数: 0

Bioorthogonal Janus microparticles for photothermal and chemo-therapy. 用于光热和化疗的生物正交Janus微粒子。

IF 12.8

Smart medicine Pub Date : 2024-11-11 eCollection Date: 2024-12-01 DOI: 10.1002/SMMD.20240038

Qingfei Zhang, Gaizhen Kuang, Kai Chen, Miaoqing Zhao, Luoran Shang

{"title":"Bioorthogonal Janus microparticles for photothermal and chemo-therapy.","authors":"Qingfei Zhang, Gaizhen Kuang, Kai Chen, Miaoqing Zhao, Luoran Shang","doi":"10.1002/SMMD.20240038","DOIUrl":"10.1002/SMMD.20240038","url":null,"abstract":"Bioorthogonal chemistry, recognized as a highly efficient tool in chemical biology, has shown significant value in cancer treatment. The primary objective is to develop efficient delivery strategies to achieve enhanced bioorthogonal drug treatment for tumors. Here, Janus microparticles (JMs) loaded with cyclooctene-modified doxorubicin prodrug (TCO-DOX) and tetrazine-modified indocyanine green (Tz-ICG) triggers are reported. Besides activating TCO-DOX, Tz-ICG is also a photothermal agent used in photothermal therapy (PTT), enabling the simultaneous use of biorthogonal chemotherapy and PTT. Additionally, the DOX could be significantly reduced in systemic toxicity with the modification of cyclooctene. Thus, the developed drug-carrying JMs system exhibits effective tumor cell killing in vitro and effectively inhibits tumor local progress and distant lung metastasis after postoperative treatment with good safety. These results demonstrate that the prepared JMs provide a paradigm for bioorthogonal prodrug activation and localized delivery, and hold great promise for cancer therapy as well as other related applications.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"3 4","pages":"e20240038"},"PeriodicalIF":12.8,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photodynamic therapy-induced precise attenuation of light-targeted semicircular canals for treating intractable vertigo. 光动力疗法诱导光靶半规管精确衰减治疗顽固性眩晕。

IF 12.8

Smart medicine Pub Date : 2024-10-19 eCollection Date: 2024-12-01 DOI: 10.1002/SMMD.20230044

Yingkun Yang, Tong Zhao, Feixue Mi, Hongzhe Li, Pingbo Huang, Fangyi Chen

{"title":"Photodynamic therapy-induced precise attenuation of light-targeted semicircular canals for treating intractable vertigo.","authors":"Yingkun Yang, Tong Zhao, Feixue Mi, Hongzhe Li, Pingbo Huang, Fangyi Chen","doi":"10.1002/SMMD.20230044","DOIUrl":"10.1002/SMMD.20230044","url":null,"abstract":"Vertigo is a common symptom of various diseases that affects a large number of people worldwide. Current leading treatments for intractable peripheral vertigo are to intratympanically inject ototoxic drugs such as gentamicin to attenuate the semicircular canal function but inevitably cause hearing injury. Photodynamic therapy (PDT) is a noninvasive therapeutic approach by precisely targeting the diseased tissue. Here, we developed a PDT-based method for treating intractable peripheral vertigo in a mouse model using a polymer-coated photosensitizer chlorin e6 excited by red light. We found that a high dose of PDT attenuated the function of both semicircular canals and otolith organs and damaged their hair cells. Conversely, the PDT exerted no effect on hearing function or cochlear hair-cell viability. These results suggest the therapeutic potential of PDT for treating intractable peripheral vertigo without hurting hearing. Besides, the attenuation level and affected area can be precisely controlled by adjusting the light exposure time. Furthermore, we demonstrated the potential of this therapeutic approach to be minimally invasive with light irradiation through bone results. Thus, our PDT-based approach for attenuating the function of the semicircular canals offers a basis for developing a less-invasive and targeted therapeutic option for treating vertigo.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"3 4","pages":"e20230044"},"PeriodicalIF":12.8,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0