Revue francophone des laboratoires : RFL最新文献

{"title":"Défaillance multiviscérale chez une patiente HbS/C","authors":"Estelle Fleuriot , Audrey Wolf , Sébastien Le Burel , Laura Medina , Aurore Bousquet","doi":"10.1016/S1773-035X(25)76412-6","DOIUrl":"10.1016/S1773-035X(25)76412-6","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 573","pages":"Pages 77-78"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144514320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Varicelle et zona : des experts OMS de bon conseil","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(25)76384-4","DOIUrl":"10.1016/S1773-035X(25)76384-4","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 573","pages":"Page 5"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144514403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"La TICM : une affaire de fer","authors":"Camille Bougeard ,&nbsp;Stéphanie Mathis ,&nbsp;Clémentine Chauvel ,&nbsp;Pierre Lemaire ,&nbsp;Valérie Bardet","doi":"10.1016/S1773-035X(25)76411-4","DOIUrl":"10.1016/S1773-035X(25)76411-4","url":null,"abstract":"<div><h3>Résumé</h3><div>Les carences martiales sont connues pour induire une anémie microcytaire fréquemment associée à une thrombocytose réactionnelle, légère à modérée. À l’inverse, les thrombopénies sont rarement observées dans ce contexte. Lors de l’association d’une thrombopénie à une carence martiale, une étiologie supplémentaire est souvent recherchée, un purpura thrombopénique immunologique (PTI) étant parfois évoqué à tort. Le cas suivant s’intéresse à une jeune femme de 16 ans présentant une thrombopénie induite par la carence martiale (TICM).</div></div><div><h3>Abstract</h3><div>Iron deficiencies are known to induce mild to moderate reactive thrombocytosis. At contrary, thrombocytopenias are rare. When thrombocytopenia is associated with iron deficiency, an additional etiology is often sought, and immune thrombocytopenia is sometimes misdiagnosed. The following case focuses on a 16-year-old young woman presenting with iron deficiency-induced thrombocytopenia (IDIT).</div></div>","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 573","pages":"Pages 72-76"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144514319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"La tularémie : une zoonose réémergente due à la bactérie Francisella tularensis","authors":"M.a.x. Maurin","doi":"10.1016/S1773-035X(25)76409-6","DOIUrl":"10.1016/S1773-035X(25)76409-6","url":null,"abstract":"<div><h3>Résumé</h3><div>La tularémie est une zoonose causée par <em>Francisella tularensis</em>, bactérie hautement virulente et agent potentiel de la menace biologique. Ce pathogène possède un réservoir animal sauvage étendu et environnemental. Les tiques Ixodidae, et les moustiques dans certains pays, servent de vecteurs. Les infections humaines surviennent lors d’un contact direct avec des animaux infectés, de la consommation d’aliments ou d’eau contaminés, d’une inoculation par arthropodes, de l’inhalation d’un aérosol ou d’un contact avec un environnement contaminés. L’incubation est généralement courte et les symptômes initiaux évoquent un syndrome pseudogrippal. La maladie peut évoluer vers six formes cliniques classiques, régionales (ulcéro-ganglionnaire, ganglionnaire, oculo-ganglionnaire et oropharyngée) ou systémiques (pulmonaire et typhoïdique). De nombreuses complications régionales ou systémiques peuvent survenir. Le diagnostic clinique est souvent tardif en raison de la rareté de la maladie et de la nature non spécifique des symptômes. Le diagnostic spécifique repose sur la sérologie et la détection de <em>F. tularensis</em> par culture ou PCR. Les antibiotiques efficaces sont la gentamicine, la doxycycline et les fluoroquinolones, parfois associés à la chirurgie. Aucun vaccin n’est disponible actuellement mais des mesures prophylactiques individuelles sont recommandées en cas d’exposition professionnelle ou récréative.