Skin health and disease最新文献_第8页

A sporadic diffuse multiple cutaneous leiomyomatosis mimicking plexiform neurofibromatosis: A surgical challenge. 模仿丛状神经纤维瘤病的散发性弥漫性多发性皮肤线粒体病：手术挑战。

Skin health and disease Pub Date : 2024-08-01 eCollection Date: 2024-10-01 DOI: 10.1002/ski2.414

Gajanand M Antakanavar, Bijaylaxmi Sahoo, Aneet Kaur, Ishu Ghiloria, Ajay Jangid, Bhavishya Shetty

引用次数: 0

Angry back 愤怒的背影

Skin health and disease Pub Date : 2024-07-25 DOI: 10.1002/ski2.428

R.W.D. Ottevanger, Roel E. Genders

引用次数: 0

Trends in disease severity and quality of life outcome measures in pemphigus clinical trials: A scoping review 丘疹性荨麻疹临床试验中疾病严重程度和生活质量结果测量的趋势：范围综述

Skin health and disease Pub Date : 2024-07-24 DOI: 10.1002/ski2.429

G. Pathak, Kush Patel, Christopher Wachuku, T. Truong, Priya Agarwal, Babar K. Rao

{"title":"Trends in disease severity and quality of life outcome measures in pemphigus clinical trials: A scoping review","authors":"G. Pathak, Kush Patel, Christopher Wachuku, T. Truong, Priya Agarwal, Babar K. Rao","doi":"10.1002/ski2.429","DOIUrl":"https://doi.org/10.1002/ski2.429","url":null,"abstract":"Pemphigus represents a spectrum of autoimmune‐mediated blistering diseases associated with high morbidity, mortality and reduced quality of life (QoL). Despite an increase in pemphigus clinical trials, the varied instrument measurements of disease severity and QoL outcomes make comparisons between studies challenging. This study aimed to evaluate trends in the use of disease severity and QoL outcome measurements in pemphigus clinical trials. A review of pemphigus clinical trials was conducted using the PubMed, Embase, Cochrane Reviews and ClinicalTrials.gov databases up until September 2023. Only pemphigus randomized clinical trials that assessed at least one disease severity and/or QoL outcome were included. Overall, 53 clinical trials were eligible for this review. All clinical trials evaluated a disease severity outcome, with the Pemphigus Disease Area Index being the most used validated questionnaire (28.3% of trials) and more popular after 2015 (47.8% of trials since). The autoimmune bullous skin disorder intensity score (7.6%) and visual analogue measurements (7.6%) have fallen out of favour. Most studies now include lab parameters (56.5% of trials after 2015), with anti‐desmoglein 1 and 3 antibody levels (30.2%), immunoglobulins (IgG and/or IgM and IgA) (11.3%), and anti‐drug antibody levels (7.6%) being frequently evaluated. A small portion of trials evaluated QoL (26.5% of studies), with the autoimmune bullous quality of life being the most common (15.1%), however QoL utilization as an outcome measure has been increasing since 2015 (61.1% of trials since). Standardising the use of validated outcome measurements allows for better data interpretation, comparability and clinical application of results.","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"58 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141807091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID‐19 vaccination‐linked granuloma annulare in two patients 两名患者出现与 COVID-19 疫苗接种相关的环状肉芽肿

Skin health and disease Pub Date : 2024-07-24 DOI: 10.1002/ski2.412

Emma McIntyre, Philina Lamb, Maxwell A. Fung, Maija Kiuru, Lawrence S. Chan

引用次数: 0

Potential role of mindfulness in the adjuvant treatment of atopic dermatitis 正念在特应性皮炎辅助治疗中的潜在作用

Skin health and disease Pub Date : 2024-07-23 DOI: 10.1002/ski2.423

Filomena Russo, A. Dattolo, D. Sordi, A.R. Giampetruzzi, Ornella de Pità, Annarita Panebianco, B. Cocuroccia

引用次数: 0

Rapidly progressing scalp melanoma in an elderly patient 一名老年患者快速进展的头皮黑色素瘤

Skin health and disease Pub Date : 2024-07-22 DOI: 10.1002/ski2.431

Christian Vestli, Assia Bassarova, Jose Hernán Alfonso

引用次数: 0

Linear atrophoderma of Moulin: A rare case report and review of the literature 穆兰线性萎缩性皮肤病：罕见病例报告和文献综述

Skin health and disease Pub Date : 2024-07-21 DOI: 10.1002/ski2.424

Moatasem Hussein Al‐janabi, Sdrah Diab, Ghina Aljammal, Lina Kassab, Z. Al-shehabi, Lina Al‐Soiufi

