Skin health and disease最新文献_第4页

Dual improvement of alopecia areata and immune thrombocytopenia with baricitinib: a case report. baricitinib对斑秃和免疫性血小板减少症的双重改善：1例报告。

Skin health and disease Pub Date : 2025-01-22 eCollection Date: 2025-02-01 DOI: 10.1093/skinhd/vzae019

Chelsea Moon, Sarah E Park, Jennifer L Hsiao, Katrina H Lee

{"title":"Dual improvement of alopecia areata and immune thrombocytopenia with baricitinib: a case report.","authors":"Chelsea Moon, Sarah E Park, Jennifer L Hsiao, Katrina H Lee","doi":"10.1093/skinhd/vzae019","DOIUrl":"10.1093/skinhd/vzae019","url":null,"abstract":"The oral Janus kinase (JAK) inhibitor baricitinib is approved by the U.S. Food and Drug Administration for the treatment of alopecia areata (AA). We report a case of dual improvement of AA and immune thrombocytopenia (ITP) with oral baricitinib monotherapy, which may suggest linked autoimmune pathophysiology. In phase III clinical trials of baricitinib for AA, reports of rare adverse haematological events include neutropenia and anaemia. While a history of haematological comorbidities may raise concern for many clinicians when considering treatment with a JAK inhibitor, this clinical vignette suggests that baricitinib may be considered and safely administered in those with concomitant AA and ITP. A 56-year-old man with a history of AA, ITP and vitiligo presented to the clinic for relapse of his steroid-resistant hair loss which had previously been treated with tofacitinib. In consultation with the patient's haematologist, baricitinib 2 mg daily was started with close platelet monitoring then doubled to 4 mg after platelets showed improvement at the 6-month follow-up. Fourteen months after initiating baricitinib, improvement in white and dark hair regrowth was observed, and platelets remained normal. Thus, baricitinib may be considered for the dual treatment of AA and ITP with regular platelet monitoring and co-management with haematology colleagues.","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 1","pages":"66-69"},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Favourable response of Blaschko linear psoriasis to interleukin-23 inhibition. Blaschko线状银屑病对白介素-23抑制的良好反应。

Skin health and disease Pub Date : 2025-01-22 eCollection Date: 2025-02-01 DOI: 10.1093/skinhd/vzae010

Jeremias L K Reich, Alexandros Onoufriadis, John A McGrath, Kristian Reich

引用次数: 0

Fixed drug eruption in a cribriform pattern: an atypical presentation. 筛网状固定药疹：非典型表现。

Skin health and disease Pub Date : 2025-01-22 eCollection Date: 2025-02-01 DOI: 10.1093/skinhd/vzae006

Mahesh Mathur, Neha Thakur, Sandhya Regmi, Supriya Paudel, Nabita Bhattarai, Sambidha Karki

引用次数: 0

Recalcitrant tinea capitis in WHIM syndrome. WHIM综合征中的顽固性头癣。

Skin health and disease Pub Date : 2025-01-22 eCollection Date: 2025-02-01 DOI: 10.1093/skinhd/vzae002

Jasmine C Meltzer, Jennifer Strong, Sophia Martinez, Abigail Salancy, Rutha Adhanom, Edward W Cowen, Leslie Castelo-Soccio, Philip M Murphy, David H McDermott, Isaac Brownell

引用次数: 0

An unusually severe case of shiitake mushroom dermatitis with features of drug reaction with eosinophilia and systemic symptoms. 异常严重的香菇皮炎病例，以嗜酸性粒细胞增多和全身症状为特征的药物反应。

Skin health and disease Pub Date : 2025-01-20 eCollection Date: 2025-02-01 DOI: 10.1093/skinhd/vzae012

Tristen Tze Wei Ng, Benjamin Andrew Wood, Patricia Le

{"title":"An unusually severe case of shiitake mushroom dermatitis with features of drug reaction with eosinophilia and systemic symptoms.","authors":"Tristen Tze Wei Ng, Benjamin Andrew Wood, Patricia Le","doi":"10.1093/skinhd/vzae012","DOIUrl":"10.1093/skinhd/vzae012","url":null,"abstract":"Shiitake mushroom dermatitis is a well-documented phenomenon in the literature seen after consuming raw or undercooked shiitake mushrooms (Lentinus edodes). However, systemic features resembling a drug reaction with eosinophilia and systemic symptoms (DRESS) are rare. We report a case of severe shiitake mushroom dermatitis with atypical systemic features resembling DRESS. A 51-year-old man presented with acute unilateral periorbital oedema and flagellate erythema with no obvious drug precipitants and was initially managed as allergic contact dermatitis in the emergency department. Further inquiry revealed a history of raw shiitake mushroom ingestion 48 h before the onset of symptoms, which led to a working diagnosis of shiitake mushroom dermatitis. Skin biopsies showed mixed spongiotic and interface inflammatory reactions with a perivascular lymphocytic infiltrate and marked eosinophilia supportive of shiitake mushroom dermatitis. Rheumatological causes of flagellate erythema and periorbital oedema were excluded from clinical and laboratory findings. The patient initially presented with apyrexia and mild eosinophilia but then developed pyrexia, hypereosinophilia, neutrophilia and transaminitis. He subsequently developed bilateral periorbital oedema with his flagellate erythema, both of which were resolved with topical and oral corticosteroids. However, there was a new widespread morbilliform eruption with dorsal oedema of his hands. A diagnosis of DRESS-like shiitake mushroom dermatitis was considered. The patient required a long course of oral prednisolone to achieve clinical and biochemical resolution of his symptoms. Our case underscores the importance of prompt recognition and management of shiitake dermatitis, especially when it presents with DRESS-like features.","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 1","pages":"56-60"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global epidemiological trends in the incidence and mortality for melanoma. 黑素瘤发病率和死亡率的全球流行病学趋势。

