Skin health and disease最新文献

{"title":"Generalized eruptive syringomas.","authors":"Shufang Chai, Aihua Wei, Rong Tao","doi":"10.1093/skinhd/vzaf096","DOIUrl":"https://doi.org/10.1093/skinhd/vzaf096","url":null,"abstract":"<p><p>This report describes an unusual clinical case of extensive syringoma involvement spanning multiple anatomical regions, offering insights into diagnostic challenges and management strategies for this rare manifestation.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 1","pages":"75"},"PeriodicalIF":0.0,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12867936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmasking: paronychia as the hidden face of pemphigus.","authors":"Anke Lambert, An Van Laethem, Julie Callens, Beatrice Verhamme, Matthias Steegmans, Francesca Bosisio, Petra De Haes","doi":"10.1093/skinhd/vzaf094","DOIUrl":"10.1093/skinhd/vzaf094","url":null,"abstract":"<p><p>Pemphigus vulgaris (PV) is a rare, potentially life-threatening autoimmune blistering disorder primarily affecting the skin and mucous membranes. We present a unique case of delayed diagnosis in a patient with PV, initially manifesting as isolated, extensive and therapy-resistant paronychia. PV was only considered after the appearance of mucocutaneous lesions - first oral, then cutaneous - more than 1 year after symptom onset. Diagnosis was ultimately established through histopathological examination, direct immunofluorescence and serological testing. Following diagnosis, the patient received rituximab therapy, resulting in a rapid and sustained clinical remission. This case underscores the importance of considering PV in the differential diagnosis of severe, chronic and treatment-resistant paronychia. Early recognition and diagnosis are crucial for timely intervention, which can significantly improve patient outcomes. Rituximab proved highly effective in this case, aligning with current evidence supporting its use as a first-line treatment for PV. We aim to raise awareness of atypical PV presentations and stress the need for thorough evaluation of persistent, treatment-resistant paronychia to prevent delayed diagnosis.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 1","pages":"71-74"},"PeriodicalIF":0.0,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12867939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of environmental pollution on acne: a systematic review.","authors":"Isobel R Okeah, Usamah M Afzal, Faisal R Ali","doi":"10.1093/skinhd/vzaf090","DOIUrl":"10.1093/skinhd/vzaf090","url":null,"abstract":"<p><p>In an increasingly urbanized world, environmental pollution is recognized for its adverse effects on both systemic and skin health. While its role in conditions such as atopic dermatitis and psoriasis is well documented, its impact on acne vulgaris remains less clear. This review aims to evaluate existing literature examining the association between environmental pollutants - such as particulate matter (PM_2.5, PM₁₀), nitrogen oxides (NO₂, NO_x) and traffic-related emissions - and the development, severity or exacerbation of acne. A systematic search of peer-reviewed English-language studies published between 2010 and 2025 was conducted using PubMed. Search terms included 'air pollution', 'particulate matter', 'PM_2.5', 'PM₁₀', 'NO₂', 'NO_x', 'environmental pollution', 'traffic pollution', 'acne' and 'acne vulgaris'. Studies were included if they investigated the relationship between environmental pollutants and acne in human populations. Of the 27 studies identified, 17 met inclusion criteria. Systematic reviews were also incorporated to provide broader context. Several studies demonstrated significant associations between pollutant exposure and acne exacerbation. A time-series study in China involving 71 625 outpatient visits found that each 10 μg m^-3 increase in SO₂ and NO₂ correlated with 1.02% and 2.13% increases in acne-related visits, respectively. Other studies appear to show pollutants being associated with increased sebum production and reduction of antioxidants. Proposed mechanisms include oxidative stress, microbiome disruption and follicular hyperkeratinization. However, study heterogeneity, lack of diversity and limited control for confounders limit generalizability. Longitudinal research is needed to clarify pollution's role in acne and inform targeted prevention strategies.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 1","pages":"12-19"},"PeriodicalIF":0.0,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12867942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation, cross-cultural adaptation and validation of an Afan Oromo version of the Dermatology Life Quality Index in individuals with cutaneous leishmaniasis in Ethiopia.","authors":"Debisa Eshatu Wendimu, Derese Bekele Daba, Sagni Chali Jira, Yohannes Hailemichael, Abebaw Yeshambel Alemu, Amel Beshir Mohammed, Fewzia Shikur Mohammed, Shimelis Nigusie Doni, Yematawork Kebede Aragaw, Mosisa Bekele Degefa, Nebiyu Sherefa, Fikregabrail Aberra Kassa, Tedros Nigusse, Eyerusalem Tesfaye Beyene, Teklu Cherkose, Saba Maria Lambert, Michael Marks, Stephen Walker, Endalamaw Gadisa","doi":"10.1093/skinhd/vzaf088","DOIUrl":"10.1093/skinhd/vzaf088","url":null,"abstract":"<p><strong>Background: </strong>The Dermatology Life Quality Index (DLQI) is a widely used instrument to assess the health-related quality of life associated with skin conditions. Afan Oromo is spoken by 40% of Ethiopians. <b>Objectives</b> This study aimed to translate, culturally adapt and validate the DLQI in Afan Oromo.