Skin health and disease最新文献

{"title":"The psychosocial impact of alopecia in men: A mixed-methods survey study.","authors":"Fabio Zucchelli, Abbi Mathews, Nick Sharratt, Kerry Montgomery, Jen Chambers","doi":"10.1002/ski2.420","DOIUrl":"10.1002/ski2.420","url":null,"abstract":"<p><strong>Background: </strong>The most common forms of hair loss in men, alopecia areata (AA) (an autoimmune condition) and androgenetic alopecia (AGA) (pattern baldness), alter individuals' appearance in ways that may impact psychological and social wellbeing. We currently have a limited understanding about this impact of alopecia in men, their support needs, and preferences.</p><p><strong>Objectives: </strong>We sought to investigate and explore the psychosocial impact of alopecia on men, alongside their experiences of treatment and support.</p><p><strong>Methods: </strong>The study used a mixed methods cross-sectional online survey with 177 men aged 17-79: 83 with AGA and 94 with AA. Quantitative questions included purpose-made rating scales of men's support experiences, and standardised measures of wellbeing and appearance-focused anxiety. Qualitative data comprised participants' answers to an open-ended question asking about their subjectively salient experiences related to their alopecia.</p><p><strong>Results: </strong>The combined findings indicate that while participants in both subsamples had sought minimal support for psychosocial concerns, such concerns were in fact commonplace. Over half of participants (56%-57%) shared qualitative accounts of depleted confidence, while wellbeing scores were on average lower than matched norms. Participants identifying as sexual minority also reported greater appearance-focused anxiety compared to those identifying as straight.</p><p><strong>Conclusions: </strong>The apparent contrast between participants' minimal help-seeking and accounts of affected wellbeing suggests an unmet support need for men with alopecia. Masculine norms may impede men from accessing psychosocial support, both by discouraging help-seeking behaviours and by encouraging minimisation of appearance concerns. The findings also suggest sexual minority status may pose a greater risk of distress in affected men.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"4 5","pages":"e420"},"PeriodicalIF":0.0,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bimekizumab as treatment for moderate to severe chronic plaque psoriasis: Real world clinical experience from a district general hospital setting.","authors":"Omowunmi Ashaolu, Tracy Smith, Amie Askins, Suchitra Rajan, Vincent Li, Sandeep Kamath, Jenny Hughes, Geraldine Haebich","doi":"10.1002/ski2.418","DOIUrl":"10.1002/ski2.418","url":null,"abstract":"","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"4 5","pages":"e418"},"PeriodicalIF":0.0,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of frequent intake of trans fatty acids and saturated fatty acids in diets with increased susceptibility of atopic dermatitis exacerbation in young Chinese adults: A cross-sectional study in Singapore/Malaysia.","authors":"Jun Jie Lim, Sing Wei Lim, Kavita Reginald, Yee-How Say, Mei Hui Liu, Fook Tim Chew","doi":"10.1002/ski2.330","DOIUrl":"10.1002/ski2.330","url":null,"abstract":"<p><strong>Background & objective: </strong>Numerous evidence has attributed diets with a high fatty acids (FAs) intake to be associated with atopic dermatitis (AD) development. Therefore, this study investigated the association between intake frequencies of five dietary FAs and AD exacerbations among young Chinese adults from Singapore and Malaysia.</p><p><strong>Methods: </strong>A validated International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was investigator-administered to 13,561 subjects to collect information on socioeconomic, anthropometric, dietary and lifestyles habits, and personal/family medical histories. Six novel dietary indices were derived to analyse the associations between total FAs, trans fatty acids (TFAs), saturated fatty acids (SFAs), monounsaturated fatty acids, linoleic acids, and alpha-linolenic acids in diets and AD exacerbation. Synergy factor (SF) analysis was used to identify interactions between the dietary FAs to influence disease susceptibility.