{"title":"Un diagnostic rapide pour une prise en charge appropriée","authors":"Bruno Baudin , Saïd Kamel","doi":"10.1016/S1773-035X(25)76464-3","DOIUrl":"10.1016/S1773-035X(25)76464-3","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 575","pages":"Page 21"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145242421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Déficit sévère en facteur XI chez un patient porteur d’un glioblastome : à propos d’un cas","authors":"Mariam Hachimi Idrissi , Driss Said , Oumaima Skalante , Khadija Essahli , Hafid Zahid","doi":"10.1016/S1773-035X(25)76471-0","DOIUrl":"10.1016/S1773-035X(25)76471-0","url":null,"abstract":"<div><h3>Résumé</h3><div>Le facteur XI, une glycoprotéine clé dans la coagulation, son déficit peut être d’origine congénitale ou acquise. Le déficit congénital, bien que rare, est plus fréquent dans la population juive ashkénaze, tandis que la forme acquise résulte de la présence d’auto-anticorps associés à diverses pathologies ou de mécanismes physiopathologiques difficilement identifiables.</div><div>Nous rapportons le cas d’un patient de 53 ans atteint d’un glioblastome temporal de stade IV, chez qui un déficit sévère en facteur XI (2 %) a été découvert fortuitement lors d’un bilan d’hémostase préopératoire, en raison d’un allongement isolé du TCA. L’épreuve de correction et l’absence d’anticoagulants circulants ont permis de confirmer ce déficit.</div><div>Le déficit en facteur XI présente une expression clinique variable, les manifestations hémorragiques étant parfois imprévisibles. Son diagnostic repose sur des tests d’hémostase, une épreuve de correction du TCA et un dosage des facteurs de coagulation.</div><div>Ce cas souligne l’importance d’un bilan préopératoire approfondi en présence d’un allongement isolé du TCA, permettant d’identifier les troubles rares de la coagulation et d’adapter la prise en charge pour prévenir les risques hémorragiques</div></div><div><h3>Abstract</h3><div>Factor XI, a key glycoprotein in coagulation, can present with either congenital or acquired deficiency. Congenital deficiency, though rare, is more common among Ashkenazi Jews, while the acquired form results from the presence of autoantibodies associated with various pathologies.</div><div>We report the case of a 53-year-old patient with stage IV temporal glioblastoma, in whom a severe factor XI deficiency (2 %) was incidentally discovered during a preoperative hemostasis workup due to an isolated prolongation of the activated partial thromboplastin time (aPTT). The correction test and the absence of circulating anticoagulants confirmed this deficiency.</div><div>Factor XI deficiency has variable clinical manifestations, with bleeding tendencies that can be unpredictable. Diagnosis relies on hemostasis tests, aPTT correction testing, and coagulation factor assays.</div><div>This case highlights the importance of a thorough preoperative evaluation in the presence of isolated aPTT prolongation, allowing for the identification of rare coagulation disorders and the adjustment of management strategies to prevent hemorrhagic risks.</div></div>","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 575","pages":"Pages 75-80"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145242454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ig anti-D : il faut corriger le risque de pénurie","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(25)76450-3","DOIUrl":"10.1016/S1773-035X(25)76450-3","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 575","pages":"Page 6"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145242411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Le nombre de pharmaciens augmente… enfin","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(25)76452-7","DOIUrl":"10.1016/S1773-035X(25)76452-7","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 575","pages":"Page 7"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145242413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Accueil de scientifiques états-uniens en France : une réponse à l'administration Trump ?","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(25)76458-8","DOIUrl":"10.1016/S1773-035X(25)76458-8","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 575","pages":"Page 10"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145242417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biologie d’urgence et organisation d’un laboratoire d’urgence","authors":"Bruno Baudin","doi":"10.1016/S1773-035X(25)76465-5","DOIUrl":"10.1016/S1773-035X(25)76465-5","url":null,"abstract":"<div><h3>Résumé</h3><div>L’urgence pour rendre un résultat d’un examen de biologie médicale peut être absolue (< 2 heures) ou relative (< 4 heures). Elle doit être assurée 24 heures sur 24 et 7 jours sur 7. Le laboratoire réalisant les examens urgents peut être détaché du laboratoire central ou en faire partie. Il est multidisciplinaire (biochimie, hématologie, microbiologie, pharmacologie/toxicologie), modulable (changement d’automates, nouveaux appareils) et relié au système informatique de laboratoire. Les examens sont réalisés par des techniciens de laboratoire, des internes en formation et parfois des biologistes prenant une garde, tous formés aux examens réalisés en urgence. Ces examens sont soit accrédités soit désignés comme représentatifs de la ligne de portée ; l’assurance qualité s’applique de la même manière au laboratoire d’urgence qu’au laboratoire central. Le laboratoire d’urgence et aussi responsable des examens de biologie médicale délocalisée (EBMD), qui prolifèrent actuellement dans les hôpitaux et en ville. En France, il existe une liste des examens pouvant être demandés en urgence qui n’est pas toujours facile à suivre et est évolutive en fonction des progrès de la recherche. Chaque laboratoire d’urgence doit définir la liste des examens réalisés, ceux qu’il doit prioriser, transmettre en urgence les résultats critiques, et définir les prélèvements précieux (difficiles à obtenir, en particulier en pédiatrie).</div></div><div><h3>Abstract</h3><div>The urgency to give a result of a medical biology examination can be absolute (< 2 hours) or relative (< 4 hours). It must be provided 24/7. The laboratory carrying out the urgent examinations may be detached from the central laboratory or be part of it. It is multidisciplinary (biochemistry, haematology, microbiology, pharmacology/ toxicology), modular (replacement of automatons, new equipment) and linked to the laboratory computer system. The examinations are carried out by laboratory technicians, interns in training and sometimes biologists on call, all trained in the examinations carried out in emergencies. These examinations are either accredited or designated as representative of the scope line; Quality assurance applies in the same way to the emergency laboratory as to the central laboratory. The emergency laboratory is also responsible for point-of-care (EBMD) examinations, which are currently proliferating in hospitals and in the city. In France, there is a list of examinations that can be requested in an emergency; This list is not always easy to follow and is evolving according to the progress of research. Each emergency laboratory must define the list of examinations performed, those it must prioritize, call critical results urgently, and define the valuable samples (difficult to obtain, especially in pediatrics).</div></div>","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 575","pages":"Pages 22-27"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145242400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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