Skin health and disease最新文献

{"title":"Irish dermatologists' experience with JAK inhibitors in alopecia areata.","authors":"Cristina Grechin, Marina O'Kane","doi":"10.1093/skinhd/vzag001","DOIUrl":"https://doi.org/10.1093/skinhd/vzag001","url":null,"abstract":"<p><p>Despite a European expert consensus statement on the systemic treatment of alopecia areata, the absence of global guidelines and limited information on the long-term safety of JAKi use still poses challenges to clinicians. A cross-sectional survey was conducted to assess the use of JAKi in AA among consultant dermatologists in Ireland.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 2","pages":"180-183"},"PeriodicalIF":0.0,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leukaemia cutis as a late, isolated extramedullary relapse: a case report of a patient with acute myeloid leukaemia 6 years after allogeneic bone marrow transplantation and remission.","authors":"Fatemeh Montazer, Sina Karaji, Nima Dastgir","doi":"10.1093/skinhd/vzaf070","DOIUrl":"https://doi.org/10.1093/skinhd/vzaf070","url":null,"abstract":"<p><p>Leukaemia cutis (LC) is characterized by the infiltration of leukaemic cells into skin tissue, presenting as various skin lesions. It can signal relapse or coexist with extramedullary or systemic relapses. Extramedullary relapse, particularly in sanctuary sites like the skin, remains a clinical challenge, demanding investigation into mechanisms and monitoring strategies. We present a unique case of isolated extramedullary relapse manifesting as LC, 6 years after successful allogeneic bone marrow transplantation for acute myeloid leukaemia. A 24-year-old man exhibited a cutaneous nodule on his scalp, prompting comprehensive evaluation. Despite achieving complete remission post-transplantation, a core needle biopsy confirmed LC. Extensive assessments, including blood tests and bone marrow biopsy, returned normal results. As the disease was confined to skin, the patient received local radiotherapy. This case instead highlights the overall challenge of detecting and treating late, isolated extramedullary relapse.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 2","pages":"146-149"},"PeriodicalIF":0.0,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin conditions in persons living with HIV during hospital admission in the UK.","authors":"Jamie McCluskey, Louis Hickling, Collins Iwuji, David J Chandler","doi":"10.1093/skinhd/vzaf116","DOIUrl":"https://doi.org/10.1093/skinhd/vzaf116","url":null,"abstract":"<p><strong>Background: </strong>The range of skin disease associated with advanced HIV infection is well described. Effective antiretroviral therapy has modified the spectrum of skin disease associated with HIV infection.</p><p><strong>Objectives: </strong>To characterize the profile of skin conditions occurring in a UK population of people living with HIV (PLHIV) during admission to a tertiary hospital.</p><p><strong>Methods: </strong>A retrospective review of inpatient admission records was conducted for all patients admitted to a tertiary hospital between January 2018 and December 2022. Data were collected using a standardized data extraction form and analysed with Microsoft Excel using descriptive statistics.</p><p><strong>Results: </strong>We identified 199 patients [median age 53 years; interquartile range (IQR) 41.5-63.0]. The median duration of HIV infection was 12.75 years (IQR 6.10-19.58), with a median duration on antiretroviral therapy of 8 years (IQR 0-14) and a median CD4 count of 368 (IQR 90-656) on admission. In total, 303 cases of skin disease were identified; the majority were skin infections (<i>n</i> = 164; 54.1%), followed by inflammatory dermatoses (<i>n</i> = 53; 17.5%), skin tumours (<i>n</i> = 39; 12.9%) and drug reactions (<i>n</i> = 13; 4.3%). In 11.2% of cases (<i>n</i> = 34), the diagnosis was unknown. Of the primary skin infections seen, 45.7% (<i>n</i> = 75/164) were bacterial, 26.8% (<i>n</i> = 44/164) were viral, 22.0% (<i>n</i> = 36/164) were fungal and 2.4% (<i>n</i> = 4/164) were parasitic. The most common condition was cellulitis, which occurred in 45 patients (22.6%). Sixty patients (30.2%) presented with advanced HIV infection (CD4 <200 cells mm^-3). The most common conditions in this group were oral candidiasis (<i>n</i> = 21; 35%), herpes simplex virus infection (<i>n</i> = 12; 20%), seborrhoeic dermatitis (<i>n</i> = 9; 15%) and Kaposi sarcoma (<i>n</i> = 9; 15%).</p><p><strong>Conclusions: </strong>Cutaneous infection was the most common category of skin problem in this population of PLHIV during hospital admission. Bacterial cellulitis was the most common dermatological condition overall, while oral candidiasis was the most common condition in those with advanced HIV infection. Further work is needed to better characterize the profile of skin disease in PLHIV, including in larger prospective cohorts and outpatient settings.