</p><p><strong>Methods: </strong>This study was nested in a large hospital-based cohort study of cutaneous leishmaniasis (CL). Forward-backward translation followed by content validity, responsiveness to change, known group comparison, and convergent and discriminant validity were done. Internal consistency and inter-rater reliability were assessed using Cronbach's alpha and intraclass correlation coefficient (ICC), respectively.</p><p><strong>Results: </strong>The DLQI showed acceptable content validity with modified kappa between 0.8 and 1.0. One hundred individuals with confirmed active CL with a mean (SD) age of 36.81 (17.46) years, were interviewed using the translated draft of the Afan Oromo DLQI. The DLQI mean (SD) score was 11.93 (7.32). The instrument showed excellent internal consistency with a Cronbach alpha of 0.87 and inter-rater reliability ICC of 0.96. The median DLQI scores were significantly different between those with different physicians determined severity (<i>P</i> = 0.01) and lesion size (<i>P</i> = 0.004). There was high convergent validity (0.74-0.93). DLQI scores on day 90 were significantly lower than scores at enrolment prior to treatment (<i>P</i> = 0.0001).</p><p><strong>Conclusions: </strong>This translation of the DLQI to Afan Oromo is a valid and reliable patient-reported outcome measure instrument for research or clinical practice.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 1","pages":"54-61"},"PeriodicalIF":0.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12867945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient perceptions of artificial intelligence integration in dermatology: a cross-sectional study of trust, comfort and equity across multiple care modalities.","authors":"Charlotte McRae, Michael Anderson, Laci Turner, Alexandra Savage, Saleem Mohammad, Rachael Cowan, Lauren V Graham","doi":"10.1093/skinhd/vzaf086","DOIUrl":"10.1093/skinhd/vzaf086","url":null,"abstract":"<p><strong>Background: </strong>Artificial intelligence (AI) and telemedicine are rapidly changing the way dermatological care is delivered. As these tools are increasingly used in tandem, understanding how patients perceive the integration of AI across different care settings is important for responsible implementation.</p><p><strong>Objectives: </strong>To assess patient perceptions of AI in dermatology across five care modalities and examine how demographic factors influence acceptance.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted among 130 adults at a US academic dermatology clinic between December 2024 and April 2025. Participants rated trust, comfort, perceived quality, privacy and confidence in equitable performance across three AI-involved modalities: standalone AI apps, AI-assisted in-person visits and AI-assisted telemedicine visits. Differences in perception outcomes across the three care modalities were analysed using repeated measures Anova. Logistic and linear regressions analysed predictors of acceptance, including age, race, skin tone, socioeconomic status, rurality and technology experience.</p><p><strong>Results: </strong>Patients strongly preferred dermatologist-involved care over standalone AI, with 73.8% trusting dermatologist-guided AI and only 1.5% trusting AI apps alone. Comfort and perceptions of equal performance across skin tones were significantly higher for telemedicine and AI-assisted visits compared with AI apps (<i>P</i> < 0.001). Darker skin tone and Black race predicted lower acceptance of AI-assisted care (<i>P</i> = 0.01 and <i>P</i> = 0.003, respectively), while greater technology familiarity predicted higher acceptance (<i>P</i> = 0.05). Comfort varied by clinical scenario, with in-person visits showing dramatically higher odds of patient comfort compared with AI apps alone [odds ratio (OR) 232.8 for new concerns, OR 137.3 for serious concerns, OR 18.4 for sensitive concerns]. AI-assisted in-person visits also showed significantly higher odds of comfort over AI apps (OR 18.4 for serious concerns, OR 3.6 for ongoing concerns).</p><p><strong>Conclusions: </strong>Patients strongly prefer AI as clinical support systems rather than autonomous decision-makers, especially for high-stakes and sensitive concerns. Differences in acceptance by race and skin tone point to the need for better representation in datasets and clearer communication about how these tools perform. Moving forward, development and implementation should emphasize clinician and patient involvement, fairness and patient choice to ensure AI is integrated into dermatology in a way that earns patient trust.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 1","pages":"35-44"},"PeriodicalIF":0.