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Application and prospect of the therapeutic strategy of inhibiting cellular senescence combined with pro‐regenerative biomaterials in regenerative medicine 抑制细胞衰老与促进再生的生物材料相结合的治疗策略在再生医学中的应用与展望
Smart medicine Pub Date : 2023-12-21 DOI: 10.1002/smmd.20230030
Qianyi Li, Zhenzhen Wang, Nuo Shi, Yang Qi, Wenfei Yao, Jie Yu, Yiming Lu
{"title":"Application and prospect of the therapeutic strategy of inhibiting cellular senescence combined with pro‐regenerative biomaterials in regenerative medicine","authors":"Qianyi Li, Zhenzhen Wang, Nuo Shi, Yang Qi, Wenfei Yao, Jie Yu, Yiming Lu","doi":"10.1002/smmd.20230030","DOIUrl":"https://doi.org/10.1002/smmd.20230030","url":null,"abstract":"Complete regeneration of damaged tissues/organs has always been the ultimate challenge in regenerative medicine. Aging has long been considered the basis of age‐related diseases, as senescent cells gradually accumulate in tissues with increasing age, tissues exhibit aging and normal physiological functions are inhibited. In recent years, in damaged tissues, scholars have found that the number of cells with features of cellular senescence continues to increase over time. The accumulation of senescent cells severely hinders the healing of damaged tissues. Furthermore, by clearing senescent cells or inhibiting the aging microenvironment, damaged tissues regained their original regenerative and repair capabilities. On the other hand, various biomaterials have been proved to have good biocompatibility and can effectively support cell regeneration after injury. Combining the two solutions, inhibiting the cellular senescence in damaged tissues and establishing a pro‐regenerative environment through biomaterial technology gradually reveals a new, unexpected treatment strategy applied to the field of regenerative medicine. In this review, we first elucidate the main characteristics of senescent cells from morphological, functional and molecular levels, and discuss in detail the process of accumulation of senescent cells in tissues. Then, we will explore in depth how the accumulation of senescent cells after damage affects tissue repair and regeneration at different stages. Finally, we will turn to how to promote tissue regeneration and repair in the field of regenerative medicine by inhibiting cellular senescence combined with biomaterial technology. Our goal is to understand the relationship between cellular senescence and tissue regeneration through this new perspective, and provide valuable references for the development of new therapeutic strategies in the future.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"23 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138948395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highly aqueously stable C60‐polymer nanoparticles with excellent photodynamic property for potential cancer treatment 具有优异光动力特性的高水稳定性 C60 聚合物纳米粒子，有望用于癌症治疗
Smart medicine Pub Date : 2023-12-20 DOI: 10.1002/smmd.20230033
Dan Wang, Jianyang Zhao, Roger J. Mulder, Julian Ratcliffe, Chunru Wang, Bo Wu, Jinquan Wang, Xiaojuan Hao
{"title":"Highly aqueously stable C60‐polymer nanoparticles with excellent photodynamic property for potential cancer treatment","authors":"Dan Wang, Jianyang Zhao, Roger J. Mulder, Julian Ratcliffe, Chunru Wang, Bo Wu, Jinquan Wang, Xiaojuan Hao","doi":"10.1002/smmd.20230033","DOIUrl":"https://doi.org/10.1002/smmd.20230033","url":null,"abstract":"Fullerenes are a class of carbon nanomaterials that find a wide range of applications in biomedical fields, especially for photodynamic cancer therapy because of its photosensitive effect. However, hydrophobic fullerenes can only be dispersed in organic solvents which hinders their biomedical applications. Here, we report a facile method to prepare highly water‐dispersible fullerene (C60)‐polymer nanoparticles with hydrodynamic sizes of 50–70 nm. Hydrophilic random copolymers containing different ratios of polyethylene glycol methyl ether methacrylate and 2‐aminoethylmethacrylamide were synthesized for