Cutaneous small vessel vasculitis in the COVID-19 era: a systematic review.

Q3 Medicine
Skin health and disease Pub Date : 2025-04-22 eCollection Date: 2025-04-01 DOI:10.1093/skinhd/vzaf004
Katherine Oakley Olson, Siddharth Patel, Prutha Pathak, Lucy Page Kelly, Mc Anto Antony, Mrudula Thiriveedi
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引用次数: 0

Abstract

Background: Dermatological adverse effects may occur after COVID-19 infection or vaccine administration. Since the beginning of the pandemic, several case reports and systematic reviews have been published on vasculitis associated with both COVID-19 infection and vaccination. Fever, malaise, urticaria, and rash are common symptoms of COVID-19. These symptoms can also occur as adverse reactions to COVID-19 vaccines. However, the occurrence of serious autoimmune reactions due to COVID-19 infection or its vaccine is rare. Cutaneous small vessel vasculitis (CSVV) is an autoimmune disorder that manifests with palpable purpura and petechiae involving the extremities. It results from neutrophilic inflammation within and around dermal vessels and is usually self-limited.

Objective: We provide a thorough systematic review on CSVV occurring in the COVID-19 era.

Methods: We followed the PRISMA 2020 checklist for systematic review, searching PubMed, Google Scholar, Cochrane, and Embase. We included case reports, case series, correspondence articles, and letters to the editor written in English. Characteristics of each were then summarized and analyzed.

Results: 39 cases were included in our review - 27 due to the COVID-19 vaccine and 12 due to COVID-19 infection. Mean age of onset was similar, but mean time to onset was sooner in the vaccination group. Common treatments included systemic steroids, and almost all patients experienced complete recovery with the exception of a few patients in the COVID-19 infection cohort.

Conclusion: While most cases are self-limiting and resolve with no long-term sequalae, the occurrence of more severe reactions appears to be associated with COVID-19 infection rather than with vaccination.

COVID-19时代皮肤小血管炎:系统综述
背景:COVID-19感染或接种疫苗后可能发生皮肤不良反应。自大流行开始以来,已就与COVID-19感染和疫苗接种相关的血管炎发表了若干病例报告和系统综述。发烧、不适、荨麻疹和皮疹是COVID-19的常见症状。这些症状也可能是COVID-19疫苗的不良反应。然而,由于COVID-19感染或其疫苗而发生严重自身免疫反应的情况很少见。皮肤小血管炎(CSVV)是一种自身免疫性疾病,表现为可触及的紫癜和累及四肢的瘀点。它是由皮肤血管内和周围的中性粒细胞炎症引起的,通常是自限性的。目的:对COVID-19时代发生的csv进行全面系统的综述。方法:我们按照PRISMA 2020检查表进行系统评价,检索PubMed、谷歌Scholar、Cochrane和Embase。我们收录了用英语写的病例报告、病例系列、通信文章和给编辑的信。然后对每一种的特点进行总结和分析。结果:39例纳入我们的综述,其中27例因接种COVID-19疫苗,12例因COVID-19感染。平均发病年龄相似,但接种组的平均发病时间更早。常见的治疗方法包括全身性类固醇,除了COVID-19感染队列中的少数患者外,几乎所有患者都完全康复。结论:虽然大多数病例是自限性的,且无长期后遗症,但更严重的反应的发生似乎与COVID-19感染有关,而不是与疫苗接种有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.70
自引率
0.00%
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