Skin health and disease最新文献

{"title":"Fomite advice for scabies: a review of online resources.","authors":"Kemi Fabusiwa, Eglantine Lebas, Kar Hung Kuet, Ananth K Nalabanda, Rebecca L McCarthy, Stephen L Walker","doi":"10.1093/skinhd/vzae014","DOIUrl":"10.1093/skinhd/vzae014","url":null,"abstract":"<p><p>Scabies is a significant global public health issue that affects 200 million people worldwide. We reviewed English language, publicly available online resources concerning the management of scabies for guidance on fomites. Information was collected from 10 resources in March 2024. We believe the quality of information used to advise individuals about appropriate decontamination of fomites should be improved.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 2","pages":"161-164"},"PeriodicalIF":0.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Haemophagocytic lymphohistiocytosis driven by disseminated <i>Mycobacterium haemophilum</i> infection.","authors":"Parissa Irom, Ivan Rodriguez, Paige Kingston, Yasmin Gutierrez, Scott Worswick","doi":"10.1093/skinhd/vzae020","DOIUrl":"10.1093/skinhd/vzae020","url":null,"abstract":"<p><p><i>Mycobacterium haemophilum</i> is a nontuberculous mycobacteria that primarily affects immunocompromised patients. It can lead to a wide variety of clinical manifestations including infections of the skin, soft tissue and joints. Due to the significant heterogeneity in clinical presentation and difficulty isolating the organism, diagnosis can be difficult and is often delayed. Our patient's course was further complicated by the development of haemophagocytic lymphohistiocytosis (HLH). Although <i>M. tuberculosis</i> infection is recognized as a potential association, HLH driven by a disseminated <i>M. haemophilum</i> infection has not yet been reported. Here we present a case of disseminated <i>M. haemophilum</i> infection in an immunocompromised patient who developed haemophagocytic lymphohistiocytosis.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 2","pages":"140-143"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective cohort study of coincident autoimmunity in dermatomyositis.","authors":"Matthew F Helm, Peter A Khoury, Kimberly F Breglio, Astia Allenzara, Steven Maczuga, Galen T Foulke","doi":"10.1093/skinhd/vzae030","DOIUrl":"10.1093/skinhd/vzae030","url":null,"abstract":"<p><p>Patients with one autoimmune disease are at an increased risk for developing more, but no studies have evaluated coincident autoimmune disease in dermatomyositis (DM). This retrospective study seeks to determine the most common coincident autoimmune diseases in patients with DM. The most common coincident autoimmune diseases in the DM cohort included ulcerative colitis (11.11%), Sjogren's syndrome (10.56%) and systemic lupus erythematosus (10.56%). Patients with DM had 15 times the odds of developing one of the coincident autoimmune diseases compared with the control group (95% confidence interval 11.71-21.35, <i>P</i> < 0.0001). Clinicians caring for patients with DM should carefully surveil their patients for development of coincident autoimmune disease.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 2","pages":"163-164"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amoxicillin-induced linear IgA bullous dermatosis mimicking erythema multiforme: a case report.","authors":"Marion Silagy, Priscille Carvalho, Billal Tedbirt, Clémence Tamarit, Marion Carrette, Florence Tétart, Alexis Lefebvre","doi":"10.1093/skinhd/vzae024","DOIUrl":"10.1093/skinhd/vzae024","url":null,"abstract":"<p><p>A 77-year-old man presented with a cutaneous rash of 3 days' duration. Seven days before onset, the patient reported a bronchopulmonary infection treated with amoxicillin. Physical examination revealed multiforme cutaneous lesions, involving the armpits, pubis, genitals and lower back. In the lower back area, lesions were erythematous, purplish targetoid-like with multiple concentric circles. In places, bullae and postblistering erosions could be seen. In places, a 'string of pearls' pattern could be observed. Nikolsky sign was negative. Herpes simplex virus polymerase chain reaction (PCR) on mucosal erosions was negative. Multiplex nasopharyngeal PCR was negative for influenza virus, COVID-19 and <i>Mycoplasma pneumoniae</i>. Histopathological examination revealed spontaneous subepithelial cleavage with neutrophilic -microabscesses. Direct immunofluorescence showed linear IgA deposition at the dermal-epidermal junction, confirming the diagnosis of linear IgA bullous dermatosis. Skin lesions were treated with topical clobetasol propionate cream and oral mucosa with corticosteroid mouth rinses. The disease course was marked by complete remission 7 days after amoxicillin discontinuation. There was no relapse after 4 months of follow-up.