{"title":"Complément d’enquête","authors":"Aurélien Bauduin, Caroline Poli, Charline Miot, Céline Beauvillain, Émeline Vinatier","doi":"10.1016/S1773-035X(26)76721-6","DOIUrl":"10.1016/S1773-035X(26)76721-6","url":null,"abstract":"<div><h3>Résumé</h3><div>Le déficit en C6 est une immunodéficience rare touchant la voie terminale du complément, particulièrement décrite dans les populations d’origine africaine/afro-américaine où une prévalence plus élevée a été rapportée. Ce déficit, de transmission autosomique récessive, compromet la formation du complexe d’attaque membranaire (CAM), exposant les patients à un risque accru d’infections sévères à <em>Neisseria meningitidis</em>. Le diagnostic repose sur une exploration biologique du complément et une analyse génétique. La prise en charge inclut des mesures préventives essentielles, telles que les vaccinations anti-méningococciques, une antibioprophylaxie prolongée dans certains cas, et un suivi régulier pour limiter le risque de complications infectieuses.</div></div><div><h3>Abstract</h3><div>Complement component C6 deficiency is a rare primary immunodeficiency affecting the terminal complement pathway. It has been reported more frequently in individuals of African or African American ancestry, in whom a higher prevalence has been observed. This autosomal recessive disorder disrupts the formation of the membrane attack complex (MAC), thereby increasing susceptibility to invasive infections caused by <em>Neisseria meningitidis</em>. Diagnosis is based on functional complement assays, followed by molecular genetic testing confirming the diagnosis. Clinical management primarily relies on preventive strategies, including meningococcal vaccination, longterm antibiotic prophylaxis in selected patients, and regular clinical follow-up to mitigate the risk of recurrent invasive infections.</div></div>","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2026 584","pages":"Pages 30-33"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148661234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicolas Martel, Chloé Dupont, Guilhem Conquet, Isabelle Pelloux, Max Maurin, Sylvain Godreuil, Chrislène Laurens
{"title":"Cas rapporté de tularémie pulmonaire humaine en France","authors":"Nicolas Martel, Chloé Dupont, Guilhem Conquet, Isabelle Pelloux, Max Maurin, Sylvain Godreuil, Chrislène Laurens","doi":"10.1016/S1773-035X(26)76725-3","DOIUrl":"10.1016/S1773-035X(26)76725-3","url":null,"abstract":"<div><h3>Résumé</h3><div>La tularémie est une zoonose potentiellement grave causée par <em>Francisella tularensis</em>. Bien que la tularémie pulmonaire soit rare, elle semble être une maladie réémergente à l’échelle mondiale. Nous rapportons ici un cas d’un patient atteint de tularémie pulmonaire, diagnostiquée fortuitement par culture en France. Les cliniciens devraient envisager ce diagnostic différentiel afin de réaliser des examens sérologiques ou moléculaires en présence de signes cliniques compatibles, et informer les laboratoires en cas d’une telle suspicion.</div></div><div><h3>Abstract</h3><div>Tularemia is a potentially severe zoonotic disease caused by Francisella tularensis. Although pulmonary tularemia is rare, it seems to be a re-emerging disease worldwide. We report the case of a patient with pulmonary tularemia fortuitously diagnosed by culture in France. Clinicians should consider this differential diagnosis to perform serological or molecular assays in front of compatible clinical signs, and to notify laboratories of such suspicion.</div></div>","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2026 584","pages":"Pages 46-49"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148661309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Steak, tique et tests : un syndrome alpha-gal débusqué","authors":"Élodie Potereau, Louise Guyot, Émeline Bruxelle, Caroline Poli, Martine Morisset, Céline Beauvillain","doi":"10.1016/S1773-035X(26)76722-8","DOIUrl":"10.1016/S1773-035X(26)76722-8","url":null,"abstract":"<div><h3>Résumé</h3><div>Le syndrome alpha-gal ou AGS (alpha-gal syndrome) est un syndrome d’hypersensibilité alimentaire et médicamenteux. Il s’agit d’une allergie au sucre galactose-alpha-1,3-galactose (alpha-gal), présent chez l’ensemble des mammifères non-primates. Cette allergie se manifeste par des anaphylaxies alimentaires différées, survenant deux à six heures après la consommation de viande de mammifères, mais également sous la forme d’anaphylaxie immédiate lors de l’utilisation de produits pharmaceutiques dérivés de mammifères. Le diagnostic repose, suite à l’interrogatoire clinique, sur des pricks-tests à la viande complétés par des dosages biologiques sériques et/ou tests d’activation des basophiles. La prise en charge inclut des mesures préventives essentielles telles que l’éviction de la consommation d’aliments contenant ce sucre.