Skin health and disease最新文献

{"title":"Novel CYLD pathogenic variant associated with multiple cylindromas of the scalp-A case report.","authors":"Inês P Amaral, Ivânia Soares, Madalena P Correia, Catarina Correia, Pedro Vasconcelos, Luis S Almeida, Paulo Filipe","doi":"10.1002/ski2.436","DOIUrl":"10.1002/ski2.436","url":null,"abstract":"<p><p>Cylindromas are rare, benign adnexal neoplasms primarily found on the scalp and face, with a higher incidence in women and typically manifesting in the second or third decade of life. These tumours can present as single or multiple nodules, with the latter form often linked to CYLD gene mutations, particularly in the context of CYLD cutaneous syndrome. Here, we report a case of a 61-year-old male presenting with multiple cylindromas of the scalp, prompting genetic testing that revealed a novel pathogenic variant in the CYLD gene.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"4 5","pages":"e436"},"PeriodicalIF":0.0,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of 3D facial photographs and clinical documentation in patients with craniofacial morphea","authors":"Tyler T. Nguyen, Stephanie M. Cohen, Katharina S. Shaw, Fatma Dedeoglu, R. A. Vleugels, Ingrid M. Ganske","doi":"10.1002/ski2.438","DOIUrl":"https://doi.org/10.1002/ski2.438","url":null,"abstract":"Diagnosis of craniofacial morphea (CM) relies upon clinical examination of progressive craniofacial changes. We assess the utility of 3D stereophotogrammetry in documenting asymmetry of the face compared to clinical notetaking. This retrospective study of 3D images and clinical documentation included 32 patients (mean age 15.7 years) with CM. A panel of specialists identified additional areas of asymmetry (those highlighted in 3D photographs that were not noted in clinical documentation) and categorised them as likely, ambiguously or unlikely related to CM. 28 patients (87.5%) had asymmetries noted on 3D photos that were not documented in clinical notes. In 46.4% of them, additional areas were deemed consistent with CM. In the remaining patients, additional asymmetries were ambiguous (42.9%) or not thought to be related to CM (10.7%). Our results suggest that adjunctive use of 3D stereophotogrammetry enhances the documentation of CM at discrete clinical time points and therefore could be a better comparative reference during later re‐examination.","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141920118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased physical activity promotes skin clearance, improves cardiovascular and psychological health, and increases functional capacity in patients with psoriasis","authors":"Rory Sheppard, W. K. Gan, Gladys L. Onambele‐Pearson, Helen S. Young","doi":"10.1002/ski2.426","DOIUrl":"https://doi.org/10.1002/ski2.426","url":null,"abstract":"Patients with psoriasis are less physically active compared to age‐matched controls, due to psoriasis‐specific barriers, which significantly limits their ability to benefit from health‐promoting levels of physical activity (PA). In addition, long‐term health outcomes for people with psoriasis are poor and include depression, metabolic syndrome and cardiovascular disease (CVD); presenting a significant challenge to healthcare services.We designed a PA intervention in partnership with patients with psoriasis hypothesising this may have therapeutic utility in the management of psoriasis.Participants with chronic plaque psoriasis were recruited to a single‐centre, 20‐week, prospective cohort study. A wrist‐worn accelerometer (GENEActiv Original; Activinsights Ltd) and a hip‐worn pedometer (Onwalk 900; Decathlon Group) were used objectively measure levels of PA. Our 10‐week PA intervention comprised twice weekly 60‐min walks within three different greenspaces in Greater Manchester, each led by a Sports and Exercise Scientist to deliver a pre‐specified volume/dose of activity. During weeks‐11–20 of the study, participants followed independent activities. Clinical evaluation, including assessment of psoriasis severity, cardiometabolic parameters, psychological wellbeing and functional capacity was made at baseline, week‐10 and ‐20.Sixteen patients with psoriasis completed the study. We observed significantly reduced Psoriasis Area and Severity Index at week‐10 (p = 0.01) and ‐20 (p = 0.001) compared to baseline, with 50% of participants achieving PASI‐50 at week‐20. Dermatology