Skin health and disease最新文献

{"title":"Multiple glomus tumours: Clinical, ultrasonographic and histopathologic findings of a rare disease.","authors":"Bárbara Wiese, Patricia F Acevedo, Rodrigo A Franceschett, Leila Riedel, Maria Cláudia A Issa","doi":"10.1002/ski2.409","DOIUrl":"10.1002/ski2.409","url":null,"abstract":"<p><p>Glomus tumour is a rare benign neoplasm originating from the glomus body, clinically presenting as a violet-coloured, painful nodule more sensitive when exposed to cold or hot. This hamartoma is typically solitary and predominantly affects the limbs, extremities and nail beds. The appearance of multiple tumours and lesions not placed in the extremities is rare and frequently misdiagnosed. At dermoscopy, it appears as a homogeneous, structureless, purplish area surrounded by a whitish region. Skin ultrasound shows a well-defined, round, hypoechoic mass. We report a case of numerous blue-purplish painful nodules distributed in the trunk and arms while sparing the extremities, with typical dermoscopy and ultrasound findings. A biopsy was performed, confirming the diagnosis of glomangioma. We call attention to this rare condition to help dermatologists make this diagnosis when facing multiple painful nodules.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"4 5","pages":"e409"},"PeriodicalIF":0.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A hybrid case of eosinophilic folliculitis and eosinophilic cellulitis associated with hypereosinophilic syndrome","authors":"D. Iatropoulou, Cathryn Sprenger, Richard Griffiths, N. Wijesuriya, Bernard Ho","doi":"10.1002/ski2.407","DOIUrl":"https://doi.org/10.1002/ski2.407","url":null,"abstract":"Eosinophilic cellulitis or Wells syndrome encompasses distinct histopathological features but can also be associated with eosinophilic related conditions like hyper eosinophilic syndrome (HES) or eosinophilic granulomatosis with polyangiitis (EGPA) (Churg–Strauss syndrome). We report a case of a Turkish 41‐year‐old female who presented in clinic with pruritus and tenderness on her chest and breasts, having received several courses of antibiotics for recurrent abscess formation. A year before she had been diagnosed with HES with multiorgan involvement that included biopsy proven eosinophilic folliculitis, and prompted further investigation including bone marrow aspiration that revealed T cell clonality. Biopsy of her rash revealed eosinophilic infiltration of the dermis with flame figures. Ongoing respiratory symptoms and a history of childhood asthma were suggestive of EGPA. This case highlights important associations that should be considered in the investigation of Wells syndrome.","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"1 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141335594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the COVID‐19 pandemic on international cutaneous squamous cell carcinoma incidence: A systematic review and meta‐analysis","authors":"James Wall, Kieran Gadsby‐Davis, K. Mistry, Nick J. Levell, Zoe C. Venables","doi":"10.1002/ski2.405","DOIUrl":"https://doi.org/10.1002/ski2.405","url":null,"abstract":"Non‐melanoma skin cancer (NMSC) is the most common cancer globally in white ethinicity populations, and cutaneous squamous cell carcinoma (cSCC) is the second most common subtype. The COVID‐19 pandemic severely impacted public and private healthcare systems. Many studies have reported reduced cancer diagnoses during the pandemic. The impact of the COVID‐19 pandemic on global cSCC and NMSC incidence is poorly reported.The aim was to conduct a systematic review and meta‐analysis to assess the impact of the COVID‐19 pandemic on global cSCC and NMSC incidence rates, compared with 2019 incidence rates. Two primary outcome measures were used: crude incidence rate ratios (CIRR) and age‐standardised incidence rate ratios (ASIRR).A structured search was undertaken on 23 March 2023 using grey literature and four electronic databases: MEDLINE, CINAHL, EMBASE and Web of Science. Studies published before January 2020 were excluded. A quality assessment was undertaken using A. Lomas quality assessment tool. CIRR outcomes were synthesised in a meta‐analysis, while ASIRR outcomes were narratively synthesised.Fourteen cancer registries were included, capturing data from 13 countries across Europe. Variation was observed in NMSC and cSCC incidence across the cancer registries. Pooled cSCC crude incidence rates in 2020 were equal to crude incidence rates in 2019 (cSCC‐CIRR 1.00 (95% confidence interval (CI) 0.94–1.06). In 2021, the pooled result indicated a non‐significant 8% increase in cSCC crude incidence rates, compared with 2019 (cSCC‐CIRR 1.08 (95% CI 0.98–1.19). Significant reductions were reported in NMSC incidence across all meta‐analyses in 2020 and 2021 compared with 2019. Heterogeneity was observed across most pooled estimates (I2>75%).There was a lack of high quality data on cSCC incidence rates recorded during the pandemic outside of Europe. The COVID‐19 pandemic resulted in no significant changes in cSCC incidence across Europe. By contrast, NMSC incidence fell across Europe following the pandemic. Significant reductions in pooled NMSC incidence rates may reflect a delay in basal cell carcinoma presentation, diagnosis and treatment. Although annual incidence rates for cSCC were not affected by the pandemic, delays in treatment may still have occurred, which may result in poorer outcomes yet to be fully understood.","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"4 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141336632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating mental health support by healthcare providers for patients with