conjugating with C60 molecules through efficient nucleophilic Michael addition reaction between amine groups from hydrophilic polymer and carbon‐carbon double bonds from C60. As a result, the amphiphilic C60‐polymer conjugates could be well dispersed and nano‐assembled in water with a C60 concentration as high as 7.8 mg/mL, demonstrating a significant improvement for the solubility of C60 in an aqueous system. Owing to the high C60 content, the C60‐polymer nanoparticles showed a strong photodynamic therapy effect on human lung cancer cells (A549) under light irradiation (450 nm) in both 2D cell culture and 3D spheroid culture, while demonstrating ignorable cytotoxicity under dark. This highly efficient and convenient method to prepare water‐dispersible C60‐polymer conjugates may have a great impact on the future biomedical applications of fullerenes.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"37 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138954569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nano‐omics: Frontier fields of fusion of nanotechnology 纳米组学：纳米技术融合的前沿领域
Smart medicine Pub Date : 2023-12-14 DOI: 10.1002/smmd.20230039
Xuan Wang, Wei-Cheng Xu, Jun Li, Chen Shi, Yuanyuan Guo, Jinjun Shan, Ruogu Qi
{"title":"Nano‐omics: Frontier fields of fusion of nanotechnology","authors":"Xuan Wang, Wei-Cheng Xu, Jun Li, Chen Shi, Yuanyuan Guo, Jinjun Shan, Ruogu Qi","doi":"10.1002/smmd.20230039","DOIUrl":"https://doi.org/10.1002/smmd.20230039","url":null,"abstract":"Nanotechnology, an emerging force, has infiltrated diverse domains like biomedical, materials, and environmental sciences. Nano‐omics, an emerging fusion, combines nanotechnology with omics, boasting amplified sensitivity and resolution. This review introduces nanotechnology basics, surveys its recent strides in nano‐omics, deliberates present challenges, and envisions future growth.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"4 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138971944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging ctDNA detection strategies in clinical cancer theranostics 新出现的ctDNA检测策略在临床癌症治疗中
Smart medicine Pub Date : 2023-11-13 DOI: 10.1002/smmd.20230031
Kexin Yi, Xiaoju Wang, Sergey K. Filippov, Hongbo Zhang
{"title":"Emerging ctDNA detection strategies in clinical cancer theranostics","authors":"Kexin Yi, Xiaoju Wang, Sergey K. Filippov, Hongbo Zhang","doi":"10.1002/smmd.20230031","DOIUrl":"https://doi.org/10.1002/smmd.20230031","url":null,"abstract":"Abstract Circulating tumor DNA (ctDNA) is naked DNA molecules shed from the tumor cells into the peripheral blood circulation. They contain tumor‐specific gene mutations and other valuable information. ctDNA is considered to be one of the most significant analytes in liquid biopsies. Over the past decades, numerous researchers have developed various detection strategies to perform quantitative or qualitative ctDNA analysis, including PCR‐based detection and sequencing‐based detection. More and more studies have illustrated the great value of ctDNA as a biomarker in the diagnosis, prognosis and heterogeneity of tumor. In this review, we first outlined the development of digital PCR (dPCR)‐based and next generation sequencing (NGS)‐based ctDNA detection systems. Besides, we presented the introduction of the emerging ctDNA analysis strategies based on various biosensors, such as electrochemical biosensors, fluorescent biosensors, surface plasmon resonance and Raman spectroscopy, as well as their applications in the field of biomedicine. Finally, we summarized the essentials of the preceding discussions, and the existing challenges and prospects for the future are also involved.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"126 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136351859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging biotechnologies and biomedical engineering technologies for hearing reconstruction (4/2023) 用于听力重建的新兴生物技术和生物医学工程技术（4/2023）
Smart medicine Pub Date : 2023-11-01 DOI: 10.1002/smmd.99
