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Functional adhesive hydrogels for biological interfaces 用于生物界面的功能性粘接水凝胶
Smart medicine Pub Date : 2023-10-07 DOI: 10.1002/smmd.20230024
Changyi Liu, Kexin Peng, Yilun Wu, Fanfan Fu
{"title":"Functional adhesive hydrogels for biological interfaces","authors":"Changyi Liu, Kexin Peng, Yilun Wu, Fanfan Fu","doi":"10.1002/smmd.20230024","DOIUrl":"https://doi.org/10.1002/smmd.20230024","url":null,"abstract":"Abstract Hydrogel adhesives are extensively employed in biological interfaces such as epidermal flexible electronics, tissue engineering, and implanted device. The development of functional hydrogel adhesives is a critical, yet challenging task since combining two or more attributes that seem incompatible into one adhesive hydrogel without sacrificing the hydrogel's pristine capabilities. In this Review, we highlight current developments in the fabrication of functional adhesive hydrogels, which are suitable for a variety of application scenarios, particularly those that occur underwater or on tissue/organ surface conditions. The design strategies for a multifunctional adhesive hydrogel with desirable properties including underwater adhesion, self‐healing, good biocompatibility, electrical conductivity, and anti‐swelling are discussed comprehensively. We then discuss the challenges faced by adhesive hydrogels, as well as their potential applications in biological interfaces. Adhesive hydrogels are the star building blocks of bio‐interface materials for individualized healthcare and other bioengineering areas.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135254997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developing conductive hydrogels for biomedical applications 开发生物医学应用的导电水凝胶
Smart medicine Pub Date : 2023-09-15 DOI: 10.1002/smmd.20230023
Yu Wang, Jiahui Guo, Xinyue Cao, Yuanjin Zhao
{"title":"Developing conductive hydrogels for biomedical applications","authors":"Yu Wang, Jiahui Guo, Xinyue Cao, Yuanjin Zhao","doi":"10.1002/smmd.20230023","DOIUrl":"https://doi.org/10.1002/smmd.20230023","url":null,"abstract":"Abstract Conductive hydrogels have attracted copious attention owing to their grateful performances, such as similarity to biological tissues, compliance, conductivity and biocompatibility. A diversity of conductive hydrogels have been developed and showed versatile potentials in biomedical applications. In this review, we highlight the recent advances in conductive hydrogels, involving the various types and functionalities of conductive hydrogels as well as their applications in biomedical fields. Furthermore, the current challenges and the reasonable outlook of conductive hydrogels are also given. It is expected that this review will provide potential guidance for the advancement of next‐generation conductive hydrogels.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"356 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135396314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Construction of cardiac fibrosis for biomedical research. 用于生物医学研究的心脏纤维化构建
Smart medicine Pub Date : 2023-08-16 eCollection Date: 2023-08-01 DOI: 10.1002/SMMD.20230020
Yixuan Shang, Rui Liu, Jingjing Gan, Yuzhi Yang, Lingyun Sun
{"title":"Construction of cardiac fibrosis for biomedical research.","authors":"Yixuan Shang, Rui Liu, Jingjing Gan, Yuzhi Yang, Lingyun Sun","doi":"10.1002/SMMD.20230020","DOIUrl":"10.1002/SMMD.20230020","url":null,"abstract":"<p><p>Cardiac remodeling is critical for effective tissue recuperation, nevertheless, excessive formation and deposition of extracellular matrix components can result in the onset of cardiac fibrosis. Despite the emergence of novel therapies, there are still no lifelong therapeutic solutions for this issue. Understanding the detrimental cardiac remodeling may aid in the development of innovative treatment strategies to prevent or reverse fibrotic alterations in the heart. Further combining the latest understanding of disease pathogenesis with cardiac tissue engineering has provided the conversion of basic laboratory studies into the therapy of cardiac fibrosis patients as an increasingly viable prospect. This review presents the current main mechanisms and the potential tissue engineering of cardiac fibrosis. Approaches using biomedical materials-based cardiac constructions are reviewed to consider key issues for simulating in vitro cardiac fibrosis, outlining a future perspective for preclinical applications.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20230020"},"PeriodicalIF":0.0,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43788238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dimensional effect of graphene nanostructures on cytoskeleton-coupled anti-tumor metastasis. 石墨烯纳米结构对细胞骨架偶联抗肿瘤转移的尺寸效应
