Radiologie (Heidelberg, Germany)最新文献_第6页

[Modern systemic treatment-bispecific antibodies and CAR-T cell therapy : Clinical management, mechanisms of action, outcomes]. [现代全身治疗-双特异性抗体和CAR-T细胞治疗：临床管理，作用机制，结果]。

Radiologie (Heidelberg, Germany) Pub Date : 2025-07-01 Epub Date: 2025-06-13 DOI: 10.1007/s00117-025-01472-8

Henriette Huber, Elke Leupolt, Lukas Kündgen, Martin Bentz

{"title":"[Modern systemic treatment-bispecific antibodies and CAR-T cell therapy : Clinical management, mechanisms of action, outcomes].","authors":"Henriette Huber, Elke Leupolt, Lukas Kündgen, Martin Bentz","doi":"10.1007/s00117-025-01472-8","DOIUrl":"10.1007/s00117-025-01472-8","url":null,"abstract":"Background: Despite chemoimmunotherapy and autologous stem cell transplants, 30-40% of all patients with aggressive B‑cell non-Hodgkin lymphoma relapse.Objective: The use of targeted therapies is necessary to optimize the survival of these patients.Results: Chimeric antigen receptor (CAR) T‑cell therapies directed against CD19 are increasingly changing the therapeutic landscape for patients with diffuse large B‑cell lymphoma (DLBCL) and other B‑cell non-Hodgkin lymphomas. Follow-up data show that 30-40% of patients with relapsed or refractory aggressive lymphomas remain disease-free and can be cured in the long term after CAR-T cell therapy. Increasingly improved management of side effects, e.g., cytokine release syndrome (CRS) and neurotoxicity (immune effector cell-associated neurotoxicity syndrome, ICANS), by trained teams improves treatment safety. Bispecific antibodies are also targeted therapies that bind and activate CD3 effector T‑cells and assemble them into B‑cell antigens in the sense of an immunological synapse, resulting in cell-dependent cytotoxicity. Some of these drugs are also approved for aggressive and some for indolent B‑cell non-Hodgkin lymphoma; they are available off the shelf and can also be used in particular for older and less fit patients.Conclusion: Both treatment options have significantly improved the prognosis of patients with lymphoma and generally have lower toxicities.","PeriodicalId":74635,"journal":{"name":"Radiologie (Heidelberg, Germany)","volume":" ","pages":"490-499"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Radiotherapy of non-Hodgkin lymphoma-discussion of modern treatment concepts and innovations]. 【非霍奇金淋巴瘤的放疗——现代治疗理念与创新探讨】。

Radiologie (Heidelberg, Germany) Pub Date : 2025-07-01 DOI: 10.1007/s00117-025-01477-3

Michael Oertel, Hans Theodor Eich

{"title":"[Radiotherapy of non-Hodgkin lymphoma-discussion of modern treatment concepts and innovations].","authors":"Michael Oertel, Hans Theodor Eich","doi":"10.1007/s00117-025-01477-3","DOIUrl":"10.1007/s00117-025-01477-3","url":null,"abstract":"Background: Radiotherapy is an established treatment modality for malignant non-Hodgkin lymphoma. However, the complexity of the treatment situations demands precise treatment indication and execution. The following review presents modern radiooncological treatment strategies.Materials and methods: A selective literature search addressing radiotherapy of malignant non-Hodgkin lymphoma was conducted, focusing on diffuse large B‑cell lymphoma, marginal zone lymphoma, and follicular lymphoma. Relevant studies as well as the German national S3 guidelines were identified and discussed.Results: Indolent lymphoma in early stages can be treated with radiotherapy in curative intent. In carefully selected cases, dose de-escalation may be possible, although it is not recommended by the German S3 guideline. In the case of aggressive non-Hodgkin lymphoma, consolidation radiotherapy is conducted after systemic therapy, addressing regions with an increased risk of recurrence. Particularly patients with positron-emission tomography (PET)-positive residuals should be irradiated. Innovations like the application of radiotherapy before or after chimeric antigen receptor T‑cell therapy and the emerging implementation of online adaptive radiotherapy will enrich the therapeutic landscape in the future.","PeriodicalId":74635,"journal":{"name":"Radiologie (Heidelberg, Germany)","volume":" ","pages":"518-524"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of deep learning reconstruction in accelerated knee MRI: comparison of visual and diagnostic performance metrics. 加速膝关节MRI中深度学习重建的评估：视觉和诊断性能指标的比较。

