Skin health and disease最新文献

{"title":"Erythematous variant of inverse pityriasis versicolor in skin of colour.","authors":"Shreya Deoghare, Ajay Dodeja","doi":"10.1093/skinhd/vzae011","DOIUrl":"10.1093/skinhd/vzae011","url":null,"abstract":"","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 1","pages":"90-91"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare paediatric case with overlapping clinical features of epidermodysplasia verruciformis and pyoderma gangrenosum with hepatosplenomegaly.","authors":"Saud Azhar, Palwasha Khan, Fahad Faizullah","doi":"10.1093/skinhd/vzae003","DOIUrl":"10.1093/skinhd/vzae003","url":null,"abstract":"<p><p>Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that typically manifests as painful ulcers, usually on the lower limbs, and is usually secondary to other conditions, for example inflammatory bowel disease and rheumatoid arthritis. Epidermodysplasia verruciformis (EDV) is an inherited or acquired primary immunodeficiency disorder linked to human papillomavirus susceptibility and an increased risk of squamous cell carcinoma. Occurrence of these conditions together has not been reported before. A 10-year-old boy presented with an extraordinary combination of clinical features consistent with PG and EDV. This unique presentation showcased recurrent nonhealing painful ulcers on the legs and body along with cribriform scarring for the last 8 years, which worsened over the last 1 year. Punch biopsy corroborated the diagnosis of PG. There were no signs and symptoms of other systemic diseases. Hypo- and hyperpigmented papules were spread all over the body with pityriasis versicolor-like macules on the forehead, neck and dorsa of the hands along with a positive family history in his younger brother, confirming the diagnosis of inherited EDV. The patient also had hepatosplenomegaly, for which paediatric workup was suggested. Treatment involved infection control, corticosteroid therapy and wound care, which led to a rapid healing response in the ulcers. This exceptional case sparks the suspicion of a novel syndrome due to its combination of EDV and PG, enhancing existing knowledge of the disease presentation.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 1","pages":"45-49"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the readability of dermatological patient information leaflets generated by ChatGPT-4 and its associated plugins.","authors":"Dominik Todorov, Jae Yong Park, James Andrew Ng Hing Cheung, Eleni Avramidou, Dushyanth Gnanappiragasam","doi":"10.1093/skinhd/vzae015","DOIUrl":"10.1093/skinhd/vzae015","url":null,"abstract":"<p><strong>Background: </strong>In the UK, 43% of adults struggle to understand health information presented in standard formats. As a result, Health Education England recommends that patient information leaflets (PILs) be written at a readability level appropriate for an 11-year-old.</p><p><strong>Objectives: </strong>To evaluate the ability of ChatGPT-4 and its three dermatology-specific plugins to generate PILs that meet readability recommendations and compare their readability with existing British Association of Dermatologists (BAD) PILs.</p><p><strong>Methods: </strong>ChatGPT-4 and its three plugins were used to generate PILs for 10 preselected dermatological conditions. The readability of these PILs was assessed using three readability formulas Simple Measure of Gobbledygook (SMOG), Flesch Reading Ease Test (FRET) and Flesch-Kincaid Grade Level Test (FKGLT) and compared against the readability of BAD PILs. A one-way ANOVA was conducted to identify any significant differences.</p><p><strong>Results: </strong>The readability scores of PILs generated by ChatGPT-4 and its plugins did not meet the recommended target range. However, some of these PILs demonstrated more favourable mean readability scores compared with those from the BAD, with certain plugins, such as Chat with a Dermatologist, showing significant differences in mean SMOG (<i>P</i> = 0.0005) and mean FKGLT (<i>P</i> = 0.002) scores. Nevertheless, the PILs generated by ChatGPT-4 were found to lack some of the content typically included in BAD PILs.</p><p><strong>Conclusions: </strong>ChatGPT-4 can produce dermatological PILs free from misleading information, occasionally surpassing BAD PILs in terms of readability. However, these PILs still fall short of being easily understood by the general public, and the content requires rigorous verification by healthcare professionals to ensure reliability and quality.