Smart medicine最新文献_第7页

Engineered photoresponsive biohybrids for tumor therapy. 用于肿瘤治疗的工程光反应生物杂合体

Smart medicine Pub Date : 2023-03-10 eCollection Date: 2023-05-01 DOI: 10.1002/SMMD.20220041

Xiaocheng Wang, Yazhi Sun, Daniel Wangpraseurt

引用次数: 0

Organ-on-a-chip technologies for biomedical research and drug development: A focus on the vasculature. 用于生物医学研究和药物开发的芯片上器官技术：聚焦血管。

Smart medicine Pub Date : 2023-02-26 Epub Date: 2023-02-24 DOI: 10.1002/SMMD.20220030

Diosangeles Soto Veliz, Kai-Lan Lin, Cecilia Sahlgren

{"title":"Organ-on-a-chip technologies for biomedical research and drug development: A focus on the vasculature.","authors":"Diosangeles Soto Veliz, Kai-Lan Lin, Cecilia Sahlgren","doi":"10.1002/SMMD.20220030","DOIUrl":"10.1002/SMMD.20220030","url":null,"abstract":"Current biomedical models fail to replicate the complexity of human biology. Consequently, almost 90% of drug candidates fail during clinical trials after decades of research and billions of investments in drug development. Despite their physiological similarities, animal models often misrepresent human responses, and instead, trigger ethical and societal debates regarding their use. The overall aim across regulatory entities worldwide is to replace, reduce, and refine the use of animal experimentation, a concept known as the Three Rs principle. In response, researchers develop experimental alternatives to improve the biological relevance of in vitro models through interdisciplinary approaches. This article highlights the emerging organ-on-a-chip technologies, also known as microphysiological systems, with a focus on models of the vasculature. The cardiovascular system transports all necessary substances, including drugs, throughout the body while in charge of thermal regulation and communication between other organ systems. In addition, we discuss the benefits, limitations, and challenges in the widespread use of new biomedical models. Coupled with patient-derived induced pluripotent stem cells, organ-on-a-chip technologies are the future of drug discovery, development, and personalized medicine.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":"2 1","pages":"e20220030"},"PeriodicalIF":0.0,"publicationDate":"2023-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9387060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reconstruction of the alveolar-capillary barrier in vitro based on a photo-responsive stretchable Janus membrane. 基于光响应可拉伸Janus膜的肺泡-毛细血管屏障体外重建

Smart medicine Pub Date : 2023-02-21 eCollection Date: 2023-02-01 DOI: 10.1002/SMMD.20220035

Changmin Shao, Ting Cao, Xiaochen Wang, Qihui Fan, Fangfu Ye

{"title":"Reconstruction of the alveolar-capillary barrier in vitro based on a photo-responsive stretchable Janus membrane.","authors":"Changmin Shao, Ting Cao, Xiaochen Wang, Qihui Fan, Fangfu Ye","doi":"10.1002/SMMD.20220035","DOIUrl":"10.1002/SMMD.20220035","url":null,"abstract":"The lung is the respiratory organ of the human body, and the alveoli are the most basic functional units of the lung. Herein, a photo-responsive stretchable Janus membrane was proposed for the reconstruction of the alveolar-capillary barrier in vitro. This Janus membrane was fabricated by photocrosslinking methylacrylamide gelatin (Gelma) hydrogel and N-isoacrylamide (NIPAM) hydrogel mixed with graphene oxide (GO). The Gelma hydrogel containing large amounts of collagen provides a natural extracellular matrix environment for cell growth, while the temperature-sensitive NIPAM hydrogel combined with GO gives the membrane a light-controlled stretching property. Based on this Janus membrane, an open polydimethylsiloxane chip was established to coculture alveolar epithelial cells and vascular endothelial cells at the air-liquid interface. It was demonstrated that the alveolar epithelial cells cultured on the upper side of the Janus membrane could express epithelial cell marker protein E-cadherin and secrete alveolar surfactant. In addition, VE-cadherin, an endothelium-specific protein located at the junction between endothelial cells, was also detected in vascular endothelial cells cultured on the underside of Janus membrane. The constructed lung tissue model with the dynamically stretchable Janus membrane is well-suited for COVID-19 infection studies and drug testing.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220035"},"PeriodicalIF":0.0,"publicationDate":"2023-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44263932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging antibacterial nanozymes for wound healing. 新兴的用于伤口愈合的抗菌纳米酶