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12867938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photothermal conditioning of platelet-rich plasma: mechanisms and emerging applications in hair regeneration.","authors":"Ilknur Nihal Ardic, Nurittin Ardic","doi":"10.1093/skinhd/vzaf089","DOIUrl":"10.1093/skinhd/vzaf089","url":null,"abstract":"<p><p>Photothermal conditioning of platelet-rich plasma (PRP) is an emerging innovation in regenerative medicine, particularly in the field of hair restoration. By using controlled electromagnetic energy, this technique modulates the biological activity of PRP, potentially enhancing the release of growth factor, production of exosomes and communication between cells. This review aims to explore the mechanisms behind photothermal PRP, summarize current preclinical and clinical findings, and evaluate its applications in hair regeneration. A comprehensive literature review was conducted across multiple databases to evaluate mechanistic data, clinical outcomes and technology platforms. Preliminary evidence suggests that photothermal conditioning enhances the bioactivity of PRP, leading to potential increases in hair density and follicular regeneration. Additionally, it may help reduce inflammation and prolong the anagen phase of the hair cycle. However, there is currently a lack of standard protocols, dosage regimens and clear understanding of the mechanisms involved. Despite these limitations, photothermal PRP shows promise as an adjunctive or alternative treatment for androgenic and inflammatory alopecia. Future clinical studies with standardized protocols and larger cohorts are necessary to confirm its efficacy, optimize treatment parameters and ensure long-term safety.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 1","pages":"20-29"},"PeriodicalIF":0.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12867943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoxia and oxidative stress related to inflammation and vascular aspects of the pathogenesis of psoriasis.","authors":"Sabina C A Hanssen, Marieke M B Seyger, Piet E J van Erp, Catharina J M van der Vleuten, Peter C M van de Kerkhof","doi":"10.1093/skinhd/vzaf007","DOIUrl":"10.1093/skinhd/vzaf007","url":null,"abstract":"<p><p>Psoriasis is a systemic autoimmune disease with roles in the innate and adaptive immune systems. Histological features include aberrant vascularization with dilated, tortuous, thin-walled capillaries and a mixed inflammatory infiltrate with mononuclear cells and neutrophils. There is increasing evidence that oxidative stress (hypoxia) plays an important role in vascular and inflammatory processes in the pathogenesis of psoriasis. In addition, it appears that systemic inflammation and oxidative stress could be a mechanistic link between psoriasis and concomitant cardiometabolic disorders. To present a unifying overview of the current literature on the general concept on the interrelationship between oxidative stress, vascular alternations and inflammation within the pathogenesis of psoriasis. More particularly, we aimed to gain insight into the pathomechanisms related to cardiovascular comorbidities - an important and distressing component of psoriatic disease. Standardized literature searches in PubMed and Embase were carried out with a focus on oxidative stress, inflammation and vascularization in psoriasis. In this article, the current knowledge on the role of oxidative stress in the inflammatory and vascular aspects of the pathogenesis of psoriasis are stated. Moreover, contemporary awareness of the pathomechanisms related to cardiovascular diseases are pointed out. The review presents arguments to underline the importance of hypoxia and oxidative stress in the inflammatory and vascular response within the pathogenesis of psoriasis and associated various cardiovascular and metabolic diseases.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12867946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microvascular alterations in nonlesional psoriatic skin versus healthy control skin: insights from optical coherence tomography angiography in psoriasis and atopic dermatitis.","authors":"Nina Moustgaard Knudsen, Lars Thrane, Thomas Emmanuel, Claus Johansen, Michael Pedersen, Christian Vestergaard","doi":"10.1093/skinhd/vzaf083","DOIUrl":"10.1093/skinhd/vzaf083","url":null,"abstract":"<p><strong>Background: </strong>Microvascular changes and angiogenesis play a key role in psoriasis and atopic dermatitis (AD), affecting lesional and, in AD, also nonlesional skin. Studies on nonlesional psoriatic skin show conflicting results. Both diseases involve inflammation-driven vascular changes. Optical coherence tomography angiography (OCTA) is a noninvasive tool for assessing capillary morphology and disease progression.</p><p><strong>Objectives: </strong>To examine microvascular alterations in psoriasis and AD using OCTA, assessing differences in lesional and nonlesional skin compared with healthy control skin; and to examine the potential of laser speckle contrast imaging (LSCI)-guided OCTA in monitoring skin in the same populations.