</p><p><strong>Results: </strong>In our multivariable model adjusted for age, gender, BMI, parental eczema, and lifestyle factors, a diet high in total estimated FAs was strongly associated with AD (Adjusted Odds Ratio (AOR): 1.227; 95% Confidence Interval (CI): 1.054-1.429; adjusted <i>p</i>-value <0.01). Particularly, high estimated total TFAs and SFAs were significantly associated with AD exacerbations including chronic and current moderate-to-severe AD. The association between TFAs and AD remained strong even controlled for the total FAs in diets and false discovery rate corrected (AOR: 1.516; 95% CI: 1.094-2.097; adjusted <i>p</i>-value <0.05). Similarly, having a high SFAs in diets was associated with AD (AOR: 1.581; 95% CI: 1.106-2.256; adjusted <i>p</i>-value <0.05) independently on the total FAs in diets. FAs in diets do not interact to influence AD.</p><p><strong>Conclusion: </strong>Overall, these results highlighted an association between high dietary TFAs and SFAs and AD exacerbations in an Asian population.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"4 4","pages":"e330"},"PeriodicalIF":0.0,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11297457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141895048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex disparities in Hispanic melanoma patients: A retrospective cohort analysis of the 2000-2020 Surveillance, Epidemiology and End Results database.","authors":"Mitchell A Taylor, Anjali Mishra, Bianca Ituarte, Michaela Clausen, Erin X Wei","doi":"10.1002/ski2.415","DOIUrl":"10.1002/ski2.415","url":null,"abstract":"","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"4 5","pages":"e415"},"PeriodicalIF":0.0,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary vulval melanoma and genital lichen sclerosus.","authors":"Evanthia Mastoraki, Georgios Kravvas, Kate Dear, Sharmaine Sim, Mariel James, Richard Watchorn, Aiman Haider, Peter Ellery, Alex Freeman, Mahfooz Basha, Emma Edmonds, Christopher B Bunker","doi":"10.1002/ski2.411","DOIUrl":"10.1002/ski2.411","url":null,"abstract":"<p><strong>Background: </strong>Lichen sclerosus (LS) is a chronic, inflammatory skin disease with a predilection for the genitalia. Although, the association between squamous cell cancer and genital LS is well established, a link with genital melanoma has not been thoroughly explored. However, we have recently published a case series of penile melanoma where 9/11 (82%) of patients seen over a 10 year period with penile melanoma were retrospectively found to have histological and/or clinical evidence of genital LS on review.</p><p><strong>Objectives: </strong>The aim of this study was to illuminate further the relationship between vulval melanoma and genital LS by reviewing all the cases managed by our hospital and undertaking a literature review.</p><p><strong>Methods: </strong>We identified all the cases with a diagnosis of vulval melanoma over a 16-year period (2006-2022) where histology was available. The clinical notes were retrospectively reviewed, and the histological features of all cases were reassessed by two independent mutually 'blinded' histopathologists. We also performed a literature review of genital LS in patients with vulval melanoma.</p><p><strong>Results: </strong>A total of 11 patients with vulval melanoma were identified for the review. Histopathological review found evidence of genital LS in seven of them (64%). Genital LS was not documented in any of the original histology reports. Clinical notes and letters were available in nine cases. The literature review identified 12 relevant studies with a total of 18 patients. Twelve cases concerned adult women, and six concerned female children.</p><p><strong>Conclusion: </strong>The presence of genital LS in as high as 64% of our vulval melanoma cases might indicate a causative relationship between genital LS and vulval melanoma. The pathogenesis of vulval melanoma remains largely unknown. Although ultraviolet radiation is an important pathogenic factor for cutaneous melanoma, it cannot be a factor in vulval melanoma. While possible mechanisms behind this association remain unclear, it is possible that chronic inflammation from genital LS leads to melanocytic distress and increased mutagenesis.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"4 4","pages":"e411"},"PeriodicalIF":0.0,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11297432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141895049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spread of shingles impeded by previous surgical scar?","authors":"Makoto Shiraishi, Masakazu Kurita","doi":"10.1002/ski2.417","DOIUrl":"https://doi.org/10.1002/ski2.417","url":null,"abstract":"<p><p>We herein report an atypical case of shingles caused by varicella zoster virus after surgery. The virus, which goes along with the cutaneous nerve from the ganglia, was unable to spread across the previous surgical scar due to damage of the cutaneous nerves, but made a detour to the upper left direction from the scar.