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Stimuli‐responsive silk fibroin for on‐demand drug delivery (2/2023) 刺激反应丝素蛋白用于按需给药(2/2023)
Smart medicine Pub Date : 2023-05-01 DOI: 10.1002/smmd.77
Xiang Lin, Lijun Cai, Xinyue Cao, Yuanjin Zhao
{"title":"Stimuli‐responsive silk fibroin for on‐demand drug delivery (2/2023)","authors":"Xiang Lin, Lijun Cai, Xinyue Cao, Yuanjin Zhao","doi":"10.1002/smmd.77","DOIUrl":"https://doi.org/10.1002/smmd.77","url":null,"abstract":"The silk fibroin protein derived from silkworm can be used as a responsive delivery material for various biomedical applications. The background of the image represents a side view of skin, symbolizing biomedical applications. Various specific examples represented by bubbles are derived from the background, including two typical examples shown in the image: one is an anti-tumor treatment method achieved through infrared-responsive drug delivery, and the other is a skin patch for heat-responsive drug delivery.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"120 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135703468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Engineered photoresponsive biohybrids for tumor therapy (2/2023) 用于肿瘤治疗的工程光反应生物杂合体(2/2023)
Smart medicine Pub Date : 2023-05-01 DOI: 10.1002/smmd.64
Xiaocheng Wang, Yazhi Sun, D. Wangpraseurt
{"title":"Engineered photoresponsive biohybrids for tumor therapy (2/2023)","authors":"Xiaocheng Wang, Yazhi Sun, D. Wangpraseurt","doi":"10.1002/smmd.64","DOIUrl":"https://doi.org/10.1002/smmd.64","url":null,"abstract":"","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47680545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Silk‐based conductive materials for smart biointerfaces (2/2023) 用于智能生物界面的丝基导电材料（2/2023）
Smart medicine Pub Date : 2023-05-01 DOI: 10.1002/smmd.67
Fanfan Fu, D. Liu, Yilun Wu
{"title":"Silk‐based conductive materials for smart biointerfaces (2/2023)","authors":"Fanfan Fu, D. Liu, Yilun Wu","doi":"10.1002/smmd.67","DOIUrl":"https://doi.org/10.1002/smmd.67","url":null,"abstract":"","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46660632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Piezoelectric biomaterials for neural tissue engineering. 神经组织工程用压电生物材料
Smart medicine Pub Date : 2023-04-26 eCollection Date: 2023-05-01 DOI: 10.1002/SMMD.20230002
Dongyu Xu, Hui Zhang, Yu Wang, Yuan Zhang, Fanglei Ye, Ling Lu, Renjie Chai
{"title":"Piezoelectric biomaterials for neural tissue engineering.","authors":"Dongyu Xu, Hui Zhang, Yu Wang, Yuan Zhang, Fanglei Ye, Ling Lu, Renjie Chai","doi":"10.1002/SMMD.20230002","DOIUrl":"10.1002/SMMD.20230002","url":null,"abstract":"<p><p>Nerve injury caused by trauma or iatrogenic trauma can lead to loss of sensory and motor function, resulting in paralysis of patients. Inspired by endogenous bioelectricity and extracellular matrix, various external physical and chemical stimuli have been introduced to treat nerve injury. Benefiting from the self-power feature and great biocompatibility, piezoelectric biomaterials have attracted widespread attention in biomedical applications, especially in neural tissue engineering. Here, we provide an overview of the development of piezoelectric biomaterials for neural tissue engineering. First, several types of piezoelectric biomaterials are introduced, including inorganic piezoelectric nanomaterials, organic piezoelectric polymers, and their derivates. Then, we focus on the in vitro and in vivo external energy-driven piezoelectric effects involving ultrasound, mechanical movement, and other external field-driven piezoelectric effects. Neuroengineering applications of the piezoelectric biomaterials as in vivo grafts for the treatment of central nerve injury and peripheral nerve injury are also discussed and highlighted. Finally, the current challenges and future development of piezoelectric biomaterials for promoting nerve regeneration and treating neurological diseases are presented.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20230002"},"PeriodicalIF":0.0,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43054384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Silk-based conductive materials for smart biointerfaces. 用于智能生物界面的丝基导电材料
Smart medicine Pub Date : 2023-04-17 eCollection Date: 2023-05-01 DOI: 10.1002/SMMD.20230004
Fanfan Fu, Dongmei Liu, Yilun Wu