Smart medicine Pub Date : 2023-08-03 eCollection Date: 2023-08-01 DOI: 10.1002/SMMD.20230014
Qiqige Du, Na Li, Jiaqi Lian, Jun Guo, Yi Zhang, Feng Zhang
{"title":"Dimensional effect of graphene nanostructures on cytoskeleton-coupled anti-tumor metastasis.","authors":"Qiqige Du, Na Li, Jiaqi Lian, Jun Guo, Yi Zhang, Feng Zhang","doi":"10.1002/SMMD.20230014","DOIUrl":"10.1002/SMMD.20230014","url":null,"abstract":"<p><p>Interactions between inorganic materials and living systems can be strongly influenced by the dimensional property of the materials, which can in turn impact biological activities. Although the role of biomaterials at the molecular and cellular scales has been studied, research investigating the effects of biomaterials across multiple dimensional scales is relatively scarce. Herein, comparing the effectiveness of two-dimensional graphene oxide nanosheets (GOs) and three-dimensional graphene oxide quantum dots (GOQDs) (though not zero-dimensional because of their significant surface area) in cancer therapies, we have discovered that GOs, with the same mass concentration, exhibit stronger anti-cancer and anti-tumor metastasis properties than GOQDs. Our research, which employed liquid-phase atomic force microscopy, revealed that lower-dimensional GOs create a more extensive nano-bio interface that impedes actin protein polymerization into the cytoskeleton, leading to the prevention of tumor metastasis. These results help to better understand the underlying mechanisms and offer a dimensional perspective on the potential of optimizing the properties of graphene-based materials for clinical applications, e.g., cancer therapy.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20230014"},"PeriodicalIF":0.0,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45724019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomimetic nanoparticles targeting atherosclerosis for diagnosis and therapy. 针对动脉粥样硬化的仿生纳米颗粒的诊断和治疗
Smart medicine Pub Date : 2023-08-03 eCollection Date: 2023-08-01 DOI: 10.1002/SMMD.20230015
Yuyu Li, Jifang Wang, Jun Xie
{"title":"Biomimetic nanoparticles targeting atherosclerosis for diagnosis and therapy.","authors":"Yuyu Li, Jifang Wang, Jun Xie","doi":"10.1002/SMMD.20230015","DOIUrl":"10.1002/SMMD.20230015","url":null,"abstract":"<p><p>Atherosclerosis is a typical chronic inflammatory vascular disease that seriously endangers human health. At present, oral lipid-lowering or anti-inflammatory drugs are clinically used to inhibit the development of atherosclerosis. However, traditional oral drug treatments have problems such as low utilization, slow response, and serious side effects. Traditional nanodrug delivery systems are difficult to interactively recognize by normal biological organisms, and it is difficult to target the delivery of drugs to target lesions. Therefore, building a biomimetic nanodrug delivery system with targeted drug delivery based on the pathological characteristics of atherosclerosis is the key to achieving efficient and safe treatment of atherosclerosis. In this review, various nanodrug delivery systems that can target atherosclerosis are summarized and discussed. In addition, the future prospects and challenges of its clinical translation are also discussed.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20230015"},"PeriodicalIF":0.0,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11236035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44769604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Near‐infrared light‐responsive Nitric oxide microcarrier for multimodal tumor therapy (3/2023) 近红外光响应型一氧化氮微载体用于多模式肿瘤治疗(3/2023)
Smart medicine Pub Date : 2023-08-01 DOI: 10.1002/smmd.84
D. D. Liang, Gaizhen Kuang, Xiang Chen, Jianhua Lu, Luoran Shang, Weijian Sun
{"title":"Near‐infrared light‐responsive Nitric oxide microcarrier for multimodal tumor therapy (3/2023)","authors":"D. D. Liang, Gaizhen Kuang, Xiang Chen, Jianhua Lu, Luoran Shang, Weijian Sun","doi":"10.1002/smmd.84","DOIUrl":"https://doi.org/10.1002/smmd.84","url":null,"abstract":"","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48756159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional biomaterials for the diagnosis and treatment of peritoneal surface malignancies (3/2023) 功能性生物材料用于腹膜表面恶性肿瘤的诊断和治疗(3/2023)