Yangnan Hu, Le Fang, Hui Zhang, Shasha Zheng, Menghui Liao, Qingyue Cui, Hao Wei, Danqi Wu, Hong Cheng, Yanru Qi, Huan Wang, Tao Xin, Tian Wang, Renjie Chai
{"title":"Emerging biotechnologies and biomedical engineering technologies for hearing reconstruction (4/2023)","authors":"Yangnan Hu, Le Fang, Hui Zhang, Shasha Zheng, Menghui Liao, Qingyue Cui, Hao Wei, Danqi Wu, Hong Cheng, Yanru Qi, Huan Wang, Tao Xin, Tian Wang, Renjie Chai","doi":"10.1002/smmd.99","DOIUrl":"https://doi.org/10.1002/smmd.99","url":null,"abstract":"","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139301118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nano‐omics: Frontier fields of fusion of nanotechnology (4/2023) 纳米组学：纳米技术融合的前沿领域（4/2023）
Smart medicine Pub Date : 2023-11-01 DOI: 10.1002/smmd.98
Xuan Wang, Wei-Cheng Xu, Jun Li, Chen Shi, Yuanyuan Guo, Jinjun Shan, Ruogu Qi
{"title":"Nano‐omics: Frontier fields of fusion of nanotechnology (4/2023)","authors":"Xuan Wang, Wei-Cheng Xu, Jun Li, Chen Shi, Yuanyuan Guo, Jinjun Shan, Ruogu Qi","doi":"10.1002/smmd.98","DOIUrl":"https://doi.org/10.1002/smmd.98","url":null,"abstract":"","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139300740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging optogenetics technologies in biomedical applications 新兴的光遗传学技术在生物医学中的应用
Smart medicine Pub Date : 2023-11-01 DOI: 10.1002/smmd.20230026
Haozhen Ren, Yi Cheng, Gaolin Wen, Jinglin Wang, Min Zhou
{"title":"Emerging optogenetics technologies in biomedical applications","authors":"Haozhen Ren, Yi Cheng, Gaolin Wen, Jinglin Wang, Min Zhou","doi":"10.1002/smmd.20230026","DOIUrl":"https://doi.org/10.1002/smmd.20230026","url":null,"abstract":"Abstract Optogenetics is a cutting‐edge technology that merges light control and genetics to achieve targeted control of tissue cells. Compared to traditional methods, optogenetics offers several advantages in terms of time and space precision, accuracy, and reduced damage to the research object. Currently, optogenetics is primarily used in pathway research, drug screening, gene expression regulation, and the stimulation of molecule release to treat various diseases. The selection of light‐sensitive proteins is the most crucial aspect of optogenetic technology; structural changes occur or downstream channels are activated to achieve signal transmission or factor release, allowing efficient and controllable disease treatment. In this review, we examine the extensive research conducted in the field of biomedicine concerning optogenetics, including the selection of light‐sensitive proteins, the study of carriers and delivery devices, and the application of disease treatment. Additionally, we offer critical insights and future implications of optogenetics in the realm of clinical medicine.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"22 1-2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135220844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exosomes: Toward a potential application in bladder cancer diagnosis and treatment 外泌体:在膀胱癌诊断和治疗中的潜在应用
Smart medicine Pub Date : 2023-10-30 DOI: 10.1002/smmd.20230027
Xiaowei Wei, Dagan Zhang, Yefei Zhu
{"title":"Exosomes: Toward a potential application in bladder cancer diagnosis and treatment","authors":"Xiaowei Wei, Dagan Zhang, Yefei Zhu","doi":"10.1002/smmd.20230027","DOIUrl":"https://doi.org/10.1002/smmd.20230027","url":null,"abstract":"Abstract Bladder cancer (BC) is a prevalent malignant tumor of the urinary system, known for its rapid progression and high likelihood of recurrence. Despite ongoing efforts, clinical diagnosis and treatment of BC remain limited. As such, there is an urgent need to investigate potential mechanisms underlying this disease. Exosomes, which contain a variety of bioactive molecules such as nucleic acids, proteins, and lipids, are regarded as extracellular messengers because they are implicated in facilitating intercellular communication in various diseases and are pivotal in tumor advancement, serving as a promising avenue for such researches. Nevertheless, the heterogeneous nature of BC necessitates further exploration of the potential involvement of exosomes in disease progression. This review comprehensively outlines the biological attributes of exosomes and their critical roles in tumorigenesis, while also discussing their potential applications in regulating the progression of BC involving clinical diagnosis, prognostication and treatment.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136022678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modification and crosslinking strategies for hyaluronic acid‐based hydrogel biomaterials 透明质酸基水凝胶生物材料的改性和交联策略