Life Quality Index (DLQI) was significantly reduced at week‐20 (p = 0.04), compared to baseline. Significant reduction in blood pressure at week‐10 (systolic: −7.4 mmHg, p = 0.002; diastolic: −4.2 mmHg, p = 0.03) and ‐20 (systolic: −8.8 mmHg, p = 0.001; diastolic: 4.1 mmHg, p = 0.008) was observed and pulse wave velocity was significantly reduced by week‐20 (p = 0.02), suggesting improvement in cardiovascular health. Despite high prevalence of anxiety and depression at baseline, we documented a significant improvement in wellbeing and psychological health. Functional capacity was significantly enhanced following completion of the study.Increasing PA constitutes a promising therapeutic intervention in the management of psoriasis. Evaluation of our intervention in a clinical trial would help determine clinical utility and establish PA guidelines for patients with psoriasis.","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"30 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141923109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of ruxolitinib cream for the treatment of vitiligo: A randomised controlled trial secondary analysis at 3 years.","authors":"John E Harris, Amit G Pandya, Mark Lebwohl, Iltefat H Hamzavi, Pearl Grimes, Alice B Gottlieb, Howard L Sofen, Angela Y Moore, Mingyue Wang, Deanna Kornacki, Kathleen Butler, David Rosmarin","doi":"10.1002/ski2.404","DOIUrl":"https://doi.org/10.1002/ski2.404","url":null,"abstract":"","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"4 6","pages":"e404"},"PeriodicalIF":0.0,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sunscreens: A narrative review.","authors":"Hamisha Salih, Cristina Psomadakis, Susannah M C George","doi":"10.1002/ski2.432","DOIUrl":"https://doi.org/10.1002/ski2.432","url":null,"abstract":"<p><p>Sunscreens are topical formulations incorporating filters that protect our skin against ultraviolet radiation (UVR) emitted by the sun. Sunscreen use has been increasingly encouraged to protect against sunburn, skin cancer and photoaging that can occur because of prolonged and cumulative sun exposure. However, sunscreens and their constituent UVR filters have been purported to be problematic themselves. In this narrative review, we will describe the history of sunscreens, types of UVR filters and how sunscreens are classified and rated. We will also explore some of the controversies regarding sunscreens, including concerns about their safety and environmental impact. Awareness of these potential consequences is paramount to the process of informed decision-making.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"4 6","pages":"e432"},"PeriodicalIF":0.0,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding subcutaneous mass on the scalp of an immunocompromised woman.","authors":"Ivan Rodriguez, Karen Lam, Simone Montgomery, Shanice McKenzie, Scott Worswick","doi":"10.1002/ski2.437","DOIUrl":"https://doi.org/10.1002/ski2.437","url":null,"abstract":"<p><p>Acute cutaneous presentations in immunocompromised patients demand careful and thorough evaluation. Here, we present the case of a 26-year-old female with acute myeloid leukaemia undergoing salvage chemotherapy, who developed an acutely expanding subcutaneous mass starting on the frontotemporal scalp to the angle of the jaw. Histopathologic evaluation was consistent with sclerosing fat necrosis with overlying psoriasiform spongiotic dermatitis. Tissue cultures revealed multi-drug resistant Pseudomonas aeruginosa. Given these findings, the patient was diagnosed with infectious panniculitis. This case underscores the necessity of comprehensive diagnostic approaches and multidisciplinary collaboration in managing unusual cutaneous presentations in immunocompromised individuals.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"4 6","pages":"e437"},"PeriodicalIF":0.0,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A diagnostic challenge of tongue botryomycosis miming mycetoma-A case report.","authors":"Emmanuel Edwar Siddig, Ayman Ahmed","doi":"10.1002/ski2.433","DOIUrl":"10.1002/ski2.433","url":null,"abstract":"<p><p>Botryomycosis of the tongue is a rare chronic bacterial infection that presents as nodular masses, mimicking other infectious or neoplastic conditions such as mycetoma. A case of an 80-year-old male was presented with painless swelling on the right lateral side of his tongue to the outpatient clinic. Biopsy and microbiological investigations revealed an unexpected <i>Staphylococcus aureus</i>-related botryomycosis. This case highlights the diagnostic challenge for unusual clinical presentations of bacterial infections. Healthcare providers in countries endemic with diseases that manifest similarly should investigate thoroughly to ensure a positive clinical outcome through early diagnosis and effective case management.