Skin health and disease最新文献

{"title":"Immune checkpoint inhibitor-associated linear IgA bullous dermatosis with recalcitrant ocular involvement: a rare presentation.","authors":"Lina Saeed, Anna-Marie Hosking, Sergei A Grando","doi":"10.1093/skinhd/vzae008","DOIUrl":"10.1093/skinhd/vzae008","url":null,"abstract":"<p><p>Programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) receptor inhibitors have become imperative in the treatment of advanced solid organ malignancies such as metastatic melanoma. With this disinhibition of certain immune responses to induce an antitumour response, numerous adverse events have been reported, many of which affect the skin. While rare, PD-1/PD-L1 inhibitor-associated severe cutaneous adverse reactions (SCARs) can cause significant morbidity and/or mortality. New SCARs are reported with increasing frequency as immune checkpoint inhibitors become more widely used. Here, we present a rare case of recalcitrant ocular linear IgA bullous dermatosis associated with a PD-1 inhibitor. Awareness of this entity will allow more rapid recognition and initiation of appropriate management and treatment, which would reduce the morbidity and/or mortality associated with these serious adverse reactions.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 1","pages":"53-55"},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin of colour dermatology education in US primary care residency programmes: a nationwide cross-sectional survey of programme directors.","authors":"Lauren C LaMonica, Thomas Hester, Reinie Thomas, Frank Wang","doi":"10.1093/skinhd/vzae001","DOIUrl":"10.1093/skinhd/vzae001","url":null,"abstract":"<p><strong>Background: </strong>Physicians-in-training report inadequate education in skin of colour (SOC) dermatology during residency. Although dermatology programmes have made progress in teaching SOC dermatology, the status of SOC dermatology education in primary care residency programmes remains unclear.</p><p><strong>Objectives: </strong>To characterize SOC didactic and clinical training opportunities available to primary care residents, laying the groundwork for future curriculum development of SOC dermatology.</p><p><strong>Methods: </strong>This cross-sectional study consisted of a nationwide 16-question survey disseminated by email between October 2022 and February 2023 to US primary care residency programmes identified using the Accreditation Council for Graduate Medical Education (ACGME) database.</p><p><strong>Results: </strong>Of responding programmes (<i>n</i> = 49/1224, 4.0%), 29/49 offered SOC didactic training, most often through integration of content within general dermatology lectures (<i>n</i> = 29/49, 59.2%) and board review sessions (<i>n</i> = 13/49, 26.5%). Over half of programmes (<i>n</i> = 35/49, 71.4%) offered SOC clinical training through rotation in a general dermatology clinic (<i>n</i> = 33/49, 67.3%) and skin-related chief concerns in primary care clinics (<i>n</i> = 29/49, 59.2%). Programmes with directors indicating that they planned to incorporate SOC education into future curricula (<i>n</i> = 20/49, 40.8%) were more likely to already have SOC didactic and clinical training opportunities (<i>P</i> = 0.01 and <i>P</i> = 0.02, respectively). Regarding future directions, programme directors were most interested in integrating SOC topics within dermatology lectures (<i>n</i> = 31/49, 63.3%); identifying an expert (<i>n</i> = 31/49, 63.3%) and allocating lecture time (<i>n</i> = 10/49, 20.4%) were the most frequently cited barriers.</p><p><strong>Conclusions: </strong>Some primary care programmes provide SOC dermatology didactic and clinical training opportunities, which are influenced by programme directors' willingness to incorporate such training into curricula, and present opportunities for dermatologists to educate primary care residents.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 1","pages":"9-13"},"PeriodicalIF":0.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disseminated blastomycosis with cutaneous involvement in a young man in Ottawa, Canada.","authors":"Jaime N Turk, Laura D Chin, Stephanie L Petkiewicz, Steven J Glassman","doi":"10.1093/skinhd/vzae016","DOIUrl":"10.1093/skinhd/vzae016","url":null,"abstract":"","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 1","pages":"92"},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual improvement of alopecia areata and immune thrombocytopenia with baricitinib: a case report.","authors":"Chelsea Moon, Sarah E Park, Jennifer L Hsiao, Katrina H Lee","doi":"10.1093/skinhd/vzae019","DOIUrl":"10.1093/skinhd/vzae019","url":null,"abstract":"<p><p>The oral Janus kinase (JAK) inhibitor baricitinib is approved by the U.S. Food and Drug Administration for the treatment of alopecia areata (AA). We report a case of dual improvement of AA and immune thrombocytopenia (ITP) with oral baricitinib monotherapy, which may suggest linked autoimmune pathophysiology. In phase III clinical trials of baricitinib for AA, reports of rare adverse haematological events include neutropenia and anaemia. While a history of haematological comorbidities may raise concern for many clinicians when considering treatment with a JAK inhibitor, this clinical vignette suggests that baricitinib may be considered and safely administered in those with concomitant AA and ITP. A 56-year-old man with a history of AA, ITP and vitiligo presented to the clinic for relapse of his steroid-resistant hair loss which had previously been treated with tofacitinib. In consultation with the patient's haematologist, baricitinib 2 mg daily was started with close platelet monitoring then doubled to 4 mg after platelets showed improvement at the 6-month follow-up. Fourteen months after initiating baricitinib, improvement in white and dark hair regrowth was observed, and platelets remained normal. Thus, baricitinib may be considered for the dual treatment of AA and ITP with regular platelet monitoring and co-management with haematology colleagues.