Skin health and disease Pub Date : 2025-01-20 eCollection Date: 2025-02-01 DOI: 10.1093/skinhd/vzae013

Nicola Cirillo

引用次数: 0

Erythematous variant of inverse pityriasis versicolor in skin of colour. 彩色皮肤的花斑型反糠疹红斑变异型。

Skin health and disease Pub Date : 2025-01-20 eCollection Date: 2025-02-01 DOI: 10.1093/skinhd/vzae011

Shreya Deoghare, Ajay Dodeja

引用次数: 0

A rare paediatric case with overlapping clinical features of epidermodysplasia verruciformis and pyoderma gangrenosum with hepatosplenomegaly. 一个罕见的小儿临床特征重叠的疣状表皮发育不良和坏疽性脓皮病伴肝脾肿大的病例。

Skin health and disease Pub Date : 2025-01-20 eCollection Date: 2025-02-01 DOI: 10.1093/skinhd/vzae003

Saud Azhar, Palwasha Khan, Fahad Faizullah

{"title":"A rare paediatric case with overlapping clinical features of epidermodysplasia verruciformis and pyoderma gangrenosum with hepatosplenomegaly.","authors":"Saud Azhar, Palwasha Khan, Fahad Faizullah","doi":"10.1093/skinhd/vzae003","DOIUrl":"10.1093/skinhd/vzae003","url":null,"abstract":"Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that typically manifests as painful ulcers, usually on the lower limbs, and is usually secondary to other conditions, for example inflammatory bowel disease and rheumatoid arthritis. Epidermodysplasia verruciformis (EDV) is an inherited or acquired primary immunodeficiency disorder linked to human papillomavirus susceptibility and an increased risk of squamous cell carcinoma. Occurrence of these conditions together has not been reported before. A 10-year-old boy presented with an extraordinary combination of clinical features consistent with PG and EDV. This unique presentation showcased recurrent nonhealing painful ulcers on the legs and body along with cribriform scarring for the last 8 years, which worsened over the last 1 year. Punch biopsy corroborated the diagnosis of PG. There were no signs and symptoms of other systemic diseases. Hypo- and hyperpigmented papules were spread all over the body with pityriasis versicolor-like macules on the forehead, neck and dorsa of the hands along with a positive family history in his younger brother, confirming the diagnosis of inherited EDV. The patient also had hepatosplenomegaly, for which paediatric workup was suggested. Treatment involved infection control, corticosteroid therapy and wound care, which led to a rapid healing response in the ulcers. This exceptional case sparks the suspicion of a novel syndrome due to its combination of EDV and PG, enhancing existing knowledge of the disease presentation.","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 1","pages":"45-49"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the readability of dermatological patient information leaflets generated by ChatGPT-4 and its associated plugins. 评估ChatGPT-4及其相关插件生成的皮肤病患者信息传单的可读性。

Skin health and disease Pub Date : 2025-01-20 eCollection Date: 2025-02-01 DOI: 10.1093/skinhd/vzae015

Dominik Todorov, Jae Yong Park, James Andrew Ng Hing Cheung, Eleni Avramidou, Dushyanth Gnanappiragasam

{"title":"Assessing the readability of dermatological patient information leaflets generated by ChatGPT-4 and its associated plugins.","authors":"Dominik Todorov, Jae Yong Park, James Andrew Ng Hing Cheung, Eleni Avramidou, Dushyanth Gnanappiragasam","doi":"10.1093/skinhd/vzae015","DOIUrl":"10.1093/skinhd/vzae015","url":null,"abstract":"Background: In the UK, 43% of adults struggle to understand health information presented in standard formats. As a result, Health Education England recommends that patient information leaflets (PILs) be written at a readability level appropriate for an 11-year-old.Objectives: To evaluate the ability of ChatGPT-4 and its three dermatology-specific plugins to generate PILs that meet readability recommendations and compare their readability with existing British Association of Dermatologists (BAD) PILs.Methods: ChatGPT-4 and its three plugins were used to generate PILs for 10 preselected dermatological conditions. The readability of these PILs was assessed using three readability formulas Simple Measure of Gobbledygook (SMOG), Flesch Reading Ease Test (FRET) and Flesch-Kincaid Grade Level Test (FKGLT) and compared against the readability of BAD PILs. A one-way ANOVA was conducted to identify any significant differences.Results: The readability scores of PILs generated by ChatGPT-4 and its plugins did not meet the recommended target range. However, some of these PILs demonstrated more favourable mean readability scores compared with those from the BAD, with certain plugins, such as Chat with a Dermatologist, showing significant differences in mean SMOG (P = 0.0005) and mean FKGLT (P = 0.002) scores. Nevertheless, the PILs generated by ChatGPT-4 were found to lack some of the content typically included in BAD PILs.Conclusions: ChatGPT-4 can produce dermatological PILs free from misleading information, occasionally surpassing BAD PILs in terms of readability. However, these PILs still fall short of being easily understood by the general public, and the content requires rigorous verification by healthcare professionals to ensure reliability and quality.","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 1","pages":"14-21"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical signs and utility of CT PET scan in eosinophilic fasciitis? 嗜酸性筋膜炎的临床征象及CT PET扫描的应用？

Skin health and disease Pub Date : 2024-12-01 DOI: 10.1002/ski2.439

Sarah R Adamson, John C Su, Sally Ng, Christopher Fong

引用次数: 0