{"title":"Dispositions relatives aux donneurs de sang porteurs d’hémochromatose génétique","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(25)76430-8","DOIUrl":"10.1016/S1773-035X(25)76430-8","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 574","pages":"Page 11"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maxime Dubois , Nathan de Morais , Julien Bonnac , Mylène de Saint Jore , Yannick Chantran , Julien Goret , pour le réseau AllergoBioNet
{"title":"L’intelligence artificielle, le Machine Learning et les modèles de langage au service de l’interprétation des bilans d’allergologie","authors":"Maxime Dubois , Nathan de Morais , Julien Bonnac , Mylène de Saint Jore , Yannick Chantran , Julien Goret , pour le réseau AllergoBioNet","doi":"10.1016/S1773-035X(25)76441-2","DOIUrl":"10.1016/S1773-035X(25)76441-2","url":null,"abstract":"<div><h3>Résumé</h3><div>L’étude et les applications de l’intelligence artificielle (IA) en santé se sont rapidement développées au cours de la dernière décennie. L’allergologie est un domaine marqué par l’hétérogénéité des pathologies et le rôle majeur de biomarqueurs immunologiques tels que les IgE spécifiques pour établir le diagnostic. Leur nombre, leurs relations entre eux et leur interprétation nécessitent des outils capables de traiter des données volumineuses. L’IA, notamment par le biais du <em>Machine Learning,</em> du <em>Deep Learning</em> et du traitement du langage naturel, facilite l’analyse de ces données. Les allergies ayant une prévalence élevée (30 % de la population en 2025 et 50 % en 2050), l’IA offre des opportunités majeures pour améliorer et personnaliser le diagnostic biologique des allergies. Ces technologies peuvent accompagner les biologistes dans l’interprétation des résultats, prédire la sévérité de la maladie, la survenue de crises ou la réussite des tests de provocation orale ou de l’immunothérapie. Cette revue de littérature expose les propositions actuelles sur l’IA au service de l’interprétation des bilans d’allergologie.</div></div><div><h3>Abstract</h3><div>The study and application of artificial intelligence (AI) in healthcare has developed rapidly over the last decade. Allergology is a field characterized by the heterogeneity of pathologies and the major role played by immunological biomarkers, such as specific IgE antibodies, in establishing a diagnosis. The number of biomarkers, their interrelationships and their interpretation require tools capable of processing large volumes of data. AI, particularly through Machine Learning, Deep Learning and natural language processing, facilitates the analysis of these data. Given the high prevalence of allergies (30% of the population in 2025 and 50% in 2050), AI offers great opportunities to improve and personalize the in vitro diagnosis of allergies.These technologies can assist immunologists in interpreting results, predicting disease severity, the occurrence of attacks or the success of oral challenge or immunotherapy. This review outlines the current issues and proposals regarding AI for the interpretation of allergology results.</div></div>","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 574","pages":"Pages 59-64"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Un hommage national en mémoire des victimes ?","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(25)76433-3","DOIUrl":"10.1016/S1773-035X(25)76433-3","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 574","pages":"Page 13"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Benjamin Bonnet , Mylène De Saint Jore , Brigitte Le Mauff , Julien Serrier
{"title":"État des lieux des approches fonctionnelles in vitro pour l’analyse des réactions d’hypersensibilité de type I et IV","authors":"Benjamin Bonnet , Mylène De Saint Jore , Brigitte Le Mauff , Julien Serrier","doi":"10.1016/S1773-035X(25)76439-4","DOIUrl":"10.1016/S1773-035X(25)76439-4","url":null,"abstract":"<div><h3>Résumé</h3><div>Les tests cellulaires permettent une évaluation fonctionnelle des mécanismes immunologiques impliqués chez les patients présentant des hypersensibilités de type I (immédiates) et IV (retardées). Le test d’activation des basophiles (TAB) présente une spécificité élevée, utile lorsque les tests cutanés ou IgE spécifiques sont insuffisants et dans les cas discordants. Il réduit le recours au test de provocation orale dans les allergies alimentaires et médicamenteuses, et permet le suivi de l’immunothérapie spécifique. Le test d’activation des mastocytes (TAM), nécessitant une différenciation in vitro de mastocytes à partir de PBMC, montre des performances complémentaires, notamment en allergie médicamenteuse. Les hypersensibilités retardées sont explorées par des tests basés sur la prolifération ou l’activation lymphocytaire (TTL, TAL, ELISpot, cyto-LTT), en particulier dans les toxidermies sévères. L’absence de standardisation, le coût et la complexité technique de ces tests limitent leur diffusion. Cette revue de la littérature présente les performances diagnostiques, les indications validées ainsi que les avantages et limites de chaque approche.</div></div><div><h3>Abstract</h3><div>Cellular assays offer a functional assessment of immune mechanisms in patients suspected of type I (immediate) and type IV (delayed) hypersensitivity reactions. The Basophil Activation Test (BAT), based on flow cytometry, quantifies surface markers (CD63, CD203c) expression after allergen stimulation. With high specificity, BAT is useful when conventional tests (skin tests, specific IgE) are inconclusive, and it reduces the need for allergen challenge, particularly in food and drug allergies. BAT also supports monitoring of allergen-specific immunotherapy. The Mast Cell Activation Test (MAT), using patient serum-sensitized mast-cells, provides complementary data, especially in drug allergy. Delayed hypersensitivity is assessed by lymphocyte-based assays (LTT, LAT, ELISpot, cyto-LTT), particularly in severe cutaneous drug reactions. Limitations include lack of standardization, technical complexity, and limited accessibility. This literature review summarizes diagnostic performances, validated clinical indications, and the advantages and limitations of each testing strategy.</div></div>","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 574","pages":"Pages 39-47"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Les États membres de l’OMS avancent sur l’accord mondial anti-pandémie","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(25)76423-0","DOIUrl":"10.1016/S1773-035X(25)76423-0","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 574","pages":"Pages 6-7"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"La vaccination zona réduirait le risque de démence","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(25)76420-5","DOIUrl":"10.1016/S1773-035X(25)76420-5","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 574","pages":"Page 5"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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