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 2","pages":"119-124"},"PeriodicalIF":0.0,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A waxy wonder: unveiling a rare dermatological mystery.","authors":"Ji Fung Yong, Li Jie Helena Yoo, Stephen Crowther, Anne-Marie Tobin, Maureen Connolly","doi":"10.1093/skinhd/vzaf120","DOIUrl":"https://doi.org/10.1093/skinhd/vzaf120","url":null,"abstract":"<p><p>A 75-year-old White woman was seen in the dermatology clinic for evaluation of a skin lesion on the right shin of unknown duration. The lesion's slightly atypical appearance made it stand out from the other benign moles present. An excisional biopsy was performed to reach a definitive diagnosis.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 2","pages":"177-179"},"PeriodicalIF":0.0,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-year outcome trends in Japanese patients with rosacea: insights from a real-world study.","authors":"Yoshimasa Nobeyama, Yoshiko Aihara","doi":"10.1093/skinhd/vzaf124","DOIUrl":"https://doi.org/10.1093/skinhd/vzaf124","url":null,"abstract":"<p><strong>Background: </strong>Rosacea is a chronic inflammatory disorder that primarily affects the facial region, significantly impacting quality of life (QOL). Outcomes in patients with rosacea may vary significantly depending on ethnicity, climatic conditions, healthcare system and cultural background. After unifying these factors, outcomes in rosacea should be evaluated over the long term.</p><p><strong>Objectives: </strong>To examine long-term outcomes in Japanese patients with rosacea using data obtained from a single institution.</p><p><strong>Methods: </strong>In this retrospective observational study, data from 63 Japanese patients with rosacea, including 42 patients who were followed up over 1 year, were analysed. Patients were treated with topical agents, with or without oral minocycline, and advised to avoid common triggers such as sun exposure and skin dryness. These data were evaluated using the Dermatology Life Quality Index (DLQI), visual analogue scale (VAS) and Investigator's Global Assessment (IGA) scoring systems.</p><p><strong>Results: </strong>Baseline data for the 63 patients showed that QOL was commonly impaired by uncomfortable sensations, such as itch, as well as by disfigurement. Most patients considered rosacea to have a small-to-moderate impact on their lives. DLQI scores were significantly correlated with VAS scores for itch, burning sensation, flushing and hypersensitivity. IGA scores were significantly correlated with VAS scores for flushing and with DLQI scores. Follow-up data for 42 patients over 1 year showed that VAS scores for itch, burning sensation, flushing and hypersensitivity, as well as DLQI and IGA scores, were significantly decreased over time. Topical therapies did not affect the scores throughout the clinical course.</p><p><strong>Conclusions: </strong>This study was conducted at a single institution in a specific geographical and climatic setting for Japanese patients with rosacea. These findings may inform follow-up care for Japanese patients and contribute to the exploration of ethnic and geographical variations in the presentation and progression of rosacea.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 2","pages":"138-145"},"PeriodicalIF":0.0,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importance of alexithymia on anxiety and depression in alopecia areata: a cohort study.","authors":"Johan Fhager, Karin Örmon, Åke Svensson, Karin Sjöström","doi":"10.1093/skinhd/vzaf092","DOIUrl":"https://doi.org/10.1093/skinhd/vzaf092","url":null,"abstract":"<p><strong>Background: </strong>Alopecia areata (AA) is an autoimmune hair loss disease, considered a psychosomatic disease with comorbid symptoms of depression and anxiety. Alexithymia, defined as difficulties in recognizing and describing feelings, has been found to be a vulnerability factor for developing anxiety and depression and somatic disease. The psychological burden of AA needs to be further investigated in larger studies by using standardized instruments developed to identify alexithymia, and clinical depression and anxiety. The outcome is important when treating patients with AA as well as for decisions on treatment.</p><p><strong>Objectives: </strong>To explore the prevalence of alexithymia and its subtypes and how they relate to depressive and anxiety symptoms in patients with AA.</p><p><strong>Methods: </strong>In this cohort study 100 patients with AA were interviewed about sociodemographic data, AA disease variables, and previous and present mental health. The Beck Depression Inventory-II (BDI-II), the Beck Anxiety Inventory (BAI) and the Toronto Alexithymia Scale-20 (TAS-20) were used to identify alexithymia, depression and anxiety. Associations between alexithymia and subtype scores - difficulties identifying feelings (DIF), difficulties describing feelings (DDF) and externally oriented thinking (EOT) - were analysed in relation to depression and anxiety scores. Relations between alexithymia, depressive and anxiety scores, and AA and sociodemographic variables were examined.