</div></div><div><h3>Abstract</h3><div>Tularemia is a zoonosis caused by <em>Francisella tularensis</em>, a highly virulent bacterium and a potential biological threat agent. This pathogen has a broad wild animal and environmental reservoir. Ixodidae ticks and mosquitoes in some countries serve as vectors. Human infections occur through direct contact with infected animals, consumption of contaminated food or water, inoculation by arthropods, inhalation of an aerosol, or contact with contaminated environments. The incubation period is generally short, and the initial symptoms resemble a flu-like syndrome. The disease can progress to six classic clinical forms: regional (ulceroglandular, glandular, oculoglandular, and oropharyngeal) or systemic (pulmonary and typhoidal). Numerous regional or systemic complications can occur. Clinical diagnosis is often delayed due to the rarity of the disease and the non-specific nature of the symptoms. Specific diagnosis relies on serology and the detection of <em>F. tularensis</em> by culture or PCR. Effective antibiotics include gentamicin, doxycycline, and fluoroquinolones, sometimes in conjunction with surgery. No vaccine is currently available, but individual prophylactic measures are recommended in cases of occupational or recreational exposure.</div></div>","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 573","pages":"Pages 60-68"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144514324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Région Europe de ľOMS : record de cas de rougeole depuis plus de 25 ans !","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(25)76389-3","DOIUrl":"10.1016/S1773-035X(25)76389-3","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 573","pages":"Pages 8-9"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144514408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pénurie de médicaments : ľenjeu crucial de la souveraineté française","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(25)76399-6","DOIUrl":"10.1016/S1773-035X(25)76399-6","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 573","pages":"Pages 14-15"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144513592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L’anaplasmose granulocytaire humaine","authors":"Éric Garnotel ,&nbsp;Hélène Astier","doi":"10.1016/S1773-035X(25)76408-4","DOIUrl":"10.1016/S1773-035X(25)76408-4","url":null,"abstract":"<div><h3>Résumé</h3><div>L’anaplasmose granulocytaire humaine est une infection rare mais probablement sous-estimée due à <em>Anaplasma phagocytophilum.</em> Elle est transmise par des tiques dures, notamment <em>Ixodides ricinus</em> en Europe. Bactérie strictement intracellulaire, elle présente un tropisme pour les polynucléaires neutrophiles. C’est une zoonose de répartition mondiale. Le taux d’infection des tiques mais aussi des animaux réservoirs de cet agent pathogène est important. L’infection de l’humain survient lors d’activités à risque de piqûres de tiques. Elle est le plus souvent asymptomatique. Les signes cliniques sont peu spécifiques : fièvre et arthromyalgie, troubles digestifs. Les complications sont rares : atteinte rénale, neurologique, pulmonaire mais parfois défaillance multiviscérale. Le diagnostic repose sur la PCR et la sérologie par immunofluorescence indirecte sur une paire de sérums. Le traitement repose, comme pour la plupart des infections transmises par les tiques, sur la doxycycline, une alternative étant la rifampicine.</div></div><div><h3>Abstract</h3><div>Human granulocytotropic anaplasmosis is a rare but probably underestimated infection due to <em>Anaplasma phagocytophilum</em> and transmitted by hard ticks, including <em>Ixodides ricinus</em> in Europe. Bacteria strictly intracellular, it has a tropism for neutrophil polynuclear. It is a zoonosis of worldwide distribution. The rate of infection of ticks but also of animals reservoirs of this pathogen is important. Human infection occurs during activities that are at risk of tick bites. The infection is most often asymptomatic. Clinical signs are not specific: fever and arthromyalgia, digestive disorders. Complications are rare: renal, neurological, pulmonary but sometimes multi-organ failure. Diagnosis is based on PCR and indirect immunofluorescence serology on a pair of sera. As with most tick-borne infections, the treatment is doxycycline, with an alternative being rifampicin.