Skin health and disease最新文献

{"title":"The important role of palpation in the examination of solitary skin lesions: mnemonic of three T's.","authors":"Alexander Salava","doi":"10.1093/skinhd/vzaf115","DOIUrl":"https://doi.org/10.1093/skinhd/vzaf115","url":null,"abstract":"<p><p>The author describes an easy applicable three-step teaching method to increase learning outcomes in dermatology education and physical examination: the mnemonic of three T's. It summarizes the three most important aspects of palpation in a methodologically simple to learn and stepwise manner and can be used to systematize teachings, indicating the important role of palpation, and to enhance communication and student motivation.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 2","pages":"184-185"},"PeriodicalIF":0.0,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Verrucous form of Hansen disease: a diagnostic dilemma.","authors":"Prajwal Pudasaini, Sushil Paudel, Sagar Gc, Bandana Parajuli, Prashanta Pudasaini, Esna Thapa, Faisal Dubash","doi":"10.1093/skinhd/vzaf114","DOIUrl":"https://doi.org/10.1093/skinhd/vzaf114","url":null,"abstract":"<p><p>In a leprosy endemic country like Nepal, Hansen disease should always be kept in the list of differential diagnoses due to its varied clinical features and also it being a common mimicker.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 2","pages":"186-188"},"PeriodicalIF":0.0,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting ST18-mediated pathomechanism in pemphigus vulgaris through voltage-dependent anion channel inhibition.","authors":"Sari Assaf, Ofer Sarig, Rawaa Ishtewy, Yazeed Zoabi, Yarden Feller, Kiril Malovitski, Janan Mohamad, Shir Bergson, Carmel Bilu, Varda Shoshan-Barmatz, Noam Shomron, Dan Vodo, Liat Samuelov, Eli Sprecher","doi":"10.1093/skinhd/vzaf107","DOIUrl":"https://doi.org/10.1093/skinhd/vzaf107","url":null,"abstract":"<p><strong>Background: </strong>Pemphigus vulgaris (PV), a severe mucocutaneous blistering disease, results from autoantibody-mediated destabilization of epidermal cell-cell adhesion. A functional risk variant at the ST18 locus was found to promote epidermal ST18 expression. Increased ST18 expression was found to aggravate the deleterious effect of PV autoantibodies in part through induction of p53-mediated proapoptotic pathways. The voltage-dependent anion channel (VDAC) is a key regulator of mitochondria-mediated apoptosis.</p><p><strong>Objectives: </strong>To delineate the interplay between ST18 and VDAC in apoptosis regulation, and the therapeutic potential of VDAC inhibitors in PV.</p><p><strong>Methods: </strong>We used global RNA sequencing (RNAseq) of human keratinocytes to assess ST18-dependent changes in <i>VDAC1</i>, <i>VDAC2</i>, <i>VDAC3</i> and <i>BCL2</i> expression. Immunostaining of skin biopsies was used to evaluate VDAC1 in patients with PV. Apoptotic activity was analysed by caspase 3/7 and TUNEL apoptosis assays, while immunoblotting and a luciferase reporter assay assessed Bcl-2 and p53 pathways. The dispase dissociation assay was used to ascertain the effect VDAC inhibition had on acantholysis.</p><p><strong>Results: </strong>Keratinocytes overexpressing ST18 showed upregulation of <i>VDAC1</i>, <i>VDAC2</i> and <i>VDAC3</i>, which encode VDAC, and downregulation of <i>BCL2</i>, which encodes the antiapoptotic protein Bcl-2. Of interest, mitochondrial VDAC and p53 antagonize Bcl-2 activity. Patients with PV had dramatically increased epidermal VDAC1 expression. Keratinocytes exposed to AK23, a pathogenic antidesmoglein 3 antibody, and overexpressing ST18, exhibited elevated apoptotic activity. VBIT-12, a VDAC oligomerization inhibitor, robustly attenuated this response and concomitantly led to upregulation of Bcl-2 and to downregulation of p53 transcriptional activity. This suggested that inhibition of VDAC -proapoptotic activity may prevent cell-cell disadhesion in PV. Indeed, VBIT-12 was found to efficiently prevent acantholysis due to PV IgG/AK23.</p><p><strong>Conclusions: </strong>Our findings identify VDAC as a novel factor in the pathogenesis of PV and thus as an innovative and attractive therapeutic target for the treatment of this disease.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 2","pages":"150-159"},"PeriodicalIF":0.0,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capillary malformations in unusual territory: Klippel-Trénaunay syndrome with penoscrotal involvement.","authors":"Mahesh Mathur, Sumit Paudel, Nabita Bhattarai, Sandhya Regmi, Himanshu Pathak, Sambidha Karki","doi":"10.1093/skinhd/vzaf103","DOIUrl":"https://doi.org/10.1093/skinhd/vzaf103","url":null,"abstract":"<p><p>Klippel-Trénaunay syndrome (KTS) is a rare congenital vascular disorder that typically presents with capillary and venous malformations, limb hypertrophy and, in some cases, lymphatic abnormalities. We report a 3-year-old boy with extensive vascular malformations affecting the left lower limb, predominantly involving the penoscrotal region - an uncommon presentation without systemic involvement. This case illustrates the diagnostic complexity of genitourinary KTS and emphasizes the need for vigilant monitoring, multidisciplinary input and tailored management to reduce complications and improve long-term outcomes.