Skin health and disease最新文献

{"title":"A case of eosinophilic pustular folliculitis involving palmoplantar successfully treated by apremilast.","authors":"Jing Xu, Yue-Meng Wu, Shang-Shang Wang","doi":"10.1093/skinhd/vzaf019","DOIUrl":"10.1093/skinhd/vzaf019","url":null,"abstract":"<p><p>Eosinophilic pustular folliculitis (EPF) is a rare inflammatory dermatosis that predominantly affects seborrheic areas. The condition's pathogenesis is linked to T helper 2-driven eosinophilic inflammation. We presented a man with EPF involving the face, palms and soles, successfully treated by apremilast, a phosphodiesterase-4 inhibitor. Apremilast's efficacy in this case adds to emerging evidence supporting its use in EPF, particularly when traditional treatments fail.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 3","pages":"223-226"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atrophoderma vermiculatum (AV) and ipsilateral cataract.","authors":"Wei Qiang Chng, Kenneth Kinwai Fong","doi":"10.1093/skinhd/vzaf027","DOIUrl":"10.1093/skinhd/vzaf027","url":null,"abstract":"<p><p>We report a young child who presented with atrophic reticulated depressions with ipsilateral cataracts, suggesting that this could represent a distinct and rare entity.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 2","pages":"166"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tirabrutinib-associated toxic epidermal necrolysis: a case report and review of the literature.","authors":"Noriko Ikegawa, Natsuko Saito-Sasaki, Yu Sawada","doi":"10.1093/skinhd/vzaf011","DOIUrl":"10.1093/skinhd/vzaf011","url":null,"abstract":"<p><p>Tirabrutinib, a Bruton tyrosine kinase (BTK) inhibitor, has shown efficacy in recurrent or refractory diffuse large B-cell lymphoma (DLBCL). However, severe drug eruptions, including toxic epidermal necrolysis (TEN), have been reported. We present a case of a 74-year-old man with refractory DLBCL who developed TEN after 1 month of tirabrutinib treatment. Severe drug eruptions linked to tirabrutinib are rare, with only three cases reported, including ours. Tirabrutinib's selective BTK inhibition may activate cytotoxic CD8⁺ T cells, contributing to Stevens-Johnson syndrome/TEN pathogenesis. Further studies are needed to clarify the mechanisms and develop better diagnostic approaches for BTK inhibitor-related drug eruptions.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 2","pages":"151-153"},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Itraconazole-associated purpuric drug eruption: a rare adverse effect of a commonly prescribed drug.","authors":"Mahesh Mathur, Sandhya Regmi, Sumit Paudel, Supriya Paudel, Nabita Bhattarai, Sambidha Karki","doi":"10.1093/skinhd/vzaf006","DOIUrl":"10.1093/skinhd/vzaf006","url":null,"abstract":"<p><p>Purpuric drug eruption (PDE) is a rare drug reaction characterized by purpuric macules, papules and confluent plaques predominantly on the lower extremities. The drugs reported to induce PDE are epidermal growth factor receptor inhibitors, ketoconazole, acetylsalicylic acid, penicillin, sulfonamides, indomethacin, lenalidomide, linezolid and vancomycin. Drug-induced thrombocytopenia, platelet dysfunction and direct toxic effects of the drug on the capillary wall leading to increased capillary fragility are the proposed aetiologies. There is only a single report of itraconazole-induced PDE in the literature to date. We herein present a case of 57-year-old woman with PDE due to itraconazole.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 2","pages":"148-150"},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fomite advice for scabies: a review of online resources.","authors":"Kemi Fabusiwa, Eglantine Lebas, Kar Hung Kuet, Ananth K Nalabanda, Rebecca L McCarthy, Stephen L Walker","doi":"10.1093/skinhd/vzae014","DOIUrl":"10.1093/skinhd/vzae014","url":null,"abstract":"<p><p>Scabies is a significant global public health issue that affects 200 million people worldwide. We reviewed English language, publicly available online resources concerning the management of scabies for guidance on fomites. Information was collected from 10 resources in March 2024. We believe the quality of information used to advise individuals about appropriate decontamination of fomites should be improved.