{"title":"Silk-based conductive materials for smart biointerfaces.","authors":"Fanfan Fu, Dongmei Liu, Yilun Wu","doi":"10.1002/SMMD.20230004","DOIUrl":"10.1002/SMMD.20230004","url":null,"abstract":"<p><p>Silk-based conductive materials are widely used in biointerface applications, such as artificial epidermal sensors, soft and implantable bioelectronics, and tissue/cell scaffolds. Such biointerface materials require coordinated physicochemical, biological, and mechanical properties to meet current practical needs and future sophisticated demands. However, it remains a challenge to formulate silk-based advanced materials with high electrical conductivity, good biocompatibility, mechanical robustness, and in some cases, tissue adhesion ability without compromising other physicochemical properties. In this review, we highlight recent progress in the development of functional conductive silk-based advanced materials with different morphologies. Then, we reviewed the advanced paradigms of these silk materials applied as wearable flexible sensors, implantable electronics, and tissue/cell engineering with perspectives on the application challenges. Silk-based conductive materials can serve as promising building blocks for biomedical devices in personalized healthcare and other fields of bioengineering.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20230004"},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11236014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45159782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multidimensional landscape of non-alcoholic fatty liver disease-related disease spectrum uncovered by big omics data: Profiling evidence and new perspectives. 大组学数据揭示的非酒精性脂肪肝相关疾病谱的多维景观：分析证据和新视角
Smart medicine Pub Date : 2023-04-17 eCollection Date: 2023-05-01 DOI: 10.1002/SMMD.20220029
Zhengyi Zhu, Yuyan Chen, Xueqian Qin, Shujun Liu, Jinglin Wang, Haozhen Ren
{"title":"Multidimensional landscape of non-alcoholic fatty liver disease-related disease spectrum uncovered by big omics data: Profiling evidence and new perspectives.","authors":"Zhengyi Zhu, Yuyan Chen, Xueqian Qin, Shujun Liu, Jinglin Wang, Haozhen Ren","doi":"10.1002/SMMD.20220029","DOIUrl":"10.1002/SMMD.20220029","url":null,"abstract":"<p><p>Characterized by hepatic lipid accumulation, non-alcoholic fatty liver disease (NAFLD) is a multifactorial metabolic disorder that could promote the progression of non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma (HCC). Benefiting from recent advances in omics technologies, such as high-throughput sequencing, voluminous profiling data in HCC-integrated molecular science into clinical medicine helped clinicians with rational guidance for treatments. In this review, we conclude the majority of publicly available omics data on the NAFLD-related disease spectrum and bring up new insights to inspire next-generation therapeutics against this increasingly prevalent disease spectrum in the post-genomic era.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220029"},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11236021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46765283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TP53 mutation-related senescence is an indicator of hepatocellular carcinoma patient outcomes from multiomics profiles. 从多组学分析来看，TP53突变相关的衰老是肝癌患者预后的一个指标
Smart medicine Pub Date : 2023-04-13 eCollection Date: 2023-05-01 DOI: 10.1002/SMMD.20230005
Yu-Yan Chen, Zheng-Yi Zhu, Tao Ma, Lu Zhang, Jing Chen, Jia-Wei Jiang, Cui-Hua Lu, Yi-Tao Ding, Wen-Xian Guan, Nan Yi, Hao-Zhen Ren
{"title":"TP53 mutation-related senescence is an indicator of hepatocellular carcinoma patient outcomes from multiomics profiles.","authors":"Yu-Yan Chen, Zheng-Yi Zhu, Tao Ma, Lu Zhang, Jing Chen, Jia-Wei Jiang, Cui-Hua Lu, Yi-Tao Ding, Wen-Xian Guan, Nan Yi, Hao-Zhen Ren","doi":"10.1002/SMMD.20230005","DOIUrl":"10.1002/SMMD.20230005","url":null,"abstract":"<p><p>TP53 mutation frequently occurs in hepatocellular carcinoma (HCC). Senescence also plays a vital role in the ongoing process of HCC. P53 is believed to regulate the advancement of senescence in HCC. However, the exact mechanism of TP53 mutation-related senescence remains unclear. In this study, we found the TP53 mutation was positively correlated with senescence in HCC, and the differential expressed genes were primarily located in macrophages. Our results proved that the risk score could have an independent and vital role in predicting the prognosis of HCC patients. In addition, HCC patients with a high risk score may most probably benefit from immune checkpoint block therapy. We also found the risk score is elevated in chemotherapy-treated HCC samples, with a high level of senescence-associated secretory phenotype. Finally, we validated the risk-score genes in the protein level and noticed the risk score is positively related with M2 polarization. Of note, we considered that the risk score under the TP53 mutation and senescence is a promising biomarker with the potential to aid in predicting prognosis, defining tumor environment characteristics, and assessing the benefits of immunotherapy for HCC patients.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20230005"},"PeriodicalIF":0.0,"publicationDate":"2023-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42436627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasound-trigged micro/nanorobots for biomedical applications. 用于生物医学应用的超声触发微/纳米机器人
Smart medicine Pub Date : 2023-04-11 eCollection Date: 2023-05-01 DOI: 10.1002/SMMD.20230003
Danqing Huang, Lijun Cai, Ning Li, Yuanjin Zhao
