Application and prospect of the therapeutic strategy of inhibiting cellular senescence combined with pro‐regenerative biomaterials in regenerative medicine

Smart medicine Pub Date : 2023-12-21 DOI:10.1002/smmd.20230030

Qianyi Li, Zhenzhen Wang, Nuo Shi, Yang Qi, Wenfei Yao, Jie Yu, Yiming Lu

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Abstract

Complete regeneration of damaged tissues/organs has always been the ultimate challenge in regenerative medicine. Aging has long been considered the basis of age‐related diseases, as senescent cells gradually accumulate in tissues with increasing age, tissues exhibit aging and normal physiological functions are inhibited. In recent years, in damaged tissues, scholars have found that the number of cells with features of cellular senescence continues to increase over time. The accumulation of senescent cells severely hinders the healing of damaged tissues. Furthermore, by clearing senescent cells or inhibiting the aging microenvironment, damaged tissues regained their original regenerative and repair capabilities. On the other hand, various biomaterials have been proved to have good biocompatibility and can effectively support cell regeneration after injury. Combining the two solutions, inhibiting the cellular senescence in damaged tissues and establishing a pro‐regenerative environment through biomaterial technology gradually reveals a new, unexpected treatment strategy applied to the field of regenerative medicine. In this review, we first elucidate the main characteristics of senescent cells from morphological, functional and molecular levels, and discuss in detail the process of accumulation of senescent cells in tissues. Then, we will explore in depth how the accumulation of senescent cells after damage affects tissue repair and regeneration at different stages. Finally, we will turn to how to promote tissue regeneration and repair in the field of regenerative medicine by inhibiting cellular senescence combined with biomaterial technology. Our goal is to understand the relationship between cellular senescence and tissue regeneration through this new perspective, and provide valuable references for the development of new therapeutic strategies in the future.

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抑制细胞衰老与促进再生的生物材料相结合的治疗策略在再生医学中的应用与展望

受损组织/器官的完全再生一直是再生医学的终极挑战。衰老一直被认为是老年性疾病的基础，随着年龄的增长，衰老细胞在组织中逐渐积累，组织呈现衰老状态，正常的生理功能受到抑制。近年来，在受损组织中，学者们发现具有细胞衰老特征的细胞数量随着时间的推移不断增加。衰老细胞的积累严重阻碍了受损组织的愈合。此外，通过清除衰老细胞或抑制衰老微环境，可使受损组织恢复原有的再生和修复能力。另一方面，各种生物材料已被证明具有良好的生物相容性，可有效支持损伤后的细胞再生。将这两种解决方案结合起来，通过生物材料技术抑制受损组织的细胞衰老并建立有利于再生的环境，逐渐揭示出一种应用于再生医学领域的意想不到的新治疗策略。在这篇综述中，我们首先从形态、功能和分子水平阐明了衰老细胞的主要特征，并详细讨论了衰老细胞在组织中的积累过程。然后，我们将深入探讨损伤后衰老细胞的积累如何在不同阶段影响组织的修复和再生。最后，我们将结合生物材料技术，探讨如何通过抑制细胞衰老促进再生医学领域的组织再生和修复。我们的目标是通过这一新的视角来理解细胞衰老与组织再生之间的关系，为未来开发新的治疗策略提供有价值的参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Smart medicine

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