atopic dermatitis: A cross‐sectional survey","authors":"Sheena Chatrath, A. Loiselle, J. Johnson, W. Begolka","doi":"10.1002/ski2.408","DOIUrl":"https://doi.org/10.1002/ski2.408","url":null,"abstract":"Atopic dermatitis (AD) is associated with psychosocial symptoms, resulting in significant mental health burden and reduced quality of life.To understand mental health support received by patients from their primary eczema provider.We administered a cross‐sectional survey (N = 954) to US caregivers and adult patients with AD.The National Eczema Association (United States) conducted an online survey in October 2022 among self‐selected patients and caregivers.Patients and caregivers of AD patients reported on mental health conversations and types of mental health support received by their/their child's provider.Many patients did not discuss (41.9%) or were not asked (50.5%) about their mental health by their eczema provider, and 64% reported not receiving a mental health referral. Patients were more likely to receive mental health support if they were male (2.00 [1.08–3.69]), low or middle education level (4.89 [2.10–11.36], 2.71 [1.36–5.40]), or had purchased insurance policies (4.43 [1.79–10.98]). Providers were most likely to refer patients to counseling services (22.5%), followed by alternative mental health therapy (14.9%), cognitive behavioural therapy (13.3%) and peer/social support groups (12.2%).Despite the strong association between AD and mental health conditions, there is a significant proportion of patients that report not receiving mental health support from their/their child's primary eczema provider. Screening with validated measures may improve the identification of patients requiring additional support. Future research should evaluate the efficacy of mental health resources and barriers to accessing and referring patients for mental health care.","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"7 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141337366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient experience: Feeling like the tin man from the Wizard of Oz","authors":"Caoimhe Dalton, L. Murphy, Carmel Ann Galligan, Susan O'Gorman, Larry Bacon, Claudine Howard‐James, Rachel Dillon, Holly Fitzgerald","doi":"10.1002/ski2.406","DOIUrl":"https://doi.org/10.1002/ski2.406","url":null,"abstract":"","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"42 35","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141340009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of a surgical logbook to improve training and patient safety: A retrospective analysis of 6 years' experience in Bristol, UK","authors":"E. Wasson, Charankumal Thandi, Adam Bray","doi":"10.1002/ski2.386","DOIUrl":"https://doi.org/10.1002/ski2.386","url":null,"abstract":"Logbooks can be a useful educational tool. Although their use in medical training has been greatly explored, there is limited research into their application throughout a clinician's career. We created a surgical logbook to allow clinicians to record their skin surgery procedures and reflect on the histological diagnosis and clearance margins achieved.We provide a retrospective analysis to evaluate the usefulness of the logbook as an analytical and educational tool in a dermatology department, particularly for maintaining exemplary complete excision rates.Data was collected from clinicians who conducted skin surgery in Bristol, UK. Cases were entered at the time of surgery, collecting data on body site, clinical margin, suspected diagnosis, type of procedure and closure. Following receipt of histological results, data on histological excision margins and tumour type was entered. Each clinician submitted data for a minimum of 3 months each year, and data collection ran from April 2012 until March 2018.Data from 5161 excision surgeries was collected over the 6‐year period. On histological diagnosis, excisions constituted 50% Basal Cell Carcinoma (BCC), 12% Squamous Cell Carcinoma (SCC), 9% Malignant Melanoma (MM) and 1% Lentigo Maligna (LM), and 28% ‘Other’ (rarer malignancies, melanoma wide local excision scars and pre‐cancerous/benign lesions). The department was found to have good diagnostic concordance: BCC 92%, SCC 87%, MM 80% and LM 53%. Overall complete excision rate was high at 97.07%. The most successfully excised cancer was BCC (97.50%), then SCC (97.14%) MM (96.48%) and LM (95.23%). The department provided many complex surgeries including 8.3% flaps and 8.5% grafts. Average lesion diameter was 11 mm (range 2–90 mm). There was a significant improvement in excision rates seen over the years for BCC, MM and LM. Although there was no significant difference found for SCC, this group began the study with already high clearance rates.This surgical logbook supports improved training and continues professional development. We encourage more departments to use this logbook and share the data that they produce. This could improve their excision rates, patient experience, and save them up to £28 000 per year.","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"2 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141378508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond caregiving: Navigating life with a developmentally disabled daughter with a severe case of Hidradenitis Suppurativa","authors":"Elisha M Myers, Janelle S. Nassim","doi":"10.1002/ski2.403","DOIUrl":"https://doi.org/10.1002/ski2.403","url":null,"abstract":"","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"8 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141266264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The acronymisation of lichen sclerosus","authors":"Georgios Kravvas, Christopher