共同制作一项关于湿疹沐浴频率的随机对照试验:公民科学方法的描述。

Q3 Medicine
Skin health and disease Pub Date : 2025-04-16 eCollection Date: 2025-04-01 DOI:10.1093/skinhd/vzaf005
Arabella Baker, Natalie Bonsu, Laura Howells, Ingrid Muller, Eleanor J Mitchell, Fiona Cowdell, Firoza Davies, Mars Eddis-Finbow, Alan Montgomery, Devin Patel, Goldie Putrym, Matthew J Ridd, Miriam Santer, Amanda Roberts, Kim S Thomas
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引用次数: 0

摘要

背景:湿疹是一种普遍的、慢性的、发痒的皮肤状况,通常持续到成年,并显著影响患者及其家人的生活质量。由于目前尚无治疗方法,因此有效的管理至关重要。虽然已经确定了与湿疹自我管理相关的重要患者优先事项,但它们很少成为大型、高质量随机对照试验(rct)的重点。目的:概述使用公民科学方法共同制作关于洗澡频率的在线随机对照试验的方法,以支持湿疹的自我管理。方法:通过一系列在线会议和调查,共同制作湿疹患者试验,包括研究优先级,干预措施开发和试验设计。结果:共同制作试验花了9个月的时间,包括13次在线会议(5次优先考虑主题,4次制定干预措施,4次设计试验),需要公众(n = 12) 39小时的时间承诺,总共花费5440英镑用于报销。一项优先级调查(n = 120)确定了最受欢迎的研究问题是多久洗澡/淋浴一次,获得了49%的投票。在联合制作小组成员之间进行迭代改进后,制定了试验研究问题。干预发展调查(n = 169)确定了当前的沐浴习惯和参与试验的兴趣。调查结果为研究材料的开发提供了信息,并影响了与试验设计相关的决策。最终确定的研究材料包括目标行为的关键信息(每周洗澡或每天洗澡)、常见问题和共同关注的问题。试验设计联合制作组确定入选标准,确定干预措施和比较者,选择结局指标,确定研究持续时间并制定招募策略。湿疹沐浴研究于2024年1月29日开始招募,在前两个月内招募了390名目标样本量的50%以上。结论:本文为与公众共同制作随机对照试验提供了一个有用的模型。它描述了试验开发的关键阶段(确定优先顺序、干预措施开发、试验设计),并包含了使用这种方法设计试验所需的时间和资源的信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Co-producing a randomized controlled trial on the frequency of bathing in eczema: description of a citizen science approach.

Background: Eczema is a prevalent, chronic, itchy skin condition that often persists into adulthood and significantly affects the quality of life of patients and their families. With no cure available at present, effective management is crucial. Although important patient priorities related to eczema self-management have been identified, they are rarely the focus of large, high-quality randomized controlled trials (RCTs).

Objectives: To outline the methodology of using a citizen science approach to co-produce an online RCT on the frequency of bathing, to support the self-management of eczema.

Methods: The co-production of the trial with patients living with eczema involved research prioritization, intervention development and trial design, all carried out through a series of online meetings and surveys.

Results: Co-producing the trial took 9 months, consisting of 13 online meetings (5 to prioritize the topic, 4 to develop the intervention and 4 to design the trial), requiring 39 h of time commitment from members of the public (n = 12) with a total spending of £5440 on reimbursements. A prioritization survey (n = 120) identified the most popular research question as how often to bath/shower, receiving 49% of votes. Following an iterative refinement among the co-production group members, the trial research question was formulated. The intervention development survey (n = 169) established current bathing practices and interest in participating in the trial. Survey results informed the development of study materials and influenced decisions related to trial design. The finalized study materials included key information about the target behaviour (weekly bathing or daily bathing), frequently asked questions and common concerns. The trial design co-production group determined the eligibility criteria, defined the intervention and comparator, selected the outcome measures, determined the study duration and developed the recruitment strategy. The Eczema Bathing Study opened to recruitment on 29 January 2024 and over 50% of the target sample size of 390 have been recruited within the first 2 months.

Conclusions: This paper provides a useful model for co-producing RCTs with members of the public. It describes the key stages of trial development (prioritization, intervention development, trial design) and contains information on the time and resources required to design trials using this approach.

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