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 1","pages":"14-21"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical signs and utility of CT PET scan in eosinophilic fasciitis?","authors":"Sarah R Adamson, John C Su, Sally Ng, Christopher Fong","doi":"10.1002/ski2.439","DOIUrl":"https://doi.org/10.1002/ski2.439","url":null,"abstract":"<p><p>A 61 year old male presented with clinical signs of Eosinophilic fasciitis (EF), a rare connective tissue disease. Early recognition of the diagnosis of EF is essential. Common examination findings are prayer sign and distal limb swelling, induration, venous guttering, and peau d'orange. CT PET scan can be helpful in supporting the diagnosis of EF.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"4 6","pages":"e439"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Numerical, phenotypic and functional differences in human dermal resident memory T cells between reticular dermal layers.","authors":"Takuya Sato, Riko Asakawa, Youichi Ogawa, Yuka Nagasaka, Manao Kinoshita, Shinji Shimada, Akira Momosawa, Tatsuyoshi Kawamura","doi":"10.1002/ski2.457","DOIUrl":"https://doi.org/10.1002/ski2.457","url":null,"abstract":"<p><strong>Background: </strong>Resident memory T (T_RM) cells and immunosuppressive Foxp3-expressing regulatory T_RM (regT_RM) cells are present in healthy, non-inflamed and inflamed human skin. Both types of cells are found in both the epidermis and dermis with the dermis being much thicker than the epidermis. However, it is unclear if T_RM and regT_RM cells differ between reticular dermal layers in terms of number, function or characteristics.</p><p><strong>Methods: </strong>This study examined numerical, phenotypic and functional differences in T_RM and regT_RM cells between the upper and lower reticular dermis in healthy, non-inflamed human skin using flow cytometry.</p><p><strong>Results: </strong>The phenotype and cytokine expressions of both types of cells were similar between reticular dermal layers. However, the cell count of both T_RM and regT_RM cells was significantly higher in the upper reticular dermis than in the lower reticular dermis.</p><p><strong>Conclusions: </strong>T_RM and regT_RM cells are phenotypically and functionally identical between reticular dermal layers. However, both types of cells are more abundant in the upper reticular dermis.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"4 6","pages":"e457"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive biases in Mohs micrographic surgery.","authors":"Faisal Dubash, Andrew Affleck, Marese O'Reilly, Kenneth G Gross","doi":"10.1002/ski2.466","DOIUrl":"https://doi.org/10.1002/ski2.466","url":null,"abstract":"<p><p>Mohs surgeons' fallibility is an important topic to explore. There are no studies on the role of cognitive biases in heuristic decision-making within Mohs micrographic surgery (MMS) as a contributing factor in mistakes or errors of clinical judgement. We reviewed established cognitive biases applied to heuristics during the pre-operative, intraoperative and reconstruction stages of MMS, and recommend conscious cognitive bias mitigating strategies for Mohs surgeons. Clinical errors/incidents may be reframed as opportunities to learn and develop, rather than evidence of competency or status. These experiences offer the opportunity to sharpen skills within metacognition and allow for more cognizant Mohs surgeons. We highly recommend all Mohs surgeons develop in-depth knowledge and maintain awareness of cognitive biases throughout clinical practice, to enhance clinical performance.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"4 6","pages":"e466"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurosensory symptoms and muscle cramping in morphea: A cross-sectional study and review.","authors":"Amanda Christine F Esquivel, Christopher B Hansen","doi":"10.1002/ski2.453","DOIUrl":"https://doi.org/10.1002/ski2.453","url":null,"abstract":"","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"4 6","pages":"e453"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"T-cell-related skin inflammatory flareups with Th1 polarity in a patient with pseudoxanthoma elasticum.","authors":"Samuel Rocour, Emeline Vinatier, Céline Fassot, Jonathan Dauvé, Agnès Toutain, Sabrina Fronteau, Marine Monnier, Laurence Preisser, Anne Croué, Olivier Le Saux, Alain Morel, Yves Delneste, Ludovic Martin","doi":"10.1002/ski2.430","DOIUrl":"https://doi.org/10.1002/ski2.430","url":null,"abstract":"<p><p>Pseudoxanthoma elasticum (PXE) is a genetic disorder characterized by ectopic calcification of tissues rich in elastic fibres (OMIM 264800). To date, PXE is considered a metabolic disease linked to an imbalance between pro- and anti-calcifying factors. The occurrence of sporadic erythematous flareups of PXE skin lesions is a complaint that we heard about on several occasions at the French PXE reference centre. However, this rare clinical aspect had never been extensively studied. We have had the opportunity to investigate a 13-year-old patient experiencing an erythematous flareup of his PXE lesions. We conducted this work to identify what type of inflammation was implicated in his lesions. An incisional skin biopsy on a recent erythematous inguinal PXE lesion was performed and sent for histological and transcriptomic analyses. The findings were compared to a non-erythematous PXE-affected skin biopsy obtained from another young PXE patient. Histological examination revealed perivascular T-cell infiltrates with Th1 polarity and elevated expression of cytotoxicity markers in RNAseq and RT-qPCR analyses. There was no increase in Th17 or Th2 markers. Our findings support the previous evidence of a possible inflammatory component in the development of PXE. Whether Th1-dependent inflammation contributes to the pathology as an active process or is an aggravating factor requires further investigations.