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 1","pages":"75-78"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous manifestation of primary nodal diffuse large B-cell lymphoma.","authors":"Thandiwe Banda, Kashini Andrew, Madhavi Maheshwari, Udoka Ogbuneke, Prabhav Singhal, Emmanuel Odega","doi":"10.1093/skinhd/vzae018","DOIUrl":"https://doi.org/10.1093/skinhd/vzae018","url":null,"abstract":"","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 2","pages":"165"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of lipid metabolism in acne risk: integrating blood metabolite and genetic insights.","authors":"Mingjuan Liu, Santiago Diaz-Torres, Brittany L Mitchell, Deborah Toledo-Flores, Puya Gharhakhani, Michael A Simpson, Hanlin Zhang, Jue-Sheng Ong, Jun Li, Miguel E Rentería","doi":"10.1093/skinhd/vzae009","DOIUrl":"10.1093/skinhd/vzae009","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Acne vulgaris is a chronic inflammatory skin condition that significantly impacts an individual's quality of life, affecting social interactions, self-esteem and body image. It primarily targets the pilosebaceous unit, where inflammation occurs. Lipid metabolism is crucial in maintaining the skin barrier and modulating inflammatory responses, with specific fatty acids, such as ω-3 and sphingomyelin acid, playing key roles. Previous studies have highlighted associations between specific dietary habits and acne, yet the precise relationship between lipid profiles, particular fatty acids, dietary patterns and acne, remains inadequately understood. This gap in knowledge necessitates a deeper investigation into the mechanisms linking lipid metabolism with acne risk.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;To investigate the causal association between acne risk and 143 dietary habits alongside 229 blood metabolite markers, focusing on lipid metabolism.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Using a Mendelian randomization (MR) framework, we leveraged summary statistics data from genome-wide association studies to explore the associations between blood lipid metabolites, dietary factors and acne risk. We used statistical correction methods, including Bonferroni and false discovery rate (FDR) adjustments, to identify robust significant associations.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Our MR analysis identified 10 lipid metabolites significantly associated with acne risk. After applying Bonferroni and FDR corrections, we pinpointed 10 and 27 serum indices or metabolites, respectively, as significantly linked to acne risk. The most prominent protective factors against acne included a higher ratio of polyunsaturated fatty acids to monounsaturated fatty acids (MUFAs) [odds ratio (OR) 0.73, 95% confidence interval (CI) 0.65-0.83, &lt;i&gt;P&lt;/i&gt; = 5.96×10-7]; a higher ratio of docosahexaenoic acid (DHA) to total fatty acids (OR 0.80, 95% CI 0.72-0.88, &lt;i&gt;P&lt;/i&gt; = 6.64×10-6); and a higher ratio of ω-3 fatty acids to total fatty acids (OR 0.86, 95% CI 0.80-0.92, &lt;i&gt;P&lt;/i&gt; = 7.54×10-6) and sphingomyelin acid (OR 0.80, 95% CI 0.72-0.88, &lt;i&gt;P&lt;/i&gt; = 1.03×10-5). Conversely, the most significant risk factors for acne included elevated ratio of MUFAs to total fatty acids (OR 1.27, 95% CI 1.14-1.40, &lt;i&gt;P&lt;/i&gt; = 6.21×10-6), higher ratio of triglycerides to total lipids in large high-density lipoprotein (OR 1.23, 95% CI 1.12-1.36, &lt;i&gt;P&lt;/i&gt; = 1.36×10-5) and an increased ratio of ω-6 to ω-3 fatty acids (OR 1.16, 95% CI 1.08-1.24, &lt;i&gt;P&lt;/i&gt; = 3.19×10-5).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Our study highlights the causal relationship between lipid markers and acne. Specifically, we identified 10 lipid traits, including monounsaturated and polyunsaturated fatty acids, ω-3/ω-6 and sphingomyelins, that influence acne development. These findings align with existing evidence on the role of lipids in skin health and comedogenesis. Further research is warranted to explore und","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 2","pages":"124-129"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The development of a keratoacanthoma following injection of hyaluronic acid-based dermal fillers into the lips.","authors":"Emma Mackender, Erin Kamp, Nicole Hendrix, Nastassia Nardini, Paul Drake","doi":"10.1093/skinhd/vzae022","DOIUrl":"10.1093/skinhd/vzae022","url":null,"abstract":"<p><p>This case report illustrates an unusual case of a keratoacanthoma (KA) developing on the lips following repeated injections with hyaluronic acid-based dermal fillers. Hyaluronic acid dermal fillers dominate nonsurgical aesthetic treatments in the UK due to their effectiveness, while also being relatively safe. The vast increase in various filler products has resulted in an increase in adverse events, although these likely remain under-reported. There have been no previously reported cases of KA directly post-hyaluronic acid injections, and KAs are not currently considered a side-effect. The patient in our case had several risk factors for developing a KA, including high sun exposure and smoking, as well as a history of repeated injections performed by a lay practitioner. Moreover, poor injection technique and repeated trauma to the lips from the injections are also likely to be implicated. Given the all-time high increase in demand for cosmetic dermal fillers, we believe that KA should be considered a possible adverse reaction of dermal fillers, particularly in patients with other significant risk factors for KA development.