Skin health and disease最新文献

{"title":"COVID‐19 vaccination‐linked granuloma annulare in two patients","authors":"Emma McIntyre, Philina Lamb, Maxwell A. Fung, Maija Kiuru, Lawrence S. Chan","doi":"10.1002/ski2.412","DOIUrl":"https://doi.org/10.1002/ski2.412","url":null,"abstract":"The COVID‐19 pandemic brought not only a huge healthcare challenge to the world but also introduced many questions of how the human immune system reacts to counter viral invasion, including vaccination. Unlike most vaccinations that are not usually linked to any specific skin eruptions, COVID‐19 vaccination has been linked to a variety of skin lesions. In this paper, we present two patients who developed granulomatous skin lesions post‐COVID‐19 vaccination, one patient has generalised granuloma annulare (GA) and the other patient develops localised GA. Both patients have good responses to treatment regimens containing systemic corticosteroids. We review the literature pertaining to COVID‐19‐linked skin diseases, particularly granulomatous diseases and discuss the possible pathomechanism of granulomatous eruptions in relation to COVID‐19 vaccination.","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"61 41","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141807181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential role of mindfulness in the adjuvant treatment of atopic dermatitis","authors":"Filomena Russo, A. Dattolo, D. Sordi, A.R. Giampetruzzi, Ornella de Pità, Annarita Panebianco, B. Cocuroccia","doi":"10.1002/ski2.423","DOIUrl":"https://doi.org/10.1002/ski2.423","url":null,"abstract":"","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"129 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141811525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapidly progressing scalp melanoma in an elderly patient","authors":"Christian Vestli, Assia Bassarova, Jose Hernán Alfonso","doi":"10.1002/ski2.431","DOIUrl":"https://doi.org/10.1002/ski2.431","url":null,"abstract":"","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"16 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141815650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linear atrophoderma of Moulin: A rare case report and review of the literature","authors":"Moatasem Hussein Al‐janabi, Sdrah Diab, Ghina Aljammal, Lina Kassab, Z. Al-shehabi, Lina Al‐Soiufi","doi":"10.1002/ski2.424","DOIUrl":"https://doi.org/10.1002/ski2.424","url":null,"abstract":"Linear atrophoderma of Moulin (LAM) is an uncommon dermatological disease characterised by linear, depressed plaques typically following Blaschko's lines. LAM generally occurs in adolescence or early adulthood and is more commonly observed in females. The aetiology of LAM is still unclear. We report a rare case of LAM in an 18‐year‐old female presenting with an atypical Blaschkoid distribution (multiple band‐like pattern) on her right trunk. A clinical examination and histopathological analysis were performed to make the diagnosis. Partial improvement was obtained with calcipotriol and colchicine. LAM is a rare condition; we were only able to identify 23 case reports in the published literature. The findings of this report contribute to the limited literature on LAM, highlighting the clinical variability of LAM and suggesting potential novel variants beyond the classic presentation, emphasising the importance of recognising diverse manifestations for accurate diagnosis and management. Early recognition of LAM is crucial for appropriate treatment and improved patient outcomes. Further research is needed to elucidate LAM's aetiology and underlying mechanisms to facilitate the development of more targeted therapeutic strategies.","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"46 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141818101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clear cell renal cell carcinoma micrometastasis: Insights from an unconventional cutaneous presentation","authors":"Mohammad Fardos, Heather Kopecky, James Sligh, Jill Browning","doi":"10.1002/ski2.427","DOIUrl":"https://doi.org/10.1002/ski2.427","url":null,"abstract":"Clear cell renal cell carcinoma (ccRCC) is a highly lethal cancer known for its propensity to metastasise, yet the mechanisms underlying metastasis are not well defined. Cutaneous metastases from ccRCC are uncommon and typically occur within 3 years post‐nephrectomy, predominantly affecting the scalp, chest or abdomen. Here, we present a unique case of a 75‐year‐old male, previously treated for ccRCC with right radical nephrectomy, who developed a singular skin lesion on the left side of the neck 19 years post‐nephrectomy. The lesion was confirmed as metastatic ccRCC through histopathological analysis, despite negative imaging findings. Micrometastases, characterised by microscopic tumour cell foci in distant sites, pose a significant diagnostic challenge, frequently evading detection on conventional imaging modalities like computed tomography and magnetic