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 2","pages":"164-167"},"PeriodicalIF":0.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breaking the cycle: successful long-term remission of chronic erythema multiforme with rituximab therapy.","authors":"Hira Ghani, Zaim Haq, Isabella Tan, Anthony Reginato, Abrar A Qureshi","doi":"10.1093/skinhd/vzaf105","DOIUrl":"https://doi.org/10.1093/skinhd/vzaf105","url":null,"abstract":"<p><p>Erythema multiforme (EM) is an immune-mediated condition marked by recurrent targetoid lesions, occasionally involving mucous membranes. Chronic or treatment-resistant cases can be difficult to manage, with limited options when standard therapies fail. We report a 37-year-old man with long-standing, refractory EM who experienced frequent flares despite trials of corticosteroids, antivirals, dapsone, methotrexate, hydroxychloroquine, ciclosporin, thalidomide and intravenous immunoglobulin. After receiving two rituximab infusions, the patient achieved complete remission, and remained symptom-free and off systemic treatment at the 5-year follow-up. This case highlights the potential role of rituximab in managing severe, treatment-resistant EM and suggests that B-cell-targeted therapy may offer long-term disease control when conventional therapies are ineffective.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 2","pages":"168-170"},"PeriodicalIF":0.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cosmeceuticals in acne vulgaris: from mechanism of action to clinical application.","authors":"Tamara N Searle, Firas Al-Niaimi, Faisal R Ali","doi":"10.1093/skinhd/vzaf104","DOIUrl":"https://doi.org/10.1093/skinhd/vzaf104","url":null,"abstract":"<p><p>The use of cosmeceuticals in acne vulgaris is becoming increasingly prevalent with many over-the-counter formulations becoming part of patients' routine skincare. Cosmeceuticals are often used successfully as an adjunctive therapy to reduce the side effects of traditional prescriptions and improve compliance. This is a review to support the use of cosmeceuticals in acne, including retinol, retinaldehyde, benzoyl peroxide (BPO), azelaic acid, beta hydroxy acids, alpha hydroxy acids, niacinamide, zinc, tea tree oil and green tea. There is most evidence, in human clinical trials, to support the use of topical retinol, BPO and azelaic acid. Further research with large-scale robust human clinical trials are required to go beyond <i>in vitro</i> studies. Most research has focused on mild-to-moderate acne and few studies have looked at the use of cosmeceuticals in more severe acne. Overall, adjunctive treatment with cosmeceuticals might reduce the side effect profile of standard therapies such as dryness, itching, scaling and erythema, promoting treatment compliance and improving acne outcomes.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 2","pages":"77-89"},"PeriodicalIF":0.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The utility of biopsy in pyoderma gangrenosum: a retrospective cohort study.","authors":"Angel M Moore, Jamie L Karch, Katherine E Bradley, Mirjana Stevanovic, Iman Salem, Dylan J Parker, Brian J Simmons","doi":"10.1093/skinhd/vzaf087","DOIUrl":"https://doi.org/10.1093/skinhd/vzaf087","url":null,"abstract":"<p><strong>Background: </strong>Pyoderma gangrenosum (PG) is a rare skin condition characterized by chronic, painful ulcerations. It is considered a diagnosis of exclusion, often resulting in diagnostic delay. Histological results in PG, even when biopsied despite a risk of pathergy, are nonspecific.</p><p><strong>Objectives: </strong>To examine retrospectively the utility of biopsies in the diagnosis of 58 patients treated for PG.</p><p><strong>Methods: </strong>Medical records were reviewed to compare biopsy results versus the efficacy of diagnostic rating systems (Delphi, Su, PARACELSUS).</p><p><strong>Results: </strong>Among 58 patients, 26 (45%) underwent biopsies, with only 10 (38%) contributing to a PG diagnosis. As a single-centre and retrospective study, documentation style and sample size limit generalizability.</p><p><strong>Conclusions: </strong>Given risk of pathergy, nonspecific histopathological findings and low sensitivity, in our opinion, based on this small sample size, biopsies have limited diagnostic value for PG.