</div></div>","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 573","pages":"Pages 50-59"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144514323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment l’aspirine stopperait l’extension du cancer","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(25)76388-1","DOIUrl":"10.1016/S1773-035X(25)76388-1","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 573","pages":"Page 8"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144514407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Le lymphome T hépatosplénique : de la cytologie au profil moléculaire","authors":"Anne Desmares ,&nbsp;Cedric Pastoret","doi":"10.1016/S1773-035X(25)76379-0","DOIUrl":"10.1016/S1773-035X(25)76379-0","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Résumé&lt;/h3&gt;&lt;div&gt;Le lymphome T hépatosplénique (HSTCL pour &lt;em&gt;Hepatosplenic T-cell Lymphoma&lt;/em&gt;) est une forme rare et agressive de lymphome résultant de la prolifération de cellules lymphoïdes T gamma-delta infiltrant les sinusoïdes du foie, de la rate et de la moelle osseuse. Le diagnostic de HSTCL est histologique, mais reste complexe en raison de sa rareté et de sa localisation extranodale. Notre étude rétrospective s’appuie sur une cohorte nationale de 24 cas de HSTCL histologiquement confirmés, recueillis via un appel à cas au sein du Groupe francophone d’hématologie cellulaire (GFHC), et comparés à seize cas de leucémies à LGL-Τγδ (LGLL-Τγδ), diagnostic différentiel principal du HSTCL. Une morphologie spécifique en “coquille d’huître” a été identifiée dans les échantillons sanguins et médullaires de HSTCL, offrant un critère diagnostique distinctif. d’un point de vue immunophénotypique, le HSTCL se caractérise souvent par un profil CD4- CD8-, par la négativité du CD5 et l’expression quasi constante du CD56 en l’absence de CD57. Le séquençage des gènes du TCR met en évidence une prédominance des réarrangements TRDV1-JD1 chez les patients HSTCL, tandis que les segments impliquant TRDV2 et TRGV9 sont plus fréquents dans les cas de LGLL Tγδ et le groupe témoin. Enfin, les mutations du gène &lt;em&gt;STAT5B&lt;/em&gt; sont fréquentes dans le HSTCL, contrastant avec les mutations de &lt;em&gt;STAT3&lt;/em&gt; majoritairement observées dans les LGLL. Ainsi, la combinaison des analyses cytologiques, phénotypiques et moléculaires à partir des ponctions de moelle osseuse permet une identification efficace des patients atteints de HSTCL, tout en évitant les prélèvements plus invasifs à visée histologique tels que la splénectomie ou la biopsie hépatique.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Abstract&lt;/h3&gt;&lt;div&gt;Hepatosplenic T-cell Lymphoma (HSTCL) is a rare and aggressive subtype of lymphoma resulting from the proliferation of gamma-delta T lymphoid cells infiltrating the sinusoids of the liver, spleen, and bone marrow. The diagnosis of HSTCL is histological but remains challenging due to its extra-nodal localization. Our retrospective study is based on a national cohort of 24 histologically confirmed cases of HSTCL, collected through a case call within the Groupe Francophone d’Hématologie Cellulaire (GFHC), and compared to 16 cases of gamma-delta T-cell LGLL, the main differential diagnosis of HSTCL. A specific “oyster shell” morphology was identified in the blood and bone marrow samples of HSTCL, providing a distinctive diagnostic criterion. From an immunophenotypic perspective, HSTCL is often characterized by a CD4- CD8- profile, CD5 negativity, and almost constant CD56 expression in the absence of CD57. T-cell receptor (TCR) gene sequencing reveals a predominance of TRDV1 -DJ1 rearrangements in HSTCL patients, while segments involving TRDV2 and TRGV9 are more frequently observed in LGLL Tγδ cases and the control group. Finally, &lt;em&gt;STAT5B&lt;/em&gt; gene mutations are frequently identi","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 572","pages":"Pages 62-70"},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"La santé auditive, un enjeu sous-estimé de santé publique","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(25)76369-8","DOIUrl":"10.1016/S1773-035X(25)76369-8","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 572","pages":"Page 14"},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}