{"title":"Linear atrophoderma of Moulin: A rare case report and review of the literature","authors":"Moatasem Hussein Al‐janabi, Sdrah Diab, Ghina Aljammal, Lina Kassab, Z. Al-shehabi, Lina Al‐Soiufi","doi":"10.1002/ski2.424","DOIUrl":"https://doi.org/10.1002/ski2.424","url":null,"abstract":"Linear atrophoderma of Moulin (LAM) is an uncommon dermatological disease characterised by linear, depressed plaques typically following Blaschko's lines. LAM generally occurs in adolescence or early adulthood and is more commonly observed in females. The aetiology of LAM is still unclear. We report a rare case of LAM in an 18‐year‐old female presenting with an atypical Blaschkoid distribution (multiple band‐like pattern) on her right trunk. A clinical examination and histopathological analysis were performed to make the diagnosis. Partial improvement was obtained with calcipotriol and colchicine. LAM is a rare condition; we were only able to identify 23 case reports in the published literature. The findings of this report contribute to the limited literature on LAM, highlighting the clinical variability of LAM and suggesting potential novel variants beyond the classic presentation, emphasising the importance of recognising diverse manifestations for accurate diagnosis and management. Early recognition of LAM is crucial for appropriate treatment and improved patient outcomes. Further research is needed to elucidate LAM's aetiology and underlying mechanisms to facilitate the development of more targeted therapeutic strategies.","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"46 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141818101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clear cell renal cell carcinoma micrometastasis: Insights from an unconventional cutaneous presentation 透明细胞肾细胞癌微转移：非传统皮肤表现的启示

Skin health and disease Pub Date : 2024-07-19 DOI: 10.1002/ski2.427

Mohammad Fardos, Heather Kopecky, James Sligh, Jill Browning

引用次数: 0

Epigenetics and ultraviolet radiation: Implications for skin ageing and carcinogenesis 表观遗传学和紫外线辐射：对皮肤老化和癌变的影响

Skin health and disease Pub Date : 2024-07-05 DOI: 10.1002/ski2.410

Bethany M. Barnes, Anya Shyne, David A. Gunn, Christopher E. M. Griffiths, Rachel E. B. Watson

{"title":"Epigenetics and ultraviolet radiation: Implications for skin ageing and carcinogenesis","authors":"Bethany M. Barnes, Anya Shyne, David A. Gunn, Christopher E. M. Griffiths, Rachel E. B. Watson","doi":"10.1002/ski2.410","DOIUrl":"https://doi.org/10.1002/ski2.410","url":null,"abstract":"Recent published data have highlighted the importance of epigenetics in the response of the skin to recreational and therapeutic ultraviolet radiation (UVR) exposure. ‘Epi’—from the Greek επί, meaning over, outside of or around—relates to the chemical modifications that occur on top of the DNA sequence (for example, DNA methylation) and its associated proteins (e.g. histone modifications, including methylation, acetylation and phosphorylation). These epigenetic processes, collectively called the ‘epigenome’, dictate the three‐dimensional conformation of the DNA, thus impacting upon gene expression and genomic stability. Given that epigenetic changes are long‐lived and mitotically heritable, an accumulation of epigenetic perturbations likely influence the pathogenesis of the chronic consequences of UVR exposure, including photoageing and skin cancer risk. In this review, we describe the multifarious epigenetic effects elicited by UVR in the skin. We further speculate on the underlying molecular mechanisms that may direct epigenetic changes, such as oxidative stress and changes in metabolism, and their impact on skin health and disease.","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141674174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review of outcome measures evaluating treatment efficacy in vulval lichen sclerosus and evaluation of patients' priorities 外阴硬皮病疗效评估指标的系统性审查和患者优先权评估

Skin health and disease Pub Date : 2024-07-05 DOI: 10.1002/ski2.422

Sara Jasionowska, A. Almadori, Mary Goble, B. Langridge, D. Iakovou, Fady Kamel, Milla McKenzie, Allan Mclean, D. Boyle, N. Zenner, V. Swale, Peter E. M. Butler

{"title":"A systematic review of outcome measures evaluating treatment efficacy in vulval lichen sclerosus and evaluation of patients' priorities","authors":"Sara Jasionowska, A. Almadori, Mary Goble, B. Langridge, D. Iakovou, Fady Kamel, Milla McKenzie, Allan Mclean, D. Boyle, N. Zenner, V. Swale, Peter E. M. Butler","doi":"10.1002/ski2.422","DOIUrl":"https://doi.org/10.1002/ski2.422","url":null,"abstract":"Vulval lichen sclerosus (VLS) is an inflammatory skin disease characterised by itching, apareunia, loss of vulval architecture and scarring. Heterogeneity in outcome reporting precludes comparison between treatments. This study aimed to systematically review outcome measures used to evaluate the efficacy of VLS treatments and present patients' treatment priorities. This review followed the PRISMA guidelines using a registered protocol (PROSPERO: CRD42022356738). Multiple databases were searched, along with grey literature on Clinicaltrials.gov, European Union Clinical Trials and International Standard Randomised controlled trial (RCT) registries. All RCTs assessing any treatment for VLS were eligible for inclusion. A total of 775 patients were assessed across 21 RCTs. The assessment tools reported outcomes in the following domains: patient‐reported symptoms assessed with one validated scale in 12 studies and seven non‐validated scales in nine studies; sexual function with validated female sexual function index and female sexual distress scale in two studies and two non‐validated scales in two studies; quality of life with three validated scales in three studies and clinician‐reported objective outcomes with two validated scales in three studies and six non‐validated scales in fourteen studies. Histological changes were assessed in 10 studies and tissue biomechanics in one study. We also carried out an online survey completed by 809 women with VLS to assess their research and disease treatment priorities and identified validated outcome measures to assess these. There is high variability in assessing treatment outcomes for VLS. We identified validated assessment tools which could be implemented in VLS studies to evaluate the effectiveness of treatments.","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141676613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0