Revue francophone des laboratoires : RFL最新文献

{"title":"Présentation atypique d’un lymphome de Hodgkin classique à infiltration médullaire isolée compliquée d’un syndrome d’activation macrophagique","authors":"Radu Chiriac,&nbsp;Lucie Jaillard,&nbsp;Lucile Baseggio","doi":"10.1016/S1773-035X(26)76727-7","DOIUrl":"10.1016/S1773-035X(26)76727-7","url":null,"abstract":"<div><h3>Résumé</h3><div>Le lymphome de Hodgkin (LH) classique se manifeste exceptionnellement par une atteinte médullaire isolée en l’absence d’adénopathie. Nous rapportons le cas d’un homme de 20 ans hospitalisé pour fièvre prolongée et altération de l’état général, chez qui le bilan a révélé une pancytopénie sévère associée à un syndrome d’activation macrophagique. L’exploration médullaire a permis l’identification de cellules de Reed-Sternberg/Hodgkin confirmant un LH classique de stade IV à présentation primitivement médullaire. Une prise en charge rapide associant traitement du syndrome inflammatoire et chimiothérapie incluant le brentuximab vedotin a permis l’obtention d’une rémission complète. Ce cas souligne la nécessité d’envisager une hémopathie lymphoïde, notamment un LH, devant tout syndrome d’activation macrophagique inexpliqué, même en l’absence d’atteinte ganglionnaire.</div></div><div><h3>Abstract</h3><div>Classical Hodgkin lymphoma (HL) rarely presents with isolated bone marrow involvement in the absence of lymphadenopathy. We report the case of a 20-yearold man admitted for prolonged fever and general deterioration, in whom laboratory evaluation revealed severe pancytopenia associated with a macrophage activation syndrome. Bone marrow examination identified Reed-Sternberg/Hodgkin cells, confirming a stage IV classical HL with a primarily medullary presentation. Prompt management combining treatment of the inflammatory syndrome and chemotherapy including brentuximab vedotin led to complete remission. This case highlights the importance of considering a lymphoid malignancy, particularly HL, in any unexplained macrophage activation syndrome, even in the absence of lymph node involvement.</div></div>","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2026 584","pages":"Pages 56-59"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148661311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obligation vaccinale grippale : rappel pressant de l’Académie de médecine aux professionnels de santé","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(26)76716-2","DOIUrl":"10.1016/S1773-035X(26)76716-2","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2026 584","pages":"Page 16"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148661470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Des idées d’articles ?","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(26)76718-6","DOIUrl":"10.1016/S1773-035X(26)76718-6","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2026 584","pages":"Page 17"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148661472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uppercut viral : quand l’EBV monte sur le ring !","authors":"Lina Achour,&nbsp;Frédérique Moreau,&nbsp;Elyanne Gault,&nbsp;Claire Deback","doi":"10.1016/S1773-035X(26)76728-9","DOIUrl":"10.1016/S1773-035X(26)76728-9","url":null,"abstract":"<div><h3>Résumé</h3><div>La mononucléose infectieuse (MNI) est la présentation clinique de la primo-infection par le virus Epstein-Barr (EBV), un virus appartenant à la famille des <em>Herpesviridae</em>. Elle touche principalement les adolescents et les jeunes adultes et évolue le plus souvent de manière bénigne et spontanément résolutive, bien que des complications viscérales puissent survenir. Nous rapportons, chez un boxeur de 17 ans, un cas de MNI de présentation atypique, associée à une hépatite aiguë, laquelle a été diagnostiquée fortuitement lors de la prise en charge d’un traumatisme thoracoabdominal gauche avec atteinte splénique consécutif à des coups reçus pendant un combat d’arts martiaux mixtes (MMA).</div></div><div><h3>Abstract</h3><div>Infectious mononucleosis (IM) is the clinical manifestation of primary infection with the Epstein-Barr virus (EBV), a virus belonging to the <em>Herpesviridae</em> family. It mainly affects adolescents and young adults and most often follows a benign, self-limiting course, although visceral complications may occur. We report a case of atypical MNI in a 17-year-old boxer, associated with acute hepatitis, which was incidentally diagnosed during the management of a left thoracoabdominal trauma with splenic injury resulting from blows sustained during a mixed martial arts (MMA) match.</div></div>","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2026 584","pages":"Pages 60-64"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148661219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L’OMS veut démasquer l’attrait et la dépendance à la nicotine","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(26)76715-0","DOIUrl":"10.1016/S1773-035X(26)76715-0","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2026 584","pages":"Page 15"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148661230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phaeohyphomycose sous-cutanée à Alternaria chez le patient transplanté rénal : une entité à savoir reconnaître en 2026","authors":"Guillaume Desoubeaux","doi":"10.1016/S1773-035X(26)76723-X","DOIUrl":"10.1016/S1773-035X(26)76723-X","url":null,"abstract":"<div><h3>Résumé</h3><div>L’alternariose constitue une infection opportuniste due à des moisissures