</p><p><strong>Results: </strong>Prevalences of depression, anxiety and alexithymia in patients with AA were 16% (<i>n</i> = 16/100), 22% (<i>n</i> = 22/100) and 32% (<i>n</i> = 32/100), respectively. There was a statistically significant relation between DIF and anxiety and between DIF, DDF and depression. Lower levels of education were related to alexithymia, depression and anxiety symptoms. Alexithymia was statistically significantly more frequent among those who were younger at AA onset, in the relapsing form of AA and with nonfamilial AA. Previous mental affective illness was reported in 77% (<i>n</i> = 77/100) of patients with AA during the life course.</p><p><strong>Conclusions: </strong>Patients with AA had a higher prevalence of depression, anxiety and alexithymia compared with normative data. Alexithymia was found among those with earlier AA onset, younger age at interview and lower educational levels. Higher EOT scores were found among those with anxiety and lower education.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 2","pages":"94-102"},"PeriodicalIF":0.0,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teleconsultations for Eczema in CHildren (TECH) feasibility study: a mixed-methods study with adolescents and parents.","authors":"Natalie King Stokes, Aoife Daly, Sarah McCusker, Manrup Hunjan, Ellen Vincent, Ashima Lowe, Carolyn Charman, Jonathan Mathers, Lea Solman, Susannah George, Esther Burden-Teh","doi":"10.1093/skinhd/vzaf123","DOIUrl":"https://doi.org/10.1093/skinhd/vzaf123","url":null,"abstract":"<p><strong>Background: </strong>Teleconsultations form a key component of the National Health Service's Long Term Plan, outpatient recovery and -transformation, and commitment to net zero. There is currently little evidence to inform their delivery within paediatric dermatology, a specialty that is increasingly difficult to access. Teleconsultations may offer convenience and widen access for patients, particularly for follow-up of chronic conditions such as eczema.</p><p><strong>Objectives: </strong>To explore patients' and parents' experiences and perceptions of teleconsultations for follow-up of eczema in secondary or tertiary care; to identify components of acceptability of different consultation types and explore how teleconsultations could be optimized; and to obtain views of a potential trial comparing face-to-face appointments with teleconsultations for paediatric eczema follow-up.</p><p><strong>Methods: </strong>A mixed-methods study comprising an online survey and qualitative interviews with patients and parents of children with eczema, who had experience of teleconsultations under secondary or tertiary care, was carried out. An online survey was completed by eligible adolescents and parents. The results informed subsequent semi-structured interviews, conducted with patients and parents, and responses were analysed thematically using framework analysis.</p><p><strong>Results: </strong>Survey responses from 31 parents and 20 adolescents were analysed. Overall, 41% were 'satisfied or very satisfied' following telephone appointments vs. 71% for video and 40% for online or mobile messaging. Preferred consultation type was face-to-face in 67%, with 31% preferring a combination of face-to-face and teleconsultations. Some 41% of participants were interested in participating in a trial comparing face-to-face and teleconsultations for eczema follow-up. Qualitative interviews were conducted with 10 parents and 2 adolescents. Six overarching themes were constructed from the interview data: the value of a dermatology appointment, what is important in an eczema consultation, concerns about patient assessment, complexity of acceptability, patient choice and optimizing teleconsultations.</p><p><strong>Conclusions: </strong>While there was a preference for face-to-face consultations, teleconsultations were acceptable in certain situations, such as for stable eczema or to avoid missing school. Patient perspectives of how teleconsultations could be improved include sending photographs before the appointment and clinician training. This study suggests that directly comparing face-to-face appointments with teleconsultations in a future trial is unlikely to be feasible. A hybrid intervention combining face-to-face and teleconsultation would be more acceptable to patients and parents.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 2","pages":"125-137"},"PeriodicalIF":0.0,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between mental health and disease severity in individuals with psoriasis.","authors":"Eva Fleischmann, Melanie Lenger, Frederike T Fellendorf, Nina Dalkner, Eva Z Reininghaus, Katja Großschaedl, Wolfgang Weger, Thomas Graier, Wolfgang Salmhofer, Rainer Hofmann-Wellenhof, Peter Wolf","doi":"10.1093/skinhd/vzaf108","DOIUrl":"https://doi.org/10.1093/skinhd/vzaf108","url":null,"abstract":"<p><strong>Background: </strong>Psoriasis and mental health are closely intertwined; however, certain aspects remain underexplored. Thus, continued research on this topic is important to deepen our understanding.</p><p><strong>Objectives: </strong>To explore the mental health of individuals with psoriasis - specifically depressive symptoms, mental functioning, stress symptoms and coping strategies - and to find associations with physical manifestations of psoriasis.