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 1","pages":"66-69"},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare finding of <i>Corynebacterium bovis</i> in a facial surgical wound.","authors":"Sach Thakker, Micah Belzberg, Elise Ng","doi":"10.1093/skinhd/vzae005","DOIUrl":"10.1093/skinhd/vzae005","url":null,"abstract":"","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 1","pages":"88-89"},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Favourable response of Blaschko linear psoriasis to interleukin-23 inhibition.","authors":"Jeremias L K Reich, Alexandros Onoufriadis, John A McGrath, Kristian Reich","doi":"10.1093/skinhd/vzae010","DOIUrl":"10.1093/skinhd/vzae010","url":null,"abstract":"","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 1","pages":"82-87"},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fixed drug eruption in a cribriform pattern: an atypical presentation.","authors":"Mahesh Mathur, Neha Thakur, Sandhya Regmi, Supriya Paudel, Nabita Bhattarai, Sambidha Karki","doi":"10.1093/skinhd/vzae006","DOIUrl":"10.1093/skinhd/vzae006","url":null,"abstract":"<p><p>Fixed drug eruption (FDE) is a distinct adverse drug reaction characterized by a well-defined, dusky, violaceous to erythematous patch that recurs at the same site upon re-exposure to causative drugs and resolves with hyperpigmentation. This unique reaction is a type IV hypersensitivity reaction mediated by memory CD8⁺ T cells that reside in the basal layer of the epidermis of the resting FDE lesion. Variants of FDE described in the literature include bullous, generalized bullous, nonpigmenting, linear, papular, erythema multiforme-like, transitory giant, annular, psoriasiform, erythema dyschromicum perstans-like and cellulitis-like. We present the case of a 12-year-old boy with FDE in a cribriform pattern that has not been defined so far.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 1","pages":"50-52"},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recalcitrant tinea capitis in WHIM syndrome.","authors":"Jasmine C Meltzer, Jennifer Strong, Sophia Martinez, Abigail Salancy, Rutha Adhanom, Edward W Cowen, Leslie Castelo-Soccio, Philip M Murphy, David H McDermott, Isaac Brownell","doi":"10.1093/skinhd/vzae002","DOIUrl":"10.1093/skinhd/vzae002","url":null,"abstract":"<p><p>WHIM syndrome is a rare primary immunodeficiency typically caused by autosomal dominant activating mutations in the <i>CXCR4</i> gene. WHIM refers to warts, hypogammaglobulinaemia, infections and myelokathexis, which are the primary phenotypes of the syndrome. Here we describe a case of tinea capitis in a patient with WHIM syndrome that was unresponsive to multiple systemic antifungal treatments for over 10 years. The patient's recalcitrant tinea infection was ultimately cured after treatment with posaconazole. These findings suggest that the <i>CXCR4</i> defects in WHIM syndrome may confer susceptibility to dermatophyte infections.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 1","pages":"41-44"},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An unusually severe case of shiitake mushroom dermatitis with features of drug reaction with eosinophilia and systemic symptoms.","authors":"Tristen Tze Wei Ng, Benjamin Andrew Wood, Patricia Le","doi":"10.1093/skinhd/vzae012","DOIUrl":"10.1093/skinhd/vzae012","url":null,"abstract":"<p><p>Shiitake mushroom dermatitis is a well-documented phenomenon in the literature seen after consuming raw or undercooked shiitake mushrooms (<i>Lentinus edodes</i>). However, systemic features resembling a drug reaction with eosinophilia and systemic symptoms (DRESS) are rare. We report a case of severe shiitake mushroom dermatitis with atypical systemic features resembling DRESS. A 51-year-old man presented with acute unilateral periorbital oedema and flagellate erythema with no obvious drug precipitants and was initially managed as allergic contact dermatitis in the emergency department. Further inquiry revealed a history of raw shiitake mushroom ingestion 48 h before the onset of symptoms, which led to a working diagnosis of shiitake mushroom dermatitis. Skin biopsies showed mixed spongiotic and interface inflammatory reactions with a perivascular lymphocytic infiltrate and marked eosinophilia supportive of shiitake mushroom dermatitis. Rheumatological causes of flagellate erythema and periorbital oedema were excluded from clinical and laboratory findings. The patient initially presented with apyrexia and mild eosinophilia but then developed pyrexia, hypereosinophilia, neutrophilia and transaminitis. He subsequently developed bilateral periorbital oedema with his flagellate erythema, both of which were resolved with topical and oral corticosteroids. However, there was a new widespread morbilliform eruption with dorsal oedema of his hands. A diagnosis of DRESS-like shiitake mushroom dermatitis was considered. The patient required a long course of oral prednisolone to achieve clinical and biochemical resolution of his symptoms. Our case underscores the importance of prompt recognition and management of shiitake dermatitis, especially when it presents with DRESS-like features.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 1","pages":"56-60"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global epidemiological trends in the incidence and mortality for melanoma.","authors":"Nicola Cirillo","doi":"10.1093/skinhd/vzae013","DOIUrl":"10.1093/skinhd/vzae013","url":null,"abstract":"<p><p>There is concern that increased surveillance is leading to the overdiagnosis of indolent melanomas that are not destined to be lethal. As overdiagnosis can only be appreciated at a population level, we analysed current and historical population trends of melanoma incidence and mortality worldwide. Epidemiological trends from GLOBOCAN data show signatures typical of overdiagnosis, with the magnitude of increased diagnoses far outpacing mortality for melanoma in most countries.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 1","pages":"84-86"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}