Revue francophone des laboratoires : RFL最新文献

{"title":"Le diagnostic anatomopathologique des tumeurs épithéliales de l’ovaire","authors":"Alexis Trecourt,&nbsp;Mojgan Devouassoux-Shisheboran","doi":"10.1016/S1773-035X(24)00395-2","DOIUrl":"10.1016/S1773-035X(24)00395-2","url":null,"abstract":"<div><h3>Résumé</h3><div>Les tumeurs épithéliales représentent les tumeurs les plus fréquentes de l’ovaire. La majorité est bénigne, environ 10 % sont des tumeurs frontières <em>(borderline)</em> et seulement 30 % sont malignes (carcinomes). Cependant, les carcinomes ovariens correspondent à plus de 80 % des cancers de l’ovaire, les tumeurs malignes germinales et les tumeurs des cordons sexuels et du stroma gonadique étant très rares. Les carcinomes ovariens sont classés en différents sous-types histologiques en fonction du type de revêtement qui les compose. Ils correspondent à plusieurs entités avec une morphologie, un profil immunohistochimique et moléculaire et un pronostic distincts. Les carcinomes ovariens sont de type séreux de haut grade prenant leur origine à partir du revêtement tubaire et se caractérisent par un déficit en recombinaison homologue dans environ 50 % des cas, ce qui ouvre la voie à une thérapie ciblée par inhibiteurs de PARP chez ces patientes. Le diagnostic de malignité, du type histologique de cancer, du sous-type histologique du carcinome ovarien, nécessite un prélèvement tissulaire, souvent obtenu par une cœlioscopie diag­nostique en raison de la carcinose péritonéale révélant la tumeur dans la majorité des cas. Ainsi, sur ce matériel tissulaire, une étude morphologique, une étude immunohistochimique par un panel large d’anticorps, et la recherche du profil moléculaire permettent une prise en charge thérapeutique adaptée. Le rôle du pathologiste est essentiel dans cette prise en charge.</div></div><div><h3>Abstract</h3><div>Epithelial tumors represent the majority of ovarian neoplasms. Most of them are benign, 10% are borderline tumors and only 30% are malignant (carcinomas). However, ovarian carcinomas represent more than 80% of all ovarian cancers, since malignant germ cell tumors and sex cord stromal tumors are very rare. Ovarian carcinomas are subdivided into different categories according to the type of epithelium composing the tumor. They are not one single lesion but represent more than 6 different entities, with distinct morphology, immunoprofile, molecular profile and prognosis. The vast majority of ovarian carcinomas are high grade serous carcinomas deriving from tubal epithelium. Tubo-ovarian high grade serous carcinomas are characterized by a homologous recombination deficiency in 50% of cases, allowing a targeted therapy using PARP inhibitors. The diagnosis of malignancy, histological type of cancer, and histological subtype of ovarian carcinoma need biopsy material, often obtained during a diagnostic coelioscopy, since the majority of cases are revealed at an advanced stage with peritoneal carcinomatosis. The tissue material allows a morphological, immunohistochemical and molecular analyses necessary for the correct diagnosis. Thus, the role of the pathologist is essential in patient care for ovarian carcinomas.</div></div>","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2024 567","pages":"Pages 30-42"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143182532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approche bayésienne versus approche conventionnelle pour l’interprétation des contrôles internes de qualité","authors":"Émilie Jousselme,&nbsp;Christophe Nougier,&nbsp;Frédéric Sobas","doi":"10.1016/S1773-035X(24)00393-9","DOIUrl":"10.1016/S1773-035X(24)00393-9","url":null,"abstract":"<div><h3>Résumé</h3><div>L’intérêt des cartes de contrôle en biologie médicale est de disposer d’un plan de contrôle interne de qualité (CIQ) permettant de s’assurer de la stabilité des méthodes utilisées pour la mesure de paramètres biologiques. Le suivi des résultats de CIQ au quotidien permet de valider la stabilité des méthodes entre deux exercices d’évaluation externe de la qualité (EEQ) qui vali­deront, eux, l’exactitude des résultats rendus.</div><div>Cet article décrit les principes de deux approches de gestion des résultats de CIQ : l’approche conven­tionnelle classiquement utilisée dans les laboratoires de biologie médicale et l’approche bayésienne nouvellement implémentée.</div></div><div><h3>Abstract</h3><div>The interest of medical biology control charts is to have an internal quality control plan (IQC) to ensure the stability of methods used for measuring biological parameters. The daily quality control monitoring allows to validate the stability between two external quality assessment exercises (EQA) which will validate the accuracy of the results.</div><div>This paper describes the principles of two approaches to manage internal quality controls: the conventional approach traditionally used in medical biology laboratories and the newly implemented Bayesian approach.