{"title":"Ultrasound-trigged micro/nanorobots for biomedical applications.","authors":"Danqing Huang, Lijun Cai, Ning Li, Yuanjin Zhao","doi":"10.1002/SMMD.20230003","DOIUrl":"10.1002/SMMD.20230003","url":null,"abstract":"<p><p>Micro- and nanorobots (MNRs) propelled by external actuations have broad potential in biomedical applications. Among the numerous external excitations, ultrasound (US) features outstanding practical significance with merits of its noninvasiveness, tunability, penetrability, and biocompatibility. Attributing to various physiochemical effects of US, it can propel the MNRs with sophisticated structures through asymmetric acoustic streaming, bubble oscillation, and so on. In this review, we introduce several advanced and representative US-propelled MNRs with inhomogeneous density distribution, asymmetric shape, hollow cavity, etc. The potential biomedical applications of these cutting-edge MNRs are also presented, including intracellular delivery, harmful substances collection, and so on. Furthermore, we conclude the advantages and limitations of US-propelled MNRs and prospect their future developments in multidisciplinary fields.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20230003"},"PeriodicalIF":0.0,"publicationDate":"2023-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45140954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Basic fibroblast growth factor-loaded methacrylate gelatin hydrogel microspheres for spinal nerve regeneration. 碱性成纤维细胞生长因子装载甲基丙烯酸酯明胶水凝胶微球用于脊神经再生
Smart medicine Pub Date : 2023-03-28 eCollection Date: 2023-05-01 DOI: 10.1002/SMMD.20220038
Xiaoyan Chen, Lei Ren, Hui Zhang, Yangnan Hu, Menghui Liao, Yingbo Shen, Kaichen Wang, Jiaying Cai, Hong Cheng, Jiamin Guo, Yanru Qi, Hao Wei, Xiaokun Li, Luoran Shang, Jian Xiao, Jingwu Sun, Renjie Chai
{"title":"Basic fibroblast growth factor-loaded methacrylate gelatin hydrogel microspheres for spinal nerve regeneration.","authors":"Xiaoyan Chen, Lei Ren, Hui Zhang, Yangnan Hu, Menghui Liao, Yingbo Shen, Kaichen Wang, Jiaying Cai, Hong Cheng, Jiamin Guo, Yanru Qi, Hao Wei, Xiaokun Li, Luoran Shang, Jian Xiao, Jingwu Sun, Renjie Chai","doi":"10.1002/SMMD.20220038","DOIUrl":"10.1002/SMMD.20220038","url":null,"abstract":"<p><p>Spinal cord injury is a severe central nervous system injury, and developing appropriate drug delivery platforms for spinal nerve regeneration is highly anticipated. Here, we propose a basic fibroblast growth factor (bFGF)-loaded methacrylate gelatin (GelMA) hydrogel microsphere with ideal performances for spinal cord injury repair. Benefitting from the precise droplet manipulation capability of the microfluidic technology, the GelMA microspheres possess uniform and satisfactory size and good stability. More importantly, by taking advantage of the porous structures and facile chemical modification of the GelMA microspheres, bFGF could be easily loaded and gradually released. By co-culturing with neural stem cells, it is validated that the bFGF-loaded GelMA microspheres could effectively promote the proliferation and differentiation of neural stem cells. We also confirm the effective role of the bFGF-loaded GelMA microspheres in nerve repair of spinal cord injury in rats. Our results demonstrate the potential value of the microspheres for applications in repairing central nervous system injuries.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220038"},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46499177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Magnetic photonic crystals for biomedical applications. 用于生物医学的磁性光子晶体
Smart medicine Pub Date : 2023-03-20 eCollection Date: 2023-05-01 DOI: 10.1002/SMMD.20220039
Hanxu Chen, Ning Li, Zhuxiao Gu, Hongcheng Gu, Jinglin Wang
{"title":"Magnetic photonic crystals for biomedical applications.","authors":"Hanxu Chen, Ning Li, Zhuxiao Gu, Hongcheng Gu, Jinglin Wang","doi":"10.1002/SMMD.20220039","DOIUrl":"10.1002/SMMD.20220039","url":null,"abstract":"<p><p>Magnetic photonic crystals (PhCs), as a representative responsive structural color material, have attracted increasing research focus due to merits such as brilliant refraction colors, instant responsiveness, and excellent manipuility, thus having been widely applied for color displaying, three-dimensional printing, sensing, and so on. Featured with traits such as contactless manner, flexible orientations, and adjustable intensity of external magnetism, magnetic PhCs have shown great superiority especially in the field of biomedical applications such as bioimaging and auxiliary clinical diagnosis. In this review, we summarize the current advancements of magnetic PhCs. We first introduce the fundamental principles and typical characteristics of PhCs. Afterward, we present several typical self-assembly strategies with their frontiers in practical applications. Finally, we analyze the current situations of magnetic PhCs and put forward the prospective challenges and future development directions.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220039"},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42045340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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