resonance imaging. This case contributes to our understanding of ccRCC metastasis, emphasising the necessity for continued clinical vigilance and thorough diagnostic scrutiny, particularly concerning atypical metastatic sites.","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":" 453","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141823588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenetics and ultraviolet radiation: Implications for skin ageing and carcinogenesis","authors":"Bethany M. Barnes, Anya Shyne, David A. Gunn, Christopher E. M. Griffiths, Rachel E. B. Watson","doi":"10.1002/ski2.410","DOIUrl":"https://doi.org/10.1002/ski2.410","url":null,"abstract":"Recent published data have highlighted the importance of epigenetics in the response of the skin to recreational and therapeutic ultraviolet radiation (UVR) exposure. ‘Epi’—from the Greek επί, meaning over, outside of or around—relates to the chemical modifications that occur on top of the DNA sequence (for example, DNA methylation) and its associated proteins (e.g. histone modifications, including methylation, acetylation and phosphorylation). These epigenetic processes, collectively called the ‘epigenome’, dictate the three‐dimensional conformation of the DNA, thus impacting upon gene expression and genomic stability. Given that epigenetic changes are long‐lived and mitotically heritable, an accumulation of epigenetic perturbations likely influence the pathogenesis of the chronic consequences of UVR exposure, including photoageing and skin cancer risk. In this review, we describe the multifarious epigenetic effects elicited by UVR in the skin. We further speculate on the underlying molecular mechanisms that may direct epigenetic changes, such as oxidative stress and changes in metabolism, and their impact on skin health and disease.","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141674174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of outcome measures evaluating treatment efficacy in vulval lichen sclerosus and evaluation of patients' priorities","authors":"Sara Jasionowska, A. Almadori, Mary Goble, B. Langridge, D. Iakovou, Fady Kamel, Milla McKenzie, Allan Mclean, D. Boyle, N. Zenner, V. Swale, Peter E. M. Butler","doi":"10.1002/ski2.422","DOIUrl":"https://doi.org/10.1002/ski2.422","url":null,"abstract":"Vulval lichen sclerosus (VLS) is an inflammatory skin disease characterised by itching, apareunia, loss of vulval architecture and scarring. Heterogeneity in outcome reporting precludes comparison between treatments. This study aimed to systematically review outcome measures used to evaluate the efficacy of VLS treatments and present patients' treatment priorities. This review followed the PRISMA guidelines using a registered protocol (PROSPERO: CRD42022356738). Multiple databases were searched, along with grey literature on Clinicaltrials.gov, European Union Clinical Trials and International Standard Randomised controlled trial (RCT) registries. All RCTs assessing any treatment for VLS were eligible for inclusion. A total of 775 patients were assessed across 21 RCTs. The assessment tools reported outcomes in the following domains: patient‐reported symptoms assessed with one validated scale in 12 studies and seven non‐validated scales in nine studies; sexual function with validated female sexual function index and female sexual distress scale in two studies and two non‐validated scales in two studies; quality of life with three validated scales in three studies and clinician‐reported objective outcomes with two validated scales in three studies and six non‐validated scales in fourteen studies. Histological changes were assessed in 10 studies and tissue biomechanics in one study. We also carried out an online survey completed by 809 women with VLS to assess their research and disease treatment priorities and identified validated outcome measures to assess these. There is high variability in assessing treatment outcomes for VLS. We identified validated assessment tools which could be implemented in VLS studies to evaluate the effectiveness of treatments.","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141676613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atopic dermatitis in 32 children treated with dupilumab in real life. A new contribution","authors":"Isabel Betlloch-Mas, María Armengol‐García, Noelia Jara-Rico, R. Hernández‐Quiles, Laura Berbegal DeGracia","doi":"10.1002/ski2.413","DOIUrl":"https://doi.org/10.1002/ski2.413","url":null,"abstract":"","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"8 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141681259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychodermatology in Hungary: Awareness and practice patterns of dermatologists","authors":"Gabriella Cápec, M. Jafferany, Szergej Cápec, Sára Hoffmann, Miklós Sárdy","doi":"10.1002/ski2.419","DOIUrl":"https://doi.org/10.1002/ski2.419","url":null,"abstract":"Psychodermatology is an interdisciplinary