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"4 5","pages":"e433"},"PeriodicalIF":0.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A sporadic diffuse multiple cutaneous leiomyomatosis mimicking plexiform neurofibromatosis: A surgical challenge.","authors":"Gajanand M Antakanavar, Bijaylaxmi Sahoo, Aneet Kaur, Ishu Ghiloria, Ajay Jangid, Bhavishya Shetty","doi":"10.1002/ski2.414","DOIUrl":"10.1002/ski2.414","url":null,"abstract":"<p><p>A 32-year-old male presented with diffuse plaques accompanied by multiple large, painful swellings predominantly distributed over the trunk, face and both upper and lower extremities for 11 years. There was no family history of similar complaints. The histopathological examination (HPE), supplemented with special stains confirmed the diagnosis of cutaneous leiomyoma (CL). The immunohistochemical analysis showed a strong expression of smooth muscle actin. The final diagnosis of sporadic diffuse multiple cutaneous leiomyomatosis was made. This presentation of CL is uncommon and resembled plexiform neurofibroma. The clinical diagnosis of this presentation was challenging. Therefore, HPE combined with special stains aided in confirming this surgically challenging rare tumour. In resource-poor settings regular screening is required for early detection of renal cancer and other associated complications.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"4 5","pages":"e414"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angry back","authors":"R.W.D. Ottevanger, Roel E. Genders","doi":"10.1002/ski2.428","DOIUrl":"https://doi.org/10.1002/ski2.428","url":null,"abstract":"","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"29 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141806021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in disease severity and quality of life outcome measures in pemphigus clinical trials: A scoping review","authors":"G. Pathak, Kush Patel, Christopher Wachuku, T. Truong, Priya Agarwal, Babar K. Rao","doi":"10.1002/ski2.429","DOIUrl":"https://doi.org/10.1002/ski2.429","url":null,"abstract":"Pemphigus represents a spectrum of autoimmune‐mediated blistering diseases associated with high morbidity, mortality and reduced quality of life (QoL). Despite an increase in pemphigus clinical trials, the varied instrument measurements of disease severity and QoL outcomes make comparisons between studies challenging. This study aimed to evaluate trends in the use of disease severity and QoL outcome measurements in pemphigus clinical trials. A review of pemphigus clinical trials was conducted using the PubMed, Embase, Cochrane Reviews and ClinicalTrials.gov databases up until September 2023. Only pemphigus randomized clinical trials that assessed at least one disease severity and/or QoL outcome were included. Overall, 53 clinical trials were eligible for this review. All clinical trials evaluated a disease severity outcome, with the Pemphigus Disease Area Index being the most used validated questionnaire (28.3% of trials) and more popular after 2015 (47.8% of trials since). The autoimmune bullous skin disorder intensity score (7.6%) and visual analogue measurements (7.6%) have fallen out of favour. Most studies now include lab parameters (56.5% of trials after 2015), with anti‐desmoglein 1 and 3 antibody levels (30.2%), immunoglobulins (IgG and/or IgM and IgA) (11.3%), and anti‐drug antibody levels (7.6%) being frequently evaluated. A small portion of trials evaluated QoL (26.5% of studies), with the autoimmune bullous quality of life being the most common (15.1%), however QoL utilization as an outcome measure has been increasing since 2015 (61.1% of trials since). Standardising the use of validated outcome measurements allows for better data interpretation, comparability and clinical application of results.","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"58 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141807091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}