</p><p><strong>Methods: </strong>A cross-sectional sample of 214 individuals with psoriasis (107 with illness duration >16 years and 107 with illness duration ≤16 years; cut-off: median) completed the Beck Depression Inventory-II, the SF-12 measuring mental and physical functioning, and the Stress and Coping Inventory. Additionally, the Psoriasis Area and Severity Index (PASI) was assessed. The study was conducted during the COVID-19 pandemic.</p><p><strong>Results: </strong>Individuals with psoriasis reported worse mental and physical health than the general population (norm sample of SF-12) but did not differ significantly from each other. While individuals with illness duration >16 years had lower psoriasis severity than those with illness duration ≤16 years, mean PASI scores indicated low illness severity overall. PASI scores did not show significant correlations with mental health inventories in either group.</p><p><strong>Conclusions: </strong>Individuals with psoriasis reported lower mental health during the COVID-19 pandemic than a healthy, prepandemic norm sample, independent of psoriasis severity. Age and illness duration seem to facilitate coping with the disease. Nevertheless, individuals with psoriasis are in need of continued mental health support, regardless of illness duration.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 2","pages":"112-118"},"PeriodicalIF":0.0,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highlighting a histopathological dilemma: atypical dermatofibrosarcoma protuberans diagnosed with multimodal dermoscopy.","authors":"Varun H, Adarshlata Singh, Ambika Kondalkar, Bhushan Madke, Vangala Naga Nitya, Anurag Mittal, Gayathri Bomma Reddy","doi":"10.1093/skinhd/vzaf113","DOIUrl":"https://doi.org/10.1093/skinhd/vzaf113","url":null,"abstract":"<p><p>An adult male agricultural worker presented with an asymptomatic, heterogeneously pigmented, indurated nodule featuring multiple protuberances on the left pelvic skin. Cross-polarized dermoscopy revealed pink structureless areas and a hyperpigmented reticular network; yellow light dermoscopy accentuated the pigmentary network and entangling vasculature. Ultraviolet-induced fluorescence dermoscopy demonstrated blue-white autofluorescence of surface keratin and milky-white fluorescence of the collagenous/myxoid stroma. Histopathology showed a monomorphic spindle-cell infiltrate without atypia; immunohistochemistry (IHC) confirmed a CD34-positive, S100-negative spindle-cell neoplasm consistent with a myxoid variant of dermatofibrosarcoma protuberans. This case highlights the diagnostic utility of multimodal dermoscopy integrated with histopathology and supportive IHC in precisely evaluating atypical cutaneous tumours.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 2","pages":"171-176"},"PeriodicalIF":0.0,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatological diagnoses among people experiencing homelessness in the USA.","authors":"Reneé Haughton, Derek Chen, Samantha Herbert, Stephen Shiboski, Jinoos Yazdany, Aileen Y Chang","doi":"10.1093/skinhd/vzaf095","DOIUrl":"10.1093/skinhd/vzaf095","url":null,"abstract":"<p><strong>Background: </strong>The experience of homelessness is a growing problem in the USA. Environmental exposures, chronic medical conditions and barriers to personal hygiene could increase risk of dermatological disease.</p><p><strong>Objectives: </strong>To evaluate the association of homelessness with receiving a dermatological diagnosis and to compare dermatological diagnoses between unhoused and housed individuals.</p><p><strong>Methods: </strong>We conducted a cross-sectional study of the 'All of Us' database, a national dataset from the USA with detailed participant-reported housing information. We constructed logistic regression models with dermatological diagnosis as binary outcome, housing status as binary exposure, and age, gender, race and ethnicity, geographical region, educational attainment, serious mental illness, alcohol-use disorder, and cocaine, opioid or stimulant drug use as confounders.</p><p><strong>Results: </strong>Among 257 701 participants, people experiencing homelessness had lower odds of being diagnosed with any dermatological disease [adjusted odds ratio (aOR) 0.68, 95% confidence interval (CI) 0.63-0.72; <i>P</i> < 0.001]. Of participants with at least one dermatological diagnosis, people experiencing homelessness had greater odds of being diagnosed with bacterial skin infections (aOR 2.20, 95% CI 1.5-2.50; <i>P</i> < 0.001) and ectoparasitic disease (aOR 3.12, 95% CI 2.30-4.17; <i>P</i> < 0.001) but lower odds of all other diseases.</p><p><strong>Conclusions: </strong>Our results underscore the need to improve access to care and water, sanitation and hygiene services for people experiencing homelessness to reduce risk of bacterial skin infection and ectoparasitic infestations.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 2","pages":"103-111"},"PeriodicalIF":0.0,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}