</p><p><strong>Methods: </strong>Ten patients with psoriasis, 10 patients with AD and 5 healthy control participants were recruited. OCTA was used to measure microvascular parameters, including capillary loop depth, superficial plexus depth, vessel diameter, vessel density, vessel length and fractal dimension. LSCI-guided OCTA identified areas with the highest degree of inflammation within lesional skin. Comparisons were made between lesional and nonlesional skin in patients with psoriasis and AD.</p><p><strong>Results: </strong>Significant differences in microvascularity were found between lesional and nonlesional skin in patients with psoriasis and AD, as well as in comparison with healthy control participants. Differences in microvascular morphology were also identified in nonlesional skin of patients with psoriasis and healthy control participants, indicating systemic capillary changes. LSCI-guided OCTA did not enhance capillary detection.</p><p><strong>Conclusions: </strong>Our results suggest that psoriasis may involve systemic microvascular changes beyond local inflammation. While OCTA is a promising noninvasive tool, further research is needed to elucidate its clinical value.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 1","pages":"45-53"},"PeriodicalIF":0.0,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12867941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical papular mucinosis with thyroid cancer: comparison of isotretinoin and erbium:YAG laser treatment.","authors":"Bana O Aburajab, Rawda Qasrawi, Taha Z Makhlouf, Muawia O Aburajab, Manar Shukri Jaber","doi":"10.1093/skinhd/vzaf085","DOIUrl":"10.1093/skinhd/vzaf085","url":null,"abstract":"<p><p>Papular mucinosis (PM), or lichen myxoedematosus, is a rare skin disorder characterized by mucin deposition in the dermis, resulting in papules and nodules. It can present as scleromyxoedema, often with systemic complications, or localized PM, which typically follows a benign course. Atypical cases may present with unique features. We present an atypical case of PM in a 23-year-old woman with concurrent Hashimoto thyroiditis and papillary thyroid carcinoma. The patient presented with numerous progressive papules on her chest and abdomen, alongside systemic symptoms, including fatigue and weight loss. Diagnosis was confirmed through skin biopsy revealing mucin deposition. Initial treatment with isotretinoin yielded minimal improvement. However, significant improvement was observed following ablative erbium:YAG laser therapy, resulting in a marked reduction of lesions with no recurrence. This case highlights the classification of PM and demonstrates the potential effectiveness of laser therapy as a treatment option for this challenging condition.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 1","pages":"66-70"},"PeriodicalIF":0.0,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12867937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erythematous, pruritic and indurated plaques following treatment for melanoma.","authors":"Hareni Srenathan, Jing Gao, Eva Kolson Kokohaare, Ferina Ismail","doi":"10.1093/skinhd/vzae004","DOIUrl":"10.1093/skinhd/vzae004","url":null,"abstract":"<p><p>A 35-year-old man presented with two itchy, nontender, indurated erythematous plaques on his forehead and upper back. Three months prior, he had completed a 12-month course of adjuvant pembrolizumab for stage IIIC melanoma. Clinical and imaging surveillance revealed no evidence of melanoma recurrence of his left cheek. Incisional biopsies of both plaques with immunohistochemistry favoured a CD4⁺ reactive lymphoid process in keeping with cutaneous pseudolymphoma (CPL), secondary to pembrolizumab, an immune checkpoint inhibitor (ICI). The conspicuous, pruritic forehead plaque was unresponsive to clobetasol proprionate under occlusion. A single course of intralesional triamcinolone acetonide 10 mg L^-1 resulted in significant improvement within days, with subsequent complete resolution in a month. The plaque on the back resolved spontaneously after 6 months. Drug-induced CPL describes an adverse cutaneous drug reaction mimicking B- or T-cell lymphomas clinically and/or histologically. It has been described with anticonvulsants, antidepressants and biologic agents, often with resolution on cessation of the responsible drug. It has been proposed that the drugs affect immune surveillance, leading to an abnormal cutaneous lymphocyte response. As with the other adverse effects of immunotherapy, it is likely that CPL with ICIs is due to an iatrogenic immune dysregulation leading to T-cell overactivity. We highlight the successful use of intralesional steroid as treatment for drug-induced CPL with an ICI. It is important to recognize CPL as an adverse cutaneous effect of immunotherapy, and that it can present after completing treatment due to an ongoing immune response.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"6 1","pages":"62-65"},"PeriodicalIF":0.0,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12867940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}