Smart medicine Pub Date : 2023-02-19 eCollection Date: 2023-08-01 DOI: 10.1002/SMMD.20220025

Jingyang Shan, Junyi Che, Chuanhui Song, Yuanjin Zhao

{"title":"Emerging antibacterial nanozymes for wound healing.","authors":"Jingyang Shan, Junyi Che, Chuanhui Song, Yuanjin Zhao","doi":"10.1002/SMMD.20220025","DOIUrl":"10.1002/SMMD.20220025","url":null,"abstract":"Wound infections continuously impose a huge economic and social burden on public healthcare. Despite the effective treatment of bacteria-infected wounds after using traditional antibiotics, the misuse of antibiotics usually causes the spread of bacterial resistance and decreases therapeutic outcomes. Therefore, the development of efficient antibacterial agents is urgently needed. Nanozymes, as a new generation of artificial enzymes, combine the intrinsic abilities of nanomaterials and natural enzymes. Recently, nanozymes has been widely developed to kill bacteria and treat wound infections by catalyzing the generation of various reactive oxygen species. Thus, this new concept of \"antibacterial nanozymes\" will promote the further advances of connecting nanozymes and bacterial elimination. To highlight these achievements, we summarize different types of antibacterial nanozymes for wound healing. It is believed that such a promising therapeutic strategy of developing antibacterial nanozymes will make a great contribution in the field of skin regeneration. We expect that antibacterial nanozymes will play the significant roles in both basic research and clinical applications.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220025"},"PeriodicalIF":0.0,"publicationDate":"2023-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47038523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stimuli-responsive silk fibroin for on-demand drug delivery. 用于按需给药的刺激响应性丝素蛋白

Smart medicine Pub Date : 2023-02-16 eCollection Date: 2023-05-01 DOI: 10.1002/SMMD.20220019

Xiang Lin, Lijun Cai, Xinyue Cao, Yuanjin Zhao

引用次数: 0

Emerging technologies for cardiac tissue engineering and artificial hearts. 心脏组织工程和人工心脏的新兴技术

Smart medicine Pub Date : 2023-02-16 eCollection Date: 2023-02-01 DOI: 10.1002/SMMD.20220040

Lingyu Sun, Yu Wang, Dongyu Xu, Yuanjin Zhao

引用次数: 0

Encoding microcarriers for biomedicine. 用于生物医学的编码微载体

Smart medicine Pub Date : 2023-02-14 eCollection Date: 2023-02-01 DOI: 10.1002/SMMD.20220009

Xiaowei Wei, Yixuan Shang, Yefei Zhu, Zhuxiao Gu, Dagan Zhang

引用次数: 0

Metal protoporphyrin-induced self-assembly nanoprobe enabling precise tracking and antioxidant protection of stem cells for ischemic stroke therapy. 金属原卟啉诱导的自组装纳米探针实现了对干细胞的精确跟踪和抗氧化保护，用于缺血性中风治疗

Smart medicine Pub Date : 2023-02-14 eCollection Date: 2023-02-01 DOI: 10.1002/SMMD.20220037

Yimeng Shu, Hui Shen, Minghua Yao, Jie Shen, Guo-Yuan Yang, Hangrong Chen, Yaohui Tang, Ming Ma