</div></div><div><h3>Abstract</h3><div>Alpha-Gal Syndrome (AGS) is a food and drug hypersensitivity disorder. Galactose-alpha-1,3-galactose (alpha-Gal), which is present in all non-primate mammals is the allergen responsible of this disorder. Exposure to mammalian meat can trigger delayed anaphylaxis, occurring two to six hours after ingestion, while mammal-derived pharmaceutical products may induce immediate anaphylactic reactions in sensitized individuals. Diagnosis is based on clinical history, meat prick-tests, complemented by serum IgE assays and/or basophil activation tests. Management primarily relies on preventive measures, including strict avoidance of foods and products containing this sugar</div></div>","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2026 584","pages":"Pages 34-37"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148660963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Médecine esthétique: quand de faux praticiens manipulent des produits professionnels","authors":"Jean-Marie Manus","doi":"10.1016/S1773-035X(26)76714-9","DOIUrl":"10.1016/S1773-035X(26)76714-9","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2026 584","pages":"Page 15"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148661229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Apprentissage par la pratique : l’intérêt des cas cliniques","authors":"Guillaume Desoubeaux","doi":"10.1016/S1773-035X(26)76720-4","DOIUrl":"10.1016/S1773-035X(26)76720-4","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2026 584","pages":"Page 29"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148661252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Uppercut viral : quand l’EBV monte sur le ring !","authors":"Lina Achour, Frédérique Moreau, Elyanne Gault, Claire Deback","doi":"10.1016/S1773-035X(26)76728-9","DOIUrl":"10.1016/S1773-035X(26)76728-9","url":null,"abstract":"<div><h3>Résumé</h3><div>La mononucléose infectieuse (MNI) est la présentation clinique de la primo-infection par le virus Epstein-Barr (EBV), un virus appartenant à la famille des <em>Herpesviridae</em>. Elle touche principalement les adolescents et les jeunes adultes et évolue le plus souvent de manière bénigne et spontanément résolutive, bien que des complications viscérales puissent survenir. Nous rapportons, chez un boxeur de 17 ans, un cas de MNI de présentation atypique, associée à une hépatite aiguë, laquelle a été diagnostiquée fortuitement lors de la prise en charge d’un traumatisme thoracoabdominal gauche avec atteinte splénique consécutif à des coups reçus pendant un combat d’arts martiaux mixtes (MMA).</div></div><div><h3>Abstract</h3><div>Infectious mononucleosis (IM) is the clinical manifestation of primary infection with the Epstein-Barr virus (EBV), a virus belonging to the <em>Herpesviridae</em> family. It mainly affects adolescents and young adults and most often follows a benign, self-limiting course, although visceral complications may occur. We report a case of atypical MNI in a 17-year-old boxer, associated with acute hepatitis, which was incidentally diagnosed during the management of a left thoracoabdominal trauma with splenic injury resulting from blows sustained during a mixed martial arts (MMA) match.</div></div>","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2026 584","pages":"Pages 60-64"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148661312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Apprentissage par la pratique : l’intérêt des cas cliniques","authors":"Guillaume Desoubeaux","doi":"10.1016/S1773-035X(26)76720-4","DOIUrl":"10.1016/S1773-035X(26)76720-4","url":null,"abstract":"","PeriodicalId":74728,"journal":{"name":"Revue francophone des laboratoires : RFL","volume":"2026 584","pages":"Page 29"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148657005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}