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 2","pages":"144-147"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of aggressive pyoderma gangrenosum with Cogan syndrome in a person with skin of colour.","authors":"Nageswary Nadarajah, Lucy Clark, Shernaz Walton","doi":"10.1093/skinhd/vzae027","DOIUrl":"10.1093/skinhd/vzae027","url":null,"abstract":"<p><p>Cogan syndrome (CS) is a rare autoimmune vasculitis affecting the audiovestibular and ocular systems. Its pathogenesis is unknown. CS was classified into typical and atypical CS in 1980 to aid its diagnosis. Its association with pyoderma gangrenosum (PG) has only been reported three times in the literature. This is also the first case of its occurrence in a person with skin of colour. CS is a diagnosis of exclusion and thus its diagnosis may present many challenges to healthcare professionals. Herein, we describe the case of a 75-year-old South Asian woman who presented acutely to the Stroke Unit following a right lacunar infarction which was treated with aspirin and clopidogrel. An enlarging nonhealing wound was noted at the site of a recent total left hip replacement. Intravenous antibiotics were started, with multiple surgical debridements performed. During admission, two new painful pustular skin lesions erupted on the chest and abdomen that ulcerated within 2 days. Painful ulcerated lesions with bluish undermined edges were also noted at the left hip wound and two pressure areas of the buttocks. A clinical diagnosis of PG was made and treatment was started with high-dose corticosteroids, which did not lead to improvement. The patient's past medical history included left eye central retinal vein occlusion with recurrent uveitis and bilateral sensorineural deafness. A diagnosis of atypical CS was made. Four pulsed cyclophosphamide infusions and hyperbaric oxygen healed the lesions. This case demonstrates the complex interplay between PG and CS, which requires further research as it can result in significant morbidity.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 1","pages":"79-81"},"PeriodicalIF":0.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of pembrolizumab-induced bullous pemphigoid treated with dupilumab.","authors":"Agnese Rossi, Donatella Brancorsini, Helena Gioacchini, Anna Campanati","doi":"10.1093/skinhd/vzae023","DOIUrl":"10.1093/skinhd/vzae023","url":null,"abstract":"<p><p>Immune checkpoint inhibitors are a class of drugs used in cancer treatment that promote the immune system's response by blocking the inhibitor signals from tumour cells, such as programmed cell death protein 1/programmed death ligand 1 and cytotoxic T-lymphocyte associated protein 4. Despite their clinical benefit, these monoclonal antibodies unspecifically activate the immune system and can lead to the development of 'immune-related adverse events'. Cutaneous toxicities are the most frequent immune-related adverse events, reported in approximately 30-50% of patients treated with immunotherapy; the most common dermatological toxicities are represented by rash, vitiligo, pruritus and lichenoid reactions. Usually, these reactions are mild and it is not necessary to suspend immunotherapy. Potentially life-threatening skin toxicities, such as immunobullous eruption, are rare and may appear in approximately 1% of patients. In this report we describe a case of bullous pemphigoid, the most frequent bullous disease, that developed after treatment with pembrolizumab for a metastatic melanoma. The diagnosis, first suspected by the referring clinic, was confirmed by performing serology and biopsy with direct immunofluorescence. The patient was first treated with high doses of systemic corticosteroids, without suspending the immunotherapy treatment. Subsequently, due to the continuous relapses, we decided to suspend pembrolizumab and systemic corticosteroid and to begin off-label treatment with dupilumab. The following case gives cause for reflection about the management of a drug-induced disease in an immunocompromised patient, while exploring the therapeutic options.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 1","pages":"70-74"},"PeriodicalIF":0.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut barrier integrity disruption in atopic dermatitis: truth or myth-a case-control study.","authors":"Naglaa M El Sayed, Merna A Riad, Raghda S Z Taleb, Eman H El Morsy","doi":"10.1093/skinhd/vzaf001","DOIUrl":"10.1093/skinhd/vzaf001","url":null,"abstract":"<p><strong>Background: </strong>Gut dysbiosis has been linked to the onset and progression of various diseases, including atopic dermatitis, by disrupting the intestinal barrier integrity. In turn, it allows the translocation of microbes and toxins into the systemic circulation, which triggers an immune response.</p><p><strong>Objectives: </strong>To measure serum levels of the gut integrity markers claudin 3 and intestinal fatty acid-binding protein in patients with atopic dermatitis.</p><p><strong>Methods: </strong>This prospective study was conducted on 43 patients with atopic dermatitis. Healthy volunteers (<i>n</i> = 35) served as controls. The serum level of claudin 3 and intestinal fatty acid-binding protein were measured using an enzyme-linked immunosorbent assay for all participants.</p><p><strong>Results: </strong>There were no significant differences in serum levels of claudin 3 and intestinal fatty acid-binding protein between patients with atopic dermatitis and the control group (<i>P</i> = 0.61 and 0.81, respectively). In addition, there was no significant correlation between the two markers, and different clinical and laboratory parameters (onset of disease, eczema area severity index, other allergic manifestations and serum IgE).</p><p><strong>Conclusion: </strong>Alterations in the intestinal barrier may be absent in the ethnically distinct group of patients with atopic dermatitis included in our study. Nevertheless, our findings might have been influenced by factors such as the duration of the disease, diet and characteristics of the study population. Further studies are needed to investigate additional biomarkers or mechanisms that may be involved in atopic dermatitis pathogenesis, especially those related to the gut-skin axis.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 1","pages":"31-36"},"PeriodicalIF":0.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}