{"title":"Metal protoporphyrin-induced self-assembly nanoprobe enabling precise tracking and antioxidant protection of stem cells for ischemic stroke therapy.","authors":"Yimeng Shu, Hui Shen, Minghua Yao, Jie Shen, Guo-Yuan Yang, Hangrong Chen, Yaohui Tang, Ming Ma","doi":"10.1002/SMMD.20220037","DOIUrl":"10.1002/SMMD.20220037","url":null,"abstract":"Mesenchymal stem cell (MSC)-based therapy has provided a promising strategy for the treatment of ischemic stroke, which is still restricted by the lack of long-term cell tracking strategy as well as the poor survival rate of stem cells in ischemic region. Herein, a dual-functional nanoprobe, cobalt protoporphyrin-induced nano-self-assembly (CPSP), has been developed through a cobalt protoporphyrin IX (CoPP) aggregation-induced self-assembly strategy, which combines CoPP and superparamagnetic iron oxide (SPION) via a simple solvent evaporation-driven method. Without any additional carrier materials, the obtained CPSP is featured with good biocompatibility and high proportions of active ingredients. The SPIONs in CPSPs form a cluster-like structure, endowing this nano-self-assembly with excellent T2-weighted magnetic resonance (MR) imaging performance. Furthermore, the CoPP released from CPSPs could effectively protect MSCs by upregulating heme oxygenase 1 (HO-1) expression. The in vivo cell tracing capacity of CPSPs is confirmed by monitoring the migration of labeled MSCs with MR imaging in a middle cerebral artery occlusion mouse model. More importantly, the sustained release of CoPP from CPSPs improves the survival of transplanted MSCs and promotes neural repair and neurobehavioral recovery of ischemic mice. Overall, this work presents a novel dual-functional nanoagent with an ingenious design for advancing MSC-based therapy.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220037"},"PeriodicalIF":0.0,"publicationDate":"2023-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11236039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42391107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nurturing the marriages of urinary liquid biopsies and nano-diagnostics for precision urinalysis of prostate cancer. 促进尿液活检和纳米诊断的结合，用于前列腺癌的精确尿液分析

Smart medicine Pub Date : 2023-02-14 eCollection Date: 2023-02-01 DOI: 10.1002/SMMD.20220020

Caizhi Liao, Zhihao Wu, Chan Lin, Xiaofeng Chen, Yaqun Zou, Wan Zhao, Xin Li, Guangqi Huang, Baisheng Xu, Giovanni E Briganti, Yan Qi, Xianshu Wang, Tao Zeng, Alain Wuethrich, Hongzhi Zou

{"title":"Nurturing the marriages of urinary liquid biopsies and nano-diagnostics for precision urinalysis of prostate cancer.","authors":"Caizhi Liao, Zhihao Wu, Chan Lin, Xiaofeng Chen, Yaqun Zou, Wan Zhao, Xin Li, Guangqi Huang, Baisheng Xu, Giovanni E Briganti, Yan Qi, Xianshu Wang, Tao Zeng, Alain Wuethrich, Hongzhi Zou","doi":"10.1002/SMMD.20220020","DOIUrl":"10.1002/SMMD.20220020","url":null,"abstract":"Prostate cancer remains the second-most common cancer diagnosed in men, despite the increasingly widespread use of serum prostate-specific antigen (PSA) screening. The controversial clinical implications and cost benefits of PSA screening have been highlighted due to its poor specificity, resulting in a high rate of overdiagnosis and underdiagnosis. Thus, the development of novel biomarkers for prostate cancer detection remains an intriguing challenge. Urine is emerging as a source for prostate cancer biomarker discovery. Currently, new urine biomarkers already outperform serum PSA in clinical diagnosis. Meanwhile, the advances in nanotechnology have provided a suite of diagnostic tools to study prostate cancer in more detail, sparking a new era of biomarker discoveries. In this review, we envision that future prostate cancer diagnosis will probably integrate multiplex nano-diagnostic approaches to detect novel urinary biomarkers. However, challenges remain in differentiating indolent from aggressive cancers to better inform treatment decisions, and clinical translation still needs to be overcome.","PeriodicalId":74816,"journal":{"name":"Smart medicine","volume":" ","pages":"e20220020"},"PeriodicalIF":0.0,"publicationDate":"2023-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11236013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42464952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microfluidic preparation of optical sensors for biomedical applications. 用于生物医学应用的光学传感器的微流体制备

Smart medicine Pub Date : 2023-02-12 eCollection Date: 2023-02-01 DOI: 10.1002/SMMD.20220027

Qiao Wang, Chong Wang, Xinyuan Yang, Jiali Wang, Zhuohao Zhang, Luoran Shang

引用次数: 0