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 2","pages":"161-164"},"PeriodicalIF":0.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Haemophagocytic lymphohistiocytosis driven by disseminated <i>Mycobacterium haemophilum</i> infection.","authors":"Parissa Irom, Ivan Rodriguez, Paige Kingston, Yasmin Gutierrez, Scott Worswick","doi":"10.1093/skinhd/vzae020","DOIUrl":"10.1093/skinhd/vzae020","url":null,"abstract":"<p><p><i>Mycobacterium haemophilum</i> is a nontuberculous mycobacteria that primarily affects immunocompromised patients. It can lead to a wide variety of clinical manifestations including infections of the skin, soft tissue and joints. Due to the significant heterogeneity in clinical presentation and difficulty isolating the organism, diagnosis can be difficult and is often delayed. Our patient's course was further complicated by the development of haemophagocytic lymphohistiocytosis (HLH). Although <i>M. tuberculosis</i> infection is recognized as a potential association, HLH driven by a disseminated <i>M. haemophilum</i> infection has not yet been reported. Here we present a case of disseminated <i>M. haemophilum</i> infection in an immunocompromised patient who developed haemophagocytic lymphohistiocytosis.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 2","pages":"140-143"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective cohort study of coincident autoimmunity in dermatomyositis.","authors":"Matthew F Helm, Peter A Khoury, Kimberly F Breglio, Astia Allenzara, Steven Maczuga, Galen T Foulke","doi":"10.1093/skinhd/vzae030","DOIUrl":"10.1093/skinhd/vzae030","url":null,"abstract":"<p><p>Patients with one autoimmune disease are at an increased risk for developing more, but no studies have evaluated coincident autoimmune disease in dermatomyositis (DM). This retrospective study seeks to determine the most common coincident autoimmune diseases in patients with DM. The most common coincident autoimmune diseases in the DM cohort included ulcerative colitis (11.11%), Sjogren's syndrome (10.56%) and systemic lupus erythematosus (10.56%). Patients with DM had 15 times the odds of developing one of the coincident autoimmune diseases compared with the control group (95% confidence interval 11.71-21.35, <i>P</i> < 0.0001). Clinicians caring for patients with DM should carefully surveil their patients for development of coincident autoimmune disease.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 2","pages":"163-164"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amoxicillin-induced linear IgA bullous dermatosis mimicking erythema multiforme: a case report.","authors":"Marion Silagy, Priscille Carvalho, Billal Tedbirt, Clémence Tamarit, Marion Carrette, Florence Tétart, Alexis Lefebvre","doi":"10.1093/skinhd/vzae024","DOIUrl":"10.1093/skinhd/vzae024","url":null,"abstract":"<p><p>A 77-year-old man presented with a cutaneous rash of 3 days' duration. Seven days before onset, the patient reported a bronchopulmonary infection treated with amoxicillin. Physical examination revealed multiforme cutaneous lesions, involving the armpits, pubis, genitals and lower back. In the lower back area, lesions were erythematous, purplish targetoid-like with multiple concentric circles. In places, bullae and postblistering erosions could be seen. In places, a 'string of pearls' pattern could be observed. Nikolsky sign was negative. Herpes simplex virus polymerase chain reaction (PCR) on mucosal erosions was negative. Multiplex nasopharyngeal PCR was negative for influenza virus, COVID-19 and <i>Mycoplasma pneumoniae</i>. Histopathological examination revealed spontaneous subepithelial cleavage with neutrophilic -microabscesses. Direct immunofluorescence showed linear IgA deposition at the dermal-epidermal junction, confirming the diagnosis of linear IgA bullous dermatosis. Skin lesions were treated with topical clobetasol propionate cream and oral mucosa with corticosteroid mouth rinses. The disease course was marked by complete remission 7 days after amoxicillin discontinuation. There was no relapse after 4 months of follow-up.