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"4 6","pages":"e430"},"PeriodicalIF":0.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applications and efficacy of minoxidil in dermatology.","authors":"Ramadan S Hussein, Salman Bin Dayel, Othman Abahussein, Abeer Ali El-Sherbiny","doi":"10.1002/ski2.472","DOIUrl":"https://doi.org/10.1002/ski2.472","url":null,"abstract":"<p><p>Minoxidil, originally developed as an antihypertensive medication, has evolved into a versatile therapeutic agent within dermatology, notably for its effectiveness in promoting hair growth. Despite its widespread use, understanding its precise mechanism of action remains a challenge. This paper addresses this gap by providing a comprehensive review of pharmacological properties, action mechanisms, clinical effectiveness and side effects associated with topical minoxidil. Furthermore, it highlights emerging trends and applications, including its role in treating androgenetic alopecia, its potential for alopecia areata management and its utilization in combination therapies. Additionally, this paper explores novel applications in scar treatment and wound healing. By synthesizing current knowledge and insights, this review adds clarity to the diverse applications of minoxidil, providing valuable guidance for clinicians and researchers aiming to optimize its therapeutic use in dermatology.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"4 6","pages":"e472"},"PeriodicalIF":0.0,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using wearable technology to objectively investigate physical behaviour and determine health outcomes of a physical activity intervention in patients with psoriasis.","authors":"Rory Sheppard, Weh K Gan, Gladys L Onambele-Pearson, Helen S Young","doi":"10.1002/ski2.473","DOIUrl":"https://doi.org/10.1002/ski2.473","url":null,"abstract":"<p><strong>Background: </strong>Sedentary behaviour has a detrimental effect on health independent of the amount of physical activity undertaken. Despite the association of cardiometabolic and psychosocial comorbidities with psoriasis, how physical behaviour influences health outcomes in patients with psoriasis is poorly understood.</p><p><strong>Objectives: </strong>We hypothesized that objective measurement of physical behaviour, using wearable digital technology, would have utility in understanding the clinical impact of an exercise intervention designed in partnership with patients with psoriasis.</p><p><strong>Methods: </strong>Fourteen patients with psoriasis completed a 20-week study. During weeks 1-10, participants followed an incrementally progressive, exercise intervention, followed by independent activities during weeks 11-20. Accelerometers (GENEActiv Original) and pedometers recorded physical behaviour. Evaluation at week-0, -10, and -20 included assessment of psoriasis, cardiometabolic disease/risk, psychological health and functional capacity.</p><p><strong>Results: </strong>Our intervention supported significantly increased physical activity, including moderate-vigorous physical activity (<i>p</i> = 0.04) and step count (<i>p</i> = 0.04). We also observed a significant association between physical activity and psoriasis area and severity index (PASI)-50 response (<i>p</i> = 0.01) and psychosocial functioning (<i>p</i> = 0.029) together with a significant negative correlation between step count and psoriasis severity (<i>p</i> = 0.012). We observed no change in total waking hour sedentary behaviour.</p><p><strong>Conclusion: </strong>Objective measurement of physical behaviour, using wearable digital technologies, offers a mechanism to further understand the clinical impact of lifestyle behaviour interventions. Crucially, despite increased levels of physical activity, we observed no change in total waking hour sedentary time. Further investigation is required to establish how modification of physical behaviour could offer an adjuvant management strategy for patients with psoriasis.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"4 6","pages":"e473"},"PeriodicalIF":0.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}