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"4 4","pages":"e417"},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11297527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141895052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pigment epithelium derived factor drives melanocyte proliferation and migration in neurofibromatosis café au lait macules.","authors":"Charlotte Lovatt, Megan Williams, Alex Gibbs, Abdullahi Mukhtar, Huw J Morgan, Simone Lanfredini, Carlotta Olivero, Gill Spurlock, Sally Davies, Charlotte Philpott, Hannah Tovell, Peter Turnpenny, Dilair Baban, Sam Knight, Hilde Brems, Julian R Sampson, Eric Legius, Meena Upadhyaya, Girish K Patel","doi":"10.1002/ski2.394","DOIUrl":"10.1002/ski2.394","url":null,"abstract":"<p><strong>Background: </strong>RASopathies, which include neurofibromatosis type 1 (NF1), are defined by Ras/mitogen-activated protein kinase (Ras/MAPK) pathway activation. They represent a group of clinically related disorders often characterised by multiple Café au Lait Macules (CALMs).</p><p><strong>Objectives: </strong>To determine, using in depth transcriptomic analysis of NF1 melanocytes from CALM and unaffected skin, (1) the gene(s) responsible for melanocyte proliferation and migration, and (2) the activated signalling pathway(s) in NF1 melanoma.</p><p><strong>Methods: </strong>Classical NF1 (<i>n</i> = 2, who develop tumours) and 3bp deletion NF1 (p. Met992del, who do not develop tumours) (<i>n</i> = 3) patients underwent skin biopsies from CALM and unaffected skin. Melanocytes were isolated and propagated, with five replicates from each tissue sample. DNA and RNA were extracted for mutational analysis and transcriptomic profiling with six replicates per sample. Mechanistic determination was undertaken using melanocyte and melanoma cell lines.</p><p><strong>Results: </strong>All CALMs in NF1 were associated with biallelic <i>NF1</i> loss, resulting in amplification of Ras/MAPK and Wnt pathway signalling. CALMs were also associated with reduced <i>SERPINF1</i> gene expression (and pigment epithelium-derived factor (PEDF) levels, the reciprocal protein), a known downstream target of the master regulator of melanocyte differentiation microphthalmia-associated transcription factor (MITF), leading to increased melanocyte proliferation, migration and invasion. In classical NF1 and melanoma, but not 3bp deletion NF1, there was also activation of the PI3K/AKT pathway. Pigment epithelium-derived factor was found to reduce cell proliferation and invasion of NF1 melanoma.</p><p><strong>Conclusions: </strong>Melanocyte proliferation and migration leading to CALMs in NF1 arises from biallelic <i>NF1</i> loss, resulting in RAS/MAPK pathway activation, and reduced expression of the tumour suppressor PEDF. Activation of the PI3K/AKT pathway in classical NF1 and NF1 melanoma may facilitate tumour growth.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"4 5","pages":"e394"},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple glomus tumours: Clinical, ultrasonographic and histopathologic findings of a rare disease.","authors":"Bárbara Wiese, Patricia F Acevedo, Rodrigo A Franceschett, Leila Riedel, Maria Cláudia A Issa","doi":"10.1002/ski2.409","DOIUrl":"10.1002/ski2.409","url":null,"abstract":"<p><p>Glomus tumour is a rare benign neoplasm originating from the glomus body, clinically presenting as a violet-coloured, painful nodule more sensitive when exposed to cold or hot. This hamartoma is typically solitary and predominantly affects the limbs, extremities and nail beds. The appearance of multiple tumours and lesions not placed in the extremities is rare and frequently misdiagnosed. At dermoscopy, it appears as a homogeneous, structureless, purplish area surrounded by a whitish region. Skin ultrasound shows a well-defined, round, hypoechoic mass. We report a case of numerous blue-purplish painful nodules distributed in the trunk and arms while sparing the extremities, with typical dermoscopy and ultrasound findings. A biopsy was performed, confirming the diagnosis of glomangioma. We call attention to this rare condition to help dermatologists make this diagnosis when facing multiple painful nodules.