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 2","pages":"90-93"},"PeriodicalIF":0.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Best foot forward: podiatrists' insight and awareness of melanoma of the foot-a questionnaire study.","authors":"","doi":"10.1093/skinhd/vzaf117","DOIUrl":"https://doi.org/10.1093/skinhd/vzaf117","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/skinhd/vzaf008.].</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 2","pages":"193"},"PeriodicalIF":0.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unexpected systemic sclerosis in a patient with atopic dermatitis receiving dupilumab: a novel case report.","authors":"Ela Gazal, Saffet Burak Başak, Yasemin Yuyucu Karabulut, Ümit Türsen","doi":"10.1093/skinhd/vzaf100","DOIUrl":"https://doi.org/10.1093/skinhd/vzaf100","url":null,"abstract":"<p><p>Dupilumab, an interleukin (IL)-4 receptor alpha antagonist, is widely used in the treatment of atopic dermatitis and has shown potential benefit in certain fibrosing skin conditions. While blockade of IL-4 and IL-13 is generally considered to inhibit fibrosis, emerging reports of localized sclerosing dermatoses paradoxically arising during dupilumab therapy suggest a more complex immunological effect. We report a 37-year-old woman with the first case of systemic sclerosis developing in a patient with atopic dermatitis treated with dupilumab. After 2 years of treatment, she presented with new-onset dyspnoea, Raynaud phenomenon and digital puffiness. Serological tests revealed positive antinuclear and anticentromere antibodies; thoracic computed tomography showed interstitial lung disease. The modified Rodnan skin score was 4, and a skin biopsy from the fingertip demonstrated compact hyperkeratosis, irregular acanthosis and fibrosis extending to the superficial dermis. The patient met the American College of Rheumatology/European Alliance of Associations for Rheumatology 2013 classification criteria for systemic sclerosis, with a total score of 10. Dupilumab was discontinued, and systemic treatments targeting vascular symptoms and pulmonary involvement were initiated, resulting in clinical improvement. This case highlights a significant potential paradoxical reaction associated with cytokine-targeted biologic therapy. It underscores the importance of monitoring for fibrotic and systemic symptoms even when using agents presumed to exert antifibrotic effects.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 2","pages":"160-163"},"PeriodicalIF":0.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A historical review of mycosis fungoides: from Alibert to mogamulizumab.","authors":"Nicholas A Johnson, Opeoluwa Fariyike, Khaylen Mistry, Zoe Venables, Nick J Levell","doi":"10.1093/skinhd/vzaf099","DOIUrl":"10.1093/skinhd/vzaf099","url":null,"abstract":"<p><p>In 1806, French physician Baron Jean-Louis Alibert saw a man with a desquamating rash and skin tumours. Alibert considered this to be a variant of yaws. In 1829 Alibert named the condition mycosis fungoides (MF), meaning 'mushroom-like fungal disease'. Over 100 years later, French dermatologist Albert Sézary published papers from 1938 to 1949 detailing a mysterious disease containing 'cellules monstrueuses', describing cutaneous 'monster cells'. In 1961, these clinical findings were collated together into 'Sézary syndrome'. In the 1870s English dermatologist William Tilbury Fox published a dermatology atlas detailing cases similar to what we know now as MF, with the name 'fibroma fungoides'. The atlas described MF as a type of fungus, before giving a description of yaws and painting a clinical picture that differed from that of a lymphoma. Over the twentieth century, our understandings of the origins of MF were changing and by 1975 the classification system and term we now recognize as cutaneous T-cell lymphoma (CTCL) was developed. Neoplastic cells have been thought to arise from chronic activation of T cells via antigen-presenting cells due to inappropriate cytokines and C-C chemokine receptors. In 2018, the World Health Organization and European Organisation for Research and Treatment of Cancer officially recognized four variants of MF. These are the classic Alibert-Bazin variant and its three variants: folliculotropic MF, pagetoid reticulosis and granulomatous slack skin. Developments in immunohistochemistry for the T-cell receptor gene in the 1990s improved the diagnosis of CTCL; however, diagnosis is still challenging. Advanced MF therapies have evolved from cytotoxic chemotherapy to novel monoclonal antibodies such as mogamulizumab, targeting proteins on T-cell lymphoma cells.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 1","pages":"30-34"},"PeriodicalIF":0.0,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12867944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}