Numerical, phenotypic and functional differences in human dermal resident memory T cells between reticular dermal layers.

Q3 Medicine

Skin health and disease Pub Date : 2024-12-01 DOI:10.1002/ski2.457

Takuya Sato, Riko Asakawa, Youichi Ogawa, Yuka Nagasaka, Manao Kinoshita, Shinji Shimada, Akira Momosawa, Tatsuyoshi Kawamura

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Abstract

Background: Resident memory T (T_RM) cells and immunosuppressive Foxp3-expressing regulatory T_RM (regT_RM) cells are present in healthy, non-inflamed and inflamed human skin. Both types of cells are found in both the epidermis and dermis with the dermis being much thicker than the epidermis. However, it is unclear if T_RM and regT_RM cells differ between reticular dermal layers in terms of number, function or characteristics.

Methods: This study examined numerical, phenotypic and functional differences in T_RM and regT_RM cells between the upper and lower reticular dermis in healthy, non-inflamed human skin using flow cytometry.

Results: The phenotype and cytokine expressions of both types of cells were similar between reticular dermal layers. However, the cell count of both T_RM and regT_RM cells was significantly higher in the upper reticular dermis than in the lower reticular dermis.

Conclusions: T_RM and regT_RM cells are phenotypically and functionally identical between reticular dermal layers. However, both types of cells are more abundant in the upper reticular dermis.

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网状真皮层间人类真皮常驻记忆T细胞的数量、表型和功能差异

背景：常驻记忆T （TRM）细胞和表达免疫抑制foxp3的调节性TRM （regTRM）细胞存在于健康、非炎症和炎症的人体皮肤中。这两种类型的细胞都存在于表皮和真皮中，真皮比表皮厚得多。然而，目前尚不清楚网状真皮层中TRM和regTRM细胞在数量、功能或特征上是否存在差异。方法：本研究采用流式细胞术检测健康非炎症人体皮肤上、下网状真皮层中TRM和regTRM细胞的数量、表型和功能差异。结果：两种细胞在网状真皮层间的表型和细胞因子表达相似。然而，上网状真皮层中TRM和regTRM细胞的数量明显高于下网状真皮层。结论：网状真皮层间TRM和regTRM细胞在表型和功能上是相同的。然而，这两种类型的细胞在网状真皮上部更为丰富。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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