Radiologie (Heidelberg, Germany) Pub Date : 2025-06-23 DOI: 10.1007/s00117-025-01464-8

Shenglian Wen, Yifan Xu, Guangxin Yang, Fuling Huang, Zisan Zeng

{"title":"Evaluation of deep learning reconstruction in accelerated knee MRI: comparison of visual and diagnostic performance metrics.","authors":"Shenglian Wen, Yifan Xu, Guangxin Yang, Fuling Huang, Zisan Zeng","doi":"10.1007/s00117-025-01464-8","DOIUrl":"https://doi.org/10.1007/s00117-025-01464-8","url":null,"abstract":"Objective: To investigate the clinical value of deep learning reconstruction (DLR) in accelerated magnetic resonance imaging (MRI) of the knee and compare its visual quality and diagnostic performance metrics with conventional fast spin-echo T2-weighted imaging with fat suppression (FSE-T2WI-FS).Methods: This prospective study included 116 patients with knee injuries. All patients underwent both conventional FSE-T2WI-FS and DLR-accelerated FSE-T2WI-FS scans on a 1.5‑T MRI scanner. Two radiologists independently evaluated overall image quality, artifacts, and image sharpness using a 5-point Likert scale. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of lesion regions were measured. Subjective scores were compared using the Wilcoxon signed-rank test, SNR/CNR differences were analyzed via paired t tests, and inter-reader agreement was assessed using Cohen's kappa.Results: The accelerated sequences with DLR achieved a 36 % reduction in total scan time compared to conventional sequences (p < 0.05), shortening acquisition from 9 min 50 s to 6 min 15 s. Moreover, DLR demonstrated superior artifact suppression and enhanced quantitative image quality, with significantly higher SNR and CNR (p < 0.001). Despite these improvements, diagnostic equivalence was maintained: No significant differences were observed in overall image quality, sharpness (p > 0.05), or lesion detection rates. Inter-reader agreement was good (κ> 0.75), further validating the clinical reliability of the DLR technique.Conclusion: Using DLR-accelerated FSE-T2WI-FS reduces scan time, suppresses artifacts, and improves quantitative image quality while maintaining diagnostic accuracy comparable to conventional sequences. This technology holds promise for optimizing clinical workflows in MRI of the knee.","PeriodicalId":74635,"journal":{"name":"Radiologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Hypersensitivity pneumonitis : S2K guideline from a radiological perspective]. [超敏性肺炎：从放射学角度看S2K指南]。

Radiologie (Heidelberg, Germany) Pub Date : 2025-06-17 DOI: 10.1007/s00117-025-01461-x

Okka W Hamer, Dirk Koschel, Beate Rehbock

引用次数: 0

[Prof. Dr. Gerhard van Kaick on his 90^th birthday]. [格哈德·范·凯克教授庆祝他90岁生日]。

Radiologie (Heidelberg, Germany) Pub Date : 2025-06-01 Epub Date: 2025-05-15 DOI: 10.1007/s00117-025-01460-y

G Layer, S Delorme, H-P Schlemmer, W Semmler

引用次数: 0

[Postsurgical follow-up and long-term monitoring of colorectal cancer : Radiology as a key component]. [结直肠癌术后随访与长期监测：放射学作为关键组成部分]。

Radiologie (Heidelberg, Germany) Pub Date : 2025-06-01 Epub Date: 2025-03-26 DOI: 10.1007/s00117-025-01435-z

