Revue francophone des laboratoires : RFL最新文献

{"title":"Des idées d’articles ?","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(25)76355-8","DOIUrl":"10.1016/S1773-035X(25)76355-8","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 572","pages":"Page 5"},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stratégie intégrée de prise en charge des LAL-T en rechute/réfractaires au laboratoire","authors":"Lucien Courtois ,&nbsp;Ludovic Lhermitte ,&nbsp;Vahid Asnafi","doi":"10.1016/S1773-035X(25)76375-3","DOIUrl":"10.1016/S1773-035X(25)76375-3","url":null,"abstract":"<div><h3>Résumé</h3><div>Les leucémies aiguës lymphoblastiques T (LAL-T) représentent un sous-type rare de leucémies aiguës, dont le pronostic reste sombre en situation de rechute ou de résistance aux protocoles de chimiothérapie. Contrairement aux LAL-B, elles ne bénéficient pas encore assez des avancées de l’immunothérapie et les stratégies thérapeutiques à la rechute restent hétérogènes. Le <em>drug testing</em> (ou criblage thérapeutique) est un test fonctionnel qui évalue la sensibilité in vitro de cellules tumorales à un panel de molécules thérapeutiques. Récemment, des stratégies thérapeutiques basées sur l’utilisation du <em>drug testing</em> ont montré des résultats prometteurs chez des patients atteints de cancer en rechute. Pourtant, des études précédentes en avaient pointé les limites. Nous retracerons ici brièvement l’historique du <em>drug testing</em>, avant de faire un rappel sur les LAL-T. Nous détaillerons ensuite la stratégie d’utilisation de ce test ainsi que son déroulement, de la prescription au rendu du résultat, dans le cadre du protocole français de prise en charge des LAL-T en rechute/réfractaires “ALL <em>TARGET</em>”. Nous terminerons enfin par un cas clinique illustrant l’intérêt de cette stratégie.</div></div><div><h3>Abstract</h3><div>T-cell acute lymphoblastic leukemias (T-ALL) represent a rare subtype of acute leukemias characterized by a poor prognosis in case of relapse or resistance to chemotherapeutic regimens. In contrast to B-ALL, they still do not benefit from recent advances in immunotherapy and therapeutic strategies at relapse remain heterogeneous. Drug testing is a functional test which assess in vitro sensitivity of tumor cells to a panel of therapeutic molecules. Recently, therapeutic strategies based on drug testing have shown promising results in patients with relapsing cancer. However, previous studies had pointed out the limitations of this test. In this article, we will briefly relate the history of drug testing, before reviewing T-ALL.We will then detail how we use this test and its process, from prescription to result generation, in the setting of the French protocol on relapsed/refractory T-ALL “ALL TARGET”. Finally, we will present a case report illustrating the relevance of this strategy.</div></div>","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 572","pages":"Pages 28-37"},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Un nouvel implant orthopédique agréé par la FDA","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(25)76361-3","DOIUrl":"10.1016/S1773-035X(25)76361-3","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 572","pages":"Page 10"},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Syndrome de stress post-traumatique : enfin un nouveau médicament","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(25)76363-7","DOIUrl":"10.1016/S1773-035X(25)76363-7","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 572","pages":"Page 11"},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Le syndrome de Sézary : le point de vue du clinicien et du pathologiste","authors":"Marie Donzel ,&nbsp;Stéphane Dalle","doi":"10.1016/S1773-035X(25)76377-7","DOIUrl":"10.1016/S1773-035X(25)76377-7","url":null,"abstract":"<div><h3>Résumé</h3><div>Le syndrome de Sézary associe érythrodermie, adénopathies et lymphocytes atypiques circulants. Le diagnostic différentiel avec d’autres pathologies dermatologiques inflammatoires et avec le mycosis fongoïde est parfois difficile.</div></div><div><h3>Abstract</h3><div>Sezary syndrome associates erythroderma, adenopathies and circulating atypical lymphocytes. The differential diagnosis with other inflammatory dermatological pathologies and with mycosis fungoides is sometimes challenging.</div></div>","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 572","pages":"Pages 50-52"},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ordonnances 2025: 230 prescriptions courantes en médecine","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(25)76365-0","DOIUrl":"10.1016/S1773-035X(25)76365-0","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 572","pages":"Page 12"},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risque d’AVC post-hémorragie intracérébrale : quid des AOD en prophylaxie?","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(25)76370-4","DOIUrl":"10.1016/S1773-035X(25)76370-4","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 572","pages":"Page 15"},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Professions de santé horizon 2030, des groupes médicaux européens veulent réagir à la crise des effectifs","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(25)76371-6","DOIUrl":"10.1016/S1773-035X(25)76371-6","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 572","pages":"Pages 16-17"},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"QCM: Évaluez-vous !","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(25)76380-7","DOIUrl":"10.1016/S1773-035X(25)76380-7","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 572","pages":"Pages 71-73"},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STOMP : un échec thérapeutique","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(25)76359-5","DOIUrl":"10.1016/S1773-035X(25)76359-5","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 572","pages":"Page 9"},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}