</p>","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"4 5","pages":"e409"},"PeriodicalIF":0.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A hybrid case of eosinophilic folliculitis and eosinophilic cellulitis associated with hypereosinophilic syndrome","authors":"D. Iatropoulou, Cathryn Sprenger, Richard Griffiths, N. Wijesuriya, Bernard Ho","doi":"10.1002/ski2.407","DOIUrl":"https://doi.org/10.1002/ski2.407","url":null,"abstract":"Eosinophilic cellulitis or Wells syndrome encompasses distinct histopathological features but can also be associated with eosinophilic related conditions like hyper eosinophilic syndrome (HES) or eosinophilic granulomatosis with polyangiitis (EGPA) (Churg–Strauss syndrome). We report a case of a Turkish 41‐year‐old female who presented in clinic with pruritus and tenderness on her chest and breasts, having received several courses of antibiotics for recurrent abscess formation. A year before she had been diagnosed with HES with multiorgan involvement that included biopsy proven eosinophilic folliculitis, and prompted further investigation including bone marrow aspiration that revealed T cell clonality. Biopsy of her rash revealed eosinophilic infiltration of the dermis with flame figures. Ongoing respiratory symptoms and a history of childhood asthma were suggestive of EGPA. This case highlights important associations that should be considered in the investigation of Wells syndrome.","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"1 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141335594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the COVID‐19 pandemic on international cutaneous squamous cell carcinoma incidence: A systematic review and meta‐analysis","authors":"James Wall, Kieran Gadsby‐Davis, K. Mistry, Nick J. Levell, Zoe C. Venables","doi":"10.1002/ski2.405","DOIUrl":"https://doi.org/10.1002/ski2.405","url":null,"abstract":"Non‐melanoma skin cancer (NMSC) is the most common cancer globally in white ethinicity populations, and cutaneous squamous cell carcinoma (cSCC) is the second most common subtype. The COVID‐19 pandemic severely impacted public and private healthcare systems. Many studies have reported reduced cancer diagnoses during the pandemic. The impact of the COVID‐19 pandemic on global cSCC and NMSC incidence is poorly reported.The aim was to conduct a systematic review and meta‐analysis to assess the impact of the COVID‐19 pandemic on global cSCC and NMSC incidence rates, compared with 2019 incidence rates. Two primary outcome measures were used: crude incidence rate ratios (CIRR) and age‐standardised incidence rate ratios (ASIRR).A structured search was undertaken on 23 March 2023 using grey literature and four electronic databases: MEDLINE, CINAHL, EMBASE and Web of Science. Studies published before January 2020 were excluded. A quality assessment was undertaken using A. Lomas quality assessment tool. CIRR outcomes were synthesised in a meta‐analysis, while ASIRR outcomes were narratively synthesised.Fourteen cancer registries were included, capturing data from 13 countries across Europe. Variation was observed in NMSC and cSCC incidence across the cancer registries. Pooled cSCC crude incidence rates in 2020 were equal to crude incidence rates in 2019 (cSCC‐CIRR 1.00 (95% confidence interval (CI) 0.94–1.06). In 2021, the pooled result indicated a non‐significant 8% increase in cSCC crude incidence rates, compared with 2019 (cSCC‐CIRR 1.08 (95% CI 0.98–1.19). Significant reductions were reported in NMSC incidence across all meta‐analyses in 2020 and 2021 compared with 2019. Heterogeneity was observed across most pooled estimates (I2>75%).There was a lack of high quality data on cSCC incidence rates recorded during the pandemic outside of Europe. The COVID‐19 pandemic resulted in no significant changes in cSCC incidence across Europe. By contrast, NMSC incidence fell across Europe following the pandemic. Significant reductions in pooled NMSC incidence rates may reflect a delay in basal cell carcinoma presentation, diagnosis and treatment. Although annual incidence rates for cSCC were not affected by the pandemic, delays in treatment may still have occurred, which may result in poorer outcomes yet to be fully understood.","PeriodicalId":74804,"journal":{"name":"Skin health and disease","volume":"4 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141336632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}