K I Ringe, I Molwitz, A G Schreyer, J Wessling, L Grenacher, M S Juchems

{"title":"[Postsurgical follow-up and long-term monitoring of colorectal cancer : Radiology as a key component].","authors":"K I Ringe, I Molwitz, A G Schreyer, J Wessling, L Grenacher, M S Juchems","doi":"10.1007/s00117-025-01435-z","DOIUrl":"10.1007/s00117-025-01435-z","url":null,"abstract":"Clinical/methodological issue: Colorectal cancer is one of the most common malignant tumors worldwide. Postsurgical follow-up and long-term monitoring are essential to detect local recurrence, metastases, or secondary tumors at an early stage.Standard radiological methods: According to the current guideline on colorectal cancer, radiologic follow-up is primarily performed using a single computed tomography (CT) scan 3 months after completion of therapy. Annual chest X‑ray examinations within the first 5 years after completion of treatment can be employed, and, due to cost-effective availability, regular abdominal ultrasound is recommended.Methodological innovations: The German guideline on colorectal cancer is currently being revised. As the sensitivity of ultrasound is inferior to CT and magnetic resonance imaging (MRI), thoracoabdominal CT will probably become crucial in follow-up care with the revised guideline, which would align with international recommendations.Performance: CT is well suited for detecting local recurrence, as well as lung or liver metastases. MRI is used in assessing local cancer grades for treatment planning and monitoring. Structured reporting, stage- and guideline-based recommendations including follow-up intervals as well as interdisciplinary tumor conferences ensure high-quality follow-up care.Achievements: Radiology is essential to interdisciplinary follow-up care for colorectal cancer.Practical recommendations: Structured reporting and clear recommendations on follow-up intervals should be standard in radiological reports. The importance of radiological follow-up for patients with colorectal cancer is likely to increase further with the guideline that is currently being revised.","PeriodicalId":74635,"journal":{"name":"Radiologie (Heidelberg, Germany)","volume":" ","pages":"436-442"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Role of radiology for primary staging of colorectal cancer]. 【放射学在结直肠癌早期分期中的作用】。

Radiologie (Heidelberg, Germany) Pub Date : 2025-06-01 Epub Date: 2025-05-19 DOI: 10.1007/s00117-025-01458-6

Sophia Wirth, Nino Bogveradze, Katharina Lampichler

{"title":"[Role of radiology for primary staging of colorectal cancer].","authors":"Sophia Wirth, Nino Bogveradze, Katharina Lampichler","doi":"10.1007/s00117-025-01458-6","DOIUrl":"10.1007/s00117-025-01458-6","url":null,"abstract":"Background: Imaging, specifically magnetic resonance imaging (MRI), has long been the cornerstone for staging rectal cancer. In contrast, computed tomography (CT) is the standard for colon cancer staging. Primary staging is essential for individualized risk stratification and therapy planning.Objectives: To summarize current international guidelines on primary colorectal cancer staging, taking into account the advantages and disadvantages of different imaging methods.Materials and methods: Based on extensive literature research, the current state of knowledge in the staging of colorectal cancer is summarized.Results: TNM staging includes local tumor extension as well as the presence of lymph node and distant metastases. For local tumor extension, MRI is very well suited for rectal cancer. In colon cancer, CT shows significant limitations regarding the sensitivity of differentiating individual stages. Lymph node metastases can pose a major challenge for both MRI and CT, which has led to the definition of several malignancy criteria. The detection of distant metastases remains primarily within the domain of CT, except for liver metastases.Conclusions: Depending on tumor location, either MRI or CT is recommended for primary staging of colorectal cancer, and a combination of both modalities may also be appropriate. Accurate assessment of the primary tumor, lymph nodes, and organs using imaging is an essential component of the therapeutic approach to colorectal cancer.","PeriodicalId":74635,"journal":{"name":"Radiologie (Heidelberg, Germany)","volume":" ","pages":"426-435"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Early-onset colorectal cancer : When should we start with screening?] 早发性结直肠癌：我们应该何时开始筛查？］

Radiologie (Heidelberg, Germany) Pub Date : 2025-06-01 DOI: 10.1007/s00117-025-01453-x

Michael Hoffmeister, Hermann Brenner

引用次数: 0

[Chemotherapy, targeted therapy and immunotherapy of metastatic colorectal cancer : What is new?] 转移性结直肠癌的化疗、靶向治疗和免疫治疗：有什么新进展？］

Radiologie (Heidelberg, Germany) Pub Date : 2025-06-01 DOI: 10.1007/s00117-025-01455-9

Mirjam Richard, Christine Koch, Jörg Trojan

引用次数: 0

[Epiphyseal space-occupying lesion in childhood]. [儿童骨骺占位性病变]。

Radiologie (Heidelberg, Germany) Pub Date : 2025-06-01 Epub Date: 2025-03-10 DOI: 10.1007/s00117-025-01428-y

Laurenz Camp, Marco Saß, Anne-Sophie Becker, Marc-André Weber

引用次数: 0