branch of medicine between psychiatry /psychology and dermatology.This study aimed to assess Hungarian dermatologists' awareness, practice patterns and attitudes towards psychodermatology.A questionnaire‐based survey was sent from October 2020 to June 2021 to 100 dermatologists (including residents in dermatology) in Hungary with a response rate of 51%. The participants were asked about understanding of the concept of psychodermatology and their training in this field, comfort in treatment, and interest in continuing medical education on dermatological disorders with psychological components.49% of the respondents understood psychodermatology as a bidirectional interaction of the patient's mental and dermatological conditions, and 25.5% were comfortable in treating psychodermatological patients. The most common dermatological diagnoses with psychological/psychiatric involvement reported were psoriasis and atopic dermatitis. Atopic dermatitis, anxiety, delusional parasitosis, and depression were the most common diagnoses when dermatologists referred patients to psychiatrists. In total, 76.5% of participants could not name any resource (magazine, website, etc.) for patients and their families where information about psychodermatology is available, and 58.8% showed a definite interest in attending training on psychodermatology.The results of our study suggest that Hungarian dermatologists have a high awareness of the term “psychodermatology”, and only a quarter of practitioners feel adequately equipped and comfortable managing patients with psychosomatic aspects in their treatment. The relatively large gap between the number of patients with a psychodermatological component and referrals by dermatologists to mental health specialists indicates the potential importance of more intensive collaboration between dermatologists, psychiatrists and/or psychologists.","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"3 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141685925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical pattern and treatment outcome of cutaneous leishmaniasis patients in Somali region, eastern Ethiopia.","authors":"Abdilahi Ibrahim Muse, Muse Obsiye Ibrahim, Muse Ahmed Ibrahim","doi":"10.1002/ski2.416","DOIUrl":"10.1002/ski2.416","url":null,"abstract":"<p><strong>Background: </strong>Neglected tropical diseases, affecting over a billion people, include leishmaniasis, a protozoan parasite found in over 20 species. It is classified into three types: visceral, cutaneous, and muco-cutaneous leishmaniasis, with cutaneous leishmaniasis being the most common. Dogs and rodents are the primary reservoirs of leishmaniasis, which is transmitted by infected female sandflies. Cutaneous leishmaniasis, found on exposed parts such as the arms, face and legs, presents with diverse clinical manifestations, including erythematous lesions, large, painless nodules, ulceration and an eventual volcanic form.</p><p><strong>Objective: </strong>To assess the clinical pattern and treatment outcome of cutaneous leishmaniasis patients in the Somali region of eastern Ethiopia.</p><p><strong>Methods: </strong>This descriptive study was conducted in the Somali region using neglected tropical disease surveillance data collected from 1 September 2023, to 8 February 2024. The data were cleaned and then exported to STATA version 17 for analysis.</p><p><strong>Results: </strong>From 1 September 2023, to 8 February 2024, 900 patients were diagnosed with cutaneous leishmaniasis. Of these, 105 (11.67%) patients had localised cutaneous leishmaniasis, 741 (82.33%) had disseminated cutaneous leishmaniasis, 20 (2.22%) had diffuse cutaneous leishmaniasis, 8 (0.89%) had mucocutaneous leishmaniasis, 12 (1.33%) had mucocutaneous and disseminated leishmaniasis and 14 (1.56%) had localised and mucocutaneous leishmaniasis. All of the cases were male; the most common signs and symptoms the patients showed were papule, nodule, ulcer and crust 791 (87.89%) and itching, fever and discharges 758 (84.22%), respectively. Most of the patients, 823 (93.34%), were given systemic pentavalent antimonials, and the cure rate was 886 (98.44%). Of the patients, 14 (100%) who were defaulted on had diffuse cutaneous leishmaniasis.</p><p><strong>Conclusions: </strong>All the participants had travelled to an area where sandflies were common. The majority of patients complained of itching, fever and discharges, with over two-thirds having disseminated cutaneous leishmaniasis (DCL) and 0.89% having mucocutaneous leishmaniasis. The regional health bureau should set up a strong surveillance system and launch educational campaigns to raise awareness about cutaneous leishmaniasis, its transmission, symptoms and preventive measures. Furthermore, patients should be advised to strictly adhere to their treatment schedule and follow-ups.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"4 5","pages":"e416"},"PeriodicalIF":0.0,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}