Smart medicine Pub Date : 2023-10-30 DOI: 10.1002/smmd.20230029
Zhiqiang Luo, Yu Wang, Ye Xu, Jinglin Wang, Yunru Yu
{"title":"Modification and crosslinking strategies for hyaluronic acid‐based hydrogel biomaterials","authors":"Zhiqiang Luo, Yu Wang, Ye Xu, Jinglin Wang, Yunru Yu","doi":"10.1002/smmd.20230029","DOIUrl":"https://doi.org/10.1002/smmd.20230029","url":null,"abstract":"Abstract Hyaluronic acid (HA) is an attractive extracellular matrix‐derived polymer. The related HA‐based hydrogels are emerging to be the hotspots in the cutting edge of biomaterials. The continuous sights concentrate on exploring modification methods and crosslinking strategies to promote the advancement of HA‐based hydrogels with enhanced physical/chemical properties and enriched biological performance. Here, the advances on modification methods and crosslinking strategies for fabricating HA‐based hydrogels with diverse capacities are summarized. Firstly, the modification reactions that occur on the active hydroxyl, carboxyl and N‐acetyl groups of HA molecule are discussed. Next, the emphasis is put on various crosslinking strategies including physical crosslinking, covalent crosslinking and dynamic covalent crosslinking. Finally, we provide a general summary and give a critical viewpoint on the remaining challenges and the future development of HA‐based hydrogels. It is hoped that this review can provide new proposals for the specific design of functional hydrogel biomaterials.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"124 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136069691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging biotechnologies and biomedical engineering technologies for hearing reconstruction 听力重建的新兴生物技术和生物医学工程技术
Smart medicine Pub Date : 2023-10-27 DOI: 10.1002/smmd.20230021
Yangnan Hu, Le Fang, Hui Zhang, Shasha Zheng, Menghui Liao, Qingyue Cui, Hao Wei, Danqi Wu, Hong Cheng, Yanru Qi, Huan Wang, Tao Xin, Tian Wang, Renjie Chai
{"title":"Emerging biotechnologies and biomedical engineering technologies for hearing reconstruction","authors":"Yangnan Hu, Le Fang, Hui Zhang, Shasha Zheng, Menghui Liao, Qingyue Cui, Hao Wei, Danqi Wu, Hong Cheng, Yanru Qi, Huan Wang, Tao Xin, Tian Wang, Renjie Chai","doi":"10.1002/smmd.20230021","DOIUrl":"https://doi.org/10.1002/smmd.20230021","url":null,"abstract":"Abstract Hearing impairment is a global health problem that affects social communications and the economy. The damage and loss of cochlear hair cells and spiral ganglion neurons (SGNs) as well as the degeneration of neurites of SGNs are the core causes of sensorineural hearing loss. Biotechnologies and biomedical engineering technologies provide new hope for the treatment of auditory diseases, which utilizes biological strategies or tissue engineering methods to achieve drug delivery and the regeneration of cells, tissues, and even organs. Here, the advancements in the applications of biotechnologies (including gene therapy and cochlear organoids) and biomedical engineering technologies (including drug delivery, electrode coating, electrical stimulation and bionic scaffolds) in the field of hearing reconstruction are presented. Moreover, we summarize the challenges and provide a perspective on this field.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"55 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136318957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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