Bunker","doi":"10.1002/ski2.401","DOIUrl":"https://doi.org/10.1002/ski2.401","url":null,"abstract":"The short communication highlights a debate over the use of acronyms in medical literature, particularly focusing on “LSc” versus “LS” for lichen sclerosus. Despite the contested nature of the issue, we argue for the adoption of “LSc” due to its clarity and to avoid confusion with other medical terms. To best reflect the evolving nature of medical terminology and the authors' expertise, we also advocate for the authors' rights in choosing acronyms within their work.","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"10 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141266397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Annular elastolytic giant cell granuloma associated with autoimmune hepatitis: Response to ciclosporin","authors":"Zaina Sharif, Shagayegh Javadzadeh, Jeanne Boissiere, Daniel Creamer","doi":"10.1002/ski2.393","DOIUrl":"https://doi.org/10.1002/ski2.393","url":null,"abstract":"A 47 year old Caucasian female with a background of type 2 diabetes mellitus, hypothyroidism, and autoimmune hepatitis presented with a painful, pruritic, papular eruption in a photosensitive distribution across the upper chest, neck, face, dorsal hands and forearms. On examination, lesions coalesced into annular plaques each with an active, raised margin and an atrophic, yellow centre. Histopathology demonstrated an absence of mucin and elastophagocytosis with giant cells engulfing dermal elastin fibres. These histopathological features favoured a diagnosis of annular elastolytic giant cell granuloma (AEGCG). The patient was managed ciclosporin monotherapy 125 mg twice daily (3 mg/kg/day). At 8 week review, there was a marked improvement in the physical appearance of the dermatosis as well as diminishing of symptoms such as itch and cutaneous pain. AEGCG is a rare inflammatory dermatosis typically affecting sun‐exposed sites. It has been proposed that AEGCG is triggered by a solar induced elastolysis however other theories suggest it is a primary granulomatous disorder and not a photodermatosis. AEGCG appears to be aligned to an autoimmune diathesis, indicated by its frequent association with autoimmune conditions such as Hashimoto’s thyroiditis, vitiligo, giant cell arteritis and, as in our patient, auto‐immune hepatitis. Diabetes mellitus occurring concurrently with AEGCG has also been observed, again like our patient. Histopathological features which distinguish AEGCG from granuloma annulare include absent mucin, absent necrobiosis, giant cells with more nuclei, non‐palisading granulomata and marked loss of elastic tissue. AEGCG is often unresponsive to standard therapies. The literature indicates varying responses to photo‐protection, topical/systemic/intralesional corticosteroids, and oral medications such as methotrexate, hydroxychloroquine, and dapsone. Few case reports have also documented improvement with ciclosporin. In aggressive forms of AEGCG, as in our patient, treatment with ciclosporin may be an effective intervention and should be initiated early in the disease.","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"41 50","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141270031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding and treating diabetic foot ulcers: Insights into the role of cutaneous microbiota and innovative therapies.","authors":"Paul Norton, Pavlos Trus, Fengyi Wang, M Julie Thornton, Chien-Yi Chang","doi":"10.1002/ski2.399","DOIUrl":"10.1002/ski2.399","url":null,"abstract":"<p><strong>Background: </strong>Notoriously known as the silent pandemic, chronic, non-healing diabetic foot ulcers (DFUs), pose a significant rate of incidence for amputation and are a major cause of morbidity. Alarmingly, the treatment and management strategies of chronic wounds represent a significant economic and health burden as well as a momentous drain on resources with billions per annum being spent in the US and UK alone. Defective wound healing is a major pathophysiological condition which propagates an acute wound to a chronic wound, further propelled by underlying conditions such as diabetes and vascular complications which are more prevalent amongst the elderly. Chronic wounds are prone to infection, which can exacerbate the condition, occasionally resulting in amputation for the patient, despite the intervention of modern therapies. However, amputation can only yield a 5-year survival rate for 50% of patients, highlighting the need for new treatments for chronic wounds.</p><p><strong>Findings: </strong>The dynamic cutaneous microbiota is comprised of diverse microorganisms that often aid wound healing. Conversely, the chronic wound microbiome consists of a combination of common skin commensals such as <i>Staphylococcus aureus</i> and <i>Staphylococcus epidermidis</i>, as well as the opportunistic pathogen <i>Pseudomonas aeruginosa</i>. These bacteria have been identified as the most prevalent bacterial pathogens isolated from chronic wounds and contribute to prolific biofilm formation decreasing the efficiency of antimicrobials and further perpetuating a hyper-inflammatory state.</p><p><strong>Discussion and conclusion: </strong>Here, we review recent advances and provide a new perspective on alternative treatments including phage and microbiome transplant therapies and how the definitive role of the cutaneous microbiota impacts the aetiology of DFUs.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"4 4","pages":"e399"},"PeriodicalIF":0.0,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11297444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141895187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}