Smart medicine Pub Date : 2023-08-01 DOI: 10.1002/smmd.83
X. Qin, M. Su, Huili Guo, Binying Peng, Rui Luo, Junwen Ye, H. Wang
{"title":"Functional biomaterials for the diagnosis and treatment of peritoneal surface malignancies (3/2023)","authors":"X. Qin, M. Su, Huili Guo, Binying Peng, Rui Luo, Junwen Ye, H. Wang","doi":"10.1002/smmd.83","DOIUrl":"https://doi.org/10.1002/smmd.83","url":null,"abstract":"","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42690207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomimetic nanoparticles targeting atherosclerosis for diagnosis and therapy (3/2023) 用于诊断和治疗的靶向动脉粥样硬化的仿生纳米颗粒（3/2023）
Smart medicine Pub Date : 2023-08-01 DOI: 10.1002/smmd.82
Yuyu Li, Jifang Wang, Jun Xie
{"title":"Biomimetic nanoparticles targeting atherosclerosis for diagnosis and therapy (3/2023)","authors":"Yuyu Li, Jifang Wang, Jun Xie","doi":"10.1002/smmd.82","DOIUrl":"https://doi.org/10.1002/smmd.82","url":null,"abstract":"","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45550093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Armored probiotics for oral delivery. 用于口服的装甲益生菌
Smart medicine Pub Date : 2023-07-20 eCollection Date: 2023-11-01 DOI: 10.1002/SMMD.20230019
Xinyuan Yang, Chong Wang, Qiao Wang, Zhuohao Zhang, Weimin Nie, Luoran Shang
{"title":"Armored probiotics for oral delivery.","authors":"Xinyuan Yang, Chong Wang, Qiao Wang, Zhuohao Zhang, Weimin Nie, Luoran Shang","doi":"10.1002/SMMD.20230019","DOIUrl":"10.1002/SMMD.20230019","url":null,"abstract":"<p><p>As a kind of intestinal flora regulator, probiotics show great potential in the treatment of many diseases. However, orally delivered probiotics are often vulnerable to unfriendly gastrointestinal environments, resulting in a low survival rate and decreased therapeutic efficacy. Decorating or encapsulating probiotics with functional biomaterials has become a facile yet useful strategy, and probiotics can be given different functions by wearing different armors. This review systematically discusses the challenges faced by oral probiotics and the research progress of armored probiotics delivery systems. We focus on how various functional armors help probiotics overcome different obstacles and achieve efficient delivery. We also introduce the applications of armor probiotics in disease treatment and analyze the future trends of developing advanced probiotics-based therapies.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"1 1","pages":"e20230019"},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46004700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional biomaterials for the diagnosis and treatment of peritoneal surface malignancies. 功能性生物材料在腹膜表面恶性肿瘤诊断和治疗中的应用
Smart medicine Pub Date : 2023-07-13 eCollection Date: 2023-08-01 DOI: 10.1002/SMMD.20230013
Xiusen Qin, Mingli Su, Huili Guo, Binying Peng, Rui Luo, Junwen Ye, Hui Wang
{"title":"Functional biomaterials for the diagnosis and treatment of peritoneal surface malignancies.","authors":"Xiusen Qin, Mingli Su, Huili Guo, Binying Peng, Rui Luo, Junwen Ye, Hui Wang","doi":"10.1002/SMMD.20230013","DOIUrl":"10.1002/SMMD.20230013","url":null,"abstract":"<p><p>Peritoneal surface malignancies (PSM) can originate from tumors in many organs and are highly malignant, and difficult to diagnose and cure, posing a serious threat to the survival of patients. Although the diagnosis and treatment of PSM have made significant progress in the past two decades, numerous challenges remain. Recently, functionalized biomaterials have shown promise for PSM diagnosis and treatment. Hence, we review the progress of functionalized biomaterials for the diagnosis and treatment of PSM. We first introduce the classification and pathogenesis of PSM. We then discuss the applications of functionalized biomaterials for the diagnosis and treatment of PSM. In particular, we focus on functionalized biomaterials as drug carriers for the treatment of PSM, including chemotherapy, immunotherapy, targeted therapy, combination therapy, and other therapies. Finally, we summarized the current challenges and provided a perspective on the diagnosis and treatment of PSM.</p>","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20230013"},"PeriodicalIF":0.0,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43426632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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