</div></div>","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2024 567","pages":"Pages 24-27"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143182545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L’hésitation vaccinale Les mots pour expliquer","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(24)00380-0","DOIUrl":"10.1016/S1773-035X(24)00380-0","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2024 567","pages":"Page 14"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143180439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bénéfice physique, psychique et social de l’APA","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(24)00385-X","DOIUrl":"10.1016/S1773-035X(24)00385-X","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2024 567","pages":"Page 17"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143182538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coqueluche : préconisations du HCSP","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(24)00371-X","DOIUrl":"10.1016/S1773-035X(24)00371-X","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2024 567","pages":"Page 9"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143180410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brève : Dégradation de la situation de la gynécologie médicale","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(24)00384-8","DOIUrl":"10.1016/S1773-035X(24)00384-8","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2024 567","pages":"Page 16"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143132192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brève : À Toulouse, une “AG en rose” pour les internes","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(24)00372-1","DOIUrl":"10.1016/S1773-035X(24)00372-1","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2024 567","pages":"Page 10"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143180409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atteintes rénales associées aux hémopathies myéloïdes chroniques","authors":"Thibaut d’Izarny-Gargas ,&nbsp;Pierre Isnard ,&nbsp;George Terinte-Balcan ,&nbsp;Marion Rabant ,&nbsp;Alexandre Karras ,&nbsp;Jean-Paul Duong-Van-Huyen","doi":"10.1016/S1773-035X(24)00398-8","DOIUrl":"10.1016/S1773-035X(24)00398-8","url":null,"abstract":"<div><h3>Résumé</h3><div>Les néphropathies survenant dans le contexte d’hémopathies myéloïdes sont mal connues, mais plusieurs études récentes ont amélioré leur description et précisé les liens avec la nature de l’hémopathie et son pronostic. Nous proposons dans cette revue de résumer les principales données concernant les atteintes rénales rencontrées au cours des néoplasies myéloprolifératives, des néoplasies myélodysplasiques et de la leucémie myélomonocytaire chronique.</div></div><div><h3>Abstract</h3><div>Kidney involvement is a little-known complication of myeloid neoplasms, but recent studies have furthered the description of these diseases and outlined their links with the type of neoplasm and its prognosis. In this review, we summarize the available knowledge regarding kidney diseases encountered in patients with myeloproliferative neoplasms, myelodysplastic neoplasms and chronic myelomonocytic leukemia.</div></div>","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2024 567","pages":"Pages 61-70"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143182541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Le pathologiste, à la conquête de l’espace","authors":"Thierry Jo Molina","doi":"10.1016/S1773-035X(24)00394-0","DOIUrl":"10.1016/S1773-035X(24)00394-0","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2024 567","pages":"Page 29"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143182542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomique spatiale : de la morphologie aux mécanismes moléculaires","authors":"Pierre Isnard ,&nbsp;Thierry Jo Molina","doi":"10.1016/S1773-035X(24)00396-4","DOIUrl":"10.1016/S1773-035X(24)00396-4","url":null,"abstract":"<div><h3>Résumé</h3><div>Les technologies \"<em>spatial-omics</em>” sont à l’origine d’une véritable révolution dans les sciences de la vie car elles permettent de mesurer un ensemble non restreint de biomolécules dans leur contexte spatial d’origine. Parmi elles, les technologies de transcriptomique spatiale (ST pour <em>spatial transcriptomics</em>) offrent la possibilité de cartographier l’expression génique et d’améliorer la compréhension de la biologie des tissus. Dans cette revue, nous décrivons les principales technologies de ST actuellement disponibles, l’analyse informatique pour l’interprétation et la visualisation des données, et enfin discutons leurs applications, leurs limites et leurs perspectives potentielles.</div></div><div><h3>Abstract</h3><div>Spatial-omics technologies are at the root of a veritable revolution in the life sciences, enabling the measurement of an unrestricted range of biomolecules in their original spatial context. Among them, spatial transcriptomics (ST) technologies offer the potential to map gene expression and improve understanding of tissue biology. In this review, we describe the main ST technologies currently available, the computational analysis for data interpretation and visualization, and finally discuss their applications, limitations and potential prospects.</div></div>","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2024 567","pages":"Pages 43-51"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143182555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}