pigmentées du genre <em>Alternaria</em>, ubiquitaire dans l’environnement. Elle survient surtout chez les patients immunodéprimés, en premier lieu les transplantés rénaux, mais aussi beaucoup plus rarement chez des sujets immunocompétents après inoculation cutanée traumatique. La présentation est dominée par des atteintes cutanées et sous-cutanées (nodules, plaques infiltrées, ulcérations des zones exposées), plus rarement respiratoires. Le diagnostic repose sur la réalisation de prélèvements superficiels ou profonds, l’examen direct montrant des filaments septés et pigmentés, et la culture des colonies brun-noir ; une confirmation moléculaire peut être utile. L’interprétation doit rester prudente car <em>Alternaria</em> demeure un contaminant fréquent. La prise en charge associe le plus souvent un azolé (itraconazole ou voriconazole), une exérèse chirurgicale des lésions localisées si possible, et une réduction de l’immunosuppression ; l’évolution est généralement favorable mais des rechutes sont possibles.</div></div><div><h3>Abstract</h3><div>Alternariosis refers to opportunistic infection caused by ubiquitous environmental molds of the genus <em>Alternaria</em>. It mainly affects immunocompromised patients but can also occur in immunocompetent hosts following traumatic cutaneous inoculation. Clinical presentation is predominantly cutaneous or subcutaneous (nodules, infiltrated plaques, ulcerations on exposed areas), with rarer respiratory or disseminated forms. Diagnosis relies on superficial or deep samples (especially biopsy), direct microscopy showing pigmented septate hyphae, culture yielding brown to black colonies; molecular tools may assist identification. Interpretation requires caution as <em>Alternaria</em> is a frequent contaminant. Management typically includes an azole (itraconazole or voriconazole), surgical excision of localized lesions when feasible, and reduction of immunosuppression; outcomes are generally favorable, although relapses can occur.</div></div>","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2026 584","pages":"Pages 38-42"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148661236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L’OMS veut démasquer l’attrait et la dépendance à la nicotine","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(26)76715-0","DOIUrl":"10.1016/S1773-035X(26)76715-0","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2026 584","pages":"Page 15"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148657079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Présentation atypique d’un lymphome de Hodgkin classique à infiltration médullaire isolée compliquée d’un syndrome d’activation macrophagique","authors":"Radu Chiriac,&nbsp;Lucie Jaillard,&nbsp;Lucile Baseggio","doi":"10.1016/S1773-035X(26)76727-7","DOIUrl":"10.1016/S1773-035X(26)76727-7","url":null,"abstract":"<div><h3>Résumé</h3><div>Le lymphome de Hodgkin (LH) classique se manifeste exceptionnellement par une atteinte médullaire isolée en l’absence d’adénopathie. Nous rapportons le cas d’un homme de 20 ans hospitalisé pour fièvre prolongée et altération de l’état général, chez qui le bilan a révélé une pancytopénie sévère associée à un syndrome d’activation macrophagique. L’exploration médullaire a permis l’identification de cellules de Reed-Sternberg/Hodgkin confirmant un LH classique de stade IV à présentation primitivement médullaire. Une prise en charge rapide associant traitement du syndrome inflammatoire et chimiothérapie incluant le brentuximab vedotin a permis l’obtention d’une rémission complète. Ce cas souligne la nécessité d’envisager une hémopathie lymphoïde, notamment un LH, devant tout syndrome d’activation macrophagique inexpliqué, même en l’absence d’atteinte ganglionnaire.</div></div><div><h3>Abstract</h3><div>Classical Hodgkin lymphoma (HL) rarely presents with isolated bone marrow involvement in the absence of lymphadenopathy. We report the case of a 20-yearold man admitted for prolonged fever and general deterioration, in whom laboratory evaluation revealed severe pancytopenia associated with a macrophage activation syndrome. Bone marrow examination identified Reed-Sternberg/Hodgkin cells, confirming a stage IV classical HL with a primarily medullary presentation. Prompt management combining treatment of the inflammatory syndrome and chemotherapy including brentuximab vedotin led to complete remission. This case highlights the importance of considering a lymphoid malignancy, particularly HL, in any unexplained macrophage activation syndrome, even in the absence of lymph node involvement.</div></div>","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2026 584","pages":"Pages 56-59"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148660968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L’artéméther-luméfantrine,: un nouveau traitement qui sauvera des nourrissons","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(26)76708-3","DOIUrl":"10.1016/S1773-035X(26)76708-3","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2026 584","pages":"Page 11"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148661251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Le cadmium sous double surveillance","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(26)76699-5","DOIUrl":"10.1016/S1773-035X(26)76699-5","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2026 584","pages":"Page 5"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148661255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}