Revue francophone des laboratoires : RFL最新文献

{"title":"Mise à jour sur la Physiopathologie de l’allergie IgE-dépendante","authors":"Bertrand Evrard ,&nbsp;Justine Cosme ,&nbsp;Marine Peyneau ,&nbsp;Clotilde Amiot","doi":"10.1016/S1773-035X(25)76438-2","DOIUrl":"10.1016/S1773-035X(25)76438-2","url":null,"abstract":"<div><h3>Résumé</h3><div>L’allergie IgE-dépendante, ou hypersensibilité de type I, est un vrai problème de société, en pleine expansion au niveau mondial. En 2050, les projections les plus citées considèrent que 50 % des enfants en seront atteints. Il s’agit d’un exemple typique de maladie multifactorielle dans laquelle un terrain génétique prédisposant, l’atopie, rencontre des modifications multiples de notre environnement liées au mode de vie occidental. Ceci induit un déséquilibre du microbiote intestinal, puis du compartiment des lymphocytes T régulateurs et in fine une réponse immunitaire de type 2 excessive, impliquant notamment les ILC2 et les lymphocytes Th2. Il en résultera la formation de plasmocytes sécrétant des IgE spécifiques de l’allergène, puis la sensibilisation des mastocytes et des polynucléaires basophiles. Dans un second temps, les polynucléaires éosinophiles seront recrutés à leur tour dans une réaction tardive complémentaire de type IVb. La compréhension des mécanismes physiopathologiques à l’origine de l’allergie a permis le développement de nouveaux biomarqueurs, ainsi que de nouvelles biothérapies, permettant désormais un phénotypage des patients et une prise en charge selon les principes de la médecine personnalisée.</div></div><div><h3>Abstract</h3><div>IgE-dependent allergy or type I hypersensitivity is a real societal problem, growing rapidly worldwide. By 2050, the most cited projections consider that 50 % of children will be affected. This is a typical example of a multifactorial disease in which a predisposing genetic background, atopy, encounters multiple changes in our environment linked to the Western lifestyle. This induces an imbalance of the intestinal microbiota, then of the regulatory T lymphocyte compartment and ultimately an excessive type 2 immune response, notably involving ILC2 and Th2 lymphocytes. This will result in the formation of plasma cells secreting allergen-specific IgE, then the sensitization of mast cells and basophils. In a second phase, eosinophils will be recruited in turn in a complementary late type IVb reaction. Understanding the pathophysiological mechanisms behind allergies is at the origin of the development of new bio-markers, as well as new biotherapies, now allowing patient phenotyping and management according to the principles of personalized medicine.</div></div>","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 574","pages":"Pages 26-38"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traitement pour maladie rare","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(25)76432-1","DOIUrl":"10.1016/S1773-035X(25)76432-1","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 574","pages":"Page 13"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Couverture vaccinale, bilan 2024 en France","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(25)76425-4","DOIUrl":"10.1016/S1773-035X(25)76425-4","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 574","pages":"Page 8"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"La santé des hommes après 40 ans","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(25)76427-8","DOIUrl":"10.1016/S1773-035X(25)76427-8","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 574","pages":"Page 10"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L’OMS lance un SOS sur les grossesses non désirées des adolescentes","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(25)76434-5","DOIUrl":"10.1016/S1773-035X(25)76434-5","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 574","pages":"Pages 14-15"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Les gants ne remplacent pas l’hygiène des mains !","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(25)76422-9","DOIUrl":"10.1016/S1773-035X(25)76422-9","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 574","pages":"Page 6"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Des vacuoles et des têtards","authors":"Zélie Mockelyn ,&nbsp;Marie-Adeline Migeon ,&nbsp;Pierre Lemaire ,&nbsp;Stéphanie Mathis ,&nbsp;Clémentine Chauvel ,&nbsp;Lou Soret ,&nbsp;Valérie Bardet","doi":"10.1016/S1773-035X(25)76445-X","DOIUrl":"10.1016/S1773-035X(25)76445-X","url":null,"abstract":"<div><h3>Résumé</h3><div>Un patient âgé de 85 ans, suivi pour un syndrome myélodysplasique (SMD), a présenté un tableau de pancytopénie associé à l’apparition concomitante d’une éruption cutanée. Les examens médullaires mettront en évidence une leucémie à cellules dendritiques plasmocytoïdes. Il s’agit d’une hémopathie rare associée à un pronostic sombre. Le diagnostic repose sur la cytométrie en flux et doit être évoqué devant un profil caractérisé par l’absence d’expression de marqueurs forts de lignées myéloïdes et lymphoïdes et par l’expression du CD4 et du CD56. Il est ensuite confirmé par l’expression de marqueurs spécifiques des cellules dendritiques plasmocytoïdes (CD123, CD303, CD304, TCL1, TCF4).</div></div><div><h3>Abstract</h3><div>An 85-year-old male patient, with a history of myelodysplastic syndrome (MDS), presented with pancytopenia accompanied by a rash. Bone marrow examination revealed blastic plasmacytoid dendritic cell neoplasm (BPDCN), a rare haematolo-gic malignancy associated with a poor prognosis. Immunophenotyping is mandatory to confirm the diagnosis. This condition should be considered in cases where the blast profile shows a lack of expression of specific markers of myeloid or lymphoid differentiation, combined with the expression of CD4 and CD56. The diagnosis is further confirmed by the presence of plasmacytoid dendritic cell lineage markers (CDI23, CD303, CD304,TCLI,TCF4).</div></div>","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 574","pages":"Pages 76-80"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Le Chikungunya dans l’Océan Indien","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(25)76435-7","DOIUrl":"10.1016/S1773-035X(25)76435-7","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 574","pages":"Page 15"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CDKL5, une nouvelle maladie rare classifiée","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(25)76424-2","DOIUrl":"10.1016/S1773-035X(25)76424-2","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 574","pages":"Page 7"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Des biomarqueurs musculaires pour un bilan précoce de gravité et d’évolution","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(25)76426-6","DOIUrl":"10.1016/S1773-035X(25)76426-6","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2025 574","pages":"Page 9"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}