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 1","pages":"75-78"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous manifestation of primary nodal diffuse large B-cell lymphoma.","authors":"Thandiwe Banda, Kashini Andrew, Madhavi Maheshwari, Udoka Ogbuneke, Prabhav Singhal, Emmanuel Odega","doi":"10.1093/skinhd/vzae018","DOIUrl":"https://doi.org/10.1093/skinhd/vzae018","url":null,"abstract":"","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 2","pages":"165"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of lipid metabolism in acne risk: integrating blood metabolite and genetic insights.","authors":"Mingjuan Liu, Santiago Diaz-Torres, Brittany L Mitchell, Deborah Toledo-Flores, Puya Gharhakhani, Michael A Simpson, Hanlin Zhang, Jue-Sheng Ong, Jun Li, Miguel E Rentería","doi":"10.1093/skinhd/vzae009","DOIUrl":"10.1093/skinhd/vzae009","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Acne vulgaris is a chronic inflammatory skin condition that significantly impacts an individual's quality of life, affecting social interactions, self-esteem and body image. It primarily targets the pilosebaceous unit, where inflammation occurs. Lipid metabolism is crucial in maintaining the skin barrier and modulating inflammatory responses, with specific fatty acids, such as ω-3 and sphingomyelin acid, playing key roles. Previous studies have highlighted associations between specific dietary habits and acne, yet the precise relationship between lipid profiles, particular fatty acids, dietary patterns and acne, remains inadequately understood. This gap in knowledge necessitates a deeper investigation into the mechanisms linking lipid metabolism with acne risk.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;To investigate the causal association between acne risk and 143 dietary habits alongside 229 blood metabolite markers, focusing on lipid metabolism.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Using a Mendelian randomization (MR) framework, we leveraged summary statistics data from genome-wide association studies to explore the associations between blood lipid metabolites, dietary factors and acne risk. We used statistical correction methods, including Bonferroni and false discovery rate (FDR) adjustments, to identify robust significant associations.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Our MR analysis identified 10 lipid metabolites significantly associated with acne risk. After applying Bonferroni and FDR corrections, we pinpointed 10 and 27 serum indices or metabolites, respectively, as significantly linked to acne risk. The most prominent protective factors against acne included a higher ratio of polyunsaturated fatty acids to monounsaturated fatty acids (MUFAs) [odds ratio (OR) 0.73, 95% confidence interval (CI) 0.65-0.83, &lt;i&gt;P&lt;/i&gt; = 5.96×10-7]; a higher ratio of docosahexaenoic acid (DHA) to total fatty acids (OR 0.80, 95% CI 0.72-0.88, &lt;i&gt;P&lt;/i&gt; = 6.64×10-6); and a higher ratio of ω-3 fatty acids to total fatty acids (OR 0.86, 95% CI 0.80-0.92, &lt;i&gt;P&lt;/i&gt; = 7.54×10-6) and sphingomyelin acid (OR 0.80, 95% CI 0.72-0.88, &lt;i&gt;P&lt;/i&gt; = 1.03×10-5). Conversely, the most significant risk factors for acne included elevated ratio of MUFAs to total fatty acids (OR 1.27, 95% CI 1.14-1.40, &lt;i&gt;P&lt;/i&gt; = 6.21×10-6), higher ratio of triglycerides to total lipids in large high-density lipoprotein (OR 1.23, 95% CI 1.12-1.36, &lt;i&gt;P&lt;/i&gt; = 1.36×10-5) and an increased ratio of ω-6 to ω-3 fatty acids (OR 1.16, 95% CI 1.08-1.24, &lt;i&gt;P&lt;/i&gt; = 3.19×10-5).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Our study highlights the causal relationship between lipid markers and acne. Specifically, we identified 10 lipid traits, including monounsaturated and polyunsaturated fatty acids, ω-3/ω-6 and sphingomyelins, that influence acne development. These findings align with existing evidence on the role of lipids in